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Liver Regeneration: Different Sub-Populations of Parenchymal Cells at Play Choreographed by an Injury-Specific Microenvironment.

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Manco, Rita [UCL] Leclercq, Isabelle [UCL] Clerbaux, Laure-Alix [UCL]

Liver regeneration is crucial for the maintenance of liver functional mass during homeostasis and diseases. In a disease context-dependent manner, liver regeneration is contributed to by hepatocytes or progenitor cells. As long as they are replicatively competent, hepatocytes are the main cell type responsible for supporting liver size homeostasisand regeneration. The concept that all hepatocytes within the lobule have the same proliferative capacity but are differentially recruited according to the localization of the wound, or whether a yet to be defined sub-population of hepatocytes supports regeneration is still debated. In a chronically or severely injured liver, hepatocytes may enter a state of replicative senescence. In such conditions, small biliary cells activate and expand, a process called ductular reaction (DR). Work in the last few decades has demonstrated that DR cells can differentiate into hepatocytes and thereby contribute to parenchymal reconstitution. In this study we will review the molecular mechanisms supporting these two processes to determine potential targets that would be amenable for therapeutic manipulation to enhance liver regeneration.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès libre
Publication date 2018
Language Anglais
Journal information "International journal of molecular sciences" - Vol. 19, no. 12, p. 4115 [1-18] (2018)
Peer reviewed yes
Publisher MDPI AG ((Switzerland) Basel)
e-issn 1422-0067
Publication status Publié
Affiliations UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie
UCL - (SLuc) Service d'hépato-gastro-entérologie
MESH Subject Animals ; Cell Differentiation ; Cell Lineage ; Cellular Microenvironment ; Hepatocytes ; Humans ; Liver ; Liver Regeneration ; Parenchymal Tissue ; Stem Cells
Keywords Ductular reaction ; Hepatectomy ; Chronic liver injury ; Liver failure ; Hepatocytes ; Liver progenitor cells
Links
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Bibliographic reference Manco, Rita ; Leclercq, Isabelle ; Clerbaux, Laure-Alix. Liver Regeneration: Different Sub-Populations of Parenchymal Cells at Play Choreographed by an Injury-Specific Microenvironment.. In: International journal of molecular sciences, Vol. 19, no. 12, p. 4115 [1-18] (2018)
Permanent URL http://hdl.handle.net/2078.1/217388