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Circadian rhythms and metabolic syndrome: from experimental genetics to human disease.

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Maury, Eléonore [UCL] Ramsey, Kathryn Moynihan Bass, Joseph

The incidence of the metabolic syndrome represents a spectrum of disorders that continue to increase across the industrialized world. Both genetic and environmental factors contribute to metabolic syndrome and recent evidence has emerged to suggest that alterations in circadian systems and sleep participate in the pathogenesis of the disease. In this review, we highlight studies at the intersection of clinical medicine and experimental genetics that pinpoint how perturbations of the internal clock system, and sleep, constitute risk factors for disorders including obesity, diabetes mellitus, cardiovascular disease, thrombosis and even inflammation. An exciting aspect of the field has been the integration of behavioral and physiological approaches, and the emerging insight into both neural and peripheral tissues in disease pathogenesis. Consideration of the cell and molecular links between disorders of circadian rhythms and sleep with metabolic syndrome has begun to open new opportunities for mechanism-based therapeutics.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès libre
Publication date 2010
Language Anglais
Journal information "Circulation research" - Vol. 106, no.3, p. 447-462 (2010)
Peer reviewed yes
Publisher Lippincott Williams & Wilkins ((United States) Baltimore, MD)
issn 0009-7330
e-issn 1524-4571
Publication status Publié
Affiliation UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition
MESH Subject ARNTL Transcription Factors ; Adipose Tissue ; Adult ; Animals ; CLOCK Proteins ; Cardiovascular Diseases ; Circadian Rhythm ; Cytokines ; Dyssomnias ; Eating ; Energy Metabolism ; Feedback, Physiological ; Gene Expression Regulation ; Hormones ; Humans ; Incidence ; Inflammation ; Lighting ; Liver ; Metabolic Syndrome ; Mice ; Mice, Knockout ; Middle Aged ; Nicotinamide Phosphoribosyltransferase ; Sirtuin 1 ; Sleep Deprivation
Keywords Clock ; Circadian ; Metabolic syndrome
Links
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Bibliographic reference Maury, Eléonore ; Ramsey, Kathryn Moynihan ; Bass, Joseph. Circadian rhythms and metabolic syndrome: from experimental genetics to human disease.. In: Circulation research, Vol. 106, no.3, p. 447-462 (2010)
Permanent URL http://hdl.handle.net/2078.1/216734