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Evidence for glucose-6-phosphate transport in rat liver microsomes.

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Gerin, Isabelle Van Schaftingen, Emile [UCL]

The existence of glucose-6-phosphate transport across the liver microsomal membrane is still controversial. In this paper, we show that S3483, a chlorogenic acid derivative known to inhibit glucose-6-phosphatase in intact microsomes, caused the intravesicular accumulation of glucose-6-phosphate when the latter was produced by glucose-6-phosphatase from glucose and carbamoyl-phosphate. S3483 also inhibited the conversion of glucose-6-phosphate to 6-phosphogluconate occurring inside microsomes in the presence of electron acceptors (NADP or metyrapone). These data indicate that liver microsomal membranes contain a reversible glucose-6-phosphate transporter, which furnishes substrate not only to glucose-6-phosphatase, but also to hexose-6-phosphate dehydrogenase.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2002
Journal information "FEBS letters" - Vol. 517, no. 1-3, p. 257-60 (2002)
Peer reviewed yes
issn 0014-5793
Publication status Publié
Affiliation UCL - MD/BICL - Département de biochimie et de biologie cellulaire
MESH Subject Animals ; Biological Transport - drug effects - physiology ; Carbohydrate Dehydrogenases - antagonists & inhibitors - metabolism ; Cyclohexanecarboxylic Acids - pharmacology ; Enzyme Inhibitors - pharmacology ; Glucose-6-Phosphate - metabolism ; Membrane Transport Proteins - metabolism ; Microsomes, Liver - drug effects - metabolism ; Rats
Links
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Bibliographic reference Gerin, Isabelle ; Van Schaftingen, Emile. Evidence for glucose-6-phosphate transport in rat liver microsomes.. In: FEBS letters, Vol. 517, no. 1-3, p. 257-60 (2002)
Permanent URL http://hdl.handle.net/2078.1/21979