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The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC.

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Frantz, Stefan Falcao-Pires, Ines Balligand, Jean-Luc [UCL] Bauersachs, Johann Brutsaert, Dirk Heymans, Stephane

Activation of the immune system in heart failure (HF) has been recognized for over 20 years. Initially, experimental studies demonstrated a maladaptive role of the immune system. However, several phase III trials failed to show beneficial effects in HF with therapies directed against an immune activation. Preclinical studies today describe positive and negative effects of immune activation in HF. These different effects depend on timing and aetiology of HF. Therefore, herein we give a detailed review on immune mechanisms and their importance for the development of HF with a special focus on commonalities and differences between different forms of cardiomyopathies. The role of the immune system in ischaemic, hypertensive, diabetic, toxic, viral, genetic, peripartum, and autoimmune cardiomyopathy is discussed in depth. Overall, initial damage to the heart leads to disease specific activation of the immune system whereas in the chronic phase of HF overlapping mechanisms occur in different aetiologies.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès interdit
Publication date 2018
Language Anglais
Journal information "European Journal of Heart Failure" - Vol. 20, no. 3, p. 445-459 (2018)
Peer reviewed yes
Publisher Oxford University Press ((United Kingdom) Oxford)
issn 1388-9842
e-issn 1879-0844
Publication status Publié
Affiliations UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique
UCL - (SLuc) Service de médecine interne et maladies infectieuses (MIMI)
Keywords Autoimmune cardiomyopathy ; Diabetic cardiomyopathy ; Genetic cardiomyopathy ; Hypertensive cardiomyopathy ; Immune system ; Ischaemic cardiomyopathy ; Macrophage ; Peripartum cardiomyopathy ; T-cell ; Toxic cardiomyopathy ; Viral cardiomyopathy
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Bibliographic reference Frantz, Stefan ; Falcao-Pires, Ines ; Balligand, Jean-Luc ; Bauersachs, Johann ; Brutsaert, Dirk ; et. al. The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC.. In: European Journal of Heart Failure, Vol. 20, no. 3, p. 445-459 (2018)
Permanent URL http://hdl.handle.net/2078.1/194194