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The oral cavity microbiota: between health, oral disease, and cancers of the aerodigestive tract.

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Le Bars, Pierre Matamoros, Sébastien [UCL] Montassier, Emmanuel Le Vacon, Françoise Potel, Gilles de La Cochetière, Marie-France

Many studies show that the human microbiome plays a critical role in the chronic pathologies of obesity, inflammatory bowel diseases, and diabetes. More recently, the interaction between cancer and the microbiome has been highlighted. Most studies have focused on the gut microbiota because it represents the most extensive bacterial community, and the body of evidence correlating it with gut syndromes is increasing. However, in the strict sense, the gastrointestinal (GI) tract begins in the oral cavity, and special attention should be paid to the specific flora of this cavity. This study reviewed the current knowledge about the various microbial ecosystems of the upper part of the GI tract and discussed their potential link to carcinogenesis. The overall composition of the microbial communities, as well as the presence or absence of "key species", in relation to carcinogenesis is addressed. Alterations in the oral microbiota can potentially be used to predict the risk of cancer. Molecular advances and the further monitoring of the microbiota will increase our understanding of the role of the microbiota in carcinogenesis and open new perspectives for future therapeutic and prophylactic modalities.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès libre
Publication date 2017
Language Anglais
Journal information "Canadian Journal of Microbiology" - Vol. 63, no.6, p. 475-492 (2017)
Peer reviewed yes
Publisher Canadian Science Publishing ((Canada) Ottawa, ON)
issn 0008-4166
e-issn 1480-3275
Publication status Publié
Affiliation UCL - SSS/LDRI - Louvain Drug Research Institute
Keywords Carcinogenesis ; Carcinogenèse ; Cavité orale ; Microbiome ; Oral cavity ; Upper aerodigestive ; Voie aérodigestives supérieures
Links
  1. Aas J. A., Paster B. J., Stokes L. N., Olsen I., Dewhirst F. E., Defining the Normal Bacterial Flora of the Oral Cavity, 10.1128/jcm.43.11.5721-5732.2005
  2. Ahn Jiyoung, Chen Calvin Y., Hayes Richard B., Oral microbiome and oral and gastrointestinal cancer risk, 10.1007/s10552-011-9892-7
  3. Aviles-Jimenez Francisco, Vazquez-Jimenez Flor, Medrano-Guzman Rafael, Mantilla Alejandra, Torres Javier, Stomach microbiota composition varies between patients with non-atrophic gastritis and patients with intestinal type of gastric cancer, 10.1038/srep04202
  4. Amodini Rajakaruna G., Umeda Makoto, Uchida Keisuke, Furukawa Asuka, Yuan Bae, Suzuki Yoshimi, Noriko Ebe, Izumi Yuichi, Eishi Yoshinobu, Possible translocation of periodontal pathogens into the lymph nodes draining the oral cavity, 10.1007/s12275-012-2030-8
  5. Bajaj Jasmohan S., Betrapally Naga S., Hylemon Phillip B., Heuman Douglas M., Daita Kalyani, White Melanie B., Unser Ariel, Thacker Leroy R., Sanyal Arun J., Kang Dae Joong, Sikaroodi Masoumeh, Gillevet Patrick M, Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy : HEPATOLOGY, Vol. XX, No. X, 2015, 10.1002/hep.27819
  6. Bassis Christine M, Tang Alice L, Young Vincent B, Pynnonen Melissa A, The nasal cavity microbiota of healthy adults, 10.1186/2049-2618-2-27
  7. Bassis Christine M., Erb-Downward John R., Dickson Robert P., Freeman Christine M., Schmidt Thomas M., Young Vincent B., Beck James M., Curtis Jeffrey L., Huffnagle Gary B., Analysis of the Upper Respiratory Tract Microbiotas as the Source of the Lung and Gastric Microbiotas in Healthy Individuals, 10.1128/mbio.00037-15
  8. Basu T., J. Cancer Res. Ther., 8, S72 (2012)
  9. Bogaert Debby, Keijser Bart, Huse Susan, Rossen John, Veenhoven Reinier, van Gils Elske, Bruin Jacob, Montijn Roy, Bonten Marc, Sanders Elisabeth, Variability and Diversity of Nasopharyngeal Microbiota in Children: A Metagenomic Analysis, 10.1371/journal.pone.0017035
  10. Bowdish D. M. E., Davidson D. J., Scott M. G., Hancock R. E. W., Immunomodulatory Activities of Small Host Defense Peptides, 10.1128/aac.49.5.1727-1732.2005
  11. Chaveli-Lopez B, Bagan-Sebastian JV, Treatment of oral mucositis due to chemotherapy, 10.4317/jced.52917
  12. Chen Z.B., Beijing Da Xue Xue Bao, 44, 29 (2012)
  13. Chen Xingdong, Winckler Björn, Lu Ming, Cheng Hongwei, Yuan Ziyu, Yang Yajun, Jin Li, Ye Weimin, Oral Microbiota and Risk for Esophageal Squamous Cell Carcinoma in a High-Risk Area of China, 10.1371/journal.pone.0143603
  14. Chen Xingdong, Yuan Ziyu, Lu Ming, Zhang Yuechan, Jin Li, Ye Weimin, Poor oral health is associated with an increased risk of esophageal squamous cell carcinoma - a population-based case-control study in China : Oral health and risk of esophageal squamous cell carcinoma, 10.1002/ijc.30484
  15. Cho Ilseung, Blaser Martin J., The human microbiome: at the interface of health and disease, 10.1038/nrg3182
  16. Collins L.M.C., Dawes C., The Surface Area of the Adult Human Mouth and Thickness of the Salivary Film Covering the Teeth and Oral Mucosa, 10.1177/00220345870660080201
  17. Costello E. K., Lauber C. L., Hamady M., Fierer N., Gordon J. I., Knight R., Bacterial Community Variation in Human Body Habitats Across Space and Time, 10.1126/science.1177486
  18. Barros da Cunha Sandra Ribeiro de, Mendes Ramos Pedro Augusto, Nesrallah Ana Cristina Aló, Parahyba Cláudia Joffily, Fregnani Eduardo Rodrigues, Corrêa Aranha Ana Cecília, The Effects of Ionizing Radiation on the Oral Cavity, 10.5005/jp-journals-10024-1740
  19. de Freitas Edimilson M., Nobre Sérgio A.M., de Oliveira Pires Maria Betânia, Faria Ronize Viviane J., Batista André Ulisses Dantas, Bonan Paulo Rogério Ferreti, Oral Candida species in head and neck cancer patients treated by radiotherapy, 10.1016/j.anl.2012.11.011
  20. de Mendonça Regina Maria Holanda, de Araújo Marcela, Levy Carlos Emilio, Morari Joseane, Silva Rosângela A., Yunes José Andres, Brandalise Silvia Regina, Prospective evaluation of HSV, Candida spp., and oral bacteria on the severity of oral mucositis in pediatric acute lymphoblastic leukemia, 10.1007/s00520-011-1190-0
  21. Deshpande Kalyani, Jain Ashish, Sharma RaviKant, Prashar Savita, Jain Rajni, Diabetes and periodontitis, 10.4103/0972-124x.76917
  22. DiGiulio Daniel B., Callahan Benjamin J., McMurdie Paul J., Costello Elizabeth K., Lyell Deirdre J., Robaczewska Anna, Sun Christine L., Goltsman Daniela S. A., Wong Ronald J., Shaw Gary, Stevenson David K., Holmes Susan P., Relman David A., Temporal and spatial variation of the human microbiota during pregnancy, 10.1073/pnas.1502875112
  23. Fabian Michael Clifford, Pachev George, Otolaryngology training during paediatric residency: A survey of paediatricians in Canada, 10.1093/pch/13.6.493
  24. Fan Xiaozhou, Alekseyenko Alexander V, Wu Jing, Peters Brandilyn A, Jacobs Eric J, Gapstur Susan M, Purdue Mark P, Abnet Christian C, Stolzenberg-Solomon Rachael, Miller George, Ravel Jacques, Hayes Richard B, Ahn Jiyoung, Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study, 10.1136/gutjnl-2016-312580
  25. Farag Y. M. K., Gaballa M. R., Diabesity: an overview of a rising epidemic, 10.1093/ndt/gfq576
  26. Farrell James J, Zhang Lei, Zhou Hui, Chia David, Elashoff David, Akin David, Paster Bruce J, Joshipura Kaumudi, Wong David T W, Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer, 10.1136/gutjnl-2011-300784
  27. Flores Gilberto E, Caporaso J Gregory, Henley Jessica B, Rideout Jai Ram, Domogala Daniel, Chase John, Leff Jonathan W, Vázquez-Baeza Yoshiki, Gonzalez Antonio, Knight Rob, Dunn Robert R, Fierer Noah, Temporal variability is a personalized feature of the human microbiome, 10.1186/s13059-014-0531-y
  28. Francescone Ralph, Hou Vivianty, Grivennikov Sergei I., Microbiome, Inflammation, and Cancer : , 10.1097/ppo.0000000000000048
  29. Galvão-Moreira Leonardo Victor, da Cruz Maria Carmen Fontoura Nogueira, Oral microbiome, periodontitis and risk of head and neck cancer, 10.1016/j.oraloncology.2015.11.013
  30. Gong Hong-Li, Shi Yi, Zhou Liang, Wu Chun-Ping, Cao Peng-Yu, Tao Lei, Xu Chen, Hou Dong-Sheng, Wang Yue-Zhu, The Composition of Microbiome in Larynx and the Throat Biodiversity between Laryngeal Squamous Cell Carcinoma Patients and Control Population, 10.1371/journal.pone.0066476
  31. González-Ramírez I, Irigoyen-Camacho ME, Ramírez-Amador V, Lizano-Soberón M, Carrillo-García A, García-Carrancá A, Sánchez-Pérez Y, Méndez-Martínez R, Granados-García M, Ruíz-Godoy LM, García-Cuellar CM, Association between age and high-risk human papilloma virus in Mexican oral cancer patients, 10.1111/odi.12071
  32. Guaní-Guerra Eduardo, Santos-Mendoza Teresa, Lugo-Reyes Saúl O., Terán Luis M., Antimicrobial peptides: General overview and clinical implications in human health and disease, 10.1016/j.clim.2009.12.004
  33. Guerrero-Preston Rafael, Godoy-Vitorino Filipa, Jedlicka Anne, Rodríguez-Hilario Arnold, González Herminio, Bondy Jessica, Lawson Fahcina, Folawiyo Oluwasina, Michailidi Christina, Dziedzic Amanda, Thangavel Rajagowthamee, Hadar Tal, Noordhuis Maartje G., Westra William, Koch Wayne, Sidransky David, 16S rRNA amplicon sequencing identifies microbiota associated with oral cancer, human papilloma virus infection and surgical treatment, 10.18632/oncotarget.9710
  34. Haiser H. J., Turnbaugh P. J., Is It Time for a Metagenomic Basis of Therapeutics?, 10.1126/science.1224396
  35. Hashemi A., Iran J. Ped. Hematol. Oncol., 15, 106 (2015)
  36. Holt Stanley C., Ebersole Jeffrey L., Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the 'red complex', a prototype polybacterial pathogenic consortium in periodontitis, 10.1111/j.1600-0757.2005.00113.x
  37. Homann N, Tillonen J, Rintamäki H, Salaspuro M, Lindqvist C, Meurman J.H, Poor dental status increases acetaldehyde production from ethanol in saliva: a possible link to increased oral cancer risk among heavy drinkers, 10.1016/s1368-8375(00)00076-2
  38. Horz Hans-Peter, Conrads Georg, MethanogenicArchaeaand oral infections – ways to unravel the black box, 10.3402/jom.v3i0.5940
  39. Hsu Y.-H., Wei C.-C., Shieh D.-B., Chan C.-H., Chang M.-S., Anti-IL-20 Monoclonal Antibody Alleviates Inflammation in Oral Cancer and Suppresses Tumor Growth, 10.1158/1541-7786.mcr-12-0276
  40. Hu Xiaosheng, Zhang Qian, Hua Hong, Chen Feng, Changes in the salivary microbiota of oral leukoplakia and oral cancer, 10.1016/j.oraloncology.2016.03.007
  41. Hu Yue-Jian, Wang Qian, Jiang Yun-Tao, Ma Rui, Xia Wen-Wei, Tang Zi-Sheng, Liu Zheng, Liang Jing-Ping, Huang Zheng-Wei, Characterization of oral bacterial diversity of irradiated patients by high-throughput sequencing, 10.1038/ijos.2013.15
  42. Human Microbiome Project Consortium. 2012. Structure, function and diversity of the healthy human microbiome. Nature, 486(7402): 207–214. 10.1038/nature11234. 22699609.
  43. Huynh H.T.T., Verneau J., Levasseur A., Drancourt M., Aboudharam G., Bacteria and archaea paleomicrobiology of the dental calculus: a review, 10.1111/omi.12118
  44. Ishikawa Shigeo, Sugimoto Masahiro, Kitabatake Kenichiro, Sugano Ayako, Nakamura Marina, Kaneko Miku, Ota Sana, Hiwatari Kana, Enomoto Ayame, Soga Tomoyoshi, Tomita Masaru, Iino Mitsuyoshi, Identification of salivary metabolomic biomarkers for oral cancer screening, 10.1038/srep31520
  45. Javaid Mohammad A., Ahmed Ahad S., Durand Robert, Tran Simon D., Saliva as a diagnostic tool for oral and systemic diseases, 10.1016/j.jobcr.2015.08.006
  46. Jimenez Monik, Krall Elizabeth A., Garcia Raul I., Vokonas Pantel S., Dietrich Thomas, Periodontitis and incidence of cerebrovascular disease in men, 10.1002/ana.21742
  47. Johannesen Katrine, Dessau Ram, Heltberg Ole, Bodtger Uffe, Bad news itself or just the messenger? The high mortality of Fusobacterium spp. infections is related to disseminated malignancy and other comorbidities, 10.3402/ecrj.v3.30287
  48. Kalus Andrea A, Fredericks L Page, Hacker Beth M, Dommisch Henrik, Presland Richard B, Kimball Janet R, Dale Beverly A, Association of a genetic polymorphism (-44 C/G SNP) in the human DEFB1 gene with expression and inducibility of multiple β-defensins in gingival keratinocytes, 10.1186/1472-6831-9-21
  49. Kanady Jesica A., Aruni A. Wilson, Ninnis Janet R., Hopper Andrew O., Blood Jamie D., Byrd Benjamin L., Holley Leighton R., Staker Michael R., Hutson Shandee, Fletcher Hansel M., Power Gordon G., Blood Arlin B., Nitrate reductase activity of bacteria in saliva of term and preterm infants, 10.1016/j.niox.2012.07.004
  50. Keijser B.J.F., Zaura E., Huse S.M., van der Vossen J.M.B.M., Schuren F.H.J., Montijn R.C., ten Cate J.M., Crielaard W., Pyrosequencing analysis of the Oral Microflora of healthy adults, 10.1177/154405910808701104
  51. Kim J.J., J. Calif. Dent. Assoc., 41, 119 (2013)
  52. Kim Jayoung, Imani Somayeh, de Araujo William R., Warchall Julian, Valdés-Ramírez Gabriela, Paixão Thiago R.L.C., Mercier Patrick P., Wang Joseph, Wearable salivary uric acid mouthguard biosensor with integrated wireless electronics, 10.1016/j.bios.2015.07.039
  53. Kim T. K., Thomas S. M., Ho M., Sharma S., Reich C. I., Frank J. A., Yeater K. M., Biggs D. R., Nakamura N., Stumpf R., Leigh S. R., Tapping R. I., Blanke S. R., Slauch J. M., Gaskins H. R., Weisbaum J. S., Olsen G. J., Hoyer L. L., Wilson B. A., Heterogeneity of Vaginal Microbial Communities within Individuals, 10.1128/jcm.00854-08
  54. Kipanyula Maulilio John, Seke Etet Paul Faustin, Vecchio Lorella, Farahna Mohammed, Nukenine Elias Nchiwan, Nwabo Kamdje Armel Hervé, Signaling pathways bridging microbial-triggered inflammation and cancer, 10.1016/j.cellsig.2012.10.014
  55. Kistler James O., Wade William G., Arirachakaran Pratanporn, Dahlén Gunnar, Poovorawan Yong, The oral microbiome in human immunodeficiency virus (HIV)-positive individuals, 10.1099/jmm.0.000128
  56. Kreimer A. R., Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A Systematic Review, 10.1158/1055-9965.epi-04-0551
  57. Lai Yuping, Gallo Richard L., AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense, 10.1016/j.it.2008.12.003
  58. Laidi Fatna, Bouziane Amal, Errachid Abdelhamid, Zaoui Fatima, Usefulness of Salivary and Serum Auto-antibodies Against Tumor Biomarkers HER2 and MUC1 in Breast Cancer Screening, 10.7314/apjcp.2016.17.1.335
  59. Lambrecht Maarten, Mercier Carole, Geussens Yasmyne, Nuyts Sandra, The effect of a supersaturated calcium phosphate mouth rinse on the development of oral mucositis in head and neck cancer patients treated with (chemo)radiation : A single-center, randomized, prospective study of a calcium phosphate mouth rinse + standard of care versus standard of care, 10.1007/s00520-013-1829-0
  60. Lamster Ira B., Smith Quenton T., Celenti Romanita S., Singer Robert E., Grbic John T., Development of a Risk Profile for Periodontal Disease: Microbial and Host Response Factors, 10.1902/jop.1994.65.5s.511
  61. Lamster Ira B., Kaufman Eliaz, Grbic John T., Winston Leslie J., Singer Robert E., β-Glucuronidase Activity in Saliva: Relationship to Clinical Periodontal Parameters, 10.1902/jop.2003.74.3.353
  62. Lebedev S. N., Bogatov V. V., Chervinets V. M., Chervinets Iu. V., Chervinets A. V., Troshin A. V., Microbiocenosis of major biotopes of the oral cavity in patients with tongue carcinoma during complex treatment, 10.17116/stomat201594130-34
  63. Leishman Shaneen J., Ford Pauline J., Do Hong Lien, Palmer Janet E., Heng Nicholas C.K., West Malcolm J., Seymour Gregory J., Cullinan Mary P., Periodontal pathogen load and increased antibody response to heat shock protein 60 in patients with cardiovascular disease, 10.1111/j.1600-051x.2012.01934.x
  64. Lemon Katherine, Comparative Analyses of the Bacterial Microbiota of the Human Nostril and Oropharynx, 10.1128/mbio.00129-10
  65. Li Y., Zhou X., St. John M.A.R., Wong D.T.W., RNA Profiling of Cell-free Saliva Using Microarray Technology, 10.1177/154405910408300303
  66. Lin Harrison W., Richmon Jeremy D., Emerick Kevin S., de Venecia Ronald K., Zeitels Steven M., Faquin William C., Lin Derrick T., Malignant transformation of a highly aggressive human papillomavirus type 11–associated recurrent respiratory papillomatosis, 10.1016/j.amjoto.2009.02.019
  67. Loo Wings TY, Liu Qing, Yip Michael CW, Wang Min, Chow Louis WC, Cheung Mary NB, Yip Adrian YS, Ng Elizabeth LY, Status of Oral Ulcerative Mucositis and Biomarkers to Monitor Posttraumatic Stress Disorder Effects in Breast Cancer Patients, 10.5301/jbm.5000025
  68. Love D. N., Bailey G. D., Collings S., Briscoe D. A., Description of Porphyromonas circumdentaria sp. nov. and Reassignment of Bacteroides salivosus (Love, Johnson, Jones, and Calverley 1987) as Porphyromonas (Shah and Collins 1988) salivosa comb. nov., 10.1099/00207713-42-3-434
  69. Lozupone Catherine A., Stombaugh Jesse I., Gordon Jeffrey I., Jansson Janet K., Knight Rob, Diversity, stability and resilience of the human gut microbiota, 10.1038/nature11550
  70. Mark Welch Jessica L., Utter Daniel R., Rossetti Blair J., Mark Welch David B., Eren A. Murat, Borisy Gary G., Dynamics of tongue microbial communities with single-nucleotide resolution using oligotyping, 10.3389/fmicb.2014.00568
  71. Maruyama Kazuichi, Asai Jun, Ii Masaaki, Thorne Tina, Losordo Douglas W., D'Amore Patricia A., Decreased Macrophage Number and Activation Lead to Reduced Lymphatic Vessel Formation and Contribute to Impaired Diabetic Wound Healing, 10.2353/ajpath.2007.060018
  72. Maruyama Takayuki, Yamanaka Reiko, Yokoi Aya, Ekuni Daisuke, Tomofuji Takaaki, Mizukawa Nobuyoshi, Onoda Tomoo, Eguchi Motoharu, Morita Manabu, Relationship Between Serum Albumin Concentration and Periodontal Condition in Patients With Head and Neck Cancer, 10.1902/jop.2011.110536
  73. Medzhitov Ruslan, Janeway CharleS. Jr, Innate immune recognition: mechanisms and pathways, 10.1034/j.1600-065x.2000.917309.x
  74. Meurman Jukka H., Grönroos Lisa, Oral and dental health care of oral cancer patients: hyposalivation, caries and infections, 10.1016/j.oraloncology.2010.02.025
  75. Meyer Mara S., Joshipura Kaumudi, Giovannucci Edward, Michaud Dominique S., A review of the relationship between tooth loss, periodontal disease, and cancer, 10.1007/s10552-008-9163-4
  76. Michaud Dominique S, Izard Jacques, Wilhelm-Benartzi Charlotte S, You Doo-Ho, Grote Verena A, Tjønneland Anne, Dahm Christina C, Overvad Kim, Jenab Mazda, Fedirko Veronika, Boutron-Ruault Marie Christine, Clavel-Chapelon Françoise, Racine Antoine, Kaaks Rudolf, Boeing Heiner, Foerster Jana, Trichopoulou Antonia, Lagiou Pagona, Trichopoulos Dimitrios, Sacerdote Carlotta, Sieri Sabina, Palli Domenico, Tumino Rosario, Panico Salvatore, Siersema Peter D, Peeters Petra HM, Lund Eiliv, Barricarte Aurelio, Huerta José-María, Molina-Montes Esther, Dorronsoro Miren, Quirós J Ramón, Duell Eric J, Ye Weimin, Sund Malin, Lindkvist Björn, Johansen Dorthe, Khaw Kay-Tee, Wareham Nick, Travis Ruth C, Vineis Paolo, Bueno-de-Mesquita H Bas, Riboli Elio, Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study, 10.1136/gutjnl-2012-303006
  77. Michelet Xavier, Legouis Renaud, Autophagy in endosomal mutants : Desperately seeking to survive, 10.4161/worm.20848
  78. Mima Kosuke, Sukawa Yasutaka, Nishihara Reiko, Qian Zhi Rong, Yamauchi Mai, Inamura Kentaro, Kim Sun A., Masuda Atsuhiro, Nowak Jonathan A., Nosho Katsuhiko, Kostic Aleksandar D., Giannakis Marios, Watanabe Hideo, Bullman Susan, Milner Danny A., Harris Curtis C., Giovannucci Edward, Garraway Levi A., Freeman Gordon J., Dranoff Glenn, Chan Andrew T., Garrett Wendy S., Huttenhower Curtis, Fuchs Charles S., Ogino Shuji, Fusobacterium nucleatumand T Cells in Colorectal Carcinoma, 10.1001/jamaoncol.2015.1377
  79. Mirrielees Jeffrey, Crofford Leslie J., Lin Yushun, Kryscio Richard J., Dawson III Dolphus R., Ebersole Jeffrey L., Miller Craig S., Rheumatoid arthritis and salivary biomarkers of periodontal disease : Rheumatoid arthritis and saliva biomarkers, 10.1111/j.1600-051x.2010.01625.x
  80. Mishra Saswat, Saadat Darius, Kwon Ohjin, Lee Yongkuk, Choi Woon-Seop, Kim Jong-Hoon, Yeo Woon-Hong, Recent advances in salivary cancer diagnostics enabled by biosensors and bioelectronics, 10.1016/j.bios.2016.02.040
  81. Mitsuhashi Kei, Nosho Katsuhiko, Sukawa Yasutaka, Matsunaga Yasutaka, Ito Miki, Kurihara Hiroyoshi, Kanno Shinichi, Igarashi Hisayoshi, Naito Takafumi, Adachi Yasushi, Tachibana Mami, Tanuma Tokuma, Maguchi Hiroyuki, Shinohara Toshiya, Hasegawa Tadashi, Imamura Masafumi, Kimura Yasutoshi, Hirata Koichi, Maruyama Reo, Suzuki Hiromu, Imai Kohzoh, Yamamoto Hiroyuki, Shinomura Yasuhisa, Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis, 10.18632/oncotarget.3109
  82. Momen-Heravi F., Trachtenberg A.J., Kuo W.P., Cheng Y.S., Genomewide Study of Salivary MicroRNAs for Detection of Oral Cancer, 10.1177/0022034514531018
  83. Monteiro Andréa M., Jardini Maria A. N., Giampaoli Viviana, Alves Sarah, Figueiredo Neto Antônio M., Gidlund Magnus, Measurement of the nonlinear optical response of low-density lipoprotein solutions from patients with periodontitis before and after periodontal treatment: evaluation of cardiovascular risk markers, 10.1117/1.jbo.17.11.115004
  84. Morita E., Narikiyo M., Nishimura E., Yano A., Tanabe C., Sasaki H., Hanada N., Molecular analysis of age-related changes ofStreptococcus anginosusgroup andStreptococcus mitisin saliva, 10.1111/j.1399-302x.2004.00173.x
  85. Mulcahy Michelle E., McLoughlin Rachel M., Host–Bacterial Crosstalk Determines Staphylococcus aureus Nasal Colonization, 10.1016/j.tim.2016.06.012
  86. Nadell Carey D., Xavier Joao B., Foster Kevin R., The sociobiology of biofilms, 10.1111/j.1574-6976.2008.00150.x
  87. Narikiyo Michihiro, Tanabe Chikako, Yamada Yukishige, Igaki Hiroyasu, Tachimori Yuji, Kato Hoichi, Muto Manabu, Montesano Ruggero, Sakamoto Hiromi, Nakajima Yoshiyuki, Sasaki Hiroki, Frequent and preferential infection of Treponema denticola, Streptococcus mitis, and Streptococcus anginosus in esophageal cancers, 10.1111/j.1349-7006.2004.tb02488.x
  88. Nasidze I., Li J., Quinque D., Tang K., Stoneking M., Global diversity in the human salivary microbiome, 10.1101/gr.084616.108
  89. Nelson-Filho Paulo, Borba Izabela Goncalves, Mesquita Kessia Suenia Fidelis de, Silva Raquel Assed Bezerra, Queiroz Alexandra Mussolino de, Silva Lea Assed Bezerra, Dynamics of Microbial Colonization of the Oral Cavity in Newborns, 10.1590/0103-6440201302266
  90. Nomura M., Kamata M., Kojima H., Hayashi K., Sawada S., Irsogladine maleate reduces the incidence of fluorouracil-based chemotherapy-induced oral mucositis, 10.1093/annonc/mds584
  91. Nosho Katsuhiko, Association ofFusobacterium nucleatumwith immunity and molecular alterations in colorectal cancer, 10.3748/wjg.v22.i2.557
  92. Nugent Zoann, Periodontal Disease may be Associated with Oral and Gastrointestinal Cancer, 10.1016/j.jebdp.2010.09.012
  93. Ordovas Jose M, Mooser Vincent, Metagenomics: the role of the microbiome in cardiovascular diseases : , 10.1097/01.mol.0000217897.75068.ba
  94. Park O.-J., Yi H., Jeon J.H., Kang S.-S., Koo K.-T., Kum K.-Y., Chun J., Yun C.-H., Han S.H., Pyrosequencing Analysis of Subgingival Microbiota in Distinct Periodontal Conditions, 10.1177/0022034515583531
  95. Park So Yeon, Kim Mi Suk, Eom Joong Sik, Lee Jin Seo, Rho Young Soo, Risk factors and etiology of surgical site infection after radical neck dissection in patients with head and neck cancer, 10.3904/kjim.2016.31.1.162
  96. Peterson Douglas E., , Öhrn Kerstin, Bowen Joanne, Fliedner Monica, Lees Judith, Loprinzi Charles, Mori Takehiko, Osaguona Anthony, Weikel Dianna S., Elad Sharon, Lalla Rajesh V., Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy, 10.1007/s00520-012-1562-0
  97. Pintos Javier, Black Martin J., Sadeghi Nader, Ghadirian Parviz, Zeitouni Anthony G., Viscidi Raphael P., Herrero Rolando, Coutlée François, Franco Eduardo L., Human papillomavirus infection and oral cancer: A case-control study in Montreal, Canada, 10.1016/j.oraloncology.2007.02.005
  98. Prasad Sahdeo, Tyagi Amit K, Aggarwal Bharat B, Detection of inflammatory biomarkers in saliva and urine: Potential in diagnosis, prevention, and treatment for chronic diseases, 10.1177/1535370216638770
  99. Prince Amanda, Antony Kathleen, Ma Jun, Aagaard Kjersti, The Microbiome and Development: A Mother's Perspective, 10.1055/s-0033-1361818
  100. Radosevich Andrew J., Mutyal Nikhil N., Rogers Jeremy D., Gould Bradley, Hensing Thomas A., Ray Daniel, Backman Vadim, Roy Hemant K., Buccal Spectral Markers for Lung Cancer Risk Stratification, 10.1371/journal.pone.0110157
  101. Rogers Geraint B., Hoffman Lucas R., Carroll Mary P., Bruce Kenneth D., Interpreting infective microbiota: the importance of an ecological perspective, 10.1016/j.tim.2013.03.004
  102. Sakamoto M., Int. J. Syst. Evol. Microbiol., 52, 841 (2002)
  103. Sasaki M, Yamaura C, Ohara-Nemoto Y, Tajika S, Kodama Y, Ohya T, Harada R, Kimura S, Streptococcus anginosus infection in oral cancer and its infection route : Streptococcus anginosus in oral cancer, 10.1111/j.1601-0825.2005.01051.x
  104. Scannapieco F. A., Genco R. J., Association of periodontal infections with atherosclerotic and pulmonary diseases, 10.1111/j.1600-0765.1999.tb02263.x
  105. SHAO Zi-Yang, TANG Zi-Sheng, YAN Chao, JIANG Yun-Tao, MA Rui, LIU Zheng, HUANG Zheng-Wei, Effects of Intensity-modulated Radiotherapy on Human Oral Microflora, 10.1269/jrr.11085
  106. Shiga K., Oncol. Rep., 8, 245 (2001)
  107. Shiga Kiyoto, Ogawa Takenori, Maki Atsuko, Amano Masanori, Kobayashi Toshimitsu, Concomitant Chemoradiotherapy as a Standard Treatment for Squamous Cell Carcinoma of the Temporal Bone, 10.1055/s-0031-1275244
  108. Sinha Anju, Chandra Shaleen, Raj Vineet, Zaidi Iram, Saxena Shikha, Dwivedi Ruby, Expression of p63 in potentially malignant and malignant oral lesions, 10.1016/j.jobcr.2015.07.001
  109. Sivadasan Priya, Gupta Manoj Kumar, Sathe Gajanan J., Balakrishnan Lavanya, Palit Priyanka, Gowda Harsha, Suresh Amritha, Kuriakose Moni Abraham, Sirdeshmukh Ravi, Human salivary proteome — a resource of potential biomarkers for oral cancer, 10.1016/j.jprot.2015.05.039
  110. SIXOU J. L., AUBRY-LEULIETTE A., DE MEDEIROS-BATTISTA O., LEJEUNE S., JOLIVET-GOUGEON A., SOLHI-PINSARD H., GANDEMER V., BARBOSA-ROGIER M., BONNAURE-MALLET M., Capnocytophaga in the dental plaque of immunocompromised children with cancer, 10.1111/j.1365-263x.2006.00697.x
  111. Soares Andréa Ferreira, Aquino Ana Rafaela Luz de, Carvalho Cyntia Helena Pereira de, Nonaka Cassiano Francisco Weege, Almeida Dulce, Pinto Leão Pereira, Frequency of oral mucositis and microbiological analysis in children with acute lymphoblastic leukemia treated with 0.12% chlorhexidine gluconate, 10.1590/s0103-64402011000400009
  112. Söder Birgitta, Yakob Maha, Meurman Jukka H., Andersson Leif C., Klinge Björn, Söder Per-Östen, Periodontal disease may associate with breast cancer, 10.1007/s10549-010-1221-4
  113. Souto Renata, Colombo Ana Paula Vieira, Detection ofHelicobacter pyloriby Polymerase Chain Reaction in the Subgingival Biofilm and Saliva of Non-Dyspeptic Periodontal Patients, 10.1902/jop.2008.070241
  114. Stanko P., Bratisl. Lek. Listy., 114, 345 (2013)
  115. Steffen M. J., Holt S. C., Ebersole J. L., Porphyromonas gingivalis induction of mediator and cytokine secretion by human gingival fibroblasts, 10.1034/j.1399-302x.2000.150305.x
  116. Su H., Eur. Rev. Med. Pharmacol. Sci., 19, 2482 (2015)
  117. Takahashi N., Oral Microbiome Metabolism : From “Who Are They?” to “What Are They Doing?”, 10.1177/0022034515606045
  118. Targosz Aneta, Brzozowski Tomasz, Pierzchalski Piotr, Szczyrk Urszula, Ptak-Belowska Agata, Konturek Stanislaw Jan, Pawlik Wieslaw, Helicobacter pylori promotes apoptosis, activates cyclooxygenase (COX)-2 and inhibits heat shock protein HSP70 in gastric cancer epithelial cells, 10.1007/s00011-012-0487-x
  119. Torres Pedro J., Fletcher Erin M., Gibbons Sean M., Bouvet Michael, Doran Kelly S., Kelley Scott T., Characterization of the salivary microbiome in patients with pancreatic cancer, 10.7717/peerj.1373
  120. Vasconcelos R.M., Sanfilippo N., Paster B.J., Kerr A.R., Li Y., Ramalho L., Queiroz E.L., Smith B., Sonis S.T., Corby P.M., Host-Microbiome Cross-talk in Oral Mucositis, 10.1177/0022034516641890
  121. Wade William G., The oral microbiome in health and disease, 10.1016/j.phrs.2012.11.006
  122. Wagner Kai Wolfgang, Schön Ralf, Schumacher Martin, Schmelzeisen Rainer, Schulze Dirk, Case report: brain and liver abscesses caused by oral infection with Streptococcus intermedius, 10.1016/j.tripleo.2006.02.010
  123. Wang Chunsaier, Li Jingnan, Pathogenic Microorganisms and Pancreatic Cancer, 10.1159/000380896
  124. Wilson Alastair J., Nussey Daniel H., What is individual quality? An evolutionary perspective, 10.1016/j.tree.2009.10.002
  125. Wood Lianna F., Chahroudi Ann, Chen Hui-Ling, Jaspan Heather B., Sodora Donald L., The oral mucosa immune environment and oral transmission of HIV/SIV, 10.1111/imr.12078
  126. Yan X., Am. J. Cancer Res., 5, 3111 (2015)
  127. Young Jason P., Young Paul H., Meningioma associated with abscess formation—a case report, 10.1016/j.surneu.2004.07.044
  128. Yu G., Gail M. H., Shi J., Klepac-Ceraj V., Paster B. J., Dye B. A., Wang G.-Q., Wei W.-Q., Fan J.-H., Qiao Y.-L., Dawsey S. M., Freedman N. D., Abnet C. C., Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach, 10.1158/1055-9965.epi-13-0855
  129. Zahnd Guillaume, Vray Didier, Sérusclat André, Alibay Djhianne, Bartold Mark, Brown Alex, Durand Marion, Jamieson Lisa M., Kapellas Kostas, Maple-Brown Louise J., O’Dea Kerin, Moulin Philippe, Celermajer David S., Skilton Michael R., Longitudinal Displacement of the Carotid Wall and Cardiovascular Risk Factors: Associations with Aging, Adiposity, Blood Pressure and Periodontal Disease Independent of Cross-Sectional Distensibility and Intima-Media Thickness, 10.1016/j.ultrasmedbio.2012.05.004
  130. Zahran F, Ghalwash D, Shaker O, Al-Johani K, Scully C, Salivary microRNAs in oral cancer, 10.1111/odi.12340
  131. Zasloff Michael, Antimicrobial peptides of multicellular organisms, 10.1038/415389a
  132. Zaura Egija, Nicu Elena A., Krom Bastiaan P., Keijser Bart J. F., Acquiring and maintaining a normal oral microbiome: current perspective, 10.3389/fcimb.2014.00085
  133. Zhang Fang, He Shenghua, Jin Jieqi, Dong Guangyan, Wu Hongkun, Exploring salivary microbiota in AIDS patients with different periodontal statuses using 454 GS-FLX Titanium pyrosequencing, 10.3389/fcimb.2015.00055
  134. Zhang Xuan, Zhang Dongya, Jia Huijue, Feng Qiang, Wang Donghui, Liang Di, Wu Xiangni, Li Junhua, Tang Longqing, Li Yin, Lan Zhou, Chen Bing, Li Yanli, Zhong Huanzi, Xie Hailiang, Jie Zhuye, Chen Weineng, Tang Shanmei, Xu Xiaoqiang, Wang Xiaokai, Cai Xianghang, Liu Sheng, Xia Yan, Li Jiyang, Qiao Xingye, Al-Aama Jumana Yousuf, Chen Hua, Wang Li, Wu Qing-jun, Zhang Fengchun, Zheng Wenjie, Li Yongzhe, Zhang Mingrong, Luo Guangwen, Xue Wenbin, Xiao Liang, Li Jun, Chen Wanting, Xu Xun, Yin Ye, Yang Huanming, Wang Jian, Kristiansen Karsten, Liu Liang, Li Ting, Huang Qingchun, Li Yingrui, Wang Jun, The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment, 10.1038/nm.3914
  135. Zhu Guopei, Lin Jin-Ching, Kim Sung-Bae, Bernier Jacques, Agarwal Jai Prakash, Vermorken Jan B., Thinh Dang Huy Quoc, Cheng Hoi-Ching, Yun Hwan Jung, Chitapanarux Imjai, Lertsanguansinchai Prasert, Reddy Vijay Anand, He Xia, Asian expert recommendation on management of skin and mucosal effects of radiation, with or without the addition of cetuximab or chemotherapy, in treatment of head and neck squamous cell carcinoma, 10.1186/s12885-016-2073-z
  136. Zheng Weiwei, Zhang Ze, Liu Cuihua, Qiao Yuanyuan, Zhou Dianrong, Qu Jia, An Huaijie, Xiong Ming, Zhu Zhiming, Zhao Xiaohang, Metagenomic sequencing reveals altered metabolic pathways in the oral microbiota of sailors during a long sea voyage, 10.1038/srep09131
Bibliographic reference Le Bars, Pierre ; Matamoros, Sébastien ; Montassier, Emmanuel ; Le Vacon, Françoise ; Potel, Gilles ; et. al. The oral cavity microbiota: between health, oral disease, and cancers of the aerodigestive tract.. In: Canadian Journal of Microbiology, Vol. 63, no.6, p. 475-492 (2017)
Permanent URL http://hdl.handle.net/2078.1/196218