Pardo-Fernández, Juan Carlos
Jiménez-Gamero, María Dolores
El Ghouch, Anouar
[UCL]
In survival analysis, it is generally assumed that every individual will someday ex- perience the event of interest. However, this is not always the case, as some individuals may not be susceptible to this event. Also, in medical studies, it is frequent that pa- tients come to scheduled interviews and that the time to the event is only known to occur between two visits. That is, the data are interval-censored with a cure fraction. Variable selection in such a setting is of outstanding interest. Covariates impacting the survival are not necessarily the same as those impacting the probability to experience the event. The objective of this paper is to develop a parametric but flexible statistical model to analyze data that are interval-censored and include a fraction of cured indi- viduals when the number of potential covariates may be large. We use the parametric mixture cure model with an accelerated failure regression model for the survival, along with the extended generalized gamma for the error term. To overcome the issue of non-stable and non-continuous variable selection procedures, we extend the adaptive LASSO to our model. By means of simulation studies, we show the good performance of our method, and discuss the behavior of estimates with varying cure and censoring proportion. Lastly, our proposed method is illustrated with a real database studying the time until conversion to amnestic Mild Cognitive Impairment, a possible precursor of Alzheimer disease.
| Bibliographic reference |
Pardo-Fernández, Juan Carlos ; Jiménez-Gamero, María Dolores ; El Ghouch, Anouar. Tests for the equality of conditional variance functions in nonparametric regression. In: Electronic Journal of Statistics, Vol. 9, no.2, p. 1826-1851 (2015) |
| Permanent URL |
http://hdl.handle.net/2078.1/180239 |
