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Better outcome with haploidentical over HLA-matched related donors in patients with Hodgkin's lymphoma undergoing allogeneic haematopoietic cell transplantation-a study by the Francophone Society of Bone Marrow Transplantation and Cellular Therapy.

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Gauthier, Jordan Poire, Xavier [UCL] Gac, Anne-Claire Leclerc, Mathieu Guillaume, Thierry Yakoub-Agha, Ibrahim

The question of the best donor type between haploidentical (HAPLO) and matched-related donors (MRD) for patients with advanced HL receiving an allogeneic hematopoietic cell transplantation (allo-HCT) is still debated. Given the lack of data comparing these two types of donor in the setting of non-myeloablative (NMA) or reduced-intensity (RIC) allo-HCT, we performed a multicentre retrospective study using graft-vs.-host disease-free relapse-free survival (GRFS) as our primary endpoint. We analysed the data of 151 consecutive HL patients who underwent NMA or RIC allo-HCT from a HAPLO (N  =  61) or MRD (N  =  90) between January 2011 and January 2016. GRFS was defined as the probability of being alive without evidence of relapse, grade 3-4 acute GVHD or chronic GVHD. In multivariable analysis, MRD donors were independently associated with lower GRFS compared to HAPLO donors (HR  =  2.95, P   < 0.001). Disease status at transplant other than CR was also associated with lower GRFS in multivariable analysis (HR  =  1.74, P  =  0.01). In addition, the administration of ATG was independently linked to higher GRFS (HR  =  0.52, P  =  0.009). In summary, we observed significantly higher GRFS in HL patients receiving an allo-HCT using the HAPLO PT-Cy platform compared to MRD.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2018
Language Anglais
Journal information "Bone Marrow Transplantation" - Vol. 53, no.4, p. 400-409 (2018)
Peer reviewed yes
Publisher Nature Publishing Group ((United Kingdom) London)
issn 0268-3369
e-issn 1476-5365
Publication status Publié
Affiliations UCL - SSS/IREC/SLUC - Pôle St.-Luc
UCL - (SLuc) Service d'hématologie
MESH Subject Adolescent ; Adult ; Aged ; Child ; Disease-Free Survival ; Female ; Graft vs Host Disease ; Hematopoietic Stem Cell Transplantation ; Hodgkin Disease ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Tissue Donors ; Transplantation, Haploidentical ; Transplantation, Homologous ; Young Adult
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Bibliographic reference Gauthier, Jordan ; Poire, Xavier ; Gac, Anne-Claire ; Leclerc, Mathieu ; Guillaume, Thierry ; et. al. Better outcome with haploidentical over HLA-matched related donors in patients with Hodgkin's lymphoma undergoing allogeneic haematopoietic cell transplantation-a study by the Francophone Society of Bone Marrow Transplantation and Cellular Therapy.. In: Bone Marrow Transplantation, Vol. 53, no.4, p. 400-409 (2018)
Permanent URL http://hdl.handle.net/2078.1/219037