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Can probiotics modulate human disease by impacting intestinal barrier function?

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Bron, Peter A Kleerebezem, Michiel Brummer, Robert-Jan Cani, Patrice D. [UCL] Mercenier, Annick Wells, Jerry M

Intestinal barrier integrity is a prerequisite for homeostasis of mucosal function, which is balanced to maximise absorptive capacity, while maintaining efficient defensive reactions against chemical and microbial challenges. Evidence is mounting that disruption of epithelial barrier integrity is one of the major aetiological factors associated with several gastrointestinal diseases, including infection by pathogens, obesity and diabetes, necrotising enterocolitis, irritable bowel syndrome and inflammatory bowel disease. The notion that specific probiotic bacterial strains can affect barrier integrity fuelled research in which in vitro cell lines, animal models and clinical trials are used to assess whether probiotics can revert the diseased state back to homeostasis and health. This review catalogues and categorises the lines of evidence available in literature for the role of probiotics in epithelial integrity and, consequently, their beneficial effect for the reduction of gastrointestinal disease symptoms.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2017
Language Anglais
Journal information "The British Journal of Nutrition : an international journal of nutritional science" - Vol. 117, no.01, p. 93-107 (2017)
Peer reviewed yes
Publisher Cambridge University Press ((United Kingdom) Wallingford, Oxon)
issn 0007-1145
e-issn 1475-2662
Publication status Publié
Affiliation UCL - SSS/LDRI - Louvain Drug Research Institute
Keywords Probiotics ; Gut microbiota ; Gut barrier ; Immunity ; Gastrointestinal disorders
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Permanent URL http://hdl.handle.net/2078.1/182977