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Dystroglycan is a scaffold for extracellular axon guidance decisions.

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Lindenmaier, L Bailey Parmentier, Nicolas [UCL] Guo, Caiying Tissir, Fadel [UCL] Wright, Kevin M

Axon guidance requires interactions between extracellular signaling molecules and transmembrane receptors, but how appropriate context-dependent decisions are coordinated outside the cell remains unclear. Here we show that the transmembrane glycoprotein Dystroglycan interacts with a changing set of environmental cues that regulate the trajectories of extending axons throughout the mammalian brain and spinal cord. Dystroglycan operates primarily as an extracellular scaffold during axon guidance, as it functions non-cell autonomously and does not require signaling through its intracellular domain. We identify the transmembrane receptor Celsr3/Adgrc3 as a binding partner for Dystroglycan, and show that this interaction is critical for specific axon guidance events in vivo. These findings establish Dystroglycan as a multifunctional scaffold that coordinates extracellular matrix proteins, secreted cues, and transmembrane receptors to regulate axon guidance.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2019
Language Anglais
Journal information "eLife" - Vol. 8 (2019) (2019)
Peer reviewed yes
e-issn 2050-084X
Publication status Publié
Affiliation UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
Keywords axon guidance ; celsr3 ; commissural axon ; dystroglycan ; extracellular matrix ; internal capsule ; mouse ; neuroscience
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Bibliographic reference Lindenmaier, L Bailey ; Parmentier, Nicolas ; Guo, Caiying ; Tissir, Fadel ; Wright, Kevin M. Dystroglycan is a scaffold for extracellular axon guidance decisions.. In: eLife, Vol. 8 (2019) (2019)
Permanent URL http://hdl.handle.net/2078.1/217391