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Cardiac computed tomography in asymptomatic siblings of patients with premature coronary disease: illustrations and current knowledge.

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Higny, Julien [UCL] Dupont, Michaël [UCL] Guedes, Antoine [UCL]

A strong family history of early-onset coronary artery disease (CAD) may represent a substantial predictor of enhanced development of subclinical atherosclerosis in a sibling population. In this population, standard cardiovascular (CV) risk assessment could be underrated with the predictive capacity of the Framingham Risk Score. At present, cardiac computed tomography (CT) provides a high diagnostic performance for the detection of coronary atherosclerosis. Nevertheless, there is a paucity of data concerning the prognostic value of this technology in apparently healthy relatives of patients with premature coronary events. In addition, little is known about the prevalence of CAD in the siblings of patients with premature cardiac events. However, we are convinced that the reclassification of cardiac risk in middle-aged adults at familial risk is a fundamental issue in preventive cardiology. In this manuscript, we report cardiac CT findings in three subjects apparently free of CV disease from families with early-onset CAD. Afterwards, we provide a summary of the current knowledge and discuss the potential usefulness of this non-invasive imaging technique in susceptible individuals. Finally, we hope that this article will help to increase awareness for the management of middle-aged adults from high-risk families.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2020
Language Anglais
Journal information "Acta cardiologica" - Vol. 75, no. 2, p. 107-115 (2020)
Peer reviewed yes
Publisher Taylor & Francis ((United Kingdom) London)
issn 0001-5385
e-issn 1784-973X
Publication status Publié
Affiliations UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire
UCL - SSS/IREC/MONT - Pôle Mont Godinne
UCL - (MGD) Service de cardiologie
UCL - (MGD) Service de radiologie - résonance magnétique
Keywords Cardiac computed tomography ; cardiovascular risk assessment ; coronary artery disease ; early-onset
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Bibliographic reference Higny, Julien ; Dupont, Michaël ; Guedes, Antoine. Cardiac computed tomography in asymptomatic siblings of patients with premature coronary disease: illustrations and current knowledge.. In: Acta cardiologica, Vol. 75, no. 2, p. 107-115 (2020)
Permanent URL http://hdl.handle.net/2078.1/214011