User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Lpp, the Braun lipoprotein, turns 50-major achievements and remaining issues.

Primary tabs

download
  • Open access
  • PDF
  • 1.12 M
Asmar, Abir T [UCL] Collet, Jean-François [UCL]

The discovery of Escherichia coli Lpp as the first protein with three acyl groups covalently attached to its N-terminal cysteine residue defined a new class of bacterial proteins, the lipoproteins. Lipoproteins are extracytoplasmic, globular proteins that are anchored to a membrane by a lipid moiety. Being anchored to the outer membrane, Lpp, which is also known as the Braun lipoprotein, is small (5.8 kDa) and folds into a trimeric helical structure. It is also the numerically most abundant protein in E. coli. A unique feature of Lpp is that its C-terminal lysine residue is covalently attached to the peptidoglycan, providing the only covalent connection between the outer membrane and the cell wall. Here, we review the knowledge gained on Lpp since its discovery in 1969 until the recent finding that Lpp functions as a major size determinant in the bacterial cell envelope. We also discuss the role played by Lpp in virulence and highlight the major questions that remain to be solved.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2018
Language Anglais
Journal information "FEMS microbiology letters" - Vol. 365, no.18 (2018)
Peer reviewed yes
e-issn 1574-6968
Publication status Publié
Affiliation UCL - SSS/DDUV/BCHM - Biochimie-Recherche métabolique
Links
  1. Aliprantis, Biochim Biophys Acta, 285, 650 (1999)
  2. Asmar, PLoS Biol, 15, e2004303 (2017)
  3. Braun, Proc Natl Acad Sci USA, 69, 970 (1972)
  4. Braun, Eur J Biochem, 28, 51 (1972)
  5. Braun, Eur J Biochem, 10, 426 (1969)
  6. Braun, Biochemistry, 9, 5041 (1970)
  7. Braun, Eur J Biochem, 70, 601 (1976)
  8. Braun, J Bacteriol, 123, 888 (1975)
  9. Braun, New Comprehensive Biochemistry, 319 (1994)
  10. Cascales, J Bacteriol, 184, 754 (2002)
  11. Chen, Microb Biotechnol, 7, 360 (2014)
  12. Cho, Cell, 159, 1652 (2014)
  13. Choi, J Biol Chem, 261, 8953 (1986)
  14. Clark, Bacterial Pathogenesis, Part C: Identification, Regulation and Function of Virulence Factors (2002)
  15. Claus, J Cell Biol, 20, 217 (1964)
  16. Cohen, Science, 356, 197 (2017)
  17. Cowles, Mol Microbiol, 79, 1168 (2011)
  18. Depuydt, Science, 326, 1109 (2009)
  19. Depuydt, Antioxid Redox Signal, 15, 49 (2011)
  20. Diao, mBio, 8, e00603 (2017)
  21. Dragan, Biochemistry, 43, 14891 (2004)
  22. Egan, Mol Microbiol, 107, 676 (2018)
  23. Erova, Front Cell Infect Microbiol, 6, 676 (2016)
  24. Fadl, Gene, 374, 121 (2006)
  25. Finke, Infect Immun, 58, 2241 (1990)
  26. Gerding, Mol Microbiol, 63, 1008 (2007)
  27. Glauner, J Biol Chem, 263, 10088 (1988)
  28. Guo, Genes Dev, 28, 1620 (2014)
  29. Hancock, J Bacteriol, 145, 628 (1981)
  30. Hantke, Eur J Biochem, 34, 284 (1973)
  31. Hayashi, J Bioenerg Biomembr, 22, 451 (1990)
  32. Hiemstra, J Bacteriol, 169, 5434 (1987)
  33. Hirashima, Nature, 242, 405 (1973)
  34. Hirota, Proc Natl Acad Sci, 74, 1417 (1977)
  35. Hoekstra, Biochim Biophys Acta, 455, 889 (1976)
  36. Ingraham, Growth of the Bacterial Cell (1983)
  37. Inouye, Proc Natl Acad Sci USA, 71, 2396 (1974)
  38. Inouye, J Biol Chem, 247, 8154 (1972)
  39. Inouye, Proc Natl Acad Sci USA, 74, 1004 (1977)
  40. Jiménez-Dalmaroni, Autoimmun Rev, 15, 1 (2016)
  41. Kroger, Cell Host Microbe, 14, 683 (2013)
  42. Lakshmikanth, Sci Rep, 6, 34666 (2016)
  43. Lee, Biochim Biophys Acta, 465, 650 (1977)
  44. Leverrier, J Biol Chem, 286, 16734 (2011)
  45. Li, Cell, 157, 624 (2014)
  46. Lima, Science, 340, 837 (2013)
  47. Liu, J Mol Biol, 318, 877 (2002)
  48. Liu, Microb Pathog, 44, 224 (2008)
  49. Magnet, J Bacteriol, 189, 3927 (2007)
  50. Nakae, J Biol Chem, 251, 2176 (1976)
  51. Nakamura, Cell, 18, 1109 (1979)
  52. Nakamura, Proc Natl Acad Sci USA, 77, 1369 (1980)
  53. Neilsen, J Immunol, 167, 231 (2001)
  54. Ni, Biotechnol Bioeng, 97, 1347 (2007)
  55. Nichols, Cell, 144, 143 (2011)
  56. Pautsch, Nat Struct Mol Biol, 5, 1013 (1998)
  57. Rogov, J Biol Chem, 286, 18775 (2011)
  58. Sanders, Microbiology, 159, 1842 (2013)
  59. Schwechheimer, BMC Microbiol, 14, 324 (2014)
  60. Schwechheimer, Microbiologyopen, 4, 375 (2015)
  61. Sha, Infect Immun, 76, 1390 (2008)
  62. Sha, Infect Immun, 72, 3987 (2004)
  63. Shin, Biotechnol Bioeng, 101, 1288 (2008)
  64. Shrivastava, Mol Microbiol, 106, 395 (2017)
  65. Shu, J Mol Biol, 299, 1101 (2000)
  66. Silhavy, Cold Spring Harb Perspect Biol, 2, a000414 (2010)
  67. Suzuki, Mol Gen Genet, 167, 1 (1978)
  68. Szewczyk, Adv Microb Physiol, 69, 1 (2016)
  69. Uhlich, Infect Immun, 77, 1543 (2009)
  70. Ushijima, Jpn J Microbiol, 11, 275 (1967)
  71. Yamagata, J Biol Chem, 256, 2194 (1981)
  72. Yem, J Bacteriol, 133, 1419 (1978)
  73. Zaman, Front Immunol, 4, 318 (2013)
  74. Zhang, J Biol Chem, 267, 19560 (1992)
Bibliographic reference Asmar, Abir T ; Collet, Jean-François. Lpp, the Braun lipoprotein, turns 50-major achievements and remaining issues.. In: FEMS microbiology letters, Vol. 365, no.18 (2018)
Permanent URL http://hdl.handle.net/2078.1/209405