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Atomic force microscopy-based characterization and design of biointerfaces

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Alsteens, David [UCL] Gaub, Hermann E. Newton, Richard Pfreundschuh, Moritz Gerber, Christoph Müller, Daniel J.

Atomic force microscopy (AFM)-based methods have matured into a powerful nanoscopic platform, enabling the characterization of a wide range of biological and synthetic biointerfaces ranging from tissues, cells, membranes, proteins, nucleic acids and functional materials. Although the unprecedented signal-to-noise ratio of AFM enables the imaging of biological interfaces from the cellular to the molecular scale, AFM-based force spectroscopy allows their mechanical, chemical, conductive or electrostatic, and biological properties to be probed. The combination of AFM-based imaging and spectroscopy structurally maps these properties and allows their 3D manipulation with molecular precision. In this Review, we survey basic and advanced AFM-related approaches and evaluate their unique advantages and limitations in imaging, sensing, parameterizing and designing biointerfaces. It is anticipated that in the next decade these AFM-related techniques will have a profound influence on the way researchers view, characterize and construct biointerfaces, thereby helping to solve and address fundamental challenges that cannot be addressed with other techniques.

Document type Article de périodique (Journal article)
Access type Accès restreint
Publication date 2017
Language Anglais
Journal information "Nature Reviews Materials" - Vol. 2, no.NAN, p. 17008 (2017)
Peer reviewed yes
Publisher Springer Nature
issn 2058-8437
e-issn 2058-8437
Publication status Publié
Affiliations UCL - SST/ISV - Institut des sciences de la vie
UCL - SST/LIBST - Louvain Institute of Biomolecular Science and Technology
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Bibliographic reference Alsteens, David ; Gaub, Hermann E. ; Newton, Richard ; Pfreundschuh, Moritz ; Gerber, Christoph ; et. al. Atomic force microscopy-based characterization and design of biointerfaces. In: Nature Reviews Materials, Vol. 2, no.NAN, p. 17008 (2017)
Permanent URL http://hdl.handle.net/2078.1/184364