Cani, Patrice D.
[UCL]
de Vos, Willem M.
Metabolic disorders associated with obesity and cardiometabolic disorders are worldwide epidemic. Among the different environmental factors, the gut microbiota is now considered as a key player interfering with energy metabolism and host susceptibility to several non-communicable diseases. Among the next-generation beneficial microbes that have been identified, Akkermansia muciniphila is a promising candidate. Indeed, A. muciniphila is inversely associated with obesity, diabetes, cardiometabolic diseases and low-grade inflammation. Besides the numerous correlations observed, a large body of evidence has demonstrated the causal beneficial impact of this bacterium in a variety of preclinical models. Translating these exciting observations to human would be the next logic step and it now appears that several obstacles that would prevent the use of A. muciniphila administration in humans have been overcome. Moreover, several lines of evidence indicate that pasteurization of A. muciniphila not only increases its stability but more importantly increases its efficacy. This strongly positions A. muciniphila in the forefront of next-generation candidates for developing novel food or pharma supplements with beneficial effects. Finally, a specific protein present on the outer membrane of A. muciniphila, termed Amuc_1100, could be strong candidate for future drug development. In conclusion, as plants and its related knowledge, known as pharmacognosy, have been the source for designing drugs over the last century, we propose that microbes and microbiomegnosy, or knowledge of our gut microbiome, can become a novel source of future therapies.
- Abdelaal Mahmoud, le Roux Carel W. , Docherty Neil G., Morbidity and mortality associated with obesity, 10.21037/atm.2017.03.107
- Ajala O., Mold F., Boughton C., Cooke D., Whyte M., Childhood predictors of cardiovascular disease in adulthood. A systematic review and meta-analysis : Childhood predictors of cardiovascular disease, 10.1111/obr.12561
- Amar Jacques, Chabo Chantal, Waget Aurélie, Klopp Pascale, Vachoux Christelle, Bermúdez-Humarán Luis G., Smirnova Natalia, Bergé Mathieu, Sulpice Thierry, Lahtinen Sampo, Ouwehand Arthur, Langella Philippe, Rautonen Nina, Sansonetti Philippe J., Burcelin Rémy, Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment : Bacterial translocation during diabetes, 10.1002/emmm.201100159
- Anhê Fernando F, Roy Denis, Pilon Geneviève, Dudonné Stéphanie, Matamoros Sébastien, Varin Thibault V, Garofalo Carole, Moine Quentin, Desjardins Yves, Levy Emile, Marette André, A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increasedAkkermansiaspp. population in the gut microbiota of mice, 10.1136/gutjnl-2014-307142
- Belzer Clara, de Vos Willem M, Microbes inside—from diversity to function: the case of Akkermansia, 10.1038/ismej.2012.6
- Brun Paola, Giron Maria Cecilia, Qesari Marsela, Porzionato Andrea, Caputi Valentina, Zoppellaro Chiara, Banzato Serena, Grillo Alessia Rosaria, Spagnol Lisa, De Caro Raffaele, Pizzuti Daniela, Barbieri Vito, Rosato Antonio, Sturniolo Giacomo Carlo, Martines Diego, Zaninotto Giovanni, Palù Giorgio, Castagliuolo Ignazio, Toll-Like Receptor 2 Regulates Intestinal Inflammation by Controlling Integrity of the Enteric Nervous System, 10.1053/j.gastro.2013.08.047
- Cani Patrice D., Gut microbiota — at the intersection of everything?, 10.1038/nrgastro.2017.54
- Cani P. D., Amar J., Iglesias M. A., Poggi M., Knauf C., Bastelica D., Neyrinck A. M., Fava F., Tuohy K. M., Chabo C., Waget A., Delmee E., Cousin B., Sulpice T., Chamontin B., Ferrieres J., Tanti J.-F., Gibson G. R., Casteilla L., Delzenne N. M., Alessi M. C., Burcelin R., Metabolic Endotoxemia Initiates Obesity and Insulin Resistance, 10.2337/db06-1491
- Cani Patrice D., Dewever Cédric, Delzenne Nathalie M., Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats, 10.1079/bjn20041225
- Cani Patrice D., Everard Amandine, Talking microbes: When gut bacteria interact with diet and host organs, 10.1002/mnfr.201500406
- Cani P. D., Knauf C., Iglesias M. A., Drucker D. J., Delzenne N. M., Burcelin R., Improvement of Glucose Tolerance and Hepatic Insulin Sensitivity by Oligofructose Requires a Functional Glucagon-Like Peptide 1 Receptor, 10.2337/db05-1360
- Cani Patrice D., Plovier Hubert, Van Hul Matthias, Geurts Lucie, Delzenne Nathalie M., Druart Céline, Everard Amandine, Endocannabinoids — at the crossroads between the gut microbiota and host metabolism, 10.1038/nrendo.2015.211
- Cani P. D., Possemiers S., Van de Wiele T., Guiot Y., Everard A., Rottier O., Geurts L., Naslain D., Neyrinck A., Lambert D. M., Muccioli G. G., Delzenne N. M., Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability, 10.1136/gut.2008.165886
- Caricilli Andréa M., Picardi Paty K., de Abreu Lélia L., Ueno Mirian, Prada Patrícia O., Ropelle Eduardo R., Hirabara Sandro Massao, Castoldi Ângela, Vieira Pedro, Camara Niels O. S., Curi Rui, Carvalheira José B., Saad Mário J. A., Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice, 10.1371/journal.pbio.1001212
- Carmody Rachel N., Gerber Georg K., Luevano Jesus M., Gatti Daniel M., Somes Lisa, Svenson Karen L., Turnbaugh Peter J., Diet Dominates Host Genotype in Shaping the Murine Gut Microbiota, 10.1016/j.chom.2014.11.010
- Catry Emilie, Bindels Laure B, Tailleux Anne, Lestavel Sophie, Neyrinck Audrey M, Goossens Jean-François, Lobysheva Irina, Plovier Hubert, Essaghir Ahmed, Demoulin Jean-Baptiste, Bouzin Caroline, Pachikian Barbara D, Cani Patrice D, Staels Bart, Dessy Chantal, Delzenne Nathalie M, Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction, 10.1136/gutjnl-2016-313316
- Collado M. C., Derrien M., Isolauri E., de Vos W. M., Salminen S., Intestinal Integrity and Akkermansia muciniphila, a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly, 10.1128/aem.01477-07
- Collado Maria Carmen, Laitinen Kirsi, Salminen Seppo, Isolauri Erika, Maternal weight and excessive weight gain during pregnancy modify the immunomodulatory potential of breast milk, 10.1038/pr.2012.42
- Dao Maria Carlota, Everard Amandine, Aron-Wisnewsky Judith, Sokolovska Nataliya, Prifti Edi, Verger Eric O, Kayser Brandon D, Levenez Florence, Chilloux Julien, Hoyles Lesley, Dumas Marc-Emmanuel, Rizkalla Salwa W, Doré Joel, Cani Patrice D, Clément Karine, , Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology, 10.1136/gutjnl-2014-308778
- David Lawrence A., Maurice Corinne F., Carmody Rachel N., Gootenberg David B., Button Julie E., Wolfe Benjamin E., Ling Alisha V., Devlin A. Sloan, Varma Yug, Fischbach Michael A., Biddinger Sudha B., Dutton Rachel J., Turnbaugh Peter J., Diet rapidly and reproducibly alters the human gut microbiome, 10.1038/nature12820
- de la Cuesta-Zuluaga Jacobo, Mueller Noel T., Corrales-Agudelo Vanessa, Velásquez-Mejía Eliana P., Carmona Jenny A., Abad José M., Escobar Juan S., Metformin Is Associated With Higher Relative Abundance of Mucin-DegradingAkkermansia muciniphilaand Several Short-Chain Fatty Acid–Producing Microbiota in the Gut, 10.2337/dc16-1324
- Derrien M., Collado M. C., Ben-Amor K., Salminen S., de Vos W. M., The Mucin Degrader Akkermansia muciniphila Is an Abundant Resident of the Human Intestinal Tract, 10.1128/aem.01226-07
- Derrien Muriel, Van Baarlen Peter, Hooiveld Guido, Norin Elisabeth, Müller Michael, de Vos Willem M., Modulation of Mucosal Immune Response, Tolerance, and Proliferation in Mice Colonized by the Mucin-Degrader Akkermansia muciniphila, 10.3389/fmicb.2011.00166
- Derrien M., Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium, 10.1099/ijs.0.02873-0
- Dewulf Evelyne M., Cani Patrice D., Neyrinck Audrey M., Possemiers Sam, Holle Ann Van, Muccioli Giulio G., Deldicque Louise, Bindels Laure B., Pachikian Barbara D., Sohet Florence M., Mignolet Eric, Francaux Marc, Larondelle Yvan, Delzenne Nathalie M., Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice, 10.1016/j.jnutbio.2010.05.009
- Douillard François P, de Vos Willem M, Functional genomics of lactic acid bacteria: from food to health, 10.1186/1475-2859-13-s1-s8
- Dubourg Grégory, Lagier Jean-Christophe, Armougom Fabrice, Robert Catherine, Audoly Gilles, Papazian Laurent, Raoult Didier, High-level colonisation of the human gut by Verrucomicrobia following broad-spectrum antibiotic treatment, 10.1016/j.ijantimicag.2012.10.012
- Everard A., Belzer C., Geurts L., Ouwerkerk J. P., Druart C., Bindels L. B., Guiot Y., Derrien M., Muccioli G. G., Delzenne N. M., de Vos W. M., Cani P. D., Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity, 10.1073/pnas.1219451110
- Everard Amandine, Lazarevic Vladimir, Derrien Muriel, Girard Myriam, Muccioli Giulio G., Neyrinck Audrey M., Possemiers Sam, Van Holle Ann, François Patrice, de Vos Willem M., Delzenne Nathalie M., Schrenzel Jacques, Cani Patrice D., Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice, 10.2337/db11-0227
- Everard Amandine, Lazarevic Vladimir, Gaïa Nadia, Johansson Maria, Ståhlman Marcus, Backhed Fredrik, Delzenne Nathalie M, Schrenzel Jacques, François Patrice, Cani Patrice D, Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity, 10.1038/ismej.2014.45
- Forslund Kristoffer, Hildebrand Falk, Nielsen Trine, Falony Gwen, Le Chatelier Emmanuelle, Sunagawa Shinichi, Prifti Edi, Vieira-Silva Sara, Gudmundsdottir Valborg, Krogh Pedersen Helle, Arumugam Manimozhiyan, Kristiansen Karsten, Yvonne Voigt Anita, Vestergaard Henrik, Hercog Rajna, Igor Costea Paul, Roat Kultima Jens, Li Junhua, Jørgensen Torben, Levenez Florence, Dore Joël, Bjørn Nielsen H., Brunak Søren, Raes Jeroen, Hansen Torben, Wang Jun, Dusko Ehrlich S., Bork Peer, Pedersen Oluf, Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota, 10.1038/nature15766
- , Health Effects of Overweight and Obesity in 195 Countries over 25 Years, 10.1056/nejmoa1614362
- Gibson Glenn R., Hutkins Robert, Sanders Mary Ellen, Prescott Susan L., Reimer Raylene A., Salminen Seppo J., Scott Karen, Stanton Catherine, Swanson Kelly S., Cani Patrice D., Verbeke Kristin, Reid Gregor, Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics, 10.1038/nrgastro.2017.75
- Gibson, J. Nutr., 125, 1401 (1995)
- Gómez-Gallego C., Pohl S., Salminen S., De Vos W.M., Kneifel W., Akkermansia muciniphila: a novel functional microbe with probiotic properties, 10.3920/bm2016.0009
- Grander Christoph, Adolph Timon E, Wieser Verena, Lowe Patrick, Wrzosek Laura, Gyongyosi Benedek, Ward Doyle V, Grabherr Felix, Gerner Romana R, Pfister Alexandra, Enrich Barbara, Ciocan Dragos, Macheiner Sophie, Mayr Lisa, Drach Matthias, Moser Patrizia, Moschen Alexander R, Perlemuter Gabriel, Szabo Gyongyi, Cassard Anne Marie, Tilg Herbert,
Recovery of ethanol-induced
Akkermansia muciniphila
depletion ameliorates alcoholic liver disease
, 10.1136/gutjnl-2016-313432
- Greer Renee L., Dong Xiaoxi, Moraes Ana Carolina F., Zielke Ryszard A., Fernandes Gabriel R., Peremyslova Ekaterina, Vasquez-Perez Stephany, Schoenborn Alexi A., Gomes Everton P., Pereira Alexandre C., Ferreira Sandra R. G., Yao Michael, Fuss Ivan J., Strober Warren, Sikora Aleksandra E., Taylor Gregory A., Gulati Ajay S., Morgun Andrey, Shulzhenko Natalia, Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism, 10.1038/ncomms13329
- Hartstra Annick V., Bouter Kristien E.C., Bäckhed Fredrik, Nieuwdorp Max, Insights Into the Role of the Microbiome in Obesity and Type 2 Diabetes, 10.2337/dc14-0769
- Hill Colin, Guarner Francisco, Reid Gregor, Gibson Glenn R., Merenstein Daniel J., Pot Bruno, Morelli Lorenzo, Canani Roberto Berni, Flint Harry J., Salminen Seppo, Calder Philip C., Sanders Mary Ellen, Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic, 10.1038/nrgastro.2014.66
- Jeurink P.V., van Bergenhenegouwen J., Jiménez E., Knippels L.M.J., Fernández L., Garssen J., Knol J., Rodríguez J.M., Martín R., Human milk: a source of more life than we imagine, 10.3920/bm2012.0040
- Korpela Katri, Flint Harry J., Johnstone Alexandra M., Lappi Jenni, Poutanen Kaisa, Dewulf Evelyne, Delzenne Nathalie, de Vos Willem M., Salonen Anne, Gut Microbiota Signatures Predict Host and Microbiota Responses to Dietary Interventions in Obese Individuals, 10.1371/journal.pone.0090702
- Leal-Díaz Ana María, Noriega Lilia G., Torre-Villalvazo Ivan, Torres Nimbe, Alemán-Escondrillas Gabriela, López-Romero Patricia, Sánchez-Tapia Mónica, Aguilar-López Miriam, Furuzawa-Carballeda Janette, Velázquez-Villegas Laura A., Avila-Nava Azalia, Ordáz Guillermo, Gutiérrez-Uribe Janet A., Serna-Saldivar Sergio O., Tovar Armando R., Aguamiel concentrate from Agave salmiana and its extracted saponins attenuated obesity and hepatic steatosis and increased Akkermansia muciniphila in C57BL6 mice, 10.1038/srep34242
- Li Jin, Lin Shaoqiang, Vanhoutte Paul M., Woo Connie W., Xu Aimin, Akkermansia MuciniphilaProtects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation inApoe−/−MiceCLINICAL PERSPECTIVE, 10.1161/circulationaha.115.019645
- Li Jing, Zhao Fangqing, Wang Yidan, Chen Junru, Tao Jie, Tian Gang, Wu Shouling, Liu Wenbin, Cui Qinghua, Geng Bin, Zhang Weili, Weldon Ryan, Auguste Kelda, Yang Lei, Liu Xiaoyan, Chen Li, Yang Xinchun, Zhu Baoli, Cai Jun, Gut microbiota dysbiosis contributes to the development of hypertension, 10.1186/s40168-016-0222-x
- Liu T.-W., Cephas K. D., Holscher H. D., Kerr K. R., Mangian H. F., Tappenden K. A., Swanson K. S., Nondigestible Fructans Alter Gastrointestinal Barrier Function, Gene Expression, Histomorphology, and the Microbiota Profiles of Diet-Induced Obese C57BL/6J Mice, 10.3945/jn.115.227504
- Marchesi Julian R, Adams David H, Fava Francesca, Hermes Gerben D A, Hirschfield Gideon M, Hold Georgina, Quraishi Mohammed Nabil, Kinross James, Smidt Hauke, Tuohy Kieran M, Thomas Linda V, Zoetendal Erwin G, Hart Ailsa, The gut microbiota and host health: a new clinical frontier, 10.1136/gutjnl-2015-309990
- Maurer Alannah D, Eller Lindsay K, Hallam Megan C, Taylor Kim, Reimer Raylene A, Consumption of diets high in prebiotic fiber or protein during growth influences the response to a high fat and sucrose diet in adulthood in rats, 10.1186/1743-7075-7-77
- Ojo B., El-Rassi G. D., Payton M. E., Perkins-Veazie P., Clarke S., Smith B. J., Lucas E. A., Mango Supplementation Modulates Gut Microbial Dysbiosis and Short-Chain Fatty Acid Production Independent of Body Weight Reduction in C57BL/6 Mice Fed a High-Fat Diet, 10.3945/jn.115.226688
- Ottman Noora, Huuskonen Laura, Reunanen Justus, Boeren Sjef, Klievink Judith, Smidt Hauke, Belzer Clara, de Vos Willem M., Characterization of Outer Membrane Proteome of Akkermansia muciniphila Reveals Sets of Novel Proteins Exposed to the Human Intestine, 10.3389/fmicb.2016.01157
- Ottman Noora, Reunanen Justus, Meijerink Marjolein, Pietilä Taija E., Kainulainen Veera, Klievink Judith, Huuskonen Laura, Aalvink Steven, Skurnik Mikael, Boeren Sjef, Satokari Reetta, Mercenier Annick, Palva Airi, Smidt Hauke, de Vos Willem M., Belzer Clara, Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function, 10.1371/journal.pone.0173004
- Ouwehand Arthur C, Derrien Muriel, de Vos Willem, Tiihonen Kirsti, Rautonen Nina, Prebiotics and other microbial substrates for gut functionality, 10.1016/j.copbio.2005.01.007
- Ouwerkerk Janneke P., van der Ark Kees C. H., Davids Mark, Claassens Nico J., Finestra Teresa Robert, de Vos Willem M., Belzer Clara, Adaptation of Akkermansia muciniphila to the Oxic-Anoxic Interface of the Mucus Layer, 10.1128/aem.01641-16
- Pachikian Barbara D., Essaghir Ahmed, Demoulin Jean-Baptiste, Catry Emilie, Neyrinck Audrey M., Dewulf Evelyne M., Sohet Florence M., Portois Laurence, Clerbaux Laure-Alix, Carpentier Yvon A., Possemiers Sam, Bommer Guido T., Cani Patrice D., Delzenne Nathalie M., Prebiotic approach alleviates hepatic steatosis: Implication of fatty acid oxidative and cholesterol synthesis pathways, 10.1002/mnfr.201200364
- Plovier Hubert, Everard Amandine, Druart Céline, Depommier Clara, Van Hul Matthias, Geurts Lucie, Chilloux Julien, Ottman Noora, Duparc Thibaut, Lichtenstein Laeticia, Myridakis Antonis, Delzenne Nathalie M, Klievink Judith, Bhattacharjee Arnab, van der Ark Kees C H, Aalvink Steven, Martinez Laurent O, Dumas Marc-Emmanuel, Maiter Dominique, Loumaye Audrey, Hermans Michel P, Thissen Jean-Paul, Belzer Clara, de Vos Willem M, Cani Patrice D, A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice, 10.1038/nm.4236
- Png Chin Wen, Lindén Sara K, Gilshenan Kristen S, Zoetendal Erwin G, McSweeney Chris S, Sly Lindsay I, McGuckin Michael A, Florin Timothy H J, Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria, 10.1038/ajg.2010.281
- Reid Danielle T., Eller Lindsay K., Nettleton Jodi E., Reimer Raylene A., Postnatal prebiotic fibre intake mitigates some detrimental metabolic outcomes of early overnutrition in rats, 10.1007/s00394-015-1047-2
- Roberfroid Marcel, Gibson Glenn R., Hoyles Lesley, McCartney Anne L., Rastall Robert, Rowland Ian, Wolvers Danielle, Watzl Bernhard, Szajewska Hania, Stahl Bernd, Guarner Francisco, Respondek Frederique, Whelan Kevin, Coxam Veronique, Davicco Marie-Jeanne, Léotoing Laurent, Wittrant Yohann, Delzenne Nathalie M., Cani Patrice D., Neyrinck Audrey M., Meheust Agnes, Prebiotic effects: metabolic and health benefits, 10.1017/s0007114510003363
- Salonen Anne, Lahti Leo, Salojärvi Jarkko, Holtrop Grietje, Korpela Katri, Duncan Sylvia H, Date Priya, Farquharson Freda, Johnstone Alexandra M, Lobley Gerald E, Louis Petra, Flint Harry J, de Vos Willem M, Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men, 10.1038/ismej.2014.63
- Schneeberger Marc, Everard Amandine, Gómez-Valadés Alicia G., Matamoros Sébastien, Ramírez Sara, Delzenne Nathalie M., Gomis Ramon, Claret Marc, Cani Patrice D., Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice, 10.1038/srep16643
- Seregin, Cell Rep., 19, 733 (2017)
- Shen Jing, Tong Xuedong, Sud Neetu, Khound Rituraj, Song Yongyan, Maldonado-Gomez Maria X., Walter Jens, Su Qiaozhu,
Low-Density Lipoprotein Receptor Signaling Mediates the Triglyceride-Lowering Action of
Akkermansia muciniphila
in Genetic-Induced HyperlipidemiaHighlights
, 10.1161/atvbaha.116.307597
- Shetty Sudarshan A., Hugenholtz Floor, Lahti Leo, Smidt Hauke, de Vos Willem M., Intestinal microbiome landscaping: insight in community assemblage and implications for microbial modulation strategies, 10.1093/femsre/fuw045
- Shin Na-Ri, Lee June-Chul, Lee Hae-Youn, Kim Min-Soo, Whon Tae Woong, Lee Myung-Shik, Bae Jin-Woo, An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice, 10.1136/gutjnl-2012-303839
- Singh Dhirendra Pratap, Singh Jagdeep, Boparai Ravneet Kaur, Zhu JianHua, Mantri Shrikant, Khare Pragyanshu, Khardori Romesh, Kondepudi Kanthi Kiran, Chopra Kanwaljit, Bishnoi Mahendra, Isomalto-oligosaccharides, a prebiotic, functionally augment green tea effects against high fat diet-induced metabolic alterations via preventing gut dysbacteriosis in mice, 10.1016/j.phrs.2017.06.015
- Song Haizhao, Chu Qiang, Yan Fujie, Yang Yunyun, Han Wen, Zheng Xiaodong, Red pitaya betacyanins protects from diet-induced obesity, liver steatosis and insulin resistance in association with modulation of gut microbiota in mice : The function of red pitaya betacyanins, 10.1111/jgh.13278
- Thaiss Christoph A., Levy Maayan, Korem Tal, Dohnalová Lenka, Shapiro Hagit, Jaitin Diego A., David Eyal, Winter Deborah R., Gury-BenAri Meital, Tatirovsky Evgeny, Tuganbaev Timur, Federici Sara, Zmora Niv, Zeevi David, Dori-Bachash Mally, Pevsner-Fischer Meirav, Kartvelishvily Elena, Brandis Alexander, Harmelin Alon, Shibolet Oren, Halpern Zamir, Honda Kenya, Amit Ido, Segal Eran, Elinav Eran, Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations, 10.1016/j.cell.2016.11.003
- Ward Tonya L, Hosid Sergey, Ioshikhes Ilya, Altosaar Illimar, Human milk metagenome: a functional capacity analysis, 10.1186/1471-2180-13-116
- Wen Li, Duffy Andrew, Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes, 10.3945/jn.116.240754
- Yassour Moran, Lim Mi Young, Yun Hyun Sun, Tickle Timothy L., Sung Joohon, Song Yun-Mi, Lee Kayoung, Franzosa Eric A., Morgan Xochitl C., Gevers Dirk, Lander Eric S., Xavier Ramnik J., Birren Bruce W., Ko GwangPyo, Huttenhower Curtis, Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes, 10.1186/s13073-016-0271-6
- Zeevi David, Korem Tal, Zmora Niv, Israeli David, Rothschild Daphna, Weinberger Adina, Ben-Yacov Orly, Lador Dar, Avnit-Sagi Tali, Lotan-Pompan Maya, Suez Jotham, Mahdi Jemal Ali, Matot Elad, Malka Gal, Kosower Noa, Rein Michal, Zilberman-Schapira Gili, Dohnalová Lenka, Pevsner-Fischer Meirav, Bikovsky Rony, Halpern Zamir, Elinav Eran, Segal Eran, Personalized Nutrition by Prediction of Glycemic Responses, 10.1016/j.cell.2015.11.001
- Zhang Xiuying, Shen Dongqian, Fang Zhiwei, Jie Zhuye, Qiu Xinmin, Zhang Chunfang, Chen Yingli, Ji Linong, Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance, 10.1371/journal.pone.0071108
- Zhu Limeng, Qin Song, Zhai Shixiang, Gao Yonglin, Li Lili, Inulin with different degrees of polymerization modulates composition of intestinal microbiota in mice, 10.1093/femsle/fnx075
Bibliographic reference |
Cani, Patrice D. ; de Vos, Willem M.. Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila. In: Frontiers in Microbiology, Vol. 8, p. 1765 [1-8] (2017) |
Permanent URL |
http://hdl.handle.net/2078.1/188038 |