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Risk for the development of Antimicrobial Resistance (AMR) due to feeding of calves with milk containing residues of antibiotics

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EFSA Panel on Biological Hazards (BIOHAZ) Ricci, Antonia Allende, Ana Bolton, Declan Chemaly, Marianne Speybroeck, Niko [UCL] Herman, Lieve

EFSA was requested to: 1) assess the risk for the development of antimicrobial resistance (AMR) due to feeding on farm of calves with colostrum potentially containing residues of antibiotics; 2) assess the risk for the development of AMR due to feeding on farm of calves with milk of cows treated during lactation with an antibiotic and milked during the withdrawal period, and 3) propose possible options to mitigate the risk for the development of AMR derived from such practices. Treatment of dairy cows during the dry period and during lactation is common in the EU Member States. Penicillins, alone or in combination with aminoglycosides, and cephalosporins are most commonly used. Residue levels of antimicrobials decrease with the length of the dry period. When the interval from the start of the drying-off treatment until calving is as long as or longer than the minimum specified in the Summary of Product Characteristics of the antimicrobial, faecal shedding of antimicrobial-resistant bacteria will not increase when calves are fed colostrum from treated cows. Milk from cows receiving antimicrobial treatment during lactation contains substantial residues during the treatment and withdrawal period. Consumption of such milk will lead to increased faecal shedding of antimicrobial-resistant bacteria by calves. A range of possible options exist for restricting the feeding of such milk to calves, which could be targeting the highest priority critically important antimicrobials. β-Lactamases can reduce the concentration of β-lactams which are the most frequently used antimicrobials in milking cows. Options to mitigate the presence of resistant bacteria in raw milk or colostrum are mainly based on thermal inactivation.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2017
Language Anglais
Journal information "EFSA Journal" - Vol. 15, no.1, p. 4665 [1-101] (2017)
Peer reviewed yes
Publisher European Food Safety Authority (EFSA) ((Italy) Parma)
issn 1831-4732
Publication status Publié
Affiliation UCL - SSS/IRSS - Institut de recherche santé et société
Keywords Antimicrobial resistance ; Antimicrobial residues ; Waste milk ; Colostrum ; Calves
Links
  1. Al Mawly J., Grinberg A., Prattley D., Moffat J., Marshall J., French N., Risk factors for neonatal calf diarrhoea and enteropathogen shedding in New Zealand dairy farms, 10.1016/j.tvjl.2015.01.010
  2. Alali W. Q., Sargeant J. M., Nagaraja T. G., DeBey B. M., Effect of antibiotics in milk replacer on fecal shedding of Escherichia coli O157:H7 in calves1, 10.2527/2004.8272148x
  3. Andersson Dan I., Hughes Diarmaid, Evolution of antibiotic resistance at non-lethal drug concentrations, 10.1016/j.drup.2012.03.005
  4. Andersson, Nature Reviews: Microbiology, 12, 465 (2014)
  5. Andrew S.M., Effect of Composition of Colostrum and Transition Milk from Holstein Heifers on Specificity Rates of Antibiotic Residue Tests, 10.3168/jds.s0022-0302(01)74457-8
  6. ANSES ANMV (Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail ‐ Agence nationale du médicament vétérinaire), 2015. Suivi des ventes de médicaments vétérinaires contenant des antibiotiques en France en 2014. 44 pp. Available online: https://www.anses.fr/en/system/files/ANMV-Ra-Antibiotiques2014.pdf
  7. Aust V., Knappstein K., Kunz H.-J., Kaspar H., Wallmann J., Kaske M., Feeding untreated and pasteurized waste milk and bulk milk to calves: effects on calf performance, health status and antibiotic resistance of faecal bacteria : Untreated and pasteurized waste and bulk milk for calves, 10.1111/jpn.12019
  8. Bachman K.C., Schairer M.L., Invited Review: Bovine Studies on Optimal Lengths of Dry Periods,, 10.3168/jds.s0022-0302(03)73902-2
  9. Baharoglu Zeynep, Mazel Didier, SOS, the formidable strategy of bacteria against aggressions, 10.1111/1574-6976.12077
  10. Bearson Bradley L., Brunelle Brian W., Fluoroquinolone induction of phage-mediated gene transfer in multidrug-resistant Salmonella, 10.1016/j.ijantimicag.2015.04.008
  11. Bedford Russell AR, Murch SH, Could peripartum antibiotics have delayed health consequences for the infant?, 10.1111/j.1471-0528.2006.00952.x
  12. Ben David Yonit, Dassa Bareket, Borovok Ilya, Lamed Raphael, Koropatkin Nicole M., Martens Eric C., White Bryan A., Bernalier-Donadille Annick, Duncan Sylvia H., Flint Harry J., Bayer Edward A., Moraïs Sarah, Ruminococcal cellulosome systems from rumen to human : Human ruminococcal cellulosome, 10.1111/1462-2920.12868
  13. Beneragama Nilmini, Moriya Yusuke, Yamashiro Takaki, Iwasaki Masahiro, Lateef Suraju A, Ying Chun, Umetsu Kazutaka, The survival of cefazolin-resistant bacteria in mesophilic co-digestion of dairy manure and waste milk, 10.1177/0734242x13477717
  14. Bengtsson Björn, Unnerstad Helle Ericsson, Ekman Torkel, Artursson Karin, Nilsson-Öst Maria, Waller Karin Persson, Antimicrobial susceptibility of udder pathogens from cases of acute clinical mastitis in dairy cows, 10.1016/j.vetmic.2008.10.024
  15. Berendsen Bjorn J.A., Wegh Robin S., Memelink Joost, Zuidema Tina, Stolker Linda A.M., The analysis of animal faeces as a tool to monitor antibiotic usage, 10.1016/j.talanta.2014.09.022
  16. Berge A.C.B., Atwill E.R., Sischo W.M., Animal and farm influences on the dynamics of antibiotic resistance in faecal Escherichia coli in young dairy calves, 10.1016/j.prevetmed.2005.01.013
  17. Berge A. C. B., Moore D. A., Sischo W. M., Field Trial Evaluating the Influence of Prophylactic and Therapeutic Antimicrobial Administration on Antimicrobial Resistance of Fecal Escherichia coli in Dairy Calves, 10.1128/aem.02239-05
  18. Berge A.C.B., Besser T.E., Moore D.A., Sischo W.M., Evaluation of the effects of oral colostrum supplementation during the first fourteen days on the health and performance of preweaned calves, 10.3168/jds.2008-1433
  19. Bertulat, Veterinary Record Open, 2, e000068 (2015)
  20. Botrel Marie-Anne, Haenni Marisa, Morignat Eric, Sulpice Philippe, Madec Jean-Yves, Calavas Didier, Distribution and Antimicrobial Resistance of Clinical and Subclinical Mastitis Pathogens in Dairy Cows in Rhône-Alpes, France, 10.1089/fpd.2009.0425
  21. Boudry G, Perrier C, Savary G, Lallès JP and Le Huërou‐Luron I, 2011. Peripartum antibiotic alters pig ileal barrier function development and modifies ileal response to a high fat diet later in life. Proceedings of the 44th Annual Meeting of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN), Sorrento, Italy (25‐28.05.2011), http://prodinra.inra.fr/record/42744
  22. Bousquet, Journal of Veterinary Pharmacology and Therapeutics, 35, 103 (2012)
  23. Bradley A.J., Green M.J., An Investigation of the Impact of Intramammary Antibiotic Dry Cow Therapy on Clinical Coliform Mastitis, 10.3168/jds.s0022-0302(01)74598-5
  24. Bradley A. J., Leach K. A., Breen J. E., Green L. E., Green M. J., Survey of the incidence and aetiology of mastitis on dairy farms in England and Wales, 10.1136/vr.160.8.253
  25. Brennan Evan, Martins Marta, McCusker Matthew P., Wang Juan, Alves Bruno Martins, Hurley Daniel, El Garch Farid, Woehrlé Frédérique, Miossec Christine, McGrath Leisha, Srikumar Shabarinath, Wall Patrick, Fanning Séamus, Multidrug-ResistantEscherichia coliin Bovine Animals, Europe, 10.3201/eid2209.160140
  26. Brunton L. A., Duncan D., Coldham N. G., Snow L. C., Jones J. R., A survey of antimicrobial usage on dairy farms and waste milk feeding practices in England and Wales, 10.1136/vr.100924
  27. Brunton L.A., Reeves H.E., Snow L.C., Jones J.R., A longitudinal field trial assesing the impact of feeding waste milk containing antibiotic residues on the prevalence of ESBL-producing Escherichia coli in calves, 10.1016/j.prevetmed.2014.08.005
  28. Bryant M.P., Small Nola, Bouma Cecelia, Robinson Isadore, Studies on the Composition of the Ruminal Flora and Fauna of Young Calves, 10.3168/jds.s0022-0302(58)91160-3
  29. BSAC (British Society for Antimicrobial Chemotherapy), 2011. Methods for Antimicrobial Susceptibility Testing. Web site for The British Society for Antimicrobial Chemotherapy web 2011. Available online: http://www.bsac.org.uk
  30. BVL (Bundesamt für Verbraucherschutz und Lebensmittelsicherheit), 2015. Resistenzsituation bei klinisch wichtigen tierpathogenen Bakterien 2011/2012. Available online: http://www.bvl.bund.de/SharedDocs/Downloads/09_Untersuchungen/Bericht_Resistenzmonitoring_2011_2012.pdf%3F__blob%3DpublicationFile%26v%3D3
  31. Call Douglas R., Davis Margaret A., Sawant Ashish A., Antimicrobial resistance in beef and dairy cattle production, 10.1017/s1466252308001515
  32. CA‐SFM , 2007a. Antibiogram Committee of the French Society of Microbiology. Recommandations 2007 du Comité de l'antibiogramme de la Société Française de Microbiologie, 51 pp.
  33. CA‐SFM , 2007b. Recommandations 2007 du comité de l'antibiogramme de la Société Française de Microbiologie, Groupe de Travail Antibiogramme Vétérinaire, 10 pp.
  34. Caudle LR, 2014. Metagenomic Analysis of Antibiotic Resistance Genes in the Fecal Microbiome Following Therapeutic and Prophylactic Antibiotic Administration in Dairy Cows. Masters, Virginia Polytechnic Institute and State University, 112 pp. Available online: http://hdl.handle.net/10919/49676
  35. Chambers Lindsey, Yang Ying, Littier Heather, Ray Partha, Zhang Tong, Pruden Amy, Strickland Michael, Knowlton Katharine, Metagenomic Analysis of Antibiotic Resistance Genes in Dairy Cow Feces following Therapeutic Administration of Third Generation Cephalosporin, 10.1371/journal.pone.0133764
  36. Champagne Claude P., Laing Richard R., Roy Denis, Mafu Akier Assanta, Griffiths Mansel W., White Charles, Psychrotrophs in dairy products: Their effects and their control, 10.1080/10408399409527648
  37. Chee-Sanford Joanne C., Mackie Roderick I., Koike Satoshi, Krapac Ivan G., Lin Yu-Feng, Yannarell Anthony C., Maxwell Scott, Aminov Rustam I., Fate and Transport of Antibiotic Residues and Antibiotic Resistance Genes following Land Application of Manure Waste, 10.2134/jeq2008.0128
  38. Church DC, 1988. The Ruminant Animal: Digestive Physiology and Nutrition. Prentice‐Hall, Inc., Englewood Cliffs. 564 pp.
  39. CLSI (Clinical and Laboratory Standards Institute), 2007. CLSI document M100‐S17. Clinical and Laboratory Standards Institute, Wayne Pennsylvania, USA. Performance Standards for Antimicrobial Susceptibility Testing; Seventeenth Informational Supplement; 153 pp.
  40. CLSI, Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals; approved standard (2008)
  41. CLSI (Clinical and Laboratory Standards Institute), 2013a. CLSI document M100‐S23. Clinical and Laboratory Standards Institute, Wayne Pennsylvania, USA. Performance Standards for Antimicrobial Susceptibility Testing; Twenty‐third Informational Supplement; 206 pp.
  42. CLSI, Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals, 94 (2013b)
  43. CLSI, Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals; second informational supplement, 168 (2013c)
  44. Codex Alimentarius Commission , 1999. Principles and guidelines for the conduct of microbiological risk assessment. CAC/GL 30‐1999. Available online: ftp://ftp.fao.org/es/esn/jemra/CAC_GL30.pdf
  45. Collignon Peter C., Conly John M., Andremont Antoine, McEwen Scott A., Aidara-Kane Awa, World Health Organization Ranking of Antimicrobials According to Their Importance in Human Medicine: A Critical Step for Developing Risk Management Strategies to Control Antimicrobial Resistance From Food Animal Production, 10.1093/cid/ciw475
  46. Conneely M., Berry D.P., Murphy J.P., Lorenz I., Doherty M.L., Kennedy E., Effect of feeding colostrum at different volumes and subsequent number of transition milk feeds on the serum immunoglobulin G concentration and health status of dairy calves, 10.3168/jds.2013-7494
  47. DANMAP , 2014. Use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, food and humans in Denmark. Published in Sept. 2015. Available online: http://www.danmap.org/~/media/projekt%20sites/danmap/danmap%20reports/danmap%202014/danmap_2014.ashx.
  48. Dargatz David A., Kopral Christine A., Erdman Matthew M., Fedorka-Cray Paula J., Prevalence and Antimicrobial Resistance ofSalmonellaIsolated from Cattle Feces in United States Feedlots in 2011, 10.1089/fpd.2016.2128
  49. Davies J., Davies D., Origins and Evolution of Antibiotic Resistance, 10.1128/mmbr.00016-10
  50. Davis, The development, nutrition, and management of the young calf, 339 (1998)
  51. D'Costa V. M., Sampling the Antibiotic Resistome, 10.1126/science.1120800
  52. DeMars Zachary, Biswas Silpak, Amachawadi Raghavendra G., Renter David G., Volkova Victoriya V., Antimicrobial Susceptibility of Enteric Gram Negative Facultative Anaerobe Bacilli in Aerobic versus Anaerobic Conditions, 10.1371/journal.pone.0155599
  53. Dolejská M., Šenk D., Čížek A., Rybaříková J., Sychra O., Literák I., Antimicrobial resistant Escherichia coli isolates in cattle and house sparrows on two Czech dairy farms, 10.1016/j.rvsc.2008.03.007
  54. Donahue M., Godden S.M., Bey R., Wells S., Oakes J.M., Sreevatsan S., Stabel J., Fetrow J., Heat treatment of colostrum on commercial dairy farms decreases colostrum microbial counts while maintaining colostrum immunoglobulin G concentrations, 10.3168/jds.2011-5220
  55. Duse Anna, Waller Karin, Emanuelson Ulf, Unnerstad Helle, Persson Ylva, Bengtsson Björn, Farming practices in Sweden related to feeding milk and colostrum from cows treated with antimicrobials to dairy calves, 10.1186/1751-0147-55-49
  56. Duse Anna, Waller Karin Persson, Emanuelson Ulf, Unnerstad Helle Ericsson, Persson Ylva, Bengtsson Björn, Risk factors for antimicrobial resistance in fecal Escherichia coli from preweaned dairy calves, 10.3168/jds.2014-8432
  57. Duse Anna, Persson Waller Karin, Emanuelson Ulf, Ericsson Unnerstad Helle, Persson Ylva, Bengtsson Björn, Occurrence and Spread of Quinolone-Resistant Escherichia coli on Dairy Farms, 10.1128/aem.03061-15
  58. , Joint Opinion on antimicrobial resistance (AMR) focused on zoonotic infections : Joint Opinion on antimicrobial resistance (AMR) focused on zoonotic infections, 10.2903/j.efsa.2009.1372
  59. Edrington T.S., Dowd S.E., Farrow R.F., Hagevoort G.R., Callaway T.R., Anderson R.C., Nisbet D.J., Development of colonic microflora as assessed by pyrosequencing in dairy calves fed waste milk, 10.3168/jds.2011-5119
  60. Edrington, Agriculture, Food and Analytical Bacteriology, 2, 162 (2012)
  61. , Scientific report on the effects of farming systems on dairy cow welfare and disease : Scientific report on the effects of farming systems on dairy cow welfare and disease, 10.2903/j.efsa.2009.1143r
  62. , Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals : ESBL/AmpC in food-producing animals and foods, 10.2903/j.efsa.2011.2322
  63. , Murphy David, Ricci Antonia, Auce Zanda, Beechinor J. Gabriel, Bergendahl Hanne, Breathnach Rory, Bureš Jiří, Duarte Da Silva João Pedro, Hederová Judita, Hekman Peter, Ibrahim Cornelia, Kozhuharov Emil, Kulcsár Gábor, Lander Persson Eva, Lenhardsson Johann M., Mačiulskis Petras, Malemis Ioannis, Markus‐Cizelj Ljiljana, Michaelidou‐Patsia Alia, Nevalainen Martti, Pasquali Paolo, Rouby Jean‐Claude, Schefferlie Johan, Schlumbohm Wilhelm, Schmit Marc, Spiteri Stephen, Srčič Stanko, Taban Lollita, Tiirats Toomas, Urbain Bruno, Vestergaard Ellen‐Margrethe, Wachnik‐Święcicka Anna, Weeks Jason, Zemann Barbara, Allende Ana, Bolton Declan, Chemaly Marianne, Fernandez Escamez Pablo Salvador, Girones Rosina, Herman Lieve, Koutsoumanis Kostas, Lindqvist Roland, Nørrung Birgit, Robertson Lucy, Ru Giuseppe, Sanaa Moez, Simmons Marion, Skandamis Panagiotis, Snary Emma, Speybroeck Niko, Ter Kuile Benno, Wahlström Helene, Baptiste Keith, Catry Boudewijn, Cocconcelli Pier Sandro, Davies Robert, Ducrot Christian, Friis Christian, Jungersen Gregers, More Simon, Muñoz Madero Cristina, Sanders Pascal, Bos Marian, Kunsagi Zoltan, Torren Edo Jordi, Brozzi Rosella, Candiani Denise, Guerra Beatriz, Liebana Ernesto, Stella Pietro, Threlfall John, Jukes Helen, EMA and EFSA Joint Scientific Opinion on measures to reduce the need to use antimicrobial agents in animal husbandry in the European Union, and the resulting impacts on food safety (RONAFA), 10.2903/j.efsa.2017.4666
  64. EMA‐CVMP (European Medicines Agency ‐ Committee for Medicinal products for Veterinary Use), 2011a. VICH GL46: Studies to evaluate the metabolism and residue kinetics of veterinary drugs in food‐producing animals: metabolism study to determine the quantity and identify the nature of residues. 2011;14 pp.
  65. EMA‐CVMP (European Medicines Agency ‐ Committee for Medicinal products for Veterinary Use), 2011b. VICH GL47: Studies to evaluate the metabolism and residue kinetics of veterinary drugs in food‐producing animals: laboratory animal comparative metabolism studies. 2011;12 pp.
  66. EMA‐CVMP (European Medicines Agency ‐ Committee for Medicinal products for Veterinary Use), 2015a. VICH topic GL48: Studies to evaluate the metabolism and residue kinetics of veterinary drugs in food‐producing animals: marker residue depletion studies to establish product withdrawal periods. 2015;16 pp.
  67. EMA‐CVMP (European Medicines Agency ‐ Committee for Medicinal products for Veterinary Use), 2015b. VICH topic GL49: Studies to evaluate the metabolism and residues kinetics of veterinary drugs in human food‐producing animals: validation of analytical methods used in residue depletion studies. 2015;21 pp.
  68. EMA‐CVMP (European Medicines Agency ‐ Committee for Medicinal products for Veterinary Use), 2016a. Guideline on the demonstration of efficacy for veterinary medicinal products containing antimicrobial substances. 18 pp.
  69. EMA‐CVMP (European Medicines Agency ‐ Committee for Medicinal products for Veterinary Use), 2016b. Guideline on the conduct of efficacy studies for intramammary products for use in cattle. 19 pp.
  70. EMEA‐CVMP (The European Agency for the Evaluation of Medicinal Products ‐ Committee for Veterinary Medicinal Products), 2000. Note for guidance for the determination of withdrawal periods for milk. 2000;26 pp.
  71. ESVAC (European Medicines Agency, European Surveillance of Veterinary Antimicrobial Consumption), 2016. Sales of veterinary antimicrobial agents in 29 European countries in 2014'. (EMA/61769/2016). Available online: http://www.ema.europa.eu/docs/en_GB/document_library/Report/2016/10/WC500214217.pdf. 2016;176 pp.
  72. Fåk Frida, Ahrné Siv, Molin Göran, Jeppsson Bengt, Weström Björn, Microbial manipulation of the rat dam changes bacterial colonization and alters properties of the gut in her offspring, 10.1152/ajpgi.00023.2007
  73. Fecteau, The Canadian Veterinary Journal, 43, 523 (2002)
  74. Feng Yanfang, Händel Nadine, de Groot Marnix, Brul Stanley, Schultsz Constance, ter Kuile Benno, Experimental Simulation of the Effects of an Initial Antibiotic Treatment on a Subsequent Treatment after Initial Therapy Failure, 10.3390/antibiotics3010049
  75. Fernández García Leticia, Álvarez Blanco Silvia, Riera Rodríguez Francisco A, Microfiltration applied to dairy streams: removal of bacteria : Microfiltration applied to dairy streams: removal of bacteria, 10.1002/jsfa.5935
  76. Fitzgerald A.C., Edrington T.S., Looper M.L., Callaway T.R., Genovese K.J., Bischoff K.M., McReynolds J.L., Thomas J.D., Anderson R.C., Nisbet D.J., Antimicrobial susceptibility and factors affecting the shedding of E. coli O157:H7 and Salmonella in dairy cattle, 10.1046/j.1472-765x.2003.01417.x
  77. Foley J.A., Hunter A.G., Otterby D.E., Absorption of Colostral Proteins by Newborn Calves Fed Unfermented, Fermented, or Buffered Colostrum, 10.3168/jds.s0022-0302(78)83748-5
  78. Fonty, Journal of General Microbiology, 133, 1835 (1987)
  79. Fulghum, Applied Microbiology, 16, 301 (1968)
  80. Galland J. C., Hyatt D. R., Crupper S. S., Acheson D. W., Prevalence, Antibiotic Susceptibility, and Diversity of Escherichia coli O157:H7 Isolates from a Longitudinal Study of Beef Cattle Feedlots, 10.1128/aem.67.4.1619-1627.2001
  81. Godden, Veterinary Clinics of North America: Food Animal Practice, 24, 19 (2008)
  82. Godden S.M., Smith S., Feirtag J.M., Green L.R., Wells S.J., Fetrow J.P., Effect of On-Farm Commercial Batch Pasteurization of Colostrum on Colostrum and Serum Immunoglobulin Concentrations in Dairy Calves, 10.3168/jds.s0022-0302(03)73736-9
  83. Godden S.M., Smolenski D.J., Donahue M., Oakes J.M., Bey R., Wells S., Sreevatsan S., Stabel J., Fetrow J., Heat-treated colostrum and reduced morbidity in preweaned dairy calves: Results of a randomized trial and examination of mechanisms of effectiveness, 10.3168/jds.2011-5275
  84. Gonggrijp M, Scherpenzeel C, Kappert C, Heuvelink A, Holtstege M, Nijenhuis E, Tijs S, Keurentjes J, Lam T and Velthuis A, 2015. Resistentieontwikkeling bij jonge kalveren (in Dutch). Report. Research number OND1358162.
  85. Gonzalez RN and Wilson DJ, 2003. Mycoplasmal mastitis in dairy herds. The Veterinary Clinics of North America: Food Animal Practice, 19, 199–221.
  86. Gullberg Erik, Cao Sha, Berg Otto G., Ilbäck Carolina, Sandegren Linus, Hughes Diarmaid, Andersson Dan I., Selection of Resistant Bacteria at Very Low Antibiotic Concentrations, 10.1371/journal.ppat.1002158
  87. Gullberg E., Albrecht L. M., Karlsson C., Sandegren L., Andersson D. I., Selection of a Multidrug Resistance Plasmid by Sublethal Levels of Antibiotics and Heavy Metals, 10.1128/mbio.01918-14
  88. Gutierrez A., Laureti L., Crussard S., Abida H., Rodríguez-Rojas A., Blázquez J., Baharoglu Z., Mazel D., Darfeuille F., Vogel J., Matic I., β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity, 10.1038/ncomms2607
  89. Halasa T., Nielen M., Whist A.C., Østerås O., Meta-analysis of dry cow management for dairy cattle. Part 2. Cure of existing intramammary infections, 10.3168/jds.2008-1741
  90. Halasa T., Østerås O., Hogeveen H., van Werven T., Nielen M., Meta-analysis of dry cow management for dairy cattle. Part 1. Protection against new intramammary infections, 10.3168/jds.2008-1740
  91. Händel Nadine, Schuurmans J. Merijn, Brul Stanley, ter Kuile Benno H., Compensation of the Metabolic Costs of Antibiotic Resistance by Physiological Adaptation in Escherichia coli, 10.1128/aac.02096-12
  92. Händel Nadine, Schuurmans Jasper M., Feng Yanfang, Brul Stanley, ter Kuile Benno H., Interaction between Mutations and Regulation of Gene Expression during Development ofDe NovoAntibiotic Resistance, 10.1128/aac.02892-14
  93. Händel Nadine, Otte Sarah, Jonker Martijs, Brul Stanley, ter Kuile Benno H., Factors That Affect Transfer of the IncI1 β-Lactam Resistance Plasmid pESBL-283 between E. coli Strains, 10.1371/journal.pone.0123039
  94. Händel Nadine, Hoeksema Marloes, Freijo Mata Marina, Brul Stanley, ter Kuile Benno H., Effects of Stress, Reactive Oxygen Species, and the SOS Response onDe NovoAcquisition of Antibiotic Resistance in Escherichia coli, 10.1128/aac.02684-15
  95. Hauck, Berliner und Munchener Tierarztliche Wochenschrift, 127, 359 (2014)
  96. Hausler K., Godden S.M., Schneider M.J., Lightfield A.R., Bulthaus M., Haines D., Hot topic: Investigating the risk of violative meat residues in bob veal calves fed colostrum from cows treated at dry-off with cephapirin benzathine, 10.3168/jds.2012-5891
  97. Heinrichs, Advances in Dairy Technology, 17, 179 (2005)
  98. HINTON M., HEDGES A.J., LINTON A.H., The ecology of Escherichia coli in market calves fed a milk-substitute diet, 10.1111/j.1365-2672.1985.tb01426.x
  99. van der Horst Michael A., Schuurmans Jasper M., Smid Marja C., Koenders Belinda B., ter Kuile Benno H., De NovoAcquisition of Resistance to Three Antibiotics byEscherichia coli, 10.1089/mdr.2010.0101
  100. van der Horst Michael A., Fabri Teun H., Schuurmans J. Merijn, Koenders Belinda B., Brul Stanley, ter Kuile Benno H., Effects of Therapeutical and Reduced Levels of Antibiotics on the Fraction of Antibiotic-Resistant Strains ofEscherichia coliin the Chicken Gut, 10.1089/fpd.2012.1217
  101. Horton R.A., Randall L.P., Bailey-Horne V., Heinrich K., Sharman M., Brunton L.A., La Ragione R.M., Jones J.R., Degradation of cefquinome in spiked milk as a model for bioremediation of dairy farm waste milk containing cephalosporin residues, 10.1111/jam.12765
  102. Horton R.A., Duncan D., Randall L.P., Chappell S., Brunton L.A., Warner R., Coldham N.G., Teale C.J., Longitudinal study of CTX-M ESBL-producing E. coli strains on a UK dairy farm, 10.1016/j.rvsc.2016.09.018
  103. Hsieh MK, Shyu CL, Liao JW, Franje CA, Huang YJ Chang SK, Shih PY, Chou CC, Correlation analysis of heat stability of veterinary antibiotics by structural degradation, changes in antimicrobial activity and genotoxicity, 10.17221/1548-vetmed
  104. Houser B.A., Donaldson S.C., Kehoe S.I., Heinrichs A.J., Jayarao B.M., A Survey of Bacteriological Quality and the Occurrence ofSalmonellain Raw Bovine Colostrum, 10.1089/fpd.2008.0141
  105. Johnson M.E., Martin J.H., Baker R.J., Parsons J.G., Persistence of Antibiotics in Milk from Cows Treated Late in the Dry Period, 10.3168/jds.s0022-0302(77)84085-x
  106. Kallman O., Motakefi A., Wretlind B., Kalin M., Olsson-Liljequist B., Giske C. G., Cefuroxime non-susceptibility in multidrug-resistant Klebsiella pneumoniae overexpressing ramA and acrA and expressing ompK35 at reduced levels, 10.1093/jac/dkn296
  107. Kalmus Piret, Aasmäe Birgit, Kärssin Age, Orro Toomas, Kask Kalle, Udder pathogens and their resistance to antimicrobial agents in dairy cows in Estonia, 10.1186/1751-0147-53-4
  108. Kanwar Neena, Scott H. Morgan, Norby Bo, Loneragan Guy H., Vinasco Javier, Cottell Jennifer L., Chalmers Gabhan, Chengappa Muckatira M., Bai Jianfa, Boerlin Patrick, Impact of treatment strategies on cephalosporin and tetracycline resistance gene quantities in the bovine fecal metagenome, 10.1038/srep05100
  109. Karami N., Nowrouzian F., Adlerberth I., Wold A. E., Tetracycline Resistance in Escherichia coli and Persistence in the Infantile Colonic Microbiota, 10.1128/aac.50.1.156-161.2006
  110. Keefe, Veterinary Clinics: Food Animal Practice, 28, 203 (2012)
  111. Kessler HG, 1996. Lebensmittel‐ und Bioverfahrenstechnik. Molkereitechnologie. Available online: http://verlag-kessler.de/joomla/images/pdf/inh_lebensm.pdf
  112. Keys J.E., Pearson R.E., Weinland B.T., Starter Culture, Temperature, and Antibiotic Residue in Fermentation of Mastitic Milk to Feed Dairy Calves, 10.3168/jds.s0022-0302(79)83437-2
  113. Khachatryan A. R., Hancock D. D., Besser T. E., Call D. R., Antimicrobial Drug Resistance Genes Do Not Convey a Secondary Fitness Advantage to Calf-Adapted Escherichia coli, 10.1128/aem.72.1.443-448.2006
  114. Khan M.A., Weary D.M., von Keyserlingk M.A.G., Invited review: Effects of milk ration on solid feed intake, weaning, and performance in dairy heifers, 10.3168/jds.2010-3733
  115. Kietzmann Manfred, Braun Michael, Schneider Marc, Pankow Rüdiger, Tissue distribution of marbofloxacin after ‘systemic’ administration into the isolated perfused bovine udder, 10.1016/j.tvjl.2007.06.020
  116. Kitazono Yumika, Ihara Ikko, Yoshida Gen, Toyoda Kiyohiko, Umetsu Kazutaka, Selective degradation of tetracycline antibiotics present in raw milk by electrochemical method, 10.1016/j.jhazmat.2012.10.009
  117. Klein D., Alispahic M., Sofka D., Iwersen M., Drillich M., Hilbert F., Prevalence and risk factors for shedding of thermophilic Campylobacter in calves with and without diarrhea in Austrian dairy herds, 10.3168/jds.2012-5987
  118. Klein-Jöbstl Daniela, Schornsteiner Elisa, Mann Evelyne, Wagner Martin, Drillich Marc, Schmitz-Esser Stephan, Pyrosequencing reveals diverse fecal microbiota in Simmental calves during early development, 10.3389/fmicb.2014.00622
  119. Klein‐Jöbstl, Acta Veterinaria Scandinavica, 57, 44 (2015)
  120. Korycka-Dahl M., Richardson T., Bradley R.L., Use of Microbial β-Lactamase to Destroy Penicillin Added to Milk, 10.3168/jds.s0022-0302(85)81049-3
  121. Kosikowski F.V., Fox P.F., Low Heat, Hydrogen Peroxide, and Bactofugation Treatments of Milk to Control Coliforms in Cheddar Cheese, 10.3168/jds.s0022-0302(68)87116-4
  122. Kosikowski F.V., Jimenez-Flores R., Removal of Penicillin G from Contaminated Milk by Ultrafiltration, 10.3168/jds.s0022-0302(85)81231-5
  123. Kreausukon K, 2011. Usage of Antimicrobials on 60 Dairy Farms in Northern Germany and Characterization of Methicillin‐Resistant Staphylococcus aureus (MRSA) and Extended Spectrum Beta‐Lactamases Producing Escherichia coli (ESBLs‐producing E. coli) Isolated from Bulk Tank Milk Samples. Doktors der Veterinärmedizin, Freien Universität Berlin, Berlin, Germany. 171 pp.
  124. Kryzer A.A., Godden S.M., Schell R., Heat-treated (in single aliquot or batch) colostrum outperforms non-heat-treated colostrum in terms of quality and transfer of immunoglobulin G in neonatal Jersey calves, 10.3168/jds.2014-8387
  125. Kuipers A., Koops W.J., Wemmenhove H., Antibiotic use in dairy herds in the Netherlands from 2005 to 2012, 10.3168/jds.2014-8428
  126. Kyselková Martina, Jirout Jiří, Vrchotová Naděžda, Schmitt Heike, Elhottová Dana, Spread of tetracycline resistance genes at a conventional dairy farm, 10.3389/fmicb.2015.00536
  127. Lallès J. P., Long term effects of pre- and early postnatal nutrition and environment on the gut1, 10.2527/jas.53904
  128. Langford F.M., Weary D.M., Fisher L., Antibiotic Resistance in Gut Bacteria from Dairy Calves: A Dose Response to the Level of Antibiotics Fed in Milk, 10.3168/jds.s0022-0302(03)74006-5
  129. Literák I., Vanko R., Dolejská M., Čížek A., Karpíšková R., Antibiotic resistant Escherichia coli and Salmonella in Russian rooks (Corvus frugilegus) wintering in the Czech Republic, 10.1111/j.1472-765x.2007.02236.x
  130. Lopez E., Blazquez J., Effect of Subinhibitory Concentrations of Antibiotics on Intrachromosomal Homologous Recombination in Escherichia coli, 10.1128/aac.00358-09
  131. Malmuthuge Nilusha, Griebel Philip J., Guan Le Luo, Taxonomic Identification of Commensal Bacteria Associated with the Mucosa and Digesta throughout the Gastrointestinal Tracts of Preweaned Calves, 10.1128/aem.03864-13
  132. Malmuthuge Nilusha, Chen Yanhong, Liang Guanxiang, Goonewardene Laksiri A., Guan Le Luo, Heat-treated colostrum feeding promotes beneficial bacteria colonization in the small intestine of neonatal calves, 10.3168/jds.2015-9607
  133. Mao Shengyong, Zhang Ruiyang, Wang Dongsheng, Zhu Weiyun, The diversity of the fecal bacterial community and its relationship with the concentration of volatile fatty acids in the feces during subacute rumen acidosis in dairy cows, 10.1186/1746-6148-8-237
  134. MARAN , 2015. Monitoring of Antimicrobial Resistance and Antibiotic Usage in Animals in the Netherlands in 2014, page 20. Available online: http://www.wur.nl/upload_mm/2/2/2/0ab4b3f5-1cf0-42e7-a460-d67136870ae5_NethmapMaran2015.pdf.
  135. Martinez Jose Luis, Fajardo Alicia, Garmendia Leonor, Hernandez Alvaro, Linares Juan Francisco, Martínez-Solano Laura, Sánchez María Blanca, A global view of antibiotic resistance, 10.1111/j.1574-6976.2008.00142.x
  136. Martinez, Nature Reviews: Microbiology, 13, 116 (2015)
  137. McMartin S., Godden S., Metzger L., Feirtag J., Bey R., Stabel J., Goyal S., Fetrow J., Wells S., Chester-Jones H., Heat Treatment of Bovine Colostrum. I: Effects of Temperature on Viscosity and Immunoglobulin G Level, 10.3168/jds.s0022-0302(06)72281-0
  138. Merle Roswitha, Hajek Peter, Käsbohrer Annemarie, Hegger-Gravenhorst Christine, Mollenhauer Yvonne, Robanus Matthias, Ungemach Fritz-R., Kreienbrock Lothar, Monitoring of antibiotic consumption in livestock: A German feasibility study, 10.1016/j.prevetmed.2011.10.013
  139. Milhaud, Recueil de Médecine Vétérinaire, 161, 579 (1985)
  140. MINATO HAJIME, OTSUKA MAKOTO, SHIRASAKA SHOJI, ITABASHI HISAO, MITSUMORI MAKOTO, Colonization of microorganisms in the rumen of young calves., 10.2323/jgam.38.447
  141. Moran, Rearing young stock on Tropical Dairy Farms in Asia, 41 (2016)
  142. More Simon J, Clegg Tracy A, O'Grady Luke, Insights into udder health and intramammary antibiotic usage on Irish dairy farms during 2003-2010, 10.1186/2046-0481-65-7
  143. Moretain J. P., Boisseau J., Excretion of penicillins and cephalexin in bovine milk following intramammary administration, 10.1080/02652038909373741
  144. Moretain J.P., Boisseau J., Elimination of aminoglycoside antibiotics in milk following intramammary administration, 10.1080/01652176.1993.9694386
  145. Morvan Brieuc, Dore Joël, Rieu-Lesme Françoise, Foucat Loïc, Fonty Gérard, Gouet Philippe, Establishment of hydrogen-utilizing bacteria in the rumen of the newborn lamb, 10.1111/j.1574-6968.1994.tb06775.x
  146. Mroz, Annals of Nutrition and Metabolism, 58, 66 (2011)
  147. Muller A.E., Theuretzbacher U., Mouton J.W., Use of old antibiotics now and in the future from a pharmacokinetic/pharmacodynamic perspective, 10.1016/j.cmi.2015.06.007
  148. Nagaraja, Applied and Environmental Microbiology, 53, 1620 (1987)
  149. Ecosystem, Hobson PN and Stewart CS, 523 (1997)
  150. NCCLS (National Committee for Clinical Laboratory Standards), 2002. Performance standards for antimicrobial diskand dilution susceptibility tests for bacteria isolated from animals. Approved standard M31‐A2. NCCLS, Wayne, PA. 2002;86 pp.
  151. NCCLS, Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically (2003)
  152. Nielsen C., Emanuelson U., Mastitis control in Swedish dairy herds, 10.3168/jds.2012-6026
  153. Oliver, Veterinary Clinics of North America: Food Animal Practice, 28, 165 (2012)
  154. Oliver S.P., Duby R.T., Prange R.W., Tritschler J.P., Residues in Colostrum Following Antibiotic Dry Cow Therapy, 10.3168/jds.s0022-0302(84)81676-8
  155. Oliver S.P., Lewis T.M., Lewis M.J., Dowlen H.H., Maki J.L., Persistence of antibiotics in bovine mammary secretions following intramammary infusion at cessation of milking, 10.1016/0167-5877(90)90076-t
  156. Oliver S.P., Lewis M.J., Gillespie B.E., Dowlen H.H., Influence of Prepartum Antibiotic Therapy on Intramammary Infections in Primigravid Heifers During Early Lactation, 10.3168/jds.s0022-0302(92)77776-5
  157. OZUTSUMI Yuhei, HAYASHI Hidenori, SAKAMOTO Mitsuo, ITABASHI Hisao, BENNO Yoshimi, Culture-Independent Analysis of Fecal Microbiota in Cattle, 10.1271/bbb.69.1793
  158. Pereira Richard Van Vleck, Siler Julie D., Bicalho Rodrigo Carvalho, Warnick Lorin D., In Vivo Selection of Resistant E. coli after Ingestion of Milk with Added Drug Residues, 10.1371/journal.pone.0115223
  159. Persson Waller K., Hårdemark V., Nyman A.-K., Duse A., Veterinary treatment strategies for clinical mastitis in dairy cows in Sweden, 10.1136/vr.103506
  160. Persson Ylva, Nyman Ann-Kristin J, Grönlund-Andersson Ulrika, Etiology and antimicrobial susceptibility of udder pathogens from cases of subclinical mastitis in dairy cows in Sweden, 10.1186/1751-0147-53-36
  161. Randall L, Sharma M, Horton R, Brunton L, Brightwell T, Teale C and Jones J, 2012. Isolation and characterisation of Extended‐Spectrum Beta‐Lactamase (ESBL) CTX‐M bacteria from waste milk samples from dairy farms in England and Wales in 2011. Proceedings of the 22nd European Congress of Clinical Microbiology and Infectious Disease (ECCMID) 2012, London, UK, Abstract and poster.
  162. Randall Luke, Heinrich Katharina, Horton Robert, Brunton Lucy, Sharman Matthew, Bailey-Horne Victoria, Sharma Meenaxi, McLaren Ian, Coldham Nick, Teale Chris, Jones Jeff, Detection of antibiotic residues and association of cefquinome residues with the occurrence of Extended-Spectrum β-Lactamase (ESBL)-producing bacteria in waste milk samples from dairy farms in England and Wales in 2011, 10.1016/j.rvsc.2013.10.009
  163. Rangel‐Lugo, Journal of the American Veterinary Medical Association, 213, 40 (1998)
  164. Roberts Marilyn C., Environmental Macrolide–Lincosamide–Streptogramin and Tetracycline Resistant Bacteria, 10.3389/fmicb.2011.00040
  165. Roca M., Castillo M., Marti P., Althaus R. L., Molina M. P., Effect of Heating on the Stability of Quinolones in Milk, 10.1021/jf9040518
  166. Roca M., Villegas L., Kortabitarte M.L., Althaus R.L., Molina M.P., Effect of heat treatments on stability of β-lactams in milk, 10.3168/jds.2010-3599
  167. Roca M., Althaus R.L., Molina M.P., Thermodynamic analysis of the thermal stability of sulphonamides in milk using liquid chromatography tandem mass spectrometry detection, 10.1016/j.foodchem.2012.08.055
  168. Roesch M., Perreten V., Doherr M.G., Schaeren W., Schällibaum M., Blum J.W., Comparison of Antibiotic Resistance of Udder Pathogens in Dairy Cows Kept on Organic and on Conventional Farms, 10.3168/jds.s0022-0302(06)72164-6
  169. Rollin E., Dhuyvetter K.C., Overton M.W., The cost of clinical mastitis in the first 30 days of lactation: An economic modeling tool, 10.1016/j.prevetmed.2015.11.006
  170. Sandegren Linus, Selection of antibiotic resistance at very low antibiotic concentrations, 10.3109/03009734.2014.904457
  171. Tortorello, Encyclopedia of food microbiology, 30 (2014)
  172. Santman-Berends I.M.G.A., Lam T.J.G.M., Keurentjes J., van Schaik G., An estimation of the clinical mastitis incidence per 100 cows per year based on routinely collected herd data, 10.3168/jds.2015-9642
  173. Scherpenzeel C.G.M., den Uijl I.E.M., van Schaik G., Riekerink R.G.M.Olde, Hogeveen H., Lam T.J.G.M., Effect of different scenarios for selective dry-cow therapy on udder health, antimicrobial usage, and economics, 10.3168/jds.2015-9963
  174. Schukken Ynte H., Wilson David J., Welcome Francis, Garrison-Tikofsky Linda, Gonzalez Ruben N., Monitoring udder health and milk quality using somatic cell counts, 10.1051/vetres:2003028
  175. Schuurmans Jasper M., van Hijum Sacha A.F.T., Piet Jurgen R., Händel Nadine, Smelt Jan, Brul Stanley, ter Kuile Benno H., Effect of growth rate and selection pressure on rates of transfer of an antibiotic resistance plasmid between E. coli strains, 10.1016/j.plasmid.2014.01.002
  176. SDa , 2015. Usage of antibiotics in Agricultural Livestock in the Netherlands in 2014. Trends and benchmarking of livestock farms and veterinarians. Netherlands Veterinary Medicines Authority, Utrecht, the Netherlands (May 2015). Available online: http://www.autoriteitdiergeneesmiddelen.nl/Userfiles/pdf/SDa-rapporten/def-sda-rapport-ab-2014-engels-v2-aangepast-102015-incl-erratum.pdf
  177. Selim, Journal of the American Veterinary Medical Association, 211, 1029 (1997)
  178. Shanks Orin C., Kelty Catherine A., Archibeque Shawn, Jenkins Michael, Newton Ryan J., McLellan Sandra L., Huse Susan M., Sogin Mitchell L., Community Structures of Fecal Bacteria in Cattle from Different Animal Feeding Operations, 10.1128/aem.02988-10
  179. Shterzer N., Mizrahi I., The animal gut as a melting pot for horizontal gene transfer, 10.1139/cjm-2015-0049
  180. Staněk S., Zink V., Doležal O., Štolc L., Survey of preweaning dairy calf-rearing practices in Czech dairy herds, 10.3168/jds.2013-7325
  181. Stevens M., Piepers S., Supré K., Dewulf J., De Vliegher S., Quantification of antimicrobial consumption in adult cattle on dairy herds in Flanders, Belgium, and associations with udder health, milk quality, and production performance, 10.3168/jds.2015-10199
  182. Straley B.A., Donaldson S.C., Hedge N.V., Sawant A.A., Srinivasan V., Oliver S.P., Jayarao B.M., Public Health Significance of Antimicrobial-Resistant Gram-Negative Bacteria in Raw Bulk Tank Milk, 10.1089/fpd.2006.3.222
  183. Svahn, International Journal of Innovation and Applied Studies, 11, 872 (2015)
  184. Swedres‐Svarm , 2015. Consumption of antibiotics and occurrence of antibiotic resistance in Sweden. Solna/Uppsala ISSN 1650‐6332. Available online: http://www.sva.se/globalassets/redesign2011/pdf/om_sva/publikationer/swedres_svarm2015.pdf
  185. Tamine, Yoghurt: Science and Technology, 619 (1999)
  186. Teixeira A.G.V., Bicalho M.L.S., Machado V.S., Oikonomou G., Kacar C., Foditsch C., Young R., Knauer W.A., Nydam D.V., Bicalho R.C., Heat and ultraviolet light treatment of colostrum and hospital milk: Effects on colostrum and hospital milk characteristics and calf health and growth parameters, 10.1016/j.tvjl.2013.03.032
  187. Tenhagen Bernd-Alois, Hansen Inken, Reinecke Annette, Heuwieser Wolfgang, Prevalence of pathogens in milk samples of dairy cows with clinical mastitis and in heifers at first parturition, 10.1017/s0022029908003786
  188. Thames Callie H., Pruden Amy, James Robert E., Ray Partha P., Knowlton Katharine F., Excretion of Antibiotic Resistance Genes by Dairy Calves Fed Milk Replacers with Varying Doses of Antibiotics, 10.3389/fmicb.2012.00139
  189. Thitaram S.N., Frank J.F., Siragusa G.R., Bailey J.S., Dargatz D.A., Lombard J.E., Haley C.A., Lyon S.A., Fedorka-Cray P.J., Antimicrobial susceptibility of Clostridium difficile isolated from food animals on farms, 10.1016/j.ijfoodmicro.2016.03.017
  190. Thomas Valérie, de Jong Anno, Moyaert Hilde, Simjee Shabbir, El Garch Farid, Morrissey Ian, Marion Hervé, Vallé Michel, Antimicrobial susceptibility monitoring of mastitis pathogens isolated from acute cases of clinical mastitis in dairy cows across Europe: VetPath results, 10.1016/j.ijantimicag.2015.03.013
  191. Toutain, Bulletin des GTV‐Groupements Techniques Veterinaires: Dossiers Techniques Veterinaires, 3, 49 (1984)
  192. Trujillo A.J., Castro N., Quevedo J.M., Argüello A., Capote J., Guamis B., Effect of Heat and High-Pressure Treatments on Microbiological Quality and Immunoglobulin G Stability of Caprine Colostrum, 10.3168/jds.s0022-0302(07)71567-9
  193. UK‐VARSS (UK Veterinary Antibiotic Resistance and Sales Surveillance), 2015. UK Veterinary Antibiotic Resistance and Sales Surveillance Report. Available online: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/571146/UK-VARSS_2015.pdf
  194. Van Vleck Pereira Richard, Lima Svetlana, Siler Julie D., Foditsch Carla, Warnick Lorin D., Bicalho Rodrigo Carvalho, Ingestion of Milk Containing Very Low Concentration of Antimicrobials: Longitudinal Effect on Fecal Microbiota Composition in Preweaned Calves, 10.1371/journal.pone.0147525
  195. Växa Sverige , 2014. Redogörelse för husdjursorganisationens djurhälsovård 2013/2014. Växa Sverige, Stockholm. pp. 28–29.
  196. Verhegghe M, De Block J, Vlaemynck G and Herman L, 2015. Reduction of Mycobacterium avium subsp. paratuberculosis (MAP) in colostrum by centrifugation and curdling. Conference Abstract. Proceedings of the Twentieth Conference on Food Microbiology, Brussels, 8‐9 October 2015.
  197. Waget Aurélie, Cabou Cendrine, Masseboeuf Myriam, Cattan Pierre, Armanet Mattieu, Karaca Mélis, Castel Julien, Garret Celine, Payros Gaëlle, Maida Adriano, Sulpice Thierry, Holst Jens J., Drucker Daniel J., Magnan Christophe, Burcelin Rémy, Physiological and Pharmacological Mechanisms through which the DPP-4 Inhibitor Sitagliptin Regulates Glycemia in Mice, 10.1210/en.2011-0286
  198. White, For Information Specialists: Interpretations of Reference and Bibliographic Work, 320 (1992)
  199. WHO, Critically important antimicrobials for human medicine, 32 (2012)
  200. WHO, Critically important antimicrobials for human medicine, 31 (2016)
  201. Wright, Nature Reviews: Microbiology, 5, 175 (2007)
  202. Yáñez-Ruiz David R., Abecia Leticia, Newbold Charles J., Manipulating rumen microbiome and fermentation through interventions during early life: a review, 10.3389/fmicb.2015.01133
  203. Yeoman Carl J., White Bryan A., Gastrointestinal Tract Microbiota and Probiotics in Production Animals, 10.1146/annurev-animal-022513-114149
  204. ZORRAQUINO M. A., ROCA M., FERNANDEZ N., MOLINA M. P., ALTHAUS R., Heat Inactivation of β-Lactam Antibiotics in Milk, 10.4315/0362-028x-71.6.1193
Bibliographic reference EFSA Panel on Biological Hazards (BIOHAZ) ; Ricci, Antonia ; Allende, Ana ; Bolton, Declan ; Chemaly, Marianne ; et. al. Risk for the development of Antimicrobial Resistance (AMR) due to feeding of calves with milk containing residues of antibiotics. In: EFSA Journal, Vol. 15, no.1, p. 4665 [1-101] (2017)
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