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The epithelial barrier and immunoglobulin A system in Allergy.

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Carlier, François [UCL] Sibille, Yves [UCL] Pilette, Charles [UCL]

Airway and intestinal epithelial layers represent first line physical barriers, playing a key role in mucosal immunity. Barrier dysfunction, characterized by alterations such as disruption of cell-cell apical junctions and aberrant epithelial responses, probably constitutes early and key events for chronic immune responses to environmental antigens in the skin and in the gut. For instance, barrier dysfunction drives Th2 responses in atopic disorders or eosinophilic esophagitis. Such epithelial impairment is also a salient feature of allergic asthma and growing evidence indicates that barrier alterations probably play a driving role in this disease. IgA has been identified as the most abundant immunoglobulin in mucosa, where it acts as an active barrier through immune exclusion of inhaled or ingested antigens or pathogens. Historically, it has been thought to represent the serum factor underlying reaginic activity before IgE was discovered. Despite several studies about regulation and major functions of IgA at mucosal surfaces, its role in allergy remains largely unclear. This review aims at summarizing findings about epithelial functions and IgA biology that are relevant to allergy, and to integrate the emerging concepts and the recent developments in mucosal immunology, and how these could translate to clinical observations in allergy. This article is protected by copyright. All rights reserved.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès restreint
Publication date 2016
Language Anglais
Journal information "Clinical and Experimental Allergy" - Vol. 46, no. 11, p. 1372-1388 (2016)
Peer reviewed yes
Publisher Wiley-Blackwell Publishing Ltd. ((United Kingdom) Oxford)
issn 0954-7894
e-issn 1365-2222
Publication status Publié
Affiliations UCL - (MGD) Service de pneumologie
UCL - SSS/IREC/LUNS - Pôle pneumologie, ORL (airways) et dermatologie (skin)
UCL - (SLuc) Service de pneumologie
Links
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Bibliographic reference Carlier, François ; Sibille, Yves ; Pilette, Charles. The epithelial barrier and immunoglobulin A system in Allergy.. In: Clinical and Experimental Allergy, Vol. 46, no. 11, p. 1372-1388 (2016)
Permanent URL http://hdl.handle.net/2078.1/177023