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Nitric oxide signalling in cardiovascular health and disease.

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Farah, Charlotte [UCL] Michel, Lauriane [UCL] Balligand, Jean-Luc [UCL]

Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in cardiovascular homeostasis. Tremendous knowledge has been accumulated on the mechanisms of the nitric oxide synthase (NOS)-NO pathway, but how this highly reactive, free radical gas signals to specific targets for precise regulation of cardiovascular function remains the focus of much intense research. In this Review, we summarize the updated paradigms on NOS regulation, NO interaction with reactive oxidant species in specific subcellular compartments, and downstream effects of NO in target cardiovascular tissues, while emphasizing the latest developments of molecular tools and biomarkers to modulate and monitor NO production and bioavailability.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès interdit
Publication date 2018
Language Anglais
Journal information "Nature Reviews Cardiology" - Vol. 15, no. 5, p. 292-316 (2018)
Peer reviewed yes
Publisher Nature Publishing Group ((United Kingdom) London)
issn 1759-5002
e-issn 1759-5010
Publication status Publié
Affiliations UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique
UCL - (SLuc) Service de médecine interne et maladies infectieuses (MIMI)
Links
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Bibliographic reference Farah, Charlotte ; Michel, Lauriane ; Balligand, Jean-Luc. Nitric oxide signalling in cardiovascular health and disease.. In: Nature Reviews Cardiology, Vol. 15, no. 5, p. 292-316 (2018)
Permanent URL http://hdl.handle.net/2078.1/194456