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Interaction between ingested engineered nanomaterials and the gastro-intestinal tract: in vitro toxicology aspects

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Laloux, Laurie [UCL] Polet, Madeleine [UCL] Schneider, Yves-Jacques [UCL]

Engineered nanomaterials (ENMs) introduced in food, either intentionally or by contamination/migration from food contact materials, are expected to be ingested and pass into the gastrointestinal tract. Based on the Nanotechnology Consumer Products Inventory, applications of silver nanoparticles (AgNPs) are found mainly in the "Health and Fitness" and in the "Food and beverage" sectors, two categories that potentially lead to ingestion. This chapter focuses on the fate of ENMs once in the gastrointestinal tract. It discusses ENMs properties modifications and interactions with digestive enzymes and food matrices as well as their impact on biological responses. The chapter also focuses on Caco-2 cells, as they are the most studied for pharmacological and toxicological assessments. In vitro models as well as various characterization methods may be useful to investigate the behavior of ENMs once ingested. In vitro models of the gut have been used for the cytotoxicity assessment of AgNPs.

Document type Contribution à ouvrage collectif (Book Chapter) – Chapitre
Publication date 2017
Language Anglais
Host document Monique A. V. Axelos, Marcel Van de Voorde ; "Nanotechnology in Agriculture and Food Science" (ISBN : 978-3-527-33989-1)
Publisher Wiley-VCH (Germany)
Publication status Publié
Affiliations UCL - SST/ISV - Institut des sciences de la vie
UCL - SST/LIBST - Louvain Institute of Biomolecular Science and Technology
Keywords Silver nanoparticles ; In vitro digestion ; Toxicity ; In vitro intestinal model
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Bibliographic reference Laloux, Laurie ; Polet, Madeleine ; Schneider, Yves-Jacques. Interaction between ingested engineered nanomaterials and the gastro-intestinal tract: in vitro toxicology aspects. In: Monique A. V. Axelos, Marcel Van de Voorde, Nanotechnology in Agriculture and Food Science, Wiley-VCH  : Germany 2017
Permanent URL http://hdl.handle.net/2078.1/189694