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Systems biology of cellular rhythms

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Goldbeter, Albert [Université libre de Bruxelles (Unit of Theoretical Biology)] Gérard, Claude [Université libre de Bruxelles (Unit of Theoretical Biology)] Gonze, Didier [Université libre de Bruxelles (Unit of Theoretical Biology)] Leloup, Jean-Christophe [Université libre de Bruxelles (Unit of Theoretical Biology)] Dupont, Geneviève [Université libre de Bruxelles (Unit of Theoretical Biology)]

Rhythms abound in biological systems, particularly at the cellular level where they originate from the feedback loops present in regulatory networks. Cellular rhythms can be investigated both by experimental and modeling approaches, and thus represent a prototypic field of research for systems biology. They have also become a major topic in synthetic biology. We review advances in the study of cellular rhythms of biochemical rather than electrical origin by considering a variety of oscillatory processes such as Ca++ oscillations, circadian rhythms, the segmentation clock, oscillations in p53 and NF-κB, synthetic oscillators, and the oscillatory dynamics of cyclin-dependent kinases driving the cell cycle. Finally we discuss the coupling between cellular rhythms and their robustness with respect to molecular noise.

Document type Article de périodique (Journal article)
Access type Accès interdit
Publication date 2012
Language Anglais
Journal information "FEBS Letters" - Vol. 586, p. 2955-2965 (2012)
Peer reviewed yes
Publisher Wiley-Blackwell
issn 0014-5793
Publication status Publié
Affiliation Université libre de Bruxelles - (Unit of Theoretical Biology)
Keywords Biophysics ; Genetics ; Cell Biology ; Biochemistry ; Molecular Biology ; Structural Biology
Links
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Permanent URL http://hdl.handle.net/2078/192963