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Mechanical endovascular thrombectomy for acute ischemic stroke: a retrospective multicenter study in Belgium.

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Fockaert, Niels Coninckx, Marieke Heye, Sam Defreyne, Luc Brisbois, Denis Goffette, Pierre [UCL] Peeters, André [UCL] Lemmens, Robin

Clinical trials have shown a beneficial effect of mechanical thrombectomy in acute ischemic stroke patients treated within six up to even 12 h after symptom onset. This treatment was already performed in selected hospitals in Belgium before completion of the randomized controlled trials. Outcome data on these procedures in Belgium have not been published. We performed a retrospective multicenter study of all patients with acute ischemic stroke treated with mechanical endovascular therapy in four hospitals in Belgium. Clinical outcomes, as measured by the modified Rankin Scale (mRS), site of arterial occlusion, reperfusion and the association between these variables were studied. The study included 80 patients: 65 patients with an occlusion in the anterior circulation and 15 with an occlusion in the posterior circulation. Good functional outcome (GFO) rates, defined as mRS 0-2 at 90 days, were 42 % in all patients, 44 % in anterior circulation stroke and 34 % in posterior circulation stroke. Reperfusion was achieved in 78 % of patients; more (100 %) in patients with posterior compared to patients with anterior circulation stroke (72 %; p = 0.02). The rate of GFO was greater in patients with reperfusion versus patients in whom reperfusion was not achieved (adjusted OR 8.2, 95 % CI 2.0-34.2). Symptomatic intracerebral hemorrhage was documented in 5 % of all patients. Endovascular treatment with mechanical devices for acute ischemic stroke in Belgium results in GFO and reperfusion rates similar to recently published results in the endovascular-treated arms of randomized clinical trials. Rates of symptomatic intracranial hemorrhage are low and comparable to other cohort studies and clinical trials.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2016
Language Anglais
Journal information "Acta Neurologica Belgica" - Vol. 116, no. 1, p. 7-14 (2016)
Peer reviewed yes
Publisher Springer ((Italy) Milano)
issn 0300-9009
e-issn 2240-2993
Publication status Publié
Affiliations UCL - SSS/IONS/NEUR - Clinical Neuroscience
UCL - (SLuc) Service de neurologie
UCL - (SLuc) Service de radiologie
Keywords Endovascular ; Ischemic stroke ; Outcome ; Reperfusion ; Thrombectomy
Links
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Bibliographic reference Fockaert, Niels ; Coninckx, Marieke ; Heye, Sam ; Defreyne, Luc ; Brisbois, Denis ; et. al. Mechanical endovascular thrombectomy for acute ischemic stroke: a retrospective multicenter study in Belgium.. In: Acta Neurologica Belgica, Vol. 116, no. 1, p. 7-14 (2016)
Permanent URL http://hdl.handle.net/2078.1/174190