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Prediabetes and associated disorders

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Buysschaert, Martin [UCL] Medina, José Luís Bergman, Michael Shah, Avni Lonier, Jaqueline

Prediabetes represents an elevation of plasma glucose above the normal range but below that of clinical diabetes. Prediabetes includes individuals with IFG, IGT, IFG with IGT and elevated HbA1c levels. Insulin resistance and β-cell dysfunction are characteristic of this disorder. The diagnosis of prediabetesis is vital as both IFG and IGT are indeed well-known risk factors for type 2 diabetes with a greater risk in the presence of combined IFG and IGT. Furthermore, as will be illustrated in this review, prediabetes is associated with associated disorders typically only considered in with established diabetes. These include cardiovascular disease, periodontal disease, cognitive dysfunction, microvascular disease, blood pressure abnormalities, obstructive sleep apnea, low testosterone, metabolic syndrome, various biomarkers, fatty liver disease, and cancer. As the vast majority of individuals with prediabetes are unaware of their diagnosis, it is therefore vital that the associated conditions are identified, particularly in the presence of mild hyperglycemia, so they may benefit from early intervention.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès restreint
Publication date 2015
Language Anglais
Journal information "Endocrine" - Vol. 48, no. 2, p. 371-393 (2015)
Peer reviewed yes
Publisher Humana Press, Inc. ((United States) Totowa, NJ)
issn 1355-008X
e-issn 1559-0100
Publication status Publié
Affiliations UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition
UCL - (SLuc) Service d'endocrinologie et de nutrition
MESH Subject Biomarkers ; Comorbidity ; Humans ; Prediabetic State
Keywords Cancer ; Cardiovascular disease ; Cognitive dysfunction ; Nonalcoholic fatty liver disease ; Prediabetes ; Testosterone deficiency
Links
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Bibliographic reference Buysschaert, Martin ; Medina, José Luís ; Bergman, Michael ; Shah, Avni ; Lonier, Jaqueline. Prediabetes and associated disorders. In: Endocrine, Vol. 48, no. 2, p. 371-393 (2015)
Permanent URL http://hdl.handle.net/2078.1/176179