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Natural and hemi-synthetic pentacyclic triterpenes as antimicrobials and resistance modifying agents against Staphylococcus aureus: a review

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Catteau, Lucy [UCL] Zhu, Li [UCL] Van Bambeke, Françoise [UCL] Quetin-Leclercq, Joëlle [UCL]

Staphylococcus aureus infections are considered as seriously problematic for human health and necessitate the development of new medicines and innovative antimicrobial strategies. Plant secondary metabolites have already demonstrated their potential as antibacterials when used alone but also in combination with other antimicrobial agents to potentiate their activity. Triterpenoids are widely distributed in the plant kingdom and known to have many beneficial effects, including anti-inflammatory, immunomodulatory, anti-proliferative, antimycotic, or antimicrobial activity. The aim of this paper is to review the activity of pentacyclic triterpenoids belonging to the ursane, oleanane, or lupane groups against Staphylococcus aureus. We summarize their activity as anti-staphylococcal compounds but also as resistance modifying agents when combined with common antibiotics.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2018
Language Anglais
Journal information "Phytochemistry Reviews" - Vol. 17, no. 5, p. 1129-1163 (2018)
Peer reviewed yes
Publisher Springer Netherlands ((Netherlands) Dordrecht)
issn 1568-7767
e-issn 1572-980X
Publication status Publié
Affiliation UCL - SSS/LDRI - Louvain Drug Research Institute
Keywords Ursane ; Oleanane ; Lupane ; MIC ; FICI ; Staphylococcus aureus ; Ursane ; Oleanane ; Lupane ; MIC ; FICI ; Staphylococcus aureus
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Permanent URL http://hdl.handle.net/2078.1/209775