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Antimalarial Terpenic Compounds Isolated from Plants Used in Traditional Medicine (2010–July 2016)

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Beaufay, Claire [UCL] Bero, Joanne [UCL] Quetin-Leclercq, Joëlle [UCL]

Malaria is an infectious tropical disease mainly affecting children and sub-Saharan Africa, being one of the major death causes with almost half of the world population at risk. Therefore and to face increasing parasite resistance to available treatments, there is an urgent need to discover new antimalarial drugs. Nature and mostly plants are a resourceful supplier of potential active metabolites, as shown by the successful example of the sesquiterpene lactone: artemisinin. Terpenoids are occurring widely in nature and display a lot of biological activities among which antiplasmodial effects. This review is a compilation of terpenic compounds isolated from plants with moderate (2 μ M < IC50 _ 11 μ M) to strong (IC50 _ 2 μ M) activity against different strains of Plasmodium published from 2010 to July 2016. Forty-seven references are identifi ed

Document type Contribution à ouvrage collectif (Book Chapter) – Chapitre
Access type Accès restreint
Publication date 2018
Language Anglais
Host document Jean-Michel Mérillon, Céline Riviere ; "Natural Antimicrobial Agents"- p. 247-268 (ISBN : 978-3-319-67043-0)
Collection Sustainable Development and Biodiversity - 19 (ISSN : 2352-474X)
Publisher Springer International Publishing AG ((Switzerland) Cham)
Publication status Publié
Affiliation UCL - SSS/LDRI - Louvain Drug Research Institute
Keywords Terpene ; Plant compounds ; Antiplasmodial activity ; Malaria ; Plasmodium falciparum
Links
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Bibliographic reference Beaufay, Claire ; Bero, Joanne ; Quetin-Leclercq, Joëlle. Antimalarial Terpenic Compounds Isolated from Plants Used in Traditional Medicine (2010–July 2016). In: Jean-Michel Mérillon, Céline Riviere, Natural Antimicrobial Agents, Springer International Publishing AG   : (Switzerland) Cham 2018, p. 247-268
Permanent URL http://hdl.handle.net/2078.1/199164