User menu

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics.

Bibliographic reference Gibson, Glenn R ; Hutkins, Robert ; Sanders, Mary Ellen ; Prescott, Susan L ; Reimer, Raylene A ; et. al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics.. In: Nature Reviews. Gastroenterology & Hepatology, Vol. 14, no.8, p. 491-502 (2017)
Permanent URL http://hdl.handle.net/2078.1/186902
  1. Prescott Susan L., Millstein Rachel A., Katzman Martin A., Logan Alan C., Biodiversity, the Human Microbiome and Mental Health: Moving toward a New Clinical Ecology for the 21st Century?, 10.1155/2016/2718275
  2. David Lawrence A., Maurice Corinne F., Carmody Rachel N., Gootenberg David B., Button Julie E., Wolfe Benjamin E., Ling Alisha V., Devlin A. Sloan, Varma Yug, Fischbach Michael A., Biddinger Sudha B., Dutton Rachel J., Turnbaugh Peter J., Diet rapidly and reproducibly alters the human gut microbiome, 10.1038/nature12820
  3. Cani Patrice D., Everard Amandine, Talking microbes: When gut bacteria interact with diet and host organs, 10.1002/mnfr.201500406
  4. Gibson G. R., J. Nutr., 125, 1401 (1995)
  5. Collins Stephanie, Reid Gregor, Distant Site Effects of Ingested Prebiotics, 10.3390/nu8090523
  6. Propst E. L., Flickinger E. A., Bauer L. L., Merchen N. R., Fahey G. C., A dose-response experiment evaluating the effects of oligofructose and inulin on nutrient digestibility, stool quality, and fecal protein catabolites in healthy adult dogs, 10.2527/2003.81123057x
  7. Park Si Hong, Lee Sang In, Ricke Steven C., Microbial Populations in Naked Neck Chicken Ceca Raised on Pasture Flock Fed with Commercial Yeast Cell Wall Prebiotics via an Illumina MiSeq Platform, 10.1371/journal.pone.0151944
  8. Dubos R., INDIGENOUS, NORMAL, AND AUTOCHTHONOUS FLORA OF THE GASTROINTESTINAL TRACT, 10.1084/jem.122.1.67
  9. Savage D C, Microbial Ecology of the Gastrointestinal Tract, 10.1146/annurev.mi.31.100177.000543
  10. Hill Colin, Guarner Francisco, Reid Gregor, Gibson Glenn R., Merenstein Daniel J., Pot Bruno, Morelli Lorenzo, Canani Roberto Berni, Flint Harry J., Salminen Seppo, Calder Philip C., Sanders Mary Ellen, Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic, 10.1038/nrgastro.2014.66
  11. Simpson H. L., Campbell B. J., Review article: dietary fibre-microbiota interactions, 10.1111/apt.13248
  12. Depeint F., Am. J. Clin. Nutr., 87, 785 (2008)
  13. Costabile Adele, Kolida Sofia, Klinder Annett, Gietl Eva, Bäuerlein Michael, Frohberg Claus, Landschütze Volker, Gibson Glenn R., A double-blind, placebo-controlled, cross-over study to establish the bifidogenic effect of a very-long-chain inulin extracted from globe artichoke ( Cynara scolymus) in healthy human subjects, 10.1017/s0007114510001571
  14. Roberfroid Marcel, Gibson Glenn R., Hoyles Lesley, McCartney Anne L., Rastall Robert, Rowland Ian, Wolvers Danielle, Watzl Bernhard, Szajewska Hania, Stahl Bernd, Guarner Francisco, Respondek Frederique, Whelan Kevin, Coxam Veronique, Davicco Marie-Jeanne, Léotoing Laurent, Wittrant Yohann, Delzenne Nathalie M., Cani Patrice D., Neyrinck Audrey M., Meheust Agnes, Prebiotic effects: metabolic and health benefits, 10.1017/s0007114510003363
  15. Schrezenmeir J., Am. J. Clin. Nutr., 73, 361S (2001)
  16. Gibson Glenn R., Probert Hollie M., Loo Jan Van, Rastall Robert A., Roberfroid Marcel B., Dietary modulation of the human colonic microbiota: updating the concept of prebiotics, 10.1079/nrr200479
  17. Pineiro Maya, Asp Nils-Georg, Reid Gregor, Macfarlane Sandra, Morelli Lorenzo, Brunser Oscar, Tuohy Kieran, FAO Technical Meeting on Prebiotics : , 10.1097/mcg.0b013e31817f184e
  18. Gibson Glenn R., Scott Karen P., Rastall Robert A., Tuohy Kieran M., Hotchkiss Arland, Dubert-Ferrandon Alix, Gareau Melanie, Murphy Eileen F., Saulnier Delphine, Loh Gunnar, Macfarlane Sandra, Delzenne Nathalie, Ringel Yehuda, Kozianowski Gunhild, Dickmann Robin, Lenoir-Wijnkoop Irene, Walker Carey, Buddington Randal, Dietary prebiotics: current status and new definition, 10.1616/1476-2137.15880
  19. Bindels Laure B., Delzenne Nathalie M., Cani Patrice D., Walter Jens, Towards a more comprehensive concept for prebiotics, 10.1038/nrgastro.2015.47
  20. Dewulf Evelyne M, Cani Patrice D, Claus Sandrine P, Fuentes Susana, Puylaert Philippe GB, Neyrinck Audrey M, Bindels Laure B, de Vos Willem M, Gibson Glenn R, Thissen Jean-Paul, Delzenne Nathalie M, Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women, 10.1136/gutjnl-2012-303304
  21. Hutkins Robert W, Krumbeck Janina A, Bindels Laure B, Cani Patrice D, Fahey George, Goh Yong Jun, Hamaker Bruce, Martens Eric C, Mills David A, Rastal Robert A, Vaughan Elaine, Sanders Mary Ellen, Prebiotics: why definitions matter, 10.1016/j.copbio.2015.09.001
  22. Louis Petra, Flint Harry J., Michel Catherine, How to Manipulate the Microbiota: Prebiotics, Microbiota of the Human Body (2016) ISBN:9783319312460 p.119-142, 10.1007/978-3-319-31248-4_9
  23. Shanahan F., Fiber man meets microbial man, 10.3945/ajcn.114.101550
  24. Verspreet Joran, Damen Bram, Broekaert Willem F., Verbeke Kristin, Delcour Jan A., Courtin Christophe M., A Critical Look at Prebiotics Within the Dietary Fiber Concept, 10.1146/annurev-food-081315-032749
  25. Canfora Emanuel E., Jocken Johan W., Blaak Ellen E., Short-chain fatty acids in control of body weight and insulin sensitivity, 10.1038/nrendo.2015.128
  26. Koh Ara, De Vadder Filipe, Kovatcheva-Datchary Petia, Bäckhed Fredrik, From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites, 10.1016/j.cell.2016.05.041
  27. Rastall Robert A., Gibson Glenn R., Recent developments in prebiotics to selectively impact beneficial microbes and promote intestinal health, 10.1016/j.copbio.2014.11.002
  28. Rastall R.A., Functional Oligosaccharides: Application and Manufacture, 10.1146/annurev.food.080708.100746
  29. Sarbini S., Func. Food Rev., 3, 93 (2011)
  30. Goh Yong Jun, Klaenhammer Todd R., Genetic Mechanisms of Prebiotic Oligosaccharide Metabolism in Probiotic Microbes, 10.1146/annurev-food-022814-015706
  31. Delcour J. A., Aman P., Courtin C. M., Hamaker B. R., Verbeke K., Prebiotics, Fermentable Dietary Fiber, and Health Claims, 10.3945/an.115.010546
  32. Ben David Yonit, Dassa Bareket, Borovok Ilya, Lamed Raphael, Koropatkin Nicole M., Martens Eric C., White Bryan A., Bernalier-Donadille Annick, Duncan Sylvia H., Flint Harry J., Bayer Edward A., Moraïs Sarah, Ruminococcal cellulosome systems from rumen to human : Human ruminococcal cellulosome, 10.1111/1462-2920.12868
  33. Garrido Daniel, Ruiz-Moyano Santiago, Lemay Danielle G., Sela David A., German J. Bruce, Mills David A., Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria, 10.1038/srep13517
  34. Oozeer R., van Limpt K., Ludwig T., Ben Amor K., Martin R., Wind R. D., Boehm G., Knol J., Intestinal microbiology in early life: specific prebiotics can have similar functionalities as human-milk oligosaccharides, 10.3945/ajcn.112.038893
  35. De Leoz Maria Lorna A., Kalanetra Karen M., Bokulich Nicholas A., Strum John S., Underwood Mark A., German J. Bruce, Mills David A., Lebrilla Carlito B., Human Milk Glycomics and Gut Microbial Genomics in Infant Feces Show a Correlation between Human Milk Oligosaccharides and Gut Microbiota: A Proof-of-Concept Study, 10.1021/pr500759e
  36. Rockova Sarka, Rada Vojtech, Nevoral Jiri, Marsik Petr, Vlkova Eva, Bunesova Vera, Inter-species differences in the growth of bifidobacteria cultured on human milk oligosaccharides, 10.1007/s12223-012-0134-5
  37. He Y., Lawlor N. T., Newburg D. S., Human Milk Components Modulate Toll-Like Receptor-Mediated Inflammation, 10.3945/an.115.010090
  38. Kulinich Anna, Liu Li, Human milk oligosaccharides: The role in the fine-tuning of innate immune responses, 10.1016/j.carres.2016.07.009
  39. Morrow A. L., J. Nutr., 135, 1304 (2005)
  40. Charbonneau Mark R., O’Donnell David, Blanton Laura V., Totten Sarah M., Davis Jasmine C.C., Barratt Michael J., Cheng Jiye, Guruge Janaki, Talcott Michael, Bain James R., Muehlbauer Michael J., Ilkayeva Olga, Wu Chao, Struckmeyer Tedd, Barile Daniela, Mangani Charles, Jorgensen Josh, Fan Yue-mei, Maleta Kenneth, Dewey Kathryn G., Ashorn Per, Newgard Christopher B., Lebrilla Carlito, Mills David A., Gordon Jeffrey I., Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition, 10.1016/j.cell.2016.01.024
  41. Marriage Barbara J., Buck Rachael H., Goehring Karen C., Oliver Jeffery S., Williams Jennifer A., Infants Fed a Lower Calorie Formula With 2′FL Show Growth and 2′FL Uptake Like Breast-Fed Infants : , 10.1097/mpg.0000000000000889
  42. Goehring K. C., Marriage B. J., Oliver J. S., Wilder J. A., Barrett E. G., Buck R. H., Similar to Those Who Are Breastfed, Infants Fed a Formula Containing 2'-Fucosyllactose Have Lower Inflammatory Cytokines in a Randomized Controlled Trial, 10.3945/jn.116.236919
  43. Elison Emma, Vigsnaes Louise K., Rindom Krogsgaard Laura, Rasmussen Julie, Sørensen Nikolaj, McConnell Bruce, Hennet Thierry, Sommer Morten O. A., Bytzer Peter, Oral supplementation of healthy adults with 2′-O-fucosyllactose and lacto-N-neotetraose is well tolerated and shifts the intestinal microbiota, 10.1017/s0007114516003354
  44. Underwood M. A., Pediatr. Res., 77, 229 (2015)
  45. Charbonneau Mark R., Blanton Laura V., DiGiulio Daniel B., Relman David A., Lebrilla Carlito B., Mills David A., Gordon Jeffrey I., A microbial perspective of human developmental biology, 10.1038/nature18845
  46. Clifford M. N., Diet-Derived Phenols in Plasma and Tissues and their Implications for Health, 10.1055/s-2004-835835
  47. Dueñas Montserrat, Muñoz-González Irene, Cueva Carolina, Jiménez-Girón Ana, Sánchez-Patán Fernando, Santos-Buelga Celestino, Moreno-Arribas M. Victoria, Bartolomé Begoña, A Survey of Modulation of Gut Microbiota by Dietary Polyphenols, 10.1155/2015/850902
  48. O'Keefe Stephen J. D., Diet, microorganisms and their metabolites, and colon cancer, 10.1038/nrgastro.2016.165
  49. Pluznick Jennifer L., Gut microbiota in renal physiology: focus on short-chain fatty acids and their receptors, 10.1016/j.kint.2016.06.033
  50. Boets Eef, Gomand Sara V., Deroover Lise, Preston Tom, Vermeulen Karen, De Preter Vicky, Hamer Henrike M., Van den Mooter Guy, De Vuyst Luc, Courtin Christophe M., Annaert Pieter, Delcour Jan A., Verbeke Kristin A., Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study : Short-chain fatty acid systemic availability and metabolism in humans, 10.1113/jp272613
  51. Canani Roberto Berni, Potential beneficial effects of butyrate in intestinal and extraintestinal diseases, 10.3748/wjg.v17.i12.1519
  52. McMillan Amy, Rulisa Stephen, Sumarah Mark, Macklaim Jean M., Renaud Justin, Bisanz Jordan E., Gloor Gregory B., Reid Gregor, A multi-platform metabolomics approach identifies highly specific biomarkers of bacterial diversity in the vagina of pregnant and non-pregnant women, 10.1038/srep14174
  53. Vulevic Jelena, Juric Aleksandra, Walton Gemma E., Claus Sandrine P., Tzortzis George, Toward Ruth E., Gibson Glenn R., Influence of galacto-oligosaccharide mixture (B-GOS) on gut microbiota, immune parameters and metabonomics in elderly persons, 10.1017/s0007114515001889
  54. DE PRETER V., VANHOUTTE T., HUYS G., SWINGS J., RUTGEERTS P., VERBEKE K., Baseline microbiota activity and initial bifidobacteria counts influence responses to prebiotic dosing in healthy subjects : RESPONSES TO PREBIOTIC DOSING OF COLONIC FLORA, 10.1111/j.1365-2036.2007.03588.x
  55. Albert Arianne Y. K., Chaban Bonnie, Wagner Emily C., Schellenberg John J., Links Matthew G., van Schalkwyk Julie, Reid Gregor, Hemmingsen Sean M., Hill Janet E., Money Deborah, , A Study of the Vaginal Microbiome in Healthy Canadian Women Utilizing cpn60-Based Molecular Profiling Reveals Distinct Gardnerella Subgroup Community State Types, 10.1371/journal.pone.0135620
  56. Korshonov V. M., Zh. Microbiol. Epidemiol. Immunobiol., 4, 74 (1999)
  57. Antonio May A. D., Rabe Lorna K., Hillier Sharon L., Colonization of the Rectum byLactobacillusSpecies and Decreased Risk of Bacterial Vaginosis, 10.1086/430926
  58. Joyce Susan A., Gahan Cormac G.M., Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health, 10.1146/annurev-food-041715-033159
  59. Kuo Shiu-Ming, Merhige Patricia M., Hagey Lee R., The Effect of Dietary Prebiotics and Probiotics on Body Weight, Large Intestine Indices, and Fecal Bile Acid Profile in Wild Type and IL10−/− Mice, 10.1371/journal.pone.0060270
  60. Savignac Helene M., Couch Yvonne, Stratford Michael, Bannerman David M., Tzortzis George, Anthony Daniel C., Burnet Philip W.J., Prebiotic administration normalizes lipopolysaccharide (LPS)-induced anxiety and cortical 5-HT2A receptor and IL1-β levels in male mice, 10.1016/j.bbi.2015.10.007
  61. Malaguarnera Mariano, Gargante Maria Pia, Malaguarnera Giulia, Salmeri Mario, Mastrojeni Silvana, Rampello Liborio, Pennisi Giovanni, Volti Giovanni Li, Galvano Fabio, Bifidobacterium combined with fructo-oligosaccharide versus lactulose in the treatment of patients with hepatic encephalopathy : , 10.1097/meg.0b013e328330a8d3
  62. Madhok V., Futamura M., Thomas K. S., Barbarot S., What's new in atopic eczema? An analysis of systematic reviews published in 2012 and 2013. Part 2. Treatment and prevention, 10.1111/ced.12591
  63. Moro G, A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age, 10.1136/adc.2006.098251
  64. Hong Ki-Bae, Jeong Mingeum, Han Ki Soo, Hwan Kim Jae, Park Yooheon, Suh Hyung Joo, Photoprotective effects of galacto-oligosaccharide and/orBifidobacterium longumsupplementation against skin damage induced by ultraviolet irradiation in hairless mice, 10.3109/09637486.2015.1088823
  65. Gao Zhan, Tseng Chi-hong, Strober Bruce E., Pei Zhiheng, Blaser Martin J., Substantial Alterations of the Cutaneous Bacterial Biota in Psoriatic Lesions, 10.1371/journal.pone.0002719
  66. Paulino L. C., Tseng C.-H., Strober B. E., Blaser M. J., Molecular Analysis of Fungal Microbiota in Samples from Healthy Human Skin and Psoriatic Lesions, 10.1128/jcm.00785-06
  67. Campanati A., Berardi R., Onofri A., Pierantoni C., Conte I., Giuliodori K., Molinelli E., Marcucci F., Cascinu S., Offidani A., A novel approach to manage skin toxicity caused by therapeutic agents targeting epidermal growth factor receptor, 10.1093/annonc/mds026
  68. Everard Amandine, Lazarevic Vladimir, Gaïa Nadia, Johansson Maria, Ståhlman Marcus, Backhed Fredrik, Delzenne Nathalie M, Schrenzel Jacques, François Patrice, Cani Patrice D, Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity, 10.1038/ismej.2014.45
  69. Paul Heather A., Bomhof Marc R., Vogel Hans J., Reimer Raylene A., Diet-induced changes in maternal gut microbiota and metabolomic profiles influence programming of offspring obesity risk in rats, 10.1038/srep20683
  70. Delzenne Nathalie M., Cani Patrice D., Daubioul Catherine, Neyrinck Audrey M., Impact of inulin and oligofructose on gastrointestinal peptides, 10.1079/bjn20041342
  71. Cani P. D, Lecourt E., Dewulf E. M, Sohet F. M, Pachikian B. D, Naslain D., De Backer F., Neyrinck A. M, Delzenne N. M, Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal, 10.3945/ajcn.2009.28095
  72. Parnell J. A, Reimer R. A, Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults, 10.3945/ajcn.2009.27465
  73. Van De Pol M. A., Lutter R., Smids B. S., Weersink E. J. M., Van Der Zee J. S., Synbiotics reduce allergen-induced T-helper 2 response and improve peak expiratory flow in allergic asthmatics : Effect of synbiotics in allergic asthmatics, 10.1111/j.1398-9995.2010.02454.x
  74. Depner M., J. Allergy Clin. Immunol., 6749, 30710 (2016)
  75. Bomar Lindsey, Brugger Silvio D., Yost Brian H., Davies Sean S., Lemon Katherine P., Corynebacterium accolensReleases Antipneumococcal Free Fatty Acids from Human Nostril and Skin Surface Triacylglycerols, 10.1128/mbio.01725-15
  76. Lozupone Catherine A., Stombaugh Jesse I., Gordon Jeffrey I., Jansson Janet K., Knight Rob, Diversity, stability and resilience of the human gut microbiota, 10.1038/nature11550
  77. Reid G., Kumar H., Khan A.I., Rautava S., Tobin J., Salminen S., The case in favour of probiotics before, during and after pregnancy: insights from the first 1,500 days, 10.3920/bm2015.0140
  78. Kellow Nicole J., Coughlan Melinda T., Reid Christopher M., Metabolic benefits of dietary prebiotics in human subjects: a systematic review of randomised controlled trials, 10.1017/s0007114513003607
  79. Beserra Bruna T.S., Fernandes Ricardo, do Rosario Vinicius A., Mocellin Michel C., Kuntz Marilyn G.F., Trindade Erasmo B.S.M., A systematic review and meta-analysis of the prebiotics and synbiotics effects on glycaemia, insulin concentrations and lipid parameters in adult patients with overweight or obesity, 10.1016/j.clnu.2014.10.004
  80. Barengolts Elena, GUT MICROBIOTA, PREBIOTICS, PROBIOTICS, AND SYNBIOTICS IN MANAGEMENT OF OBESITY AND PREDIABETES: REVIEW OF RANDOMIZED CONTROLLED TRIALS, 10.4158/ep151157.ra
  81. Parnell Jill A., Raman Maitreyi, Rioux Kevin P., Reimer Raylene A., The potential role of prebiotic fibre for treatment and management of non-alcoholic fatty liver disease and associated obesity and insulin resistance, 10.1111/j.1478-3231.2011.02730.x
  82. Vulevic J., Juric A., Tzortzis G., Gibson G. R., A Mixture of trans-Galactooligosaccharides Reduces Markers of Metabolic Syndrome and Modulates the Fecal Microbiota and Immune Function of Overweight Adults, 10.3945/jn.112.166132
  83. Cani P. D., Knauf C., Iglesias M. A., Drucker D. J., Delzenne N. M., Burcelin R., Improvement of Glucose Tolerance and Hepatic Insulin Sensitivity by Oligofructose Requires a Functional Glucagon-Like Peptide 1 Receptor, 10.2337/db05-1360
  84. Verhoef Sanne P. M., Meyer Diederick, Westerterp Klaas R., Effects of oligofructose on appetite profile, glucagon-like peptide 1 and peptide YY3-36 concentrations and energy intake, 10.1017/s0007114511002194
  85. Schmidt Kristin, Cowen Philip J., Harmer Catherine J., Tzortzis George, Errington Steven, Burnet Philip W. J., Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers, 10.1007/s00213-014-3810-0
  86. Sherwin Eoin, Rea Kieran, Dinan Timothy G., Cryan John F., A gut (microbiome) feeling about the brain : , 10.1097/mog.0000000000000244
  87. Kim Y. Y., Nutr. Sci., 7, 151 (2004)
  88. Holloway Leah, Moynihan Sharon, Abrams Steven A., Kent Kyla, Hsu Andrew R., Friedlander Anne L., Effects of oligofructose-enriched inulin on intestinal absorption of calcium and magnesium and bone turnover markers in postmenopausal women, 10.1017/s000711450733674x
  89. McCabe Laura, Britton Robert A., Parameswaran Narayanan, Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome, 10.1007/s11914-015-0292-x
  90. Firmansyah A., Asia Pac. J. Clin. Nutr., 25, 652 (2016)
  91. Abrams S. A., Am. J. Clin. Nutr., 82, 471 (2005)
  92. KANO Mitsuyoshi, MASUOKA Norie, KAGA Chiaki, SUGIMOTO Saho, IIZUKA Ryoko, MANABE Katsuyuki, SONE Toshiro, OEDA Kazutoshi, NONAKA Chiaki, MIYAZAKI Kouji, ISHIKAWA Fumiyasu, Consecutive Intake of Fermented Milk Containing Bifidobacterium breve Strain Yakult and Galacto-oligosaccharides Benefits Skin Condition in Healthy Adult Women, 10.12938/bmfh.32.33
  93. Miyazaki K., Masuoka N., Kano M., Iizuka R., Bifidobacteriumfermented milk and galacto-oligosaccharides lead to improved skin health by decreasing phenols production by gut microbiota, 10.3920/bm2012.0066
  94. Cuello-Garcia Carlos A., Fiocchi Alessandro, Pawankar Ruby, Yepes-Nuñez Juan José, Morgano Gian Paolo, Zhang Yuan, Ahn Kangmo, Al-Hammadi Suleiman, Agarwal Arnav, Gandhi Shreyas, Beyer Kirsten, Burks Wesley, Canonica Giorgio W., Ebisawa Motohiro, Kamenwa Rose, Lee Bee Wah, Li Haiqi, Prescott Susan, Riva John J., Rosenwasser Lanny, Sampson Hugh, Spigler Michael, Terracciano Luigi, Vereda Andrea, Waserman Susan, Schünemann Holger J., Brożek Jan L., World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Prebiotics, 10.1186/s40413-016-0102-7
  95. Osborn D. A., Cochrane Database Syst. Rev., 3, CD006474 (2013)
  96. Dang Dan, Zhou Wenli, Lun Zhi Jun, Mu Xin, Wang Dong Xuan, Wu Hui, Meta-analysis of probiotics and/or prebiotics for the prevention of eczema, 10.1177/0300060513493692
  97. Boyle R. J., Tang M. L.-K., Chiang W. C., Chua M. C., Ismail I., Nauta A., Hourihane J. O'B., Smith P., Gold M., Ziegler J., Peake J., Quinn P., Rao R., Brown N., Rijnierse A., Garssen J., Warner J. O., , Prebiotic-supplemented partially hydrolysed cow's milk formula for the prevention of eczema in high-risk infants: a randomized controlled trial, 10.1111/all.12848
  98. Ghouri Y. A., Clin. Exp. Gastroenterol., 7, 473 (2014)
  99. Coste Isabelle, Judlin Philippe, Lepargneur Jean-Pierre, Bou-Antoun Sami, Safety and Efficacy of an Intravaginal Prebiotic Gel in the Prevention of Recurrent Bacterial Vaginosis: A Randomized Double-Blind Study, 10.1155/2012/147867
  100. Giovannini Marcello, Verduci Elvira, Gregori Dario, Ballali Simonetta, Soldi Sara, Ghisleni Diana, Riva Enrica, , Prebiotic Effect of an Infant Formula Supplemented with Galacto-Oligosaccharides: Randomized Multicenter Trial, 10.1080/07315724.2013.878232
  101. Radke Michael, Picaud Jean-Charles, Loui Andrea, Cambonie Gilles, Faas Dirk, Lafeber Harry N., de Groot Nanda, Pecquet Sophie S., Steenhout Philippe G., Hascoet Jean-Michel, Starter formula enriched in prebiotics and probiotics ensures normal growth of infants and promotes gut health: a randomized clinical trial, 10.1038/pr.2016.270
  102. Martinez Rafael Chacon Ruiz, Bedani Raquel, Saad Susana Marta Isay, Scientific evidence for health effects attributed to the consumption of probiotics and prebiotics: an update for current perspectives and future challenges, 10.1017/s0007114515003864
  103. Valdez Yanet, Brown Eric M., Finlay B. Brett, Influence of the microbiota on vaccine effectiveness, 10.1016/j.it.2014.07.003
  104. Lohner Szimonetta, Küllenberg Daniela, Antes Gerd, Decsi Tamás, Meerpohl Joerg J, Prebiotics in healthy infants and children for prevention of acute infectious diseases: a systematic review and meta-analysis, 10.1111/nure.12117
  105. Chatchatee Pantipa, Lee Way S., Carrilho Eugenia, Kosuwon Pensri, Simakachorn Nipat, Yavuz Yalcin, Schouten Bastiaan, Graaff Patricia Logtens-de, Szajewska Hania, Effects of Growing-Up Milk Supplemented With Prebiotics and LCPUFAs on Infections in Young Children : , 10.1097/mpg.0000000000000252
  106. Luoto Raakel, Ruuskanen Olli, Waris Matti, Kalliomäki Marko, Salminen Seppo, Isolauri Erika, Prebiotic and probiotic supplementation prevents rhinovirus infections in preterm infants: A randomized, placebo-controlled trial, 10.1016/j.jaci.2013.08.020
  107. Armanian A. M., Int. J. Prev. Med., 5, 1387 (2014)
  108. SILK D. B. A., DAVIS A., VULEVIC J., TZORTZIS G., GIBSON G. R., Clinical trial: the effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome, 10.1111/j.1365-2036.2008.03911.x
  109. Drakoularakou A, Tzortzis G, Rastall R A, Gibson G R, A double-blind, placebo-controlled, randomized human study assessing the capacity of a novel galacto-oligosaccharide mixture in reducing travellers' diarrhoea, 10.1038/ejcn.2009.120
  110. Christodoulides S., Dimidi E., Fragkos K. C., Farmer A. D., Whelan K., Scott S. M., Systematic review with meta-analysis: effect of fibre supplementation on chronic idiopathic constipation in adults, 10.1111/apt.13662
  111. Closa-Monasterolo R., Int. J. Food Sci. Nutr., 8, 1 (2016)
  112. Vulevic J., Am. J. Clin. Nutr., 88, 1438 (2008)
  113. Matsuki Takahiro, Yahagi Kana, Mori Hiroshi, Matsumoto Hoshitaka, Hara Taeko, Tajima Saya, Ogawa Eishin, Kodama Hiroko, Yamamoto Kazuya, Yamada Takuji, Matsumoto Satoshi, Kurokawa Ken, A key genetic factor for fucosyllactose utilization affects infant gut microbiota development, 10.1038/ncomms11939
  114. Marques Tatiana Milena, Wall Rebecca, Ross R Paul, Fitzgerald Gerald F, Ryan C Anthony, Stanton Catherine, Programming infant gut microbiota: influence of dietary and environmental factors, 10.1016/j.copbio.2010.03.020
  115. Blaser M. J., Antibiotic use and its consequences for the normal microbiome, 10.1126/science.aad9358
  116. Rogler Gerhard, Zeitz Jonas, Biedermann Luc, The Search for Causative Environmental Factors in Inflammatory Bowel Disease, 10.1159/000447283
  117. Griffin Nicholas W., Ahern Philip P., Cheng Jiye, Heath Andrew C., Ilkayeva Olga, Newgard Christopher B., Fontana Luigi, Gordon Jeffrey I., Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions, 10.1016/j.chom.2016.12.006
  118. Stevens C. E., Physiol. Rev., 78, 393 (1998)
  119. Respondek F., J. Nutr., 138, 1712 (2008)
  120. Apanavicius C. J., J. Nutr., 137, 1923 (2007)
  121. Gouveia E.M.M.F., Silva I.S., Nakazato G., Onselem V.J.V., Corrêa R.A.C., Araujo F.R., Chang M.R., Action of phosphorylated mannanoligosaccharides on immune and hematological responses and fecal consistency of dogs experimentally infected with enteropathogenic Escherichia coli strains, 10.1590/s1517-83822013000200027
  122. Kanakupt K., Vester Boler B. M., Dunsford B. R., Fahey G. C., Effects of short-chain fructooligosaccharides and galactooligosaccharides, individually and in combination, on nutrient digestibility, fecal fermentative metabolite concentrations, and large bowel microbial ecology of healthy adults cats, 10.2527/jas.2010-3201
  123. Verbrugghe Adronie, Hesta Myriam, Gommeren Kris, Daminet Sylvie, Wuyts Birgitte, Buyse Johan, Janssens Geert P. J., Oligofructose and inulin modulate glucose and amino acid metabolism through propionate production in normal-weight and obese cats, 10.1017/s0007114509288982
  124. Correa-Matos N. J., J. Nutr., 133, 1845 (2003)
  125. Liu P., Piao X. S., Kim S. W., Wang L., Shen Y. B., Lee H. S., Li S. Y., Effects of chito-oligosaccharide supplementation on the growth performance, nutrient digestibility, intestinal morphology, and fecal shedding of Escherichia coli and Lactobacillus in weaning pigs, 10.2527/jas.2007-0668
  126. Che T. M., Johnson R. W., Kelley K. W., Van Alstine W. G., Dawson K. A., Moran C. A., Pettigrew J. E., Mannan oligosaccharide improves immune responses and growth efficiency of nursery pigs experimentally infected with porcine reproductive and respiratory syndrome virus, 10.2527/jas.2010-3208
  127. Halas Veronika, Nochta Imre, Mannan Oligosaccharides in Nursery Pig Nutrition and Their Potential Mode of Action, 10.3390/ani2020261
  128. Quigley J.D., Drewry J.J., Murray L.M., Ivey S.J., Body Weight Gain, Feed Efficiency, and Fecal Scores of Dairy Calves in Response to Galactosyl-Lactose or Antibiotics in Milk Replacers, 10.3168/jds.s0022-0302(97)76108-3
  129. Ghosh Sudipta, Mehla Ram Kumar, Influence of dietary supplementation of prebiotics (mannanoligosaccharide) on the performance of crossbred calves, 10.1007/s11250-011-9944-8
  130. Mohamadi Roodposhti Pezhman, Dabiri Najafgholi, Effects of Probiotic and Prebiotic on Average Daily Gain, Fecal Shedding of Escherichia Coli, and Immune System Status in Newborn Female Calves, 10.5713/ajas.2011.11312
  131. Baines Danica, Erb Stephanie, Characterization of Shiga toxin – producing Escherichia coli infections in beef feeder calves and the effectiveness of a prebiotic in alleviating Shiga toxin - producing Escherichia coli infections, 10.1186/2046-0481-66-17
  132. Ortiz L.T., Rodríguez M.L., Alzueta C., Rebolé A., Treviño J., Effect of inulin on growth performance, intestinal tract sizes, mineral retention and tibial bone mineralisation in broiler chickens, 10.1080/00071660902806962
  133. Sohail M. U., Hume M. E., Byrd J. A., Nisbet D. J., Ijaz A., Sohail A., Shabbir M. Z., Rehman H., Effect of supplementation of prebiotic mannan-oligosaccharides and probiotic mixture on growth performance of broilers subjected to chronic heat stress, 10.3382/ps.2012-02182
  134. Shanmugasundaram R., Sifri M., Selvaraj R. K., Effect of yeast cell product supplementation on broiler cecal microflora species and immune responses during an experimental coccidial infection, 10.3382/ps.2012-02991
  135. Cho J. H., Kim I. H., Effects of lactulose supplementation on performance, blood profiles, excreta microbial shedding ofLactobacillusandEscherichia coli, relative organ weight and excreta noxious gas contents in broilers, 10.1111/jpn.12086
  136. Roto Stephanie M., Kwon Young Min, Ricke Steven C., Applications of In Ovo Technique for the Optimal Development of the Gastrointestinal Tract and the Potential Influence on the Establishment of Its Microbiome in Poultry, 10.3389/fvets.2016.00063
  137. Pruszynska-Oszmalek E., Kolodziejski P. A., Stadnicka K., Sassek M., Chalupka D., Kuston B., Nogowski L., Mackowiak P., Maiorano G., Jankowski J., Bednarczyk M., In ovo injection of prebiotics and synbiotics affects the digestive potency of the pancreas in growing chickens, 10.3382/ps/pev162
  138. Bednarczyk M., Stadnicka K., Kozłowska I., Abiuso C., Tavaniello S., Dankowiakowska A., Sławińska A., Maiorano G., Influence of different prebiotics and mode of their administration on broiler chicken performance, 10.1017/s1751731116000173
  139. Li P., J. Nutr., 137, 2763 (2007)
  140. Hoseinifar Seyed Hossein, Khalili Mohsen, Khoshbavar Rostami Hosseinali, Esteban M. Ángeles, Dietary galactooligosaccharide affects intestinal microbiota, stress resistance, and performance of Caspian roach (Rutilus rutilus) fry, 10.1016/j.fsi.2013.08.007
  141. Hoseinifar Seyed Hossein, Soleimani Narges, Ringø Einar, Effects of dietary fructo-oligosaccharide supplementation on the growth performance, haemato-immunological parameters, gut microbiota and stress resistance of common carp (Cyprinus carpio) fry, 10.1017/s0007114514002037
  142. Morgan L.M., Coverdale J.A., Froetschel M.A., Yoon I., Effect of Yeast Culture Supplementation on Digestibility of Varying Forage Quality in Mature Horses, 10.1016/j.jevs.2007.04.009
  143. Respondek F., Goachet A. G., Julliand V., Effects of dietary short-chain fructooligosaccharides on the intestinal microflora of horses subjected to a sudden change in diet, 10.2527/jas.2006-782
  144. Respondek F., Myers K., Smith T. L., Wagner A., Geor R. J., Dietary supplementation with short-chain fructo-oligosaccharides improves insulin sensitivity in obese horses, 10.2527/jas.2010-3108
  145. EFSA J., 14, 4594 (2016)