User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Further characterization of cardiodigin, Na+, K+-ATPase inhibitor extracted from mammalian tissues.

Primary tabs

Fagoo, M. Godfraind, Theophile [UCL]

This study was undertaken to characterize endogenous digitalis-like activity in water extract from mammalian tissues. Prepurified samples obtained from guinea-pig heart were analysed by reverse-phase HPLC using an acetonitrile gradient. The eluent was assayed for its activity as inhibitor of human heart Na+, K+-ATPase and digoxin-like immunoreactivity. Both activities were recovered in the same fraction after two successive chromatographic steps. These results provide further evidence for the presence of an endogenous digitalis-like factor, cardiodigin, in mammalian heart.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Publication date 1985
Journal information "FEBS letters" - Vol. 184, no. 1, p. 150-4 (1985)
Peer reviewed yes
issn 0014-5793
Publication status Publié
Affiliation UCL
MESH Subject Animals ; Biological Products - isolation & purification - pharmacology ; Cardiac Glycosides ; Chromatography, High Pressure Liquid ; Digoxin - analysis ; Guinea Pigs ; Myocardium - analysis ; Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors
Links
  1. Kramer Herbert J., Natriuretic hormone — A circulating inhibitor of sodium- and potassium-activated adenosine triphesphatase : Its potential role in body fluid and blood pressure regulation, 10.1007/bf01747753
  2. De Wardener H. E., THE NATRIURETIC HORMONE, 10.1113/expphysiol.1982.sp002651
  3. Castan̂eda-Hernandez G., Godfraind T., Effect of High Sodium Intake on Tissue Distribution of Endogenous Digitalis-Like Material in the Rat, 10.1042/cs0660225
  4. Godfraind, Arch. Int. Pharmacodyn. Ther., 258, 165 (1982)
  5. Godfraind T., Castañeda-Hernández G., Ghysel-Burton J., De Pover A., Hypothesis for the Mechanism of Stimulation of the Na/K Pump by Cardiac Glycosides—Role of Endogenous Digitalis-Like Factor, Current Topics in Membranes and Transport (1983) ISBN:9780121533199 p.913-915, 10.1016/s0070-2161(08)60650-4
  6. De Pover Alain, Endogenous digitalis-like factor and inotropic receptor sites in rat heart, 10.1016/0014-2999(84)90149-3
  7. DE WARDENER H. E., MACGREGOR G. A., The Relation of a Circulating Sodium Transport Inhibitor (the Natriuretic Hormone?) to Hypertension : , 10.1097/00005792-198309000-00004
  8. Buckalew V M, Gruber K A, Natriuretic Hormone, 10.1146/annurev.ph.46.030184.002015
  9. Haddy F. J., The Role of a Humoral Na+, K+-ATPase Inhibitor in Regulating Precapillary Vessel Tone : , 10.1097/00005344-198406002-00019
  10. De Pover Alain, Castañeda-Hernández Gilberto, Godfraind Théophile, Water versus acetone-HCl extraction of digitalis-like factor from guinea-pig heart, 10.1016/0006-2952(82)90224-6
  11. Godfraind Théophile, De Pover Alain, Verbeke Norbert, Influence of pH and sodium on the inhibition of guinie-pig heart (Na+ + K+)-ATPase by calcium, 10.1016/0005-2744(77)90152-8
  12. Bais Renze, A rapid and sensitive radiometric assay for adenosine triphosphatase activity using Cerenkov radiation, 10.1016/0003-2697(75)90215-8
  13. Plasma Digitalis-like Factor(s) Increase with Salt Loading, 10.1056/nejm198312083092316
  14. GRAVES STEVEN W., An Endogenous Digoxin-Like Substance in Patients with Renal Impairment, 10.7326/0003-4819-99-5-604
  15. Gruber Kenneth A., Whitaker Janice M., Buckalew Vardaman M., Endogenous digitalis-like substance in plasma of volume-expanded dogs, 10.1038/287743a0
  16. Crabos M., Wainer I.W., Cloix J.F., Measurement of endogenous Na+,K+-ATPase inhibitors in human plasma and urine using high-performance liquid chromatography, 10.1016/0014-5793(84)80946-1
  17. Kojima Itaru, Circulating digitalis-like substance is increased in doca-salt hypertension, 10.1016/0006-291x(84)90449-2
  18. Hicks Jocelyn M., Brett Elaine M., Falsely Increased Digoxin Concentrations in Samples from Neonates and Infants : , 10.1097/00007691-198412000-00015
  19. Klingmüller D., Weiler E., Kramer H. J., Digoxin-like natriuretic activity in the urine of salt loaded healthy subjects, 10.1007/bf01716732
  20. CHRISTIANSEN C., RØDBRO P., CHRISTENSEN MERETE S., HARTNACK BIRGITTE, IS 1,25-DIHYDROXY-CHOLECALCIFEROL HARMFUL TO RENAL FUNCTION IN PATIENTS WITH CHRONIC RENAL FAILURE?, 10.1111/j.1365-2265.1981.tb00659.x
  21. Hamlyn John M., Ringel Richard, Schaeffer Juergen, Levinson Paul D., Hamilton Bruce P., Kowarski A. Avinoam, Blaustein Mordecai P., A circulating inhibitor of (Na+ + K+) ATPase associated with essential hypertension, 10.1038/300650a0
  22. Capps, Pharmacy Int., 5, 12 (1984)
  23. Capps, Pharmacy Int., 5, 292 (1984)
  24. Soldin S.J., Papanastasiou-Diamandi A., Heyes J., Lingwood C., Olley P., Are immunoassays for digoxin reliable?, 10.1016/s0009-9120(84)90637-4
  25. Soldin S.J., Papanastasiou-Diamandi A., Heyes J., Lingwood C., Olley P., Are immunoassays for digoxin reliable?, 10.1016/s0009-9120(84)90637-4
  26. Vinge, N. Engl. J. Med., 310, 725 (1984)
  27. Whitmer Kyra R., Wallick Earl T., Epps Dennis E., Lane Lois K., Collins John H., Schwartz Arnold, Effects of extracts of rat brain on the digitalis receptor, 10.1016/0024-3205(82)90253-3
  28. Kracke, J. Lab. Clin. Rev., 101, 105 (1983)
Bibliographic reference Fagoo, M. ; Godfraind, Theophile. Further characterization of cardiodigin, Na+, K+-ATPase inhibitor extracted from mammalian tissues.. In: FEBS letters, Vol. 184, no. 1, p. 150-4 (1985)
Permanent URL http://hdl.handle.net/2078.1/21805