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Circadian clocks and metabolism.

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Marcheva, Biliana Ramsey, Kathryn M Peek, Clara B Affinati, Alison Maury, Eléonore [UCL] Bass, Joseph

Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals, circadian integration of metabolic systems optimizes energy harvesting and utilization across the light/dark cycle. Disruption of clock genes has recently been linked to sleep disorders and to the development of cardiometabolic disease. Conversely, aberrant nutrient signaling affects circadian rhythms of behavior. This chapter reviews the emerging relationship between the molecular clock and metabolic systems and examines evidence that circadian disruption exerts deleterious consequences on human health.

Document type Contribution à ouvrage collectif (Book Chapter) – Chapitre
Access type Accès libre
Publication date 2013
Language Anglais
Host document Achim Kramer, Martha Merrow ; "Circadian Clocks"- p. 127-155 (ISBN : 978-3-642-25949-4)
Collection Handbook of Experimental Pharmacology - 217 (ISSN : 0171-2004)
Peer reviewed yes
Publisher Springer ((Germany) Berlin)
Publication status Publié
Affiliation UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition
MESH Subject Animals ; Circadian Clocks ; Circadian Rhythm ; Humans ; Light ; Mice ; NAD ; Phenotype ; Polymorphism, Genetic ; Receptors, Cytoplasmic and Nuclear ; Transcription, Genetic
Keywords Circadian clock ; Metabolism ; Energy homeostasis ; Metabolic disease ; Nutrient sensing
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Permanent URL http://hdl.handle.net/2078.1/216721