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Systemic Venous Inflow to the Liver Allograft to Overcome Diffuse Splanchnic Venous Thrombosis

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Lupascu, Cristian Darius, Tom [UCL] Goffette, Pierre [UCL] Lerut, Jan [UCL]

Diffuse splanchnic venous thrombosis (DSVT), formerly defined as contraindication for liver transplantation (LT), is a serious challenge to the liver transplant surgeon. Portal vein arterialisation, cavoportal hemitransposition and renoportal anastomosis, and finally combined liver and small bowel transplantation are all possible alternatives to deal with this condition. Five patients with preoperatively confirmed extensive splanchnic venous thrombosis were transplanted using cavoportal hemitransposition (4x) and renoportal anastomosis (1x). Median follow-up was 58 months (range: 0,5 to 130 months). Two patients with previous radiation-induced peritoneal injury died, respectively, 18 days and 2 months after transplantation. The three other patients had excellent long-term survival, despite the fact that two of them needed a surgical reintervention for severe gastrointestinal bleeding. Extensive splanchnic venous thrombosis is no longer an absolute contraindication to liver transplantation. Although cavoportal hemitransposition and renoportal anastomosis undoubtedly are life-saving procedures allowing for ensuring adequate allograft portal flow, careful follow-up of these patients remains necessary as both methods are unable to completely eliminate the complications of (segmental) portal hypertension.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2015
Language Anglais
Journal information "Gastroenterology Research and Practice" - Vol. 2015, p. Article ID 810851, 6 pages (2015)
Peer reviewed yes
Publisher Hindawi Publishing Corporation ((Egypt) Cairo)
issn 1687-6121
e-issn 1687-630X
Publication status Publié
Affiliations UCL - SSS/IONS/NEUR - Clinical Neuroscience
UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation
UCL - (SLuc) Service de radiologie
UCL - (SLuc) Service de chirurgie et transplantation abdominale
Links
  1. Lerut J. P., Mazza Davide, Donataccio Matteo, de Goyet J. Ville, Beers Bernard Van, Bourlier Pascal, Goffette Pierre, Otte Jean-Bernard, van Leeuw V�ronique, Laterre Pierre-Francois, Puttemans Thierry, Adult liver transplantation and abnormalities of splanchnic veins: experience in 53 patients, 10.1007/s001470050025
  2. Yerdel Mehmet Ali, Gunson Bridget, Mirza Darius, Karayal??in Kaan, Olliff Simon, Buckels John, Mayer David, McMaster Paul, Pirenne Jacques, PORTAL VEIN THROMBOSIS IN ADULTS UNDERGOING LIVER TRANSPLANTATION : Risk Factors, Screening, Management, and Outcome1, 10.1097/00007890-200005150-00023
  3. Gerunda G, Cavoportal hemitransposition: A successful way to overcome the problem of total portosplenomesenteric thrombosis in liver transplantation, 10.1053/jlts.2002.30404
  4. Rodríguez-Castro Kryssia I., Porte Robert J., Nadal Elena, Germani Giacomo, Burra Patrizia, Senzolo Marco, Management of Nonneoplastic Portal Vein Thrombosis in the Setting of Liver Transplantation : A Systematic Review, 10.1097/tp.0b013e31826e8e53
  5. D'Amico G., Tarantino G., Spaggiari M., Ballarin R., Serra V., Rumpianesi G., Montalti R., De Ruvo N., Cautero N., Begliomini B., Gerunda G.E., Di Benedetto F., Multiple Ways to Manage Portal Thrombosis During Liver Transplantation: Surgical Techniques and Outcomes, 10.1016/j.transproceed.2013.07.046
  6. Roberts John P., Brown Robert S., Edwards Erick B., Farmer Douglas G., Freeman Richard B., Wiesner Russell H., Merion Robert M., Liver and intestine transplantation, 10.1034/j.1600-6143.3.s4.8.x
  7. STARZL THOMAS E., PUTNAM CHARLES W., PORTER KEN A., HALGRIMSON CHARLES C., CORMAN JACQUES, BROWN BARBARA I., COTLIN RONALD W., RODCERSON DENIS O., CREENE HARRY L., Portal Diversion for the Treatment of Glycogen Storage Disease in Humans : , 10.1097/00000658-197310000-00015
  8. LERUT JAN, TZAKIS ANDREAS G., BRON KLAUS, GORDON ROBERT D., IWATSUKI SHUNZABURO, ESQUIVEL CARLOS O., MAKOWKA LEONARD, TODO SATORU, STARZL THOMAS E., Complications of Venous Reconstruction in Human Orthotopic Liver Transplantation : , 10.1097/00000658-198704000-00011
  9. Tzakis Andreas G., Kirkegaard Preben, Pinna Antonio D., Jovine Elio, Misiakos Evangelos P., Maziotti Alighieri, Dodson Forrest, Khan Farrukh, Nery Jose, Rasmussen Allan, Fung John J., Demetris Anthony, Ruiz Philip J., LIVER TRANSPLANTATION WITH CAVOPORTAL HEMITRANSPOSITION IN THE PRESENCE OF DIFFUSE PORTAL VEIN THROMBOSIS : , 10.1097/00007890-199803150-00004
  10. Clinical Transplantation, 11, 71 (1997)
  11. Gastroenterologie Clinique et Biologique, 26, 325 (2002)
  12. Kato Tomoaki, Liver Transplantation With Renoportal Anastomosis After Distal Splenorenal Shunt, 10.1001/archsurg.135.12.1401
  13. Ceulemans B., Aerts R., Monbaliu D., Coosemans W., Verslype C., Van Steenbergen W., Yap P., Fevery J., Nevens F., Pirenne J., Liver Transplantation Using Cavoportal Transposition: An Effective Treatment in Patients With Complete Splanchnic Venous Thrombosis, 10.1016/j.transproceed.2004.12.047
  14. OTTE JEAN-BERNARD, REYNAERT MARC, HEMPTINNE BERNARD DE, GEUBEL ANDRÉ, CARLIER MARIANNE, JAMART JACQUES, LAMBOTTE LUC, KESTENS PAUL-JACQUES, Arterialization of the Portal Vein in Conjunction with a Therapeutic Portacaval Shunt Hemodynamic Investigations and Results in 75 Patients : , 10.1097/00000658-198212001-00007
  15. Transplant International, 11, 147 (1998)
  16. ERHARD JOCHEN, LANGE REINHARD, GIEBLER RAINER, RAUEN URSULA, GROOT HERBERT DE, EIGLER FRIEDRICH WILHELM, ARTERIALIZATION OF THE PORTAL VEIN IN ORTHOTOPIC AND AUXILIARY LIVER TRANSPLANTATION : A REPORT OF THREE CASES, 10.1097/00007890-199510270-00020
  17. Bonnet S., Sauvanet A., Bruno O., Sommacale D., Francoz C., Dondero F., Durand F., Belghiti J., Long-term survival after portal vein arterialization for portal vein thrombosis in orthotopic liver transplantation, 10.1016/j.gcb.2009.05.013
  18. Annals of Hepatology, 7, 200 (2008)
  19. Bhangui Prashant, Lim Chetana, Salloum Chady, Andreani Paola, Sebbagh Mylene, Hoti Emir, Ichai Philippe, Saliba Faouzi, Adam Rene, Castaing Denis, Azoulay Daniel, Caval Inflow to the Graft for Liver Transplantation in Patients With Diffuse Portal Vein Thrombosis : A 12-Year Experience, 10.1097/sla.0b013e31822d7894
  20. Uchida Hajime, Sakamoto Seisuke, Shigeta Takanobu, Hamano Ikumi, Kanazawa Hiroyuki, Fukuda Akinari, Karaki Chiaki, Nakazawa Atsuko, Kasahara Mureo, Living Donor Liver Transplantation with Renoportal Anastomosis for a Patient with Congenital Absence of the Portal Vein, 10.1155/2012/670289
  21. Mori Akira, Iida Taku, Iwasaki Junji, Ogawa Kohei, Fujimoto Yasuhiro, Uemura Tadahiro, Hatano Etsuro, Okajima Hideaki, Kaido Toshimi, Uemoto Shinji, Portal vein reconstruction in adult living donor liver transplantation for patients with portal vein thrombosis in single center experience, 10.1002/jhbp.235
  22. Pathology Annual, 23, part 1, 297 (1988)
  23. Russell Nicola S., Hoving Saske, Heeneman Sylvia, Hage J. Joris, Woerdeman Leonie A.E., de Bree Remco, Lohuis Peter J.F.M., Smeele Ludi, Cleutjens Jack, Valenkamp Addy, Dorresteijn Lucille D.A., Dalesio Otilia, Daemen Mat J., Stewart Fiona A., Novel insights into pathological changes in muscular arteries of radiotherapy patients, 10.1016/j.radonc.2009.05.021
  24. Mantel Hendrik T.J., Rosen Charles B., Heimbach Julie K., Nyberg Scott L., Ishitani Michael B., Andrews James C., McKusick Michael A., Haddock Michael G., Alberts Steven R., Gores Gregory J., Vascular complications after orthotopic liver transplantation after neoadjuvant therapy for hilar cholangiocarcinoma, 10.1002/lt.21107
  25. Wu Youmin, Johlin Frederick C., Rayhill Stephen C., Jensen Chris S., Xie Jin, Cohen Michael B., Mitros Frank A., Long-term, tumor-free survival after radiotherapy combining hepatectomy-Whipple en bloc and orthotopic liver transplantation for early-stage hilar cholangiocarcinoma, 10.1002/lt.21287
Bibliographic reference Lupascu, Cristian ; Darius, Tom ; Goffette, Pierre ; Lerut, Jan. Systemic Venous Inflow to the Liver Allograft to Overcome Diffuse Splanchnic Venous Thrombosis. In: Gastroenterology Research and Practice, Vol. 2015, p. Article ID 810851, 6 pages (2015)
Permanent URL http://hdl.handle.net/2078.1/174346