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Staphylococcal versus Streptococcal infective endocarditis in a tertiary hospital in Belgium: epidemiology, clinical characteristics and outcome

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Yombi, Jean Cyr [UCL] Yuma, Sandra Nyota [UCL] Pasquet, Agnes [UCL] Astarci, Parla [UCL] Robert, Annie [UCL] Rodriguez-Villalobos, Hector [UCL]

(eng) Infective endocarditis (IE) is a rare but serious illness associated with a high mortality. Staphylococcus spp and Streptococcus spp are the most frequent causative pathogens. In this study, we compared the epidemiology, clinical characteristics and outcomes of patients with Staphylococcal and Streptococcal IE in a tertiary hospital. Using our institutional database 'Medical Explorer', we collected all cases of IE retrospectively between January 2005 and December 2010 at the Cliniques Universitaires Saint Luc and then focused on Staphylococcal and Streptococcal IE. Of the 212 patients with IE included in our study, Staphylococcus spp accounted for 35.9% (76/212) of the cases, Streptococcus spp for 35.4% (75/212) and the remainder 18% (61/212) of cases were caused by other pathogens. Negative blood culture IE accounted for 10.4% of all cases. Demographic and clinical characteristics such as age, gender, fever, presence of a heart murmur, heart failure, nature of the affected valve, location of the endocarditis, duration of antibiotics, length of stay and complication were not different when comparing Staphylococcal and Streptococcal IE; only mortality differed. The mortality rate was 21.4 and 6.6% (p = 0.02) for Staphylococcal and Streptococcal IE, respectively. In the multivariate analysis, age >60 years, Staphylococcal IE, presence of complications and absence of surgery were independent risk factors for mortality.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2017
Language Anglais
Journal information "Acta Clinica Belgica" - Vol. 72, no. 6, p. 417-423 (2017)
Peer reviewed yes
Publisher Taylor & Francis ((United Kingdom) Abingdon)
issn 1784-3286
e-issn 2295-3337
Publication status Publié
Affiliations UCL - (SLuc) Service de microbiologie
UCL - (SLuc) Service de médecine interne et maladies infectieuses (MIMI)
UCL - (SLuc) Service de cardiologie
UCL - SSS/IREC/EPID - Pôle d'épidémiologie et biostatistique
UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire
UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale
UCL - SSS/IREC/SLUC - Pôle St.-Luc
Keywords General Medicine ; Clinical characteristics ; Infective endocarditis ; Outcome ; Staphylococcus ; Streptococcus ; Surgery
Links
  1. Hogevik Harriet, Olaison Lars, Andersson Rune, Lindberg Johan, Alestig Kjell, Epidemiologic Aspects of Infective Endocarditis in an Urban Population: A 5-Year Prospective Study : , 10.1097/00005792-199511000-00003
  2. Bedeir Kareem, Reardon Michael, Ramlawi Basel, Infective endocarditis: Perioperative management and surgical principles, 10.1016/j.jtcvs.2013.11.022
  3. Hoen Bruno, Duval Xavier, Infective Endocarditis, 10.1056/nejmcp1206782
  4. Venezio Frank R., Infective Endocarditis in a Community Hospital, 10.1001/archinte.1982.00340170145023
  5. Kim Emery L., Ching Diane L., Pien Francis D., Bacterial Endocarditis at a Small Community Hospital, 10.1097/00000441-199002000-00002
  6. WATANAKUNAKORN CHATRCHAI, BURKERT TOM, Infective Endocarditis at a Large Community Teaching Hospital, 1980–1990 : A Review of 210 Episodes, 10.1097/00005792-199303000-00003
  7. Hill E. E., Herijgers P., Claus P., Vanderschueren S., Herregods M.-C., Peetermans W. E., Infective endocarditis: changing epidemiology and predictors of 6-month mortality: a prospective cohort study, 10.1093/eurheartj/ehl427
  8. Cabell Christopher H., Jollis James G., Peterson Gail E., Corey G. Ralph, Anderson Deverick J., Sexton Daniel J., Woods Christopher W., Reller L. Barth, Ryan Thomas, Fowler Vance G., Changing Patient Characteristics and the Effect on Mortality in Endocarditis, 10.1001/archinte.162.1.90
  9. Fernández-Hidalgo Nuria, Tornos Mas Pilar, Epidemiología de la endocarditis infecciosa en España en los últimos 20 años, 10.1016/j.recesp.2013.05.003
  10. Li J. S., Sexton D. J., Mick N., Nettles R., Fowler V. G., Ryan T., Bashore T., Corey G. R., Proposed Modifications to the Duke Criteria for the Diagnosis of Infective Endocarditis, 10.1086/313753
  11. Fowler Vance G., Miro Jose M., Hoen Bruno, Cabell Christopher H., Abrutyn Elias, Rubinstein Ethan, Corey G. Ralph, Spelman Denis, Bradley Suzanne F., Barsic Bruno, Pappas Paul A., Anstrom Kevin J., Wray Dannah, Fortes Claudio Q., Anguera Ignasi, Athan Eugene, Jones Philip, van der Meer Jan T. M., Elliott Tom S. J., Levine Donald P., Bayer Arnold S., ICE Investigators for the, Staphylococcus aureus Endocarditis : A Consequence of Medical Progress, 10.1001/jama.293.24.3012
  12. Manne Mahesh B., Shrestha Nabin K., Lytle Bruce W., Nowicki Edward R., Blackstone Eugene, Gordon Steven M., Pettersson Gosta, Fraser Thomas G., Outcomes After Surgical Treatment of Native and Prosthetic Valve Infective Endocarditis, 10.1016/j.athoracsur.2011.10.063
  13. Poesen K., Pottel H., Colaert J., Niel C De., Epidemiology of infective endocarditis in a large Belgian non-referral hospital, 10.1179/0001551214z.00000000046
  14. Kim D.-H., Kang D.-H., Lee M.-Z., Yun S.-C., Kim Y.-J., Song J.-M., Song J.-K., Lee J.-W., Sohn D.-W., Impact of Early Surgery on Embolic Events in Patients With Infective Endocarditis, 10.1161/circulationaha.109.927665
  15. Nakagawa Tom, Wada Hiroshi, Sakakura Kenichi, Yamada Yoko, Ishida Kohki, Ibe Tatsuro, Ikeda Nahoko, Sugawara Yoshitaka, Ako Junya, Momomura Shin-ichi, Clinical features of infective endocarditis: Comparison between the 1990s and 2000s, 10.1016/j.jjcc.2013.06.007
  16. Leone S., Ravasio V., Durante-Mangoni E., Crapis M., Carosi G., Scotton P. G., Barzaghi N., Falcone M., Chinello P., Pasticci M. B., Grossi P., Utili R., Viale P., Rizzi M., Suter F., Epidemiology, characteristics, and outcome of infective endocarditis in Italy: the Italian Study on Endocarditis, 10.1007/s15010-012-0285-y
  17. Tornos Pilar, Gonzalez-Alujas Teresa, Thuny Frank, Habib Gilbert, Infective Endocarditis: The European Viewpoint, 10.1016/j.cpcardiol.2011.03.004
  18. Slipczuk Leandro, Codolosa J. Nicolas, Davila Carlos D., Romero-Corral Abel, Yun Jeong, Pressman Gregg S., Figueredo Vincent M., Infective Endocarditis Epidemiology Over Five Decades: A Systematic Review, 10.1371/journal.pone.0082665
  19. Hoen Bruno, Changing Profile of Infective EndocarditisResults of a 1-Year Survey in France, 10.1001/jama.288.1.75
  20. Cahill Thomas J., Baddour Larry M., Habib Gilbert, Hoen Bruno, Salaun Erwan, Pettersson Gosta B., Schäfers Hans Joachim, Prendergast Bernard D., Challenges in Infective Endocarditis, 10.1016/j.jacc.2016.10.066
  21. Cabell Christopher H, Abrutyn Elias, Progress toward a global understanding of infective endocarditis, 10.1016/s0891-5520(01)00007-1
  22. Chu V. H., Early Predictors of In-Hospital Death in Infective Endocarditis, 10.1161/01.cir.0000124719.61827.7f
  23. Hasbun Rodrigo, Vikram Holenarasipur R., Barakat Lydia A., Buenconsejo Joan, Quagliarello Vincent J., Complicated Left-Sided Native Valve Endocarditis in Adults : Risk Classification for Mortality, 10.1001/jama.289.15.1933
  24. Lu K.J., Kearney L.G., Ord M., Jones E., Burrell L.M., Srivastava P.M., Age adjusted Charlson Co-morbidity Index is an independent predictor of mortality over long-term follow-up in infective endocarditis, 10.1016/j.ijcard.2013.08.023
  25. Vogkou Christiana T., Vlachogiannis Nikolaos I., Palaiodimos Leonidas, Kousoulis Antonis A., The causative agents in infective endocarditis: a systematic review comprising 33,214 cases, 10.1007/s10096-016-2660-6
  26. Garcia-Cabrera E., Fernandez-Hidalgo N., Almirante B., Ivanova-Georgieva R., Noureddine M., Plata A., Lomas J. M., Galvez-Acebal J., Hidalgo-Tenorio C., Ruiz-Morales J., Martinez-Marcos F. J., Reguera J. M., de la Torre-Lima J., Gonzalez A. d. A., , Neurological Complications of Infective Endocarditis: Risk Factors, Outcome, and Impact of Cardiac Surgery: A Multicenter Observational Study, 10.1161/circulationaha.112.000813
  27. Lowes J.A., Williams G., Tabaqchali S., Hill I.M., Hamer J., Houang E., Shaw E.J., Rees G.M., 10 YEARS OF INFECTIVE ENDOCARDITIS AT ST. BARTHOLOMEW'S HOSPITAL: ANALYSIS OF CLINICAL FEATURES AND TREATMENT IN RELATION TO PROGNOSIS AND MORTALITY, 10.1016/s0140-6736(80)90614-5
  28. Alexiou Christos, Langley Stephen M, Stafford Helena, Lowes John A, Livesey Steven A, Monro James L, Surgery for active culture-positive endocarditis: determinants of early and late outcome, 10.1016/s0003-4975(00)01139-5
  29. d'Udekem Y, David T.E, Feindel C.M, Armstrong S, Sun Z, Long-term results of surgery for active infective endocarditis1, 10.1016/s1010-7940(96)01020-2
  30. Dodge A, Eur J Cardiothorac Surg, 111, 198 (1995)
  31. Vikram Holenarasipur R., Buenconsejo Joan, Hasbun Rodrigo, Quagliarello Vincent J., Impact of Valve Surgery on 6-Month Mortality in Adults With Complicated, Left-Sided Native Valve Endocarditis : A Propensity Analysis, 10.1001/jama.290.24.3207
  32. Mourvillier Bruno, Trouillet Jean-Louis, Timsit Jean-François, Baudot Jérome, Chastre Jean, Régnier Bernard, Gibert Claude, Wolff Michel, Infective endocarditis in the intensive care unit: clinical spectrum and prognostic factors in 228 consecutive patients, 10.1007/s00134-004-2436-9
  33. Cabell Christopher H., Abrutyn Elias, Fowler Vance G., Hoen Bruno, Miro Jose M., Corey G. Ralph, Olaison Lars, Pappas Paul, Anstrom Kevin J., Stafford Judith A., Eykyn Susannah, Habib Gilbert, Mestres Carlos A., Wang Andrew, Use of surgery in patients with native valve infective endocarditis: Results from the International Collaboration on Endocarditis Merged Database, 10.1016/j.ahj.2005.03.057
  34. Wang Andrew, Pappas Paul, Anstrom Kevin J., Abrutyn Elias, Fowler Vance G., Hoen Bruno, Miro Jose M., Corey G. Ralph, Olaison Lars, Stafford Judith A., Mestres Carlos A., Cabell Christopher H., The use and effect of surgical therapy for prosthetic valve infective endocarditis: A propensity analysis of a multicenter, international cohort, 10.1016/j.ahj.2005.01.023
  35. Aksoy O., Sexton D. J., Wang A., Pappas P. A., Kourany W., Chu V., Fowler V. G., Woods C. W., Engemann J. J., Corey G. R., Harding T., Cabell C. H., Early Surgery in Patients with Infective Endocarditis: A Propensity Score Analysis, 10.1086/510583
  36. Tleyjeh I. M., Ghomrawi H. M.K., Steckelberg J. M., Hoskin T. L., Mirzoyev Z., Anavekar N. S., Enders F., Moustafa S., Mookadam F., Huskins W. C., Wilson W. R., Baddour L. M., The Impact of Valve Surgery on 6-Month Mortality in Left-Sided Infective Endocarditis, 10.1161/circulationaha.106.658831
  37. Bannay A., Hoen B., Duval X., Obadia J.-F., Selton-Suty C., Le Moing V., Tattevin P., Iung B., Delahaye F., Alla F., Leport C., Beguinot I., Bouvet A., Briancon S., Bruneval P., Danchin N., Etienne J., Goulet V., Mainardi J. L., Roudaut R., Ruimy R., Salamon R., Texier-Maugein J., Vandenesch F., Bernard Y., Duchene F., Plesiat P., Doco-Lecompte T., Selton-Suty C., Weber M., Beguinot I., Nazeyrollas P., Vernet V., Garin B., Lacassin F., Robert J., Andremont A., Garbaz E., Le Moing V., Leport C., Mainardi J. L., Ruimy R., Chidiac C., Delahaye F., Etienne J., Vandenesch F., Boucherit S., Bourezane Y., Nouioua W., Renaud D., Bouvet A., Collobert G., Merad B., Schlegel L., Bes M., Etienne J., Vandenesch F., , The impact of valve surgery on short- and long-term mortality in left-sided infective endocarditis: do differences in methodological approaches explain previous conflicting results?, 10.1093/eurheartj/ehp008
  38. Lalani T., Cabell C. H., Benjamin D. K., Lasca O., Naber C., Fowler V. G., Corey G. R., Chu V. H., Fenely M., Pachirat O., Tan R.-S., Watkin R., Ionac A., Moreno A., Mestres C. A., Casabe J., Chipigina N., Eisen D. P., Spelman D., Delahaye F., Peterson G., Olaison L., Wang A., , Analysis of the Impact of Early Surgery on In-Hospital Mortality of Native Valve Endocarditis: Use of Propensity Score and Instrumental Variable Methods to Adjust for Treatment-Selection Bias, 10.1161/circulationaha.109.864488
  39. Thuny F., Habib G., When should we operate on patients with acute infective endocarditis?, 10.1136/hrt.2008.151936
  40. Baddour L. M., Infective Endocarditis: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Statement for Healthcare Professionals From the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: Endorsed by the Infectious Diseases Society of America, 10.1161/circulationaha.105.165564
Bibliographic reference Yombi, Jean Cyr ; Yuma, Sandra Nyota ; Pasquet, Agnes ; Astarci, Parla ; Robert, Annie ; et. al. Staphylococcal versus Streptococcal infective endocarditis in a tertiary hospital in Belgium: epidemiology, clinical characteristics and outcome. In: Acta Clinica Belgica, Vol. 72, no. 6, p. 417-423 (2017)
Permanent URL http://hdl.handle.net/2078.1/190381