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Transancestral mapping and genetic load in systemic lupus erythematosus

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Vyse, Timothy J. Langefeld, Carl D. Ainsworth, Hannah C. Graham, Deborah S. Cunninghame Kelly, Jennifer A. Lauwerys, Bernard [UCL] Silverman, Earl D.

(eng) Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (∼50% of these regions have multiple independent associations); these include 24 novel SLE regions (P<5 × 10-8), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2017
Language Anglais
Journal information "Nature Communications" - Vol. 8, p. 16021 [1-18] (2017)
Peer reviewed yes
Publisher Nature Pub. Group ((United Kingdom) London)
e-issn 2041-1723
Publication status Publié
Affiliations UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales
UCL - (SLuc) Service de rhumatologie
Links
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Bibliographic reference Vyse, Timothy J. ; Langefeld, Carl D. ; Ainsworth, Hannah C. ; Graham, Deborah S. Cunninghame ; Kelly, Jennifer A. ; et. al. Transancestral mapping and genetic load in systemic lupus erythematosus. In: Nature Communications, Vol. 8, p. 16021 [1-18] (2017)
Permanent URL http://hdl.handle.net/2078.1/202946