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Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL.

Bibliographic reference De Leo, Maria Giovanna ; Staiano, Leopoldo ; Vicinanza, Mariella ; Luciani, Alessandro ; Carissimo, Annamaria ; et. al. Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL.. In: Nature Cell Biology, Vol. 18, no.8, p. 839-850 (2016)
Permanent URL http://hdl.handle.net/2078.1/175996
  1. Attree Olivier, Olivos Isabelle M., Okabe Ichiro, Bailey L. Charles, Nelson David L., Lewis Richard A., Mclnnes Roderick R., Nussbaum Robert L., The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase, 10.1038/358239a0
  2. Staiano Leopoldo, De Leo Maria Giovanna, Persico Maria, De Matteis Maria Antonietta, Mendelian disorders of PI metabolizing enzymes, 10.1016/j.bbalip.2014.12.001
  3. Mehta Zenobia B., Pietka Grzegorz, Lowe Martin, The Cellular and Physiological Functions of the Lowe Syndrome Protein OCRL1 : Cellular and Physiological Functions of OCRL1, 10.1111/tra.12160
  4. Nández Ramiro, Balkin Daniel M, Messa Mirko, Liang Liang, Paradise Summer, Czapla Heather, Hein Marco Y, Duncan James S, Mann Matthias, De Camilli Pietro, A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells, 10.7554/elife.02975
  5. Vicinanza Mariella, Di Campli Antonella, Polishchuk Elena, Santoro Michele, Di Tullio Giuseppe, Godi Anna, Levtchenko Elena, De Leo Maria Giovanna, Polishchuk Roman, Sandoval Lisette, Marzolo Maria-Paz, De Matteis Maria Antonietta, OCRL controls trafficking through early endosomes via PtdIns4,5P2-dependent regulation of endosomal actin : OCRL controls endocytic receptor recycling, 10.1038/emboj.2011.354
  6. Carvalho-Neto Arnolfo de, Ono Sergio Eiji, Cardoso Georgina de Melo, Santos Mara Lucia Schmitz Ferreira, Celidonio Izabela, Oculocerebrorenal syndrome of Lowe: magnetic resonance imaging findings in the first six years of life, 10.1590/s0004-282x2009000200027
  7. Allmendinger A. M., J. Radiol. Case Rep., 8, 1 (2014)
  8. Settembre C., Di Malta C., Polito V. A., Arencibia M. G., Vetrini F., Erdin S., Erdin S. U., Huynh T., Medina D., Colella P., Sardiello M., Rubinsztein D. C., Ballabio A., TFEB Links Autophagy to Lysosomal Biogenesis, 10.1126/science.1204592
  9. Oltrabella Francesca, Pietka Grzegorz, Ramirez Irene Barinaga-Rementeria, Mironov Aleksandr, Starborg Toby, Drummond Iain A., Hinchliffe Katherine A., Lowe Martin, The Lowe Syndrome Protein OCRL1 Is Required for Endocytosis in the Zebrafish Pronephric Tubule, 10.1371/journal.pgen.1005058
  10. Ramirez Irene Barinaga-Rementeria, Pietka Grzegorz, Jones David R., Divecha Nullin, Alia A., Baraban Scott C., Hurlstone Adam F. L., Lowe Martin, Impaired neural development in a zebrafish model for Lowe syndrome, 10.1093/hmg/ddr608
  11. Zhang Xiaoling, Hartz Patricia A., Philip Elizabeth, Racusen Lorraine C., Majerus Philip W., Cell Lines from Kidney Proximal Tubules of a Patient with Lowe Syndrome Lack OCRL Inositol Polyphosphate 5-Phosphatase and Accumulate Phosphatidylinositol 4,5-Bisphosphate, 10.1074/jbc.273.3.1574
  12. Jiang P., Nishimura T., Sakamaki Y., Itakura E., Hatta T., Natsume T., Mizushima N., The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17, 10.1091/mbc.e13-08-0447
  13. Köchl Robert, Hu Xiao Wen, Chan Edmond Y. W., Tooze Sharon A., Microtubules Facilitate Autophagosome Formation and Fusion of Autophagosomes with Endosomes : Role of Microtubules in AV Formation, 10.1111/j.1600-0854.2005.00368.x
  14. Itakura Eisuke, Mizushima Noboru, Syntaxin 17 : The autophagosomal SNARE, 10.4161/auto.24109
  15. Choudhury Rawshan, Noakes Christopher J., McKenzie Edward, Kox Corinne, Lowe Martin, Differential Clathrin Binding and Subcellular Localization of OCRL1 Splice Isoforms, 10.1074/jbc.m807442200
  16. Mao Yuxin, Balkin Daniel M, Zoncu Roberto, Erdmann Kai S, Tomasini Livia, Hu Fenghua, Jin Moonsoo M, Hodsdon Michael E, De Camilli Pietro, A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism, 10.1038/emboj.2009.155
  17. Traub L. M., AP-2-containing clathrin coats assemble on mature lysosomes, 10.1083/jcb.135.6.1801
  18. Yu Li, McPhee Christina K., Zheng Lixin, Mardones Gonzalo A., Rong Yueguang, Peng Junya, Mi Na, Zhao Ying, Liu Zhihua, Wan Fengyi, Hailey Dale W., Oorschot Viola, Klumperman Judith, Baehrecke Eric H., Lenardo Michael J., Termination of autophagy and reformation of lysosomes regulated by mTOR, 10.1038/nature09076
  19. Rong Yueguang, Liu Mei, Ma Liang, Du Wanqing, Zhang Hanshuo, Tian Yuan, Cao Zhen, Li Ying, Ren He, Zhang Chuanmao, Li Lin, Chen She, Xi Jianzhong, Yu Li, Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation, 10.1038/ncb2557
  20. Sridhar Sunandini, Patel Bindi, Aphkhazava David, Macian Fernando, Santambrogio Laura, Shields Dennis, Cuervo Ana Maria, The lipid kinase PI4KIIIβ preserves lysosomal identity, 10.1038/emboj.2012.341
  21. Zoncu R., Bar-Peled L., Efeyan A., Wang S., Sancak Y., Sabatini D. M., mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase, 10.1126/science.1207056
  22. Shoji-Kawata Sanae, Sumpter Rhea, Leveno Matthew, Campbell Grant R., Zou Zhongju, Kinch Lisa, Wilkins Angela D., Sun Qihua, Pallauf Kathrin, MacDuff Donna, Huerta Carlos, Virgin Herbert W., Helms J. Bernd, Eerland Ruud, Tooze Sharon A., Xavier Ramnik, Lenschow Deborah J., Yamamoto Ai, King David, Lichtarge Olivier, Grishin Nick V., Spector Stephen A., Kaloyanova Dora V., Levine Beth, Identification of a candidate therapeutic autophagy-inducing peptide, 10.1038/nature11866
  23. Mudaliar H., Pollock C., Komala M. G., Chadban S., Wu H., Panchapakesan U., The role of Toll-like receptor proteins (TLR) 2 and 4 in mediating inflammation in proximal tubules, 10.1152/ajprenal.00398.2012
  24. Benigni Ariela, Caroli Cristina, Longaretti Lorena, Gagliardini Elena, Zoja Carla, Galbusera Miriam, Moioli Daniela, Romagnani Paola, Tincani Angela, Andreoli Laura, Remuzzi Giuseppe, Involvement of renal tubular toll-like receptor 9 in the development of tubulointerstitial injury in systemic lupus, 10.1002/art.22524
  25. Li X., Urology, 81, 1379 e15-2 (2013)
  26. Brencicova Eva, Diebold Sandra S., Nucleic acids and endosomal pattern recognition: how to tell friend from foe?, 10.3389/fcimb.2013.00037
  27. O'Neill Luke A. J., Golenbock Douglas, Bowie Andrew G., The history of Toll-like receptors — redefining innate immunity, 10.1038/nri3446
  28. Zhang Qin, Raoof Mustafa, Chen Yu, Sumi Yuka, Sursal Tolga, Junger Wolfgang, Brohi Karim, Itagaki Kiyoshi, Hauser Carl J., Circulating mitochondrial DAMPs cause inflammatory responses to injury, 10.1038/nature08780
  29. Lee Bettina L, Moon Joanne E, Shu Jeffrey H, Yuan Lin, Newman Zachary R, Schekman Randy, Barton Gregory M, UNC93B1 mediates differential trafficking of endosomal TLRs, 10.7554/elife.00291
  30. Wu Jing-Yiing, Kuo Cheng-Chin, ADP-Ribosylation Factor 3 Mediates Cytidine-Phosphate-Guanosine Oligodeoxynucleotide-Induced Responses by Regulating Toll-Like Receptor 9 Trafficking, 10.1159/000430785
  31. Zhang J. Z., Int. J. Mol. Med., 33, 817 (2014)
  32. Oka Takafumi, Hikoso Shungo, Yamaguchi Osamu, Taneike Manabu, Takeda Toshihiro, Tamai Takahito, Oyabu Jota, Murakawa Tomokazu, Nakayama Hiroyuki, Nishida Kazuhiko, Akira Shizuo, Yamamoto Akitsugu, Komuro Issei, Otsu Kinya, Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure, 10.1038/nature10992
  33. Carchman E. H., Whelan S., Loughran P., Mollen K., Stratamirovic S., Shiva S., Rosengart M. R., Zuckerbraun B. S., Experimental sepsis-induced mitochondrial biogenesis is dependent on autophagy, TLR4, and TLR9 signaling in liver, 10.1096/fj.13-229476
  34. Pawaria Sudesh, Moody Krishna, Busto Patricia, Nündel Kerstin, Choi Chee-Ho, Ghayur Tariq, Marshak-Rothstein Ann, Cutting Edge: DNase II Deficiency Prevents Activation of Autoreactive B Cells by Double-Stranded DNA Endogenous Ligands, 10.4049/jimmunol.1402893
  35. Chen Guo, Han Zhe, Feng Du, Chen Yanfang, Chen Linbo, Wu Hao, Huang Li, Zhou Changqian, Cai Xiangyu, Fu Changying, Duan Liangwei, Wang Xiaohui, Liu Lei, Liu Xinqi, Shen Yuequan, Zhu Yushan, Chen Quan, A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy, 10.1016/j.molcel.2014.02.034
  36. Ding Wen-Xing, Ni Hong-Min, Li Min, Liao Yong, Chen Xiaoyun, Stolz Donna B., Dorn Gerald W., Yin Xiao-Ming, Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming, 10.1074/jbc.m110.119537
  37. Narendra Derek, Tanaka Atsushi, Suen Der-Fen, Youle Richard J., Parkin is recruited selectively to impaired mitochondria and promotes their autophagy, 10.1083/jcb.200809125
  38. Nguyen Tu Thi Ngoc, Kim Yong Min, Kim T. Doohun, Le Oanh Thi Tu, Kim Jae Jin, Kang Ho Chul, Hasegawa Hiroshi, Kanaho Yasunori, Jou Ilo, Lee Sang Yoon, Phosphatidylinositol 4-Phosphate 5-Kinase α Facilitates Toll-like Receptor 4-mediated Microglial Inflammation through Regulation of the Toll/Interleukin-1 Receptor Domain-containing Adaptor Protein (TIRAP) Location, 10.1074/jbc.m112.410126
  39. Kimura Shunsuke, Noda Takeshi, Yoshimori Tamotsu, Dissection of the Autophagosome Maturation Process by a Novel Reporter Protein, Tandem Fluorescent-Tagged LC3, 10.4161/auto.4451
  40. Platt Nick, Speak Annelise O., Colaco Alexandria, Gray James, Smith David A., Williams Ian M., Wallom Kerri-Lee, Platt Frances M., Immune dysfunction in Niemann-Pick disease type C, 10.1111/jnc.13138
  41. Ravikumar Brinda, Moreau Kevin, Jahreiss Luca, Puri Claudia, Rubinsztein David C., Plasma membrane contributes to the formation of pre-autophagosomal structures, 10.1038/ncb2078
  42. Klionsky Daniel J., Abdalla Fabio C., Abeliovich Hagai, Abraham Robert T., Acevedo-Arozena Abraham, Adeli Khosrow, Agholme Lotta, Agnello Maria, Agostinis Patrizia, Aguirre-Ghiso Julio A., Ahn Hyung Jun, Ait-Mohamed Ouardia, Ait-Si-Ali Slimane, Akematsu Takahiko, Akira Shizuo, Al-Younes Hesham M., Al-Zeer Munir A., Albert Matthew L., Albin Roger L., Alegre-Abarrategui Javier, Aleo Maria Francesca, Alirezaei Mehrdad, Almasan Alexandru, Almonte-Becerril Maylin, Amano Atsuo, Amaravadi Ravi K., Amarnath Shoba, Amer Amal O., Andrieu-Abadie Nathalie, Anantharam Vellareddy, Ann David K., Anoopkumar-Dukie Shailendra, Aoki Hiroshi, Apostolova Nadezda, Arancia Giuseppe, Aris John P., Asanuma Katsuhiko, Asare Nana Y.O., Ashida Hisashi, Askanas Valerie, Askew David S., Auberger Patrick, Baba Misuzu, Backues Steven K., Baehrecke Eric H., Bahr Ben A., Bai Xue-Yuan, Bailly Yannick, Baiocchi Robert, Baldini Giulia, Balduini Walter, Ballabio Andrea, Bamber Bruce A., Bampton Edward T.W., Juhász Gábor, Bartholomew Clinton R., Bassham Diane C., Bast Robert C., Batoko Henri, Bay Boon-Huat, Beau Isabelle, Béchet Daniel M., Begley Thomas J., Behl Christian, Behrends Christian, Bekri Soumeya, Bellaire Bryan, Bendall Linda J., Benetti Luca, Berliocchi Laura, Bernardi Henri, Bernassola Francesca, Besteiro Sébastien, Bhatia-Kissova Ingrid, Bi Xiaoning, Biard-Piechaczyk Martine, Blum Janice S., Boise Lawrence H., Bonaldo Paolo, Boone David L., Bornhauser Beat C., Bortoluci Karina R., Bossis Ioannis, Bost Frédéric, Bourquin Jean-Pierre, Boya Patricia, Boyer-Guittaut Michaël, Bozhkov Peter V., Brady Nathan R, Brancolini Claudio, Brech Andreas, Brenman Jay E., Brennand Ana, Bresnick Emery H., Brest Patrick, Bridges Dave, Bristol Molly L., Brookes Paul S., Brown Eric J., Brumell John H., Brunetti-Pierri Nicola, Brunk Ulf T., Bulman Dennis E., Bultman Scott J., Bultynck Geert, Burbulla Lena F., Bursch Wilfried, Butchar Jonathan P., Buzgariu Wanda, Bydlowski Sergio P., Cadwell Ken, Cahová Monika, Cai Dongsheng, Cai Jiyang, Cai Qian, Calabretta Bruno, Calvo-Garrido Javier, Camougrand Nadine, Campanella Michelangelo, Campos-Salinas Jenny, Candi Eleonora, Cao Lizhi, Caplan Allan B., Carding Simon R., Cardoso Sandra M., Carew Jennifer S., Carlin Cathleen R., Carmignac Virginie, Carneiro Leticia A.M., Carra Serena, Caruso Rosario A., Casari Giorgio, Casas Caty, Castino Roberta, Cebollero Eduardo, Cecconi Francesco, Celli Jean, Chaachouay Hassan, Chae Han-Jung, Chai Chee-Yin, Chan David C., Chan Edmond Y., Chang Raymond Chuen-Chung, Che Chi-Ming, Chen Ching-Chow, Chen Guang-Chao, Chen Guo-Qiang, Chen Min, Chen Quan, Chen Steve S.-L., Chen WenLi, Chen Xi, Chen Xiangmei, Chen Xiequn, Chen Ye-Guang, Chen Yingyu, Chen Yongqiang, Chen Yu-Jen, Chen Zhixiang, Cheng Alan, Cheng Christopher H.K., Cheng Yan, Cheong Heesun, Cheong Jae-Ho, Cherry Sara, Chess-Williams Russ, Cheung Zelda H., Chevet Eric, Chiang Hui-Ling, Chiarelli Roberto, Chiba Tomoki, Chin Lih-Shen, Chiou Shih-Hwa, Chisari Francis V., Cho Chi Hin, Cho Dong-Hyung, Choi Augustine M.K., Choi DooSeok, Choi Kyeong Sook, Choi Mary E., Chouaib Salem, Choubey Divaker, Choubey Vinay, Chu Charleen T., Chuang Tsung-Hsien, Chueh Sheau-Huei, Chun Taehoon, Chwae Yong-Joon, Chye Mee-Len, Ciarcia Roberto, Ciriolo Maria R., Clague Michael J., Clark Robert S.B., Clarke Peter G.H., Clarke Robert, Codogno Patrice, Coller Hilary A., Colombo María I., Comincini Sergio, Condello Maria, Condorelli Fabrizio, Cookson Mark R., Coombs Graham H., Coppens Isabelle, Corbalan Ramon, Cossart Pascale, Costelli Paola, Costes Safia, Coto-Montes Ana, Couve Eduardo, Coxon Fraser P., Cregg James M., Crespo José L., Cronjé Marianne J., Cuervo Ana Maria, Cullen Joseph J., Czaja Mark J., D'Amelio Marcello, Darfeuille-Michaud Arlette, Davids Lester M., Davies Faith E., De Felici Massimo, de Groot John F., de Haan Cornelis A.M., De Martino Luisa, De Milito Angelo, De Tata Vincenzo, Debnath Jayanta, Degterev Alexei, Dehay Benjamin, Delbridge Lea M.D., Demarchi Francesca, Deng Yi Zhen, Dengjel Jörn, Dent Paul, Denton Donna, Deretic Vojo, Desai Shyamal D., Devenish Rodney J., Di Gioacchino Mario, Di Paolo Gilbert, Di Pietro Chiara, Díaz-Araya Guillermo, Díaz-Laviada Inés, Diaz-Meco Maria T., Diaz-Nido Javier, Dikic Ivan, Dinesh-Kumar Savithramma P., Ding Wen-Xing, Distelhorst Clark W., Diwan Abhinav, Djavaheri-Mergny Mojgan, Dokudovskaya Svetlana, Dong Zheng, Dorsey Frank C., Dosenko Victor, Dowling James J., Doxsey Stephen, Dreux Marlène, Drew Mark E., Duan Qiuhong, Duchosal Michel A., Duff Karen E., Dugail Isabelle, Durbeej Madeleine, Duszenko Michael, Edelstein Charles L., Edinger Aimee L., Egea Gustavo, Eichinger Ludwig, Eissa N. Tony, Ekmekcioglu Suhendan, El-Deiry Wafik S., Elazar Zvulun, Elgendy Mohamed, Ellerby Lisa M., Eng Kai Er, Engelbrecht Anna-Mart, Engelender Simone, Erenpreisa Jekaterina, Escalante Ricardo, Esclatine Audrey, Eskelinen Eeva-Liisa, Espert Lucile, Espina Virginia, Fan Huizhou, Fan Jia, Fan Qi-Wen, Fan Zhen, Fang Shengyun, Fang Yongqi, Fanto Manolis, Fanzani Alessandro, Farkas Thomas, Farre Jean-Claude, Faure Mathias, Fechheimer Marcus, Feng Carl G., Feng Jian, Feng Qili, Feng Youji, Fésüs László, Feuer Ralph, Figueiredo-Pereira Maria E., Fimia Gian Maria, Fingar Diane C., Finkbeiner Steven, Finkel Toren, Finley Kim D., Fiorito Filomena, Fisher Edward A., Fisher Paul B., Flajolet Marc, Florez-McClure Maria L., Florio Salvatore, Fon Edward A., Fornai Francesco, Fortunato Franco, Fotedar Rati, Fowler Daniel H., Fox Howard S., Franco Rodrigo, Frankel Lisa B., Fransen Marc, Fuentes José M., Fueyo Juan, Fujii Jun, Fujisaki Kozo, Fujita Eriko, Fukuda Mitsunori, Furukawa Ruth H., Gaestel Matthias, Gailly Philippe, Gajewska Malgorzata, Galliot Brigitte, Galy Vincent, Ganesh Subramaniam, Ganetzky Barry, Ganley Ian G., Gao Fen-Biao, Gao George F., Gao Jinming, Garcia Lorena, Garcia-Manero Guillermo, Garcia-Marcos Mikel, Garmyn Marjan, Gartel Andrei L., Gatti Evelina, Gautel Mathias, Gawriluk Thomas R., Gegg Matthew E., Geng Jiefei, Germain Marc, Gestwicki Jason E., Gewirtz David A., Ghavami Saeid, Ghosh Pradipta, Giammarioli Anna M., Giatromanolaki Alexandra N., Gibson Spencer B., Gilkerson Robert W., Ginger Michael L., Ginsberg Henry N., Golab Jakub, Goligorsky Michael S., Golstein Pierre, Gomez-Manzano Candelaria, Goncu Ebru, Gongora Céline, Gonzalez Claudio D., Gonzalez Ramon, González-Estévez Cristina, González-Polo Rosa Ana, Gonzalez-Rey Elena, Gorbunov Nikolai V., Gorski Sharon, Goruppi Sandro, Gottlieb Roberta A., Gozuacik Devrim, Granato Giovanna Elvira, Grant Gary D., Green Kim N., Gregorc Ales, Gros Frédéric, Grose Charles, Grunt Thomas W., Gual Philippe, Guan Jun-Lin, Guan Kun-Liang, Guichard Sylvie M., Gukovskaya Anna S., Gukovsky Ilya, Gunst Jan, Gustafsson Åsa B., Halayko Andrew J., Hale Amber N., Halonen Sandra K., Hamasaki Maho, Han Feng, Han Ting, Hancock Michael K., Hansen Malene, Harada Hisashi, Harada Masaru, Hardt Stefan E., Harper J. Wade, Harris Adrian L., Harris James, Harris Steven D., Hashimoto Makoto, Haspel Jeffrey A., Hayashi Shin-ichiro, Hazelhurst Lori A., He Congcong, He You-Wen, Hébert Marie-Josée, Heidenreich Kim A., Helfrich Miep H., Helgason Gudmundur V., Henske Elizabeth P., Herman Brian, Herman Paul K., Hetz Claudio, Hilfiker Sabine, Hill Joseph A., Hocking Lynne J., Hofman Paul, Hofmann Thomas G., Höhfeld Jörg, Holyoake Tessa L., Hong Ming-Huang, Hood David A., Hotamisligil Gökhan S., Houwerzijl Ewout J., Høyer-Hansen Maria, Hu Bingren, Hu Chien-an A., Hu Hong-Ming, Hua Ya, Huang Canhua, Huang Ju, Huang Shengbing, Huang Wei-Pang, Huber Tobias B., Huh Won-Ki, Hung Tai-Ho, Hupp Ted R., Hur Gang Min, Hurley James B., Hussain Sabah N.A., Hussey Patrick J., Hwang Jung Jin, Hwang Seungmin, Ichihara Atsuhiro, Ilkhanizadeh Shirin, Inoki Ken, Into Takeshi, Iovane Valentina, Iovanna Juan L., Ip Nancy Y., Isaka Yoshitaka, Ishida Hiroyuki, Isidoro Ciro, Isobe Ken-ichi, Iwasaki Akiko, Izquierdo Marta, Izumi Yotaro, Jaakkola Panu M., Jäättelä Marja, Jackson George R., Jackson William T., Janji Bassam, Jendrach Marina, Jeon Ju-Hong, Jeung Eui-Bae, Jiang Hong, Jiang Hongchi, Jiang Jean X., Jiang Ming, Jiang Qing, Jiang Xuejun, Jiang Xuejun, Jiménez Alberto, Jin Meiyan, Jin Shengkan V., Joe Cheol O., Johansen Terje, Johnson Daniel E., Johnson Gail V.W., Jones Nicola L., Joseph Bertrand, Joseph Suresh K., Joubert Annie M., Juhász Gábor, Juillerat-Jeanneret Lucienne, Jung Chang Hwa, Jung Yong-Keun, Kaarniranta Kai, Kaasik Allen, Kabuta Tomohiro, Kadowaki Motoni, Kågedal Katarina, Kamada Yoshiaki, Kaminskyy Vitaliy O., Kampinga Harm H., Kanamori Hiromitsu, Kang Chanhee, Kang Khong Bee, Kang Kwang Il, Kang Rui, Kang Yoon-A, Kanki Tomotake, Kanneganti Thirumala-Devi, Kanno Haruo, Kanthasamy Anumantha G., Kanthasamy Arthi, Karantza Vassiliki, Kaushal Gur P., Kaushik Susmita, Kawazoe Yoshinori, Ke Po-Yuan, Kehrl John H., Kelekar Ameeta, Kerkhoff Claus, Kessel David H., Khalil Hany, Kiel Jan A.K.W., Kiger Amy A., Kihara Akio, Kim Deok Ryong, Kim Do-Hyung, Kim Dong-Hou, Kim Eun-Kyoung, Kim Hyung-Ryong, Kim Jae-Sung, Kim Jeong Hun, Kim Jin Cheon, Kim John K., Kim Peter K., Kim Seong Who, Kim Yong-Sun, Kim Yonghyun, Kimchi Adi, Kimmelman Alec C., King Jason S., Kinsella Timothy J., Kirkin Vladimir, Kirshenbaum Lorrie A., Kitamoto Katsuhiko, Kitazato Kaio, Klein Ludger, Klimecki Walter T., Klucken Jochen, Knecht Erwin, Ko Ben C.B., Koch Jan C., Koga Hiroshi, Koh Jae-Young, Koh Young Ho, Koike Masato, Komatsu Masaaki, Kominami Eiki, Kong Hee Jeong, Kong Wei-Jia, Korolchuk Viktor I., Kotake Yaichiro, Koukourakis Michael I., Flores Juan B. Kouri, Kovács Attila L., Kraft Claudine, Krainc Dimitri, Krämer Helmut, Kretz-Remy Carole, Krichevsky Anna M., Kroemer Guido, Krüger Rejko, Krut Oleg, Ktistakis Nicholas T., Kuan Chia-Yi, Kucharczyk Roza, Kumar Ashok, Kumar Raj, Kumar Sharad, Kundu Mondira, Kung Hsing-Jien, Kurz Tino, Kwon Ho Jeong, La Spada Albert R., Lafont Frank, Lamark Trond, Landry Jacques, Lane Jon D., Lapaquette Pierre, Laporte Jocelyn F., László Lajos, Lavandero Sergio, Lavoie Josée N., Layfield Robert, Lazo Pedro A., Le Weidong, Le Cam Laurent, Ledbetter Daniel J., Lee Alvin J.X., Lee Byung-Wan, Lee Gyun Min, Lee Jongdae, lee Ju-hyun, Lee Michael, Lee Myung-Shik, Lee Sug Hyung, Leeuwenburgh Christiaan, Legembre Patrick, Legouis Renaud, Lehmann Michael, Lei Huan-Yao, Lei Qun-Ying, Leib David A., Leiro José, Lemasters John J., Lemoine Antoinette, Lesniak Maciej S., Lev Dina, Levenson Victor V., Levine Beth, Levy Efrat, Li Faqiang, Li Jun-Lin, Li Lian, Li Sheng, Li Weijie, Li Xue-Jun, Li Yan-Bo, Li Yi-Ping, Liang Chengyu, Liang Qiangrong, Liao Yung-Feng, Liberski Pawel P., Lieberman Andrew, Lim Hyunjung J., Lim Kah-Leong, Lim Kyu, Lin Chiou-Feng, Lin Fu-Cheng, Lin Jian, Lin Jiandie D., Lin Kui, Lin Wan-Wan, Lin Weei-Chin, Lin Yi-Ling, Linden Rafael, Lingor Paul, Lippincott-Schwartz Jennifer, Lisanti Michael P., Liton Paloma B., Liu Bo, Liu Chun-Feng, Liu Kaiyu, Liu Leyuan, Liu Qiong A., Liu Wei, Liu Young-Chau, Liu Yule, Lockshin Richard A., Lok Chun-Nam, Lonial Sagar, Loos Benjamin, Lopez-Berestein Gabriel, López-Otín Carlos, Lossi Laura, Lotze Michael T., Low Peter, Lu Binfeng, Lu Bingwei, Lu Bo, Lu Zhen, Luciano Fréderic, Lukacs Nicholas W., Lund Anders H., Lynch-Day Melinda A., Ma Yong, Macian Fernando, MacKeigan Jeff P., Macleod Kay F., Madeo Frank, Maiuri Luigi, Maiuri Maria Chiara, Malagoli Davide, Malicdan May Christine V., Malorni Walter, Man Na, Mandelkow Eva-Maria, Manon Stephen, Manov Irena, Mao Kai, Mao Xiang, Mao Zixu, Marambaud Philippe, Marazziti Daniela, Marcel Yves L., Marchbank Katie, Marchetti Piero, Marciniak Stefan J., Marcondes Mateus, Mardi Mohsen, Marfe Gabriella, Mariño Guillermo, Markaki Maria, Marten Mark R., Martin Seamus J., Martinand-Mari Camille, Martinet Wim, Martinez-Vicente Marta, Masini Matilde, Matarrese Paola, Matsuo Saburo, Matteoni Raffaele, Mayer Andreas, Mazure Nathalie M., McConkey David J., McConnell Melanie J., McDermott Catherine, McDonald Christine, McInerney Gerald M., McKenna Sharon L., McLaughlin BethAnn, McLean Pamela J., McMaster Christopher R., McQuibban G. Angus, Meijer Alfred J., Meisler Miriam H., Meléndez Alicia, Melia Thomas J., Melino Gerry, Mena Maria A., Menendez Javier A., Menna-Barreto Rubem F. S., Menon Manoj B., Menzies Fiona M., Mercer Carol A., Merighi Adalberto, Merry Diane E., Meschini Stefania, Meyer Christian G., Meyer Thomas F., Miao Chao-Yu, Miao Jun-Ying, Michels Paul A.M., Michiels Carine, Mijaljica Dalibor, Milojkovic Ana, Minucci Saverio, Miracco Clelia, Miranti Cindy K., Mitroulis Ioannis, Miyazawa Keisuke, Mizushima Noboru, Mograbi Baharia, Mohseni Simin, Molero Xavier, Mollereau Bertrand, Mollinedo Faustino, Momoi Takashi, Monastyrska Iryna, Monick Martha M., Monteiro Mervyn J., Moore Michael N., Mora Rodrigo, Moreau Kevin, Moreira Paula I., Moriyasu Yuji, Moscat Jorge, Mostowy Serge, Mottram Jeremy C., Motyl Tomasz, Moussa Charbel E.-H., Müller Sylke, Muller Sylviane, Münger Karl, Münz Christian, Murphy Leon O., Murphy Maureen E., Musarò Antonio, Mysorekar Indira, Nagata Eiichiro, Nagata Kazuhiro, Nahimana Aimable, Nair Usha, Nakagawa Toshiyuki, Nakahira Kiichi, Nakano Hiroyasu, Nakatogawa Hitoshi, Nanjundan Meera, Naqvi Naweed I., Narendra Derek P., Narita Masashi, Navarro Miguel, Nawrocki Steffan T., Nazarko Taras Y., Nemchenko Andriy, Netea Mihai G., Neufeld Thomas P., Ney Paul A., Nezis Ioannis P., Nguyen Huu Phuc, Nie Daotai, Nishino Ichizo, Nislow Corey, Nixon Ralph A., Noda Takeshi, Noegel Angelika A., Nogalska Anna, Noguchi Satoru, Notterpek Lucia, Novak Ivana, Nozaki Tomoyoshi, Nukina Nobuyuki, Nürnberger Thorsten, Nyfeler Beat, Obara Keisuke, Oberley Terry D., Oddo Salvatore, Ogawa Michinaga, Ohashi Toya, Okamoto Koji, Oleinick Nancy L., Oliver F. Javier, Olsen Laura J., Olsson Stefan, Opota Onya, Osborne Timothy F., Ostrander Gary K., Otsu Kinya, Ou Jing-hsiung James, Ouimet Mireille, Overholtzer Michael, Ozpolat Bulent, Paganetti Paolo, Pagnini Ugo, Pallet Nicolas, Palmer Glen E., Palumbo Camilla, Pan Tianhong, Panaretakis Theocharis, Pandey Udai Bhan, Papackova Zuzana, Papassideri Issidora, Paris Irmgard, Park Junsoo, Park Ohkmae K., Parys Jan B., Parzych Katherine R., Patschan Susann, Patterson Cam, Pattingre Sophie, Pawelek John M., Peng Jianxin, Perlmutter David H., Perrotta Ida, Perry George, Pervaiz Shazib, Peter Matthias, Peters Godefridus J., Petersen Morten, Petrovski Goran, Phang James M., Piacentini Mauro, Pierre Philippe, Pierrefite-Carle Valérie, Pierron Gérard, Pinkas-Kramarski Ronit, Piras Antonio, Piri Natik, Platanias Leonidas C., Pöggeler Stefanie, Poirot Marc, Poletti Angelo, Poüs Christian, Pozuelo-Rubio Mercedes, Prætorius-Ibba Mette, Prasad Anil, Prescott Mark, Priault Muriel, Produit-Zengaffinen Nathalie, Progulske-Fox Ann, Proikas-Cezanne Tassula, Przedborski Serge, Przyklenk Karin, Puertollano Rosa, Puyal Julien, Qian Shu-Bing, Qin Liang, Qin Zheng-Hong, Quaggin Susan E., Raben Nina, Rabinowich Hannah, Rabkin Simon W., Rahman Irfan, Rami Abdelhaq, Ramm Georg, Randall Glenn, Randow Felix, Rao V. Ashutosh, Rathmell Jeffrey C., Ravikumar Brinda, Ray Swapan K., Reed Bruce H., Reed John C., Reggiori Fulvio, Régnier-Vigouroux Anne, Reichert Andreas S., Reiners, Jr. John J., Reiter Russel J., Ren Jun, Revuelta José L., Rhodes Christopher J., Ritis Konstantinos, Rizzo Elizete, Robbins Jeffrey, Roberge Michel, Roca Hernan, Roccheri Maria C., Rocchi Stephane, Rodemann H. Peter, Rodríguez de Córdoba Santiago, Rohrer Bärbel, Roninson Igor B., Rosen Kirill, Rost-Roszkowska Magdalena M., Rouis Mustapha, Rouschop Kasper M.A., Rovetta Francesca, Rubin Brian P., Rubinsztein David C., Ruckdeschel Klaus, Rucker Edmund B., Rudich Assaf, Rudolf Emil, Ruiz-Opazo Nelson, Russo Rossella, Rusten Tor Erik, Ryan Kevin M., Ryter Stefan W., Sabatini David M., Sadoshima Junichi, Saha Tapas, Saitoh Tatsuya, Sakagami Hiroshi, Sakai Yasuyoshi, Salekdeh Ghasem Hoseini, Salomoni Paolo, Salvaterra Paul M., Salvesen Guy, Salvioli Rosa, Sanchez Anthony M.J., Sánchez-Alcázar José A., Sánchez-Prieto Ricardo, Sandri Marco, Sankar Uma, Sansanwal Poonam, Santambrogio Laura, Saran Shweta, Sarkar Sovan, Sarwal Minnie, Sasakawa Chihiro, Sasnauskiene Ausra, Sass Miklós, Sato Ken, Sato Miyuki, Schapira Anthony H.V., Scharl Michael, Schätzl Hermann M., Scheper Wiep, Schiaffino Stefano, Schneider Claudio, Schneider Marion E., Schneider-Stock Regine, Schoenlein Patricia V., Schorderet Daniel F., Schüller Christoph, Schwartz Gary K., Scorrano Luca, Sealy Linda, Seglen Per O., Segura-Aguilar Juan, Seiliez Iban, Seleverstov Oleksandr, Sell Christian, Seo Jong Bok, Separovic Duska, Setaluri Vijayasaradhi, Setoguchi Takao, Settembre Carmine, Shacka John J., Shanmugam Mala, Shapiro Irving M., Shaulian Eitan, Shaw Reuben J., Shelhamer James H., Shen Han-Ming, Shen Wei-Chiang, Sheng Zu-Hang, Shi Yang, Shibuya Kenichi, Shidoji Yoshihiro, Shieh Jeng-Jer, Shih Chwen-Ming, Shimada Yohta, Shimizu Shigeomi, Shintani Takahiro, Shirihai Orian S., Shore Gordon C., Sibirny Andriy A., Sidhu Stan B., Sikorska Beata, Silva-Zacarin Elaine C.M., Simmons Alison, Simon Anna Katharina, Simon Hans-Uwe, Simone Cristiano, Simonsen Anne, Sinclair David A., Singh Rajat, Sinha Debasish, Sinicrope Frank A., Sirko Agnieszka, Siu Parco M., Sivridis Efthimios, Skop Vojtech, Skulachev Vladimir P., Slack Ruth S., Smaili Soraya S., Smith Duncan R., Soengas Maria S., Soldati Thierry, Song Xueqin, Sood Anil K., Soong Tuck Wah, Sotgia Federica, Spector Stephen A., Spies Claudia D., Springer Wolfdieter, Srinivasula Srinivasa M., Stefanis Leonidas, Steffan Joan S., Stendel Ruediger, Stenmark Harald, Stephanou Anastasis, Stern Stephan T., Sternberg Cinthya, Stork Björn, Strålfors Peter, Subauste Carlos S., Sui Xinbing, Sulzer David, Sun Jiaren, Sun Shi-Yong, Sun Zhi-Jun, Sung Joseph J.Y., Suzuki Kuninori, Suzuki Toshihiko, Swanson Michele S., Swanton Charles, Sweeney Sean T., Sy Lai-King, Szabadkai György, Tabas Ira, Taegtmeyer Heinrich, Tafani Marco, Takács-Vellai Krisztina, Takano Yoshitaka, Takegawa Kaoru, Takemura Genzou, Takeshita Fumihiko, Talbot Nicholas J., Tan Kevin S.W., Tanaka Keiji, Tanaka Kozo, Tang Daolin, Tang Dingzhong, Tanida Isei, Tannous Bakhos A., Tavernarakis Nektarios, Taylor Graham S., Taylor Gregory A., Taylor J. Paul, Terada Lance S., Terman Alexei, Tettamanti Gianluca, Thevissen Karin, Thompson Craig B., Thorburn Andrew, Thumm Michael, Tian FengFeng, Tian Yuan, Tocchini-Valentini Glauco, Tolkovsky Aviva M., Tomino Yasuhiko, Tönges Lars, Tooze Sharon A., Tournier Cathy, Tower John, Towns Roberto, Trajkovic Vladimir, Travassos Leonardo H., Tsai Ting-Fen, Tschan Mario P., Tsubata Takeshi, Tsung Allan, Turk Boris, Turner Lorianne S., Tyagi Suresh C., Uchiyama Yasuo, Ueno Takashi, Umekawa Midori, Umemiya-Shirafuji Rika, Unni Vivek K., Vaccaro Maria I., Valente Enza Maria, Van den Berghe Greet, van der Klei Ida J., van Doorn Wouter G., van Dyk Linda F., van Egmond Marjolein, van Grunsven Leo A., Vandenabeele Peter, Vandenberghe Wim P., Vanhorebeek Ilse, Vaquero Eva C., Velasco Guillermo, Vellai Tibor, Vicencio José Miguel, Vierstra Richard D., Vila Miquel, Vindis Cécile, Viola Giampietro, Viscomi Maria Teresa, Voitsekhovskaja Olga V., von Haefen Clarissa, Votruba Marcela, Wada Keiji, Wade-Martins Richard, Walker Cheryl L., Walsh Craig M., Walter Jochen, Wan Xiang-Bo, Wang Aimin, Wang Chenguang, Wang Dawei, Wang Fan, Wang Fen, Wang Guanghui, Wang Haichao, Wang Hong-Gang, Wang Horng-Dar, Wang Jin, Wang Ke, Wang Mei, Wang Richard C., Wang Xinglong, Wang Xiujie J., Wang Ying-Jan, Wang Yipeng, Wang Zhen-Bo, Wang Zhigang Charles, Wang Zhinong, Wansink Derick G., Ward Diane M., Watada Hirotaka, Waters Sarah L., Webster Paul, Wei Lixin, Weihl Conrad C., Weiss William A., Welford Scott M., Wen Long-Ping, Whitehouse Caroline A., Whitton J. Lindsay, Whitworth Alexander J., Wileman Tom, Wiley John W., Wilkinson Simon, Willbold Dieter, Williams Roger L., Williamson Peter R., Wouters Bradly G., Wu Chenghan, Wu Dao-Cheng, Wu William K.K., Wyttenbach Andreas, Xavier Ramnik J., Xi Zhijun, Xia Pu, Xiao Gengfu, Xie Zhiping, Xie Zhonglin, Xu Da-zhi, Xu Jianzhen, Xu Liang, Xu Xiaolei, Yamamoto Ai, Yamamoto Akitsugu, Yamashina Shunhei, Yamashita Michiaki, Yan Xianghua, Yanagida Mitsuhiro, Yang Dun-Sheng, Yang Elizabeth, Yang Jin-Ming, Yang Shi Yu, Yang Wannian, Yang Wei Yuan, Yang Zhifen, Yao Meng-Chao, Yao Tso-Pang, Yeganeh Behzad, Yen Wei-Lien, Yin Jia-Jing, Yin Xiao-Ming, Yoo Ook-Joon, Yoon Gyesoon, Yoon Seung-Yong, Yorimitsu Tomohiro, Yoshikawa Yuko, Yoshimori Tamotsu, Yoshimoto Kohki, You Ho Jin, Youle Richard J., Younes Anas, Yu Li, Yu Long, Yu Seong-Woon, Yu Wai Haung, Yuan Zhi-Min, Yue Zhenyu, Yun Cheol-Heui, Yuzaki Michisuke, Zabirnyk Olga, Silva-Zacarin Elaine, Zacks David, Zacksenhaus Eldad, Zaffaroni Nadia, Zakeri Zahra, Zeh, III Herbert J., Zeitlin Scott O., Zhang Hong, Zhang Hui-Ling, Zhang Jianhua, Zhang Jing-Pu, Zhang Lin, Zhang Long, Zhang Ming-Yong, Zhang Xu Dong, Zhao Mantong, Zhao Yi-Fang, Zhao Ying, Zhao Zhizhuang J., Zheng Xiaoxiang, Zhivotovsky Boris, Zhong Qing, Zhou Cong-Zhao, Zhu Changlian, Zhu Wei-Guo, Zhu Xiao-Feng, Zhu Xiongwei, Zhu Yuangang, Zoladek Teresa, Zong Wei-Xing, Zorzano Antonio, Zschocke Jürgen, Zuckerbraun Brian, Guidelines for the use and interpretation of assays for monitoring autophagy, 10.4161/auto.19496
  43. Pirruccello Michelle, Nandez Ramiro, Idevall-Hagren Olof, Alcazar-Roman Abel, Abriola Laura, Berwick Shana Alexandra, Lucast Louise, Morel Dayna, De Camilli Pietro, Identification of Inhibitors of Inositol 5-Phosphatases through Multiple Screening Strategies, 10.1021/cb500161z
  44. Zhang X., Li X., Xu H., Phosphoinositide isoforms determine compartment-specific ion channel activity, 10.1073/pnas.1202194109
  45. Vergarajauregui Silvia, Connelly Patricia S., Daniels Mathew P., Puertollano Rosa, Autophagic dysfunction in mucolipidosis type IV patients, 10.1093/hmg/ddn174
  46. Abe K., Puertollano R., Role of TRP Channels in the Regulation of the Endosomal Pathway, 10.1152/physiol.00048.2010
  47. Grimm Christian, Jörs Simone, Saldanha S. Adrian, Obukhov Alexander G., Pan Bifeng, Oshima Kazuo, Cuajungco Math P., Chase Peter, Hodder Peter, Heller Stefan, Small Molecule Activators of TRPML3, 10.1016/j.chembiol.2009.12.016
  48. Xu Haoxing, Ren Dejian, Lysosomal Physiology, 10.1146/annurev-physiol-021014-071649
  49. Nikoletopoulou V, Papandreou M-E, Tavernarakis N, Autophagy in the physiology and pathology of the central nervous system, 10.1038/cdd.2014.204
  50. Di Fruscio Giuseppina, Schulz Angela, De Cegli Rossella, Savarese Marco, Mutarelli Margherita, Parenti Giancarlo, Banfi Sandro, Braulke Thomas, Nigro Vincenzo, Ballabio Andrea, Lysoplex: An efficient toolkit to detect DNA sequence variations in the autophagy-lysosomal pathway, 10.1080/15548627.2015.1043077
  51. Yuan Yanggang, Chen Ying, Zhang Ping, Huang Songming, Zhu Chunhua, Ding Guixia, Liu Bicheng, Yang Tianxin, Zhang Aihua, Mitochondrial dysfunction accounts for aldosterone-induced epithelial-to-mesenchymal transition of renal proximal tubular epithelial cells, 10.1016/j.freeradbiomed.2012.03.015
  52. Gautier L., Cope L., Bolstad B. M., Irizarry R. A., affy--analysis of Affymetrix GeneChip data at the probe level, 10.1093/bioinformatics/btg405
  53. Irizarry R. A., Exploration, normalization, and summaries of high density oligonucleotide array probe level data, 10.1093/biostatistics/4.2.249
  54. Baldi P., Long A. D., A Bayesian framework for the analysis of microarray expression data: regularized t -test and statistical inferences of gene changes, 10.1093/bioinformatics/17.6.509
  55. Kuhn R. M., Haussler D., Kent W. J., The UCSC genome browser and associated tools, 10.1093/bib/bbs038
  56. Wasserman Wyeth W., Sandelin Albin, Applied bioinformatics for the identification of regulatory elements, 10.1038/nrg1315
  57. Sardiello M., Science, 325, 473 (2009)
  58. Ashley Neil, Harris Dot, Poulton Joanna, Detection of mitochondrial DNA depletion in living human cells using PicoGreen staining, 10.1016/j.yexcr.2004.10.013
  59. Schneider Caroline A, Rasband Wayne S, Eliceiri Kevin W, NIH Image to ImageJ: 25 years of image analysis, 10.1038/nmeth.2089
  60. Hammond Gerald R. V., Schiavo Giampietro, Irvine Robin F., Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4Pand PtdIns(4,5)P2, 10.1042/bj20090428
  61. Carpenter Anne E, Jones Thouis R, Lamprecht Michael R, Clarke Colin, Kang In, Friman Ola, Guertin David A, Chang Joo, Lindquist Robert A, Moffat Jason, Golland Polina, Sabatini David M, 10.1186/gb-2006-7-10-r100
  62. Ladoire Sylvain, Chaba Kariman, Martins Isabelle, Sukkurwala Abdul Qader, Adjemian Sandy, Michaud Mickaël, Poirier-Colame Vichnou, Andreiuolo Felipe, Galluzzi Lorenzo, White Eileen, Rosenfeldt Mathias, Ryan Kevin M., Zitvogel Laurence, Kroemer Guido, Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens, 10.4161/auto.20353
  63. Polishchuk Elena V., Polishchuk Roman S., Luini Alberto, Correlative Light–Electron Microscopy as a Tool to Study In Vivo Dynamics and Ultrastructure of Intracellular Structures, Methods in Molecular Biology (2012) ISBN:9781627030557 p.413-422, 10.1007/978-1-62703-056-4_20
  64. Luciani Alessandro, Villella Valeria Rachela, Esposito Speranza, Brunetti-Pierri Nicola, Medina Diego, Settembre Carmine, Gavina Manuela, Pulze Laura, Giardino Ida, Pettoello-Mantovani Massimo, D'Apolito Maria, Guido Stefano, Masliah Eliezer, Spencer Brian, Quaratino Sonia, Raia Valeria, Ballabio Andrea, Maiuri Luigi, Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition, 10.1038/ncb2090