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Loss of membranous expression of beta-catenin is associated with tumor progression in cutaneous melanoma and rarely caused by exon 3 mutations.

Bibliographic reference Demunter, Anouk ; Libbrecht, Louis ; Degreef, Hugo ; De Wolf-Peeters, Chris ; van den Oord, Joost J. Loss of membranous expression of beta-catenin is associated with tumor progression in cutaneous melanoma and rarely caused by exon 3 mutations.. In: Modern Pathology, Vol. 15, no.4, p. 454-461 (2002)
Permanent URL http://hdl.handle.net/2078/187230
  1. Silye R., Karayiannakis A. J., Syrigos K. N., Poole S., Van Noorden S., Batchelor W., Regele H., Sega W., Boesmueller H., Krausz T., Pignatelli M., E-cadherin/catenin complex in benign and malignant melanocytic lesions, 10.1002/(sici)1096-9896(199812)186:4<350::aid-path181>3.0.co;2-k
  2. Tang A, Eller MS, Hara M, Yaar M, Hirohashi S, Gilchrest BA . E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro. J Cell Sci 1994; 107: 983–992.
  3. Gumbiner B. M., McCrea P. D., Catenins as mediators of the cytoplasmic functions of cadherins, 10.1242/jcs.1993.supplement_17.22
  4. Behrens Jürgen, von Kries Jens P., Kühl Michael, Bruhn Laurakay, Wedlich Doris, Grosschedl Rudolf, Birchmeier Walter, Functional interaction of β-catenin with the transcription factor LEF-1, 10.1038/382638a0
  5. Munemitsu S., Albert I., Souza B., Rubinfeld B., Polakis P., Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein., 10.1073/pnas.92.7.3046
  6. Rubinfeld B., Albert I., Porfiri E., Fiol C., Munemitsu S., Polakis P., Binding of GSK3beta to the APC-beta -Catenin Complex and Regulation of Complex Assembly, 10.1126/science.272.5264.1023
  7. Behrens J., Functional Interaction of an Axin Homolog, Conductin, with -Catenin, APC, and GSK3, 10.1126/science.280.5363.596
  8. Aberle Hermann, Bauer Andreas, Stappert Jörg, Kispert Andreas, Kemler Rolf, β-catenin is a target for the ubiquitin–proteasome pathway, 10.1093/emboj/16.13.3797
  9. Korinek V., Constitutive Transcriptional Activation by a beta -Catenin-Tcf Complex in APC-/- Colon Carcinoma, 10.1126/science.275.5307.1784
  10. Rubinfeld B., Stabilization of beta -Catenin by Genetic Defects in Melanoma Cell Lines, 10.1126/science.275.5307.1790
  11. Takayama T, Shiozaki H, Shibamoto S, et al. Beta-catenin expression in human cancers. Am J Pathol 1996; 148: 39–46.
  12. Shimazui T, Schalken JA, Giroldi LA, et al. Prognostic value of cadherin-associated molecules (alpha-, beta- and gamma-catenins and p120cas) in bladder tumors. Cancer Res 1996; 56: 4154–4158.
  13. Richmond PJ, Karayiannakis AJ, Nagafuchi A, et al. Aberrant E-cadherin and alpha-catenin expression in prostate cancer: correlation with patient survival. Cancer Res 1997; 57: 3189–3193.
  14. Rimm David L., Caca Karel, Hu Gang, Harrison Frank B., Fearon Eric R., Frequent Nuclear/Cytoplasmic Localization of β-Catenin without Exon 3 Mutations in Malignant Melanoma, 10.1016/s0002-9440(10)65278-9
  15. Omholt Katarina, Platz Anton, Ringborg Ulrik, Hansson Johan, Cytoplasmic and nuclear accumulation of ?-catenin is rarely caused byCTNNB1 exon 3 mutations in cutaneous malignant melanoma, 10.1002/ijc.1270
  16. Fuchs Elaine, Chan Edward, Gat Uri, McNiff Jennifer M, 10.1038/7747
  17. Demunter A, Ahmadian MR, Libbrecht L, Stas M, Baens M, Scheffzek K, et al. A novel N-RAS mutation in malignant melanoma is associated with excellent prognosis. Cancer Res 2001; 61: 4916–4922.
  18. Heid C A, Stevens J, Livak K J, Williams P M, Real time quantitative PCR., 10.1101/gr.6.10.986
  19. Bieche I, Onody P, Laurendeau I, Olivi M, Vivaud D, Lidereau R, et al. Real-time reverse transcription–PCR assay for future management of ERBB2-based clinical applications. Clin Chem 1999; 45: 1148–1156.
  20. Morin P. J., Activation of beta -Catenin-Tcf Signaling in Colon Cancer by Mutations in beta -Catenin or APC, 10.1126/science.275.5307.1787
  21. Nakanishi Y, Ochiai A, Akimoto S, Kato H, Watanabe H, Tachimori Y, et al. Expression of E-cadherin, α-catenin, β-catenin and plakoglobin in esophageal carcinomas and its prognostic significance. Lab Invest 1997; 54: 158–165.
  22. Woo DK, Kim HS, Lee HS, Kang YH, Yang HK, Kim WH . Altered expression and mutation of β-catenin gene in gastric carcinomas and cell lines. Int J Cancer (Pred Oncol) 2001; 95: 108–113.
  23. Voeller HJ, Truica CL, Gelmann EP . Beta-catenin mutations in human prostate cancer. Cancer Res 1998; 58: 2520–2523.
  24. Huang Huatao, Fujii Hideki, Sankila Anna, Mahler-Araujo Betania M., Matsuda Masanori, Cathomas Gieri, Ohgaki Hiroko, β-Catenin Mutations Are Frequent in Human Hepatocellular Carcinomas Associated with Hepatitis C Virus Infection, 10.1016/s0002-9440(10)65496-x
  25. Miyoshi Y, Iwao K, Nagasawa Y, Aihara T, Sasaki Y, Imaoka S, et al. Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res 1998; 58: 2524–2527.
  26. Ichihashi Naoki, Kitajima Yasuo, Loss of heterozygosity of adenomatous polyposis coli gene in cutaneous tumors as determined by using polymerase chain reaction and paraffin section preparations, 10.1016/s0923-1811(99)00052-3
  27. Ruiz Anna, Nadal Marga, Puig Susana, Estivill Xavier, Cloning of the human phospholipase A2 activating protein (hPLAP) gene on the chromosome 9p21 melanoma deleted region, 10.1016/s0378-1119(99)00354-6
  28. Herlyn M., Berking C., Li G., Satyamoorthy K., Lessons from melanocyte development for understanding the biological events in naevus and melanoma formation : , 10.1097/00008390-200008000-00001
  29. Hsu MY, Wheelock MJ, Johnson KR, Herlyn M . Shifts in cadherin profiles between human normal melanocytes and melanomas. J Invest Dermatol Symp Proc 1996; 1(2): 188–194.
  30. Li G, Satyamoorthy K, Herlyn M . N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells. Cancer Res 2001; 61: 3819–3825.
  31. Kitching P. A., Patel V., Harach H. R., Adrenocortical oncocytoma, 10.1136/jcp.52.2.151