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Neuroinflammation in Alzheimer's, Parkinson's and Huntington's Diseases

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Sastre, Magdalena Katsouri, Loukia Birch, Amy M. Renziehausen, Alexander Dexter, David Trevor Crichton, Robert [UCL] Ward, Roberta

Neuroinflammation and oxidative stress are involved in the pathogenesis of Alzheimer's, Parkinson's and Huntington's diseases. This is caused mainly by the presence of misfolded proteins which act as a catalyst for the activation and sustained activity of glial cells. Activated microglial cells are involved in both the initiation and progression of the disease, which will lead to the release of many pro-inflammatory mediators which induce neuronal injury and death. In addition, astrocytes may play an important role; their ability to secrete important neurotrophic factors may be impaired, while the release of pro-inflammatory cytokines may contribute to the cellular destruction. Activation of the innate and adaptive immune responses is evident in these diseases, while the production of reactive oxygen and nitrogen species will contribute to the neuronal destruction

Document type Contribution à ouvrage collectif (Book Chapter) – Chapitre
Publication date 2014
Language Anglais
Host document Nicola Woodroofe, Sandra Amor ; "Neuroinflammation and CNS Disorders"- p. 111-150 (ISBN : 9781118406410)
Publisher Wiley-Blackwell Publishing Ltd. ((United States) New York, NY)
Publication status Publié
Affiliations UCL - SST/ELI - Earth and Life Institute
UCL - SST/IMCN/MOST - Molecules, Solids and Reactivity
Keywords Alzheimer ; Huntington ; Inflammation ; Misfolded protein ; Parkinson
Links
  1. Akiyama, Aging, 21, 383 (2000)
  2. Amara Francis M, Junaid Asad, Clough Richard R, Liang Binhua, TGF-β1, regulation of Alzheimer amyloid precursor protein mRNA expression in a normal human astrocyte cell line: mRNA stabilization, 10.1016/s0169-328x(99)00158-8
  3. Apelt Jenny, Ach Katrin, Schliebs Reinhard, Aging-related down-regulation of neprilysin, a putative β-amyloid-degrading enzyme, in transgenic Tg2576 Alzheimer-like mouse brain is accompanied by an astroglial upregulation in the vicinity of β-amyloid plaques, 10.1016/s0304-3940(03)00030-2
  4. Arosio, Aging, 25, 1009 (2004)
  5. Banati R. B., Goerres G. W., Myers R., Gunn R. N., Turkheimer F. E., Kreutzberg G. W., Brooks D. J., Jones T., Duncan J. S., [11C](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen's encephalitis, 10.1212/wnl.53.9.2199
  6. Bard Frédérique, Cannon Catherine, Barbour Robin, Burke Rae-Lyn, Games Dora, Grajeda Henry, Guido Teresa, Hu Kang, Huang Jiping, Johnson-Wood Kelly, Khan Karen, Kholodenko Dora, Lee Mike, Lieberburg Ivan, Motter Ruth, Nguyen Minh, Soriano Ferdie, Vasquez Nicki, Weiss Kim, Welch Brent, Seubert Peter, Schenk Dale, Yednock Ted, 10.1038/78682
  7. Bartzokis, Aging, 25, 5 (2004)
  8. Bartzokis George, Cummings Jeffrey, Perlman Susan, Hance Darwood B., Mintz Jim, Increased Basal Ganglia Iron Levels in Huntington Disease, 10.1001/archneur.56.5.569
  9. Bartzokis George, Lu Po H., Tishler Todd A., Fong Sophia M., Oluwadara Bolanle, Finn J. Paul, Huang Danny, Bordelon Yvette, Mintz Jim, Perlman Susan, Myelin Breakdown and Iron Changes in Huntington’s Disease: Pathogenesis and Treatment Implications, 10.1007/s11064-007-9352-7
  10. Bartzokis, Metal Ions in Life Sciences (2006)
  11. Bartzokis, Cell Molec. Biol, 46, 821 (2000)
  12. Benavides Jes�S, Cornu Philippe, Dennis Trevor, Dubois Alain, Hauw Jean-Jacques, Mackenzie Eric T., Sazdovitch V�ronique, Scatton Bernard, Imaging of human brain lesions with an ?3 site radioligand, 10.1002/ana.410240603
  13. Bessler H., Djaldetti R., Salman H., Bergman M., Djaldetti M., IL-1β, IL-2, IL-6 and TNF-α production by peripheral blood mononuclear cells from patients with Parkinson's disease, 10.1016/s0753-3322(99)80079-1
  14. Björkqvist Maria, Wild Edward J., Thiele Jenny, Silvestroni Aurelio, Andre Ralph, Lahiri Nayana, Raibon Elsa, Lee Richard V., Benn Caroline L., Soulet Denis, Magnusson Anna, Woodman Ben, Landles Christian, Pouladi Mahmoud A., Hayden Michael R., Khalili-Shirazi Azadeh, Lowdell Mark W., Brundin Patrik, Bates Gillian P., Leavitt Blair R., Möller Thomas, Tabrizi Sarah J., A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease, 10.1084/jem.20080178
  15. Bodovitz Steven, Falduto Michael T., Frail Donald E., Klein William L., Iron Levels Modulate α-Secretase Cleavage of Amyloid Precursor Protein, 10.1046/j.1471-4159.1995.64010307.x
  16. Bogdanov Misha B., Andreassen Ole A., Dedeoglu Alpaslan, Ferrante Robert J., Beal M. Flint, Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease : OH8dG in Huntington's mice, 10.1046/j.1471-4159.2001.00689.x
  17. Bolmont T., Haiss F., Eicke D., Radde R., Mathis C. A., Klunk W. E., Kohsaka S., Jucker M., Calhoun M. E., Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance, 10.1523/jneurosci.4814-07.2008
  18. BONIFATI D, KISHORE U, Role of complement in neurodegeneration and neuroinflammation, 10.1016/j.molimm.2006.03.007
  19. Braak Heiko, Sastre Magdalena, Del Tredici Kelly, Development of α-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson’s disease, 10.1007/s00401-007-0244-3
  20. Brenner S. R., Kurlan R., Coleman P., Federoff H., A focus on the synapse for neuroprotection in Alzheimer disease and other dementias, 10.1212/wnl.64.11.1991
  21. Breitner J.C.S., Haneuse S. J.P.A., Walker R., Dublin S., Crane P. K., Gray S. L., Larson E. B., Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort, 10.1212/wnl.0b013e3181a18691
  22. Brochard, Clin. Invest, 119, 182 (2009)
  23. Browne T. C., McQuillan K., McManus R. M., O'Reilly J.-A., Mills K. H. G., Lynch M. A., IFN-  Production by Amyloid  -Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease, 10.4049/jimmunol.1200947
  24. Bruunsgaard H., Andersen-Ranberg K., Jeune B., Pedersen A. N., Skinhoj P., Pedersen B. K., A High Plasma Concentration of TNF-  Is Associated With Dementia in Centenarians, 10.1093/gerona/54.7.m357
  25. Bush, J. Alzheimer's Dis, 33, S277 (2013)
  26. Butterfield D. Allan, Swomley Aaron M., Sultana Rukhsana, Amyloidβ-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression, 10.1089/ars.2012.5027
  27. Cagnin Annachiara, Brooks David J, Kennedy Angus M, Gunn Roger N, Myers R, Turkheimer Federico E, Jones Terry, Banati Richard B, In-vivo measurement of activated microglia in dementia, 10.1016/s0140-6736(01)05625-2
  28. Carter S. F., Scholl M., Almkvist O., Wall A., Engler H., Langstrom B., Nordberg A., Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG, 10.2967/jnumed.110.087031
  29. Castellani Rudy J., Nugent Summer L., Morrison Alan L., Zhu Xiongwei, Lee Hyoung-gon, Harris Peggy L. R., Bajić Vladan, Sharma Hari S., Chen Shu G., Oettgen Peter, Perry George, Smith Mark A., CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson’s disease, 10.1007/s00702-010-0485-5
  30. Chami Linda, Checler Frédéric, BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease, 10.1186/1750-1326-7-52
  31. Chen Chiung-Mei, Wu Yih-Ru, Cheng Mei-Ling, Liu Jun-Liang, Lee Yu-May, Lee Po-Wei, Soong Bing-Wen, Chiu Daniel Tsun-Yee, Increased oxidative damage and mitochondrial abnormalities in the peripheral blood of Huntington’s disease patients, 10.1016/j.bbrc.2007.05.093
  32. Chen Ming-Kai, Guilarte Tomás R., Translocator protein 18 kDa (TSPO): Molecular sensor of brain injury and repair, 10.1016/j.pharmthera.2007.12.004
  33. Chen Dexiang, Endres Ryan L., Erickson Cherie A., Weis Kathleen F., McGregor Martha W., Kawaoka Yoshihiro, Payne Lendon G., 10.1038/80538
  34. Choi Dennis W., Neurodegeneration: Cellular defences destroyed, 10.1038/433696a
  35. Choi Yoori, Kim Hye-Sun, Shin Ki Young, Kim Eun-Mee, Kim Minji, Kim Hyun-Soo, Park Cheol Hyoung, Jeong Yun Ha, Yoo Jongman, Lee Jean-Pyo, Chang Keun-A, Kim Seonghan, Suh Yoo-Hun, Minocycline Attenuates Neuronal Cell Death and Improves Cognitive Impairment in Alzheimer's Disease Models, 10.1038/sj.npp.1301377
  36. Collins Louise M., Toulouse André, Connor Thomas J., Nolan Yvonne M., Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease, 10.1016/j.neuropharm.2012.01.028
  37. Combarros Onofre, van Duijn Cornelia M, Hammond Naomi, Belbin Olivia, Arias-Vásquez Alejandro, Cortina-Borja Mario, Lehmann Michael G, Aulchenko Yurii S, Schuur Maaike, Kölsch Heike, Heun Reinhard, Wilcock Gordon K, Brown Kristelle, Kehoe Patrick G, Harrison Rachel, Coto Eliecer, Alvarez Victoria, Deloukas Panos, Mateo Ignacio, Gwilliam Rhian, Morgan Kevin, Warden Donald R, Smith A David, Lehmann Donald J, Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease, 10.1186/1742-2094-6-22
  38. Combs, J. Neurosci., 21, 1179 (2001)
  39. Cornett, Neurotoxicology, 19, 339 (1998)
  40. Cosenza-Nashat M., Zhao M.-L., Suh H.-S., Morgan J., Natividad R., Morgello S., Lee S. C., Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain, 10.1111/j.1365-2990.2008.01006.x
  41. Couch Yvonne, Alvarez-Erviti Lydia, Sibson Nicola R, Wood Matthew JA, Anthony Daniel C, The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation, 10.1186/1742-2094-8-166
  42. Crichton Robert R., Dexter David T., Ward Roberta J., Brain iron metabolism and its perturbation in neurological diseases, 10.1007/s00702-010-0470-z
  43. Crichton, From Molecular Mechanisms to Therapeutic Strategies (2006)
  44. Crichton , R.R. Ward , R.J. 2013 Metal Based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies, 2nd ed John Wiley and Sons Chichester, UK
  45. Dalrymple Annette, Wild Edward J., Joubert Richard, Sathasivam Kirupa, Björkqvist Maria, Petersén Åsa, Jackson Graham S., Isaacs Jeremy D., Kristiansen Mark, Bates Gillian P., Leavitt Blair R., Keir Geoff, Ward Malcolm, Tabrizi Sarah J., Proteomic Profiling of Plasma in Huntington's Disease Reveals Neuroinflammatory Activation and Biomarker Candidates, 10.1021/pr0700753
  46. De Luca Gabriele, Russo Maria Teresa, Degan Paolo, Tiveron Cecilia, Zijno Andrea, Meccia Ettore, Ventura Ilenia, Mattei Elisabetta, Nakabeppu Yusaku, Crescenzi Marco, Pepponi Rita, Pèzzola Antonella, Popoli Patrizia, Bignami Margherita, A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration, 10.1371/journal.pgen.1000266
  47. del Hoyo Pilar, García-Redondo Alberto, de Bustos Fernando, Molina José Antonio, Sayed Youssef, Alonso-Navarro Hortensia, Caballero Luis, Arenas Joaquín, Jiménez-Jiménez Félix Javier, Oxidative Stress in Skin Fibroblasts Cultures of Patients with Huntington’s Disease, 10.1007/s11064-006-9110-2
  48. Dexter , D.T. 2013 Parkinson's disease R.J. Ward R.R. Crichton D.T. Dexter Royal Society of Chemistry London 1 213
  49. Dexter David T., Jenner Peter, Parkinson disease: from pathology to molecular disease mechanisms, 10.1016/j.freeradbiomed.2013.01.018
  50. Dexter David T., Jenner Peter, Schapira Anthony H. V., Marsden C. David, , Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia, 10.1002/ana.410320716
  51. Thameem Dheen S., Kaur Charanjit, Ling Eng-Ang, Microglial Activation and its Implications in the Brain Diseases, 10.2174/092986707780597961
  52. Di Bona, J. Alzheimer's Dis, 29, 751 (2012)
  53. Dickson Dennis W., Lee Sunhee C., Mattiace Linda A., Yen Shu-Hui C., Brosnan Celia, Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease, 10.1002/glia.440070113
  54. Dill J., Patel A. R., Yang X.-L., Bachoo R., Powell C. M., Li S., A Molecular Mechanism for Ibuprofen-Mediated RhoA Inhibition in Neurons, 10.1523/jneurosci.5045-09.2010
  55. Ding Bei, Chen Ke-Min, Ling Hua-Wei, Sun Fei, Li Xia, Wan Tao, Chai Wei-Min, Zhang Huan, Zhan Ying, Guan Yong-Jing, Correlation of iron in the hippocampus with MMSE in patients with Alzheimer's disease, 10.1002/jmri.21730
  56. Du Y., Dodel R. C., Eastwood B. J., Bales K. R., Gao F., Lohmuller F., Muller U., Kurz A., Zimmer R., Evans R. M., Hake A., Gasser T., Oertel W. H., Griffin W. S. T., Paul S. M., Farlow M. R., Association of an interleukin 1  polymorphism with Alzheimer's disease, 10.1212/wnl.55.4.480
  57. Dumas Eve M., Versluis Maarten J., van den Bogaard Simon J.A., van Osch Matthias J.P., Hart Ellen P., van Roon-Mom Willeke M.C., van Buchem Mark A., Webb Andrew G., van der Grond Jeroen, Roos Raymund A.C., Elevated brain iron is independent from atrophy in Huntington's Disease, 10.1016/j.neuroimage.2012.03.056
  58. Khoury Joseph El, Luster Andrew D., Mechanisms of microglia accumulation in Alzheimer’s disease: therapeutic implications, 10.1016/j.tips.2008.08.004
  59. Falsig Jeppe, van Beek Johan, Hermann Corinna, Leist Marcel, Molecular basis for detection of invading pathogens in the brain, 10.1002/jnr.21590
  60. Familian Atoosa, Boshuizen Ronald S., Eikelenboom Piet, Veerhuis Robert, Inhibitory effect of minocycline on amyloid β fibril formation and human microglial activation, 10.1002/glia.20268
  61. Farina Cinthia, Aloisi Francesca, Meinl Edgar, Astrocytes are active players in cerebral innate immunity, 10.1016/j.it.2007.01.005
  62. Faulkner J. R., Reactive Astrocytes Protect Tissue and Preserve Function after Spinal Cord Injury, 10.1523/jneurosci.3547-03.2004
  63. Ferretti Maria Teresa, Allard Simon, Partridge Vanessa, Ducatenzeiler Adriana, Cuello A Claudio, Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology, 10.1186/1742-2094-9-62
  64. Festuccia William T., Oztezcan Serdar, Laplante Mathieu, Berthiaume Magalie, Michel Chantal, Dohgu Shinya, Denis Raphaël G., Brito Marcia N., Brito Nilton A., Miller David S., Banks William A., Bartness Timothy J., Richard Denis, Deshaies Yves, Peroxisome Proliferator-Activated Receptor-γ-Mediated Positive Energy Balance in the Rat Is Associated with Reduced Sympathetic Drive to Adipose Tissues and Thyroid Status, 10.1210/en.2007-1553
  65. Fillit Howard, Ding Wanhong, Buee Luc, Kalman Jill, Altstiel Larry, Lawlor Brian, Wolf-Klein Giselle, Elevated circulating tumor necrosis factor levels in Alzheimer's disease, 10.1016/0304-3940(91)90490-k
  66. Forder J.P., Tymianski M., Postsynaptic mechanisms of excitotoxicity: Involvement of postsynaptic density proteins, radicals, and oxidant molecules, 10.1016/j.neuroscience.2008.10.021
  67. Frautschy, Amer. J. Pathol., 152, 307 (1998)
  68. Frenkel Dan, Maron Ruth, Burt David S., Weiner Howard L., Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears β-amyloid in a mouse model of Alzheimer disease, 10.1172/jci23241
  69. Furuta, Amer. J. Pathol., 146, 357 (1995)
  70. Games Dora, Adams David, Alessandrini Ree, Barbour Robin, Borthelette Patricia, Blackwell Catherine, Carr Tony, Clemens James, Donaldson Thomas, Gillespie Frances, Guido Terry, Hagopian Stephanie, Johnson-Wood Kelly, Khan Karen, Lee Mike, Leibowitz Paul, Lieberburg Ivan, Little Sheila, Masliah Eliezer, McConlogue Lisa, Montoya-Zavala Martin, Mucke Lennart, Paganini Lisa, Penniman Elizabeth, Power Mike, Schenk Dale, Seubert Peter, Snyder Ben, Soriano Ferdie, Tan Hua, Vitale James, Wadsworth Sam, Wolozin Ben, Zhao Jun, Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein, 10.1038/373523a0
  71. Gao Hui-Ming, Hong Jau-Shyong, Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression, 10.1016/j.it.2008.05.002
  72. Gegg M. E., Beltran B., Salas-Pino S., Bolanos J. P., Clark J. B., Moncada S., Heales S. J. R., Differential effect of nitric oxide on glutathione metabolism and mitochondrial function in astrocytes and neurones: implications for neuroprotection/neurodegeneration? : Effect of NO on GSH metabolism, 10.1046/j.1471-4159.2003.01821.x
  73. Gerhard Alexander, Pavese Nicola, Hotton Gary, Turkheimer Federico, Es Meltem, Hammers Alexander, Eggert Karla, Oertel Wolfgang, Banati Richard B., Brooks David J., In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease, 10.1016/j.nbd.2005.08.002
  74. Ghosh S., Wu M. D., Shaftel S. S., Kyrkanides S., LaFerla F. M., Olschowka J. A., O'Banion M. K., Sustained Interleukin-1  Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model, 10.1523/jneurosci.4361-12.2013
  75. Giasson B. I., Oxidative Damage Linked to Neurodegeneration by Selective alpha -Synuclein Nitration in Synucleinopathy Lesions, 10.1126/science.290.5493.985
  76. G�mez-Tortosa Estrella, MacDonald Marcy E., Friend Julia C., Taylor Sherryl A.M., Weiler Larry J., Cupples L. Adrienne, Srinidhi Jayalakshmi, Gusella James F., Bird Edward D., Vonsattel Jean-Paul, Myers Richard H., Quantitative neuropathological changes in presymptomatic Huntington's disease, 10.1002/1531-8249(200101)49:1<29::aid-ana7>3.0.co;2-b
  77. GÖTZ MARIO E., DOUBLE KAY, GERLACH MANFRED, YOUDIM MOUSSA B. H., RIEDERERE PETER, The Relevance of Iron in the Pathogenesis of Parkinson's Disease, 10.1196/annals.1306.017
  78. Griffin, J. Leuko. Biol., 72, 233 (2002)
  79. Griffin W, The pervasiveness of interleukin-1 in Alzheimer pathogenesis: a role for specific polymorphisms in disease risk, 10.1016/s0531-5565(00)00110-8
  80. T. Griffin W. Sue, Sheng Jin Gen, Roberts Gareth W., Mrak Robert E., Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease : Significance in Plaque Evalution, 10.1097/00005072-199503000-00014
  81. Griffin W. S., Stanley L. C., Ling C., White L., MacLeod V., Perrot L. J., White C. L., Araoz C., Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease., 10.1073/pnas.86.19.7611
  82. Grimaldi Luigi M. E., Casadei Valeria M., Ferri Cinzia, Veglia Fabrizio, Licastro Federico, Annoni Giorgio, Biunno Ida, De Bellis Gianluca, Sorbi Sandro, Mariani Claudio, Canal Nicola, Griffin W. Sue T., Franceschi Massimo, Association of early-onset Alzheimer's disease with an interleukin-1? gene polymorphism, 10.1002/1531-8249(200003)47:3<361::aid-ana12>3.0.co;2-n
  83. Guglielmotto, Oxidative stress mediates the pathogenic effect of different Alzheimer’s disease risk factors, 10.3389/neuro.24.003.2010
  84. Guidetti Paolo, Charles Vinod, Chen Er-Yun, Reddy P.Hemachandra, Kordower Jeffrey H., Whetsell William O., Schwarcz Robert, Tagle Danilo A., Early Degenerative Changes in Transgenic Mice Expressing Mutant Huntingtin Involve Dendritic Abnormalities but No Impairment of Mitochondrial Energy Production, 10.1006/exnr.2000.7626
  85. Guo, J. Neurosci., 22, 5900 (2002)
  86. Hacker, Sci. Signall., 357, re13 (2006)
  87. Hafer-Macko Charlene E., Dyck Peter J., Koski Carol Lee, Complement activation in acquired and hereditary amyloid neuropathy, 10.1046/j.1529-8027.2000.00018.x
  88. Hanyu Haruo, Sato Tomohiko, Kiuchi Akihiro, Sakurai Hirofumi, Iwamoto Toshihiko, PIOGLITAZONE IMPROVED COGNITION IN A PILOT STUDY ON PATIENTS WITH ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT WITH DIABETES MELLITUS : LETTERS TO THE EDITOR, 10.1111/j.1532-5415.2009.02067.x
  89. Haque, Today, 3, 175 (1997)
  90. Hayden K. M., Zandi P. P., Khachaturian A. S., Szekely C. A., Fotuhi M., Norton M. C., Tschanz J. T., Pieper C. F., Corcoran C., Lyketsos C. G., Breitner J.C.S., Welsh-Bohmer K. A., , Does NSAID use modify cognitive trajectories in the elderly?: The Cache County Study, 10.1212/01.wnl.0000265223.25679.2a
  91. Hayes A, A polymorphic variation in the interleukin 1A gene increases brain microglial cell activity in Alzheimer's disease, 10.1136/jnnp.2003.030866
  92. Helmy Azza A., Abdel Naseer Maged M., El Shafie Shahira, Nada Mona A.F., Role of Interleukin 6 and Alpha-Globulins in Differentiating Alzheimer and Vascular Dementias, 10.1159/000329568
  93. Heneka Michael T, Sastre Magdalena, Dumitrescu-Ozimek Lucia, Dewachter Ilse, Walter Jochen, Klockgether Thomas, Van Leuven Fred, 10.1186/1742-2094-2-22
  94. S. Hernandes Marina, R.G. Britto Luiz, NADPH Oxidase and Neurodegeneration, 10.2174/157015912804499483
  95. Hickman S. E., Allison E. K., El Khoury J., Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice, 10.1523/jneurosci.0616-08.2008
  96. Hunot, J Neurosci., 19, 3440 (1999)
  97. Hwang Onyou, Role of Oxidative Stress in Parkinson's Disease, 10.5607/en.2013.22.1.11
  98. Imamura Kazuhiro, Hishikawa Nozomi, Sawada Makoto, Nagatsu Toshiharu, Yoshida Mari, Hashizume Yoshio, Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains, 10.1007/s00401-003-0766-2
  99. Janelsins Michelle C, Mastrangelo Michael A, Oddo Salvatore, LaFerla Frank M, Federoff Howard J, Bowers William J, 10.1186/1742-2094-2-23
  100. Janelsins Michelle C., Mastrangelo Michael A., Park Keigan M., Sudol Kelly L., Narrow Wade C., Oddo Salvatore, LaFerla Frank M., Callahan Linda M., Federoff Howard J., Bowers William J., Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice, 10.2353/ajpath.2008.080528
  101. Jimenez S., Baglietto-Vargas D., Caballero C., Moreno-Gonzalez I., Torres M., Sanchez-Varo R., Ruano D., Vizuete M., Gutierrez A., Vitorica J., Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic, 10.1523/jneurosci.3024-08.2008
  102. Karuppagounder, Aging, 30, 1587 (2009)
  103. Kato Senri, Gondo Toshikazu, Hoshii Yoshinobu, Takahashi Mutsuo, Yamada Michio, Ishihara Tokuhiro, Confocal observation of senile plaques in Alzheimer's disease: Senile plaque morphology and relationship between senile plaques and astrocytes, 10.1111/j.1440-1827.1998.tb03915.x
  104. Kebir Hania, Kreymborg Katharina, Ifergan Igal, Dodelet-Devillers Aurore, Cayrol Romain, Bernard Monique, Giuliani Fabrizio, Arbour Nathalie, Becher Burkhard, Prat Alexandre, Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation, 10.1038/nm1651
  105. Keene C Dirk, Cudaback Eiron, Li Xianwu, Montine Kathleen S, Montine Thomas J, Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease, 10.1016/j.conb.2011.08.002
  106. Khoshnan A., Activation of the I B Kinase Complex and Nuclear Factor- B Contributes to Mutant Huntingtin Neurotoxicity, 10.1523/jneurosci.2675-04.2004
  107. Khoshnan Ali, Patterson Paul H., The role of IκB kinase complex in the neurobiology of Huntington's disease, 10.1016/j.nbd.2011.04.015
  108. Kiyota T, Ingraham K L, Swan R J, Jacobsen M T, Andrews S J, Ikezu T, AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice, 10.1038/gt.2011.126
  109. Klepac N., Relja M., Klepac R., Hećimović S., Babić T., Trkulja V., Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington’s disease gene carriers and healthy subjects : A cross-sectional study, 10.1007/s00415-007-0611-y
  110. Kobayashi K, Imagama S, Ohgomori T, Hirano K, Uchimura K, Sakamoto K, Hirakawa A, Takeuchi H, Suzumura A, Ishiguro N, Kadomatsu K, Minocycline selectively inhibits M1 polarization of microglia, 10.1038/cddis.2013.54
  111. Koenigsknecht-Talboo J., Meyer-Luehmann M., Parsadanian M., Garcia-Alloza M., Finn M. B., Hyman B. T., Bacskai B. J., Holtzman D. M., Rapid Microglial Response Around Amyloid Pathology after Systemic Anti-A  Antibody Administration in PDAPP Mice, 10.1523/jneurosci.4147-08.2008
  112. Koistinaho Milla, Lin Suizhen, Wu Xin, Esterman Michail, Koger Deanna, Hanson Jeffrey, Higgs Richard, Liu Feng, Malkani Seema, Bales Kelly R, Paul Steven M, Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides, 10.1038/nm1058
  113. Kosloski, J. Neurochem, 114, 261 (2010)
  114. Kummer Markus P., Hermes Michael, Delekarte Andrea, Hammerschmidt Thea, Kumar Sathish, Terwel Dick, Walter Jochen, Pape Hans-Christian, König Simone, Roeber Sigrun, Jessen Frank, Klockgether Thomas, Korte Martin, Heneka Michael T., Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation, 10.1016/j.neuron.2011.07.001
  115. Leal María C., Casabona Juan C., Puntel Mariana, Pitossi Fernando J., Interleukin-1β and tumor necrosis factor-α: reliable targets for protective therapies in Parkinson’s Disease?, 10.3389/fncel.2013.00053
  116. Lee Yong B., Nagai Atsushi, Kim Seung U., Cytokines, chemokines, and cytokine receptors in human microglia, 10.1002/jnr.10253
  117. Lee Mosley, Cold Spring Harbor Persp. Med, 2, a009381 (2012)
  118. Levesque Shannon, Wilson Belinda, Gregoria Vincent, Thorpe Laura B., Dallas Shannon, Polikov Vadim S., Hong Jau-Shyong, Block Michelle L., Reactive microgliosis: extracellular μ-calpain and microglia-mediated dopaminergic neurotoxicity, 10.1093/brain/awp333
  119. Li Chuanyu, Zhao Rui, Gao Kai, Wei Zheng, Yaoyao Yin Michael, Ting Lau Lok, Chui Dehua, Cheung Hoi Yu Albert, Astrocytes: Implications for Neuroinflammatory Pathogenesis of Alzheimers Disease, 10.2174/156720511794604543
  120. Li R., Tumor Necrosis Factor Death Receptor Signaling Cascade Is Required for Amyloid-  Protein-Induced Neuron Death, 10.1523/jneurosci.4580-03.2004
  121. Liu B., Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention, 10.1124/jpet.102.035048
  122. Ma Li, Nicholson Louise F.B, Expression of the receptor for advanced glycation end products in Huntington's disease caudate nucleus, 10.1016/j.brainres.2004.05.052
  123. Maksimović, Vojnosanitetski pregled, 58, 237 (2001)
  124. Mandrekar S., Jiang Q., Lee C. Y. D., Koenigsknecht-Talboo J., Holtzman D. M., Landreth G. E., Microglia Mediate the Clearance of Soluble A  through Fluid Phase Macropinocytosis, 10.1523/jneurosci.5572-08.2009
  125. Mandrekar-Colucci S., Karlo J. C., Landreth G. E., Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease, 10.1523/jneurosci.5268-11.2012
  126. Maragakis Nicholas J, Rothstein Jeffrey D, Mechanisms of Disease: astrocytes in neurodegenerative disease, 10.1038/ncpneuro0355
  127. Marinova-Mutafchieva Lilia, Sadeghian Mona, Broom Lauren, Davis John B., Medhurst Andrew D., Dexter David T., Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson’s disease, 10.1111/j.1471-4159.2009.06189.x
  128. Mark, J. Neurosci., 17, 1046 (1997)
  129. Matsuoka Y, Picciano M, La Francois J, Duff K, Fibrillar β-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer’s disease, 10.1016/s0306-4522(01)00115-4
  130. McGeer, Disorders, 2, 331 (1998a)
  131. McGeer P. L., Itagaki S., Boyes B. E., McGeer E. G., Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains, 10.1212/wnl.38.8.1285
  132. McGeer P. L., Itagaki S., McGeer E. G., Expression of the histocompatibility glycoprotein HLA-DR in neurological disease, 10.1007/bf00689592
  133. McGeer P. L., McGeer E. G., Mechanisms of cell death in Alzheimer disease — immunopathology, Alzheimer’s Disease — From Basic Research to Clinical Applications (1998) ISBN:9783211831120 p.159-166, 10.1007/978-3-7091-7508-8_15
  134. McTigue Dana M., Tripathi Richa B., The life, death, and replacement of oligodendrocytes in the adult CNS, 10.1111/j.1471-4159.2008.05570.x
  135. Mecocci, J. Alzheimer's Dis, 6, 159 (2004)
  136. Meda Lucia, Cassatella Marco A., Szendrei Gyorgyi I., Otvos Laszlo, Baron Pierluigi, Villalba Martin, Ferrari Davide, Rossi Filippo, Activation of microglial cells by β-amyloid protein and interferon-γ, 10.1038/374647a0
  137. Medeiros Rodrigo, LaFerla Frank M., Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony, 10.1016/j.expneurol.2012.10.007
  138. Mehlhorn Gaby, Hollborn Margrit, Schliebs Reinhard, Induction of cytokines in glial cells surrounding cortical β-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology, 10.1016/s0736-5748(00)00012-5
  139. Meßmer Kirsten, Reynolds Gavin P, Increased peripheral benzodiazepine binding sites in the brain of patients with Huntington's disease, 10.1016/s0304-3940(97)00967-1
  140. Meyer-Luehmann Melanie, Spires-Jones Tara L., Prada Claudia, Garcia-Alloza Monica, de Calignon Alix, Rozkalne Anete, Koenigsknecht-Talboo Jessica, Holtzman David M., Bacskai Brian J., Hyman Bradley T., Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease, 10.1038/nature06616
  141. Milnerwood Austen J., Raymond Lynn A., Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease, 10.1016/j.tins.2010.08.002
  142. Mirza B., Hadberg H., Thomsen P., Moos T., The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson's disease, 10.1016/s0306-4522(99)00455-8
  143. Möller Thomas, Neuroinflammation in Huntington’s disease, 10.1007/s00702-010-0430-7
  144. Montgomery Sara L., Narrow Wade C., Mastrangelo Michael A., Olschowka John A., O'Banion M. Kerry, Bowers William J., Chronic Neuron- and Age-Selective Down-Regulation of TNF Receptor Expression in Triple-Transgenic Alzheimer Disease Mice Leads to Significant Modulation of Amyloid- and Tau-Related Pathologies, 10.1016/j.ajpath.2013.02.030
  145. Morgan Michael J, Liu Zheng-gang, Crosstalk of reactive oxygen species and NF-κB signaling, 10.1038/cr.2010.178
  146. Morris, Neurodegeneration, 3, 267 (1994)
  147. Mrak, Aging, 26, 349 (2005)
  148. Myer D. J., Essential protective roles of reactive astrocytes in traumatic brain injury, 10.1093/brain/awl165
  149. Myers R. H., Vonsattel J. P., Paskevich P. A., Kiely D. K., Stevens T. J., Cupples L. A., Richardson E. P., Bird E. D., Decreased Neuronal and Increased Oligodendroglial Densities in Huntington's Disease Caudate Nucleus, 10.1097/00005072-199111000-00005
  150. Mythri Rajeswara Babu, Venkateshappa C., Harish G., Mahadevan Anita, Muthane Uday B., Yasha T. C., Srinivas Bharath M. M., Shankar S. K., Evaluation of Markers of Oxidative Stress, Antioxidant Function and Astrocytic Proliferation in the Striatum and Frontal Cortex of Parkinson’s Disease Brains, 10.1007/s11064-011-0471-9
  151. Niranjan , R. 2013 The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson's disease: focus on astrocytes. Molec. Neurobiol. June 20. [Epub ahead of print]
  152. Noble W., Garwood C., Stephenson J., Kinsey A. M., Hanger D. P., Anderton B. H., Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease, 10.1096/fj.08-113795
  153. Nolan Yvonne M., Sullivan Aideen M., Toulouse André, Parkinson's disease in the nuclear age of neuroinflammation, 10.1016/j.molmed.2012.12.003
  154. Nunomura Akihiko, Perry George, Aliev Gjumrakch, Hirai Keisuke, Takeda Atsushi, Balraj Elizabeth K., Jones Paul K., Ghanbari Hossein, Wataya Takafumi, Shimohama Shun, Chiba Shigeru, Atwood Craig S., Petersen Robert B., Smith Mark A., Oxidative Damage Is the Earliest Event in Alzheimer Disease, 10.1093/jnen/60.8.759
  155. Nunomura, J. Neurosci., 19, 1959 (1999)
  156. Okello A., Edison P., Archer H. A., Turkheimer F. E., Kennedy J., Bullock R., Walker Z., Kennedy A., Fox N., Rossor M., Brooks D. J., Microglial activation and amyloid deposition in mild cognitive impairment: A PET study, 10.1212/01.wnl.0000338622.27876.0d
  157. Ouchi Yasuomi, Yoshikawa Etsuji, Sekine Yoshimoto, Futatsubashi Masami, Kanno Toshihiko, Ogusu Tomomi, Torizuka Tatsuo, Microglial activation and dopamine terminal loss in early Parkinson's disease, 10.1002/ana.20338
  158. Pappolla, Amer. J. Pathol., 152, 871 (1998)
  159. Pavese N., Gerhard A., Tai Y. F., Ho A. K., Turkheimer F., Barker R. A., Brooks D. J., Piccini P., Microglial activation correlates with severity in Huntington disease: A clinical and PET study, 10.1212/01.wnl.0000222734.56412.17
  160. Pérez-Severiano Francisca, Rı́os Camilo, Segovia José, Striatal oxidative damage parallels the expression of a neurological phenotype in mice transgenic for the mutation of Huntington’s disease, 10.1016/s0006-8993(00)02082-5
  161. Peters A., Oligodendrocytes, their Progenitors and other Neuroglial Cells in the Aging Primate Cerebral Cortex, 10.1093/cercor/bhh060
  162. Pihlaja Rea, Koistinaho Jari, Kauppinen Riitta, Sandholm Jouko, Tanila Heikki, Koistinaho Milla, Multiple cellular and molecular mechanisms Are involved in human Aβ clearance by transplanted adult astrocytes, 10.1002/glia.21212
  163. Pihlaja Rea, Koistinaho Jari, Malm Tarja, Sikkilä Herkko, Vainio Seppo, Koistinaho Milla, Transplanted astrocytes internalize deposited β-amyloid peptides in a transgenic mouse model of Alzheimer's disease, 10.1002/glia.20599
  164. Pike V.W., Halldin C., Crouzel C., Barré L., Nutt D.J., Osman S., Shah F., Turton D.R., Waters S.L., Radioligands for PET studies of central benzodiazepine receptors and PK (peripheral benzodiazepine) binding sites—current status, 10.1016/0969-8051(93)90082-6
  165. Polazzi Elisabetta, Monti Barbara, Microglia and neuroprotection: From in vitro studies to therapeutic applications, 10.1016/j.pneurobio.2010.06.009
  166. Politis M., Pavese N., Tai Y. F., Tabrizi S. J., Barker R. A., Piccini P., Hypothalamic involvement in Huntington's disease: an in vivo PET study, 10.1093/brain/awn244
  167. Politis Marios, Pavese Nicola, Tai Yen F., Kiferle Lorenzo, Mason Sarah L, Brooks David J., Tabrizi Sarah J., Barker Roger A., Piccini Paola, Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: A multimodal imaging study, 10.1002/hbm.21008
  168. Pratic� Domenico, Clark Christopher M., Lee Virginia M.-Y., Trojanowski John Q., Rokach Joshua, FitzGerald Garret A., Increased 8,12-iso-iPF2?-VI in Alzheimer's disease: Correlation of a noninvasive index of lipid peroxidation with disease severity, 10.1002/1531-8249(200011)48:5<809::aid-ana19>3.0.co;2-9
  169. Praticò Domenico, Clark Christopher M., Liun Feyan, Lee Virginia Y.-M., Trojanowski John Q., Increase of Brain Oxidative Stress in Mild Cognitive Impairment : A Possible Predictor of Alzheimer Disease, 10.1001/archneur.59.6.972
  170. Praticò, J. Neurosci., 21, 4183 (2001)
  171. Qiu Wei Qiao, Walsh Dominic M., Ye Zhen, Vekrellis Konstantinos, Zhang Jimin, Podlisny Marcia B., Rosner Marsha Rich, Safavi Afshin, Hersh Louis B., Selkoe Dennis J., Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation, 10.1074/jbc.273.49.32730
  172. Qiu Wei Qiao, Ye Zhen, Kholodenko Dora, Seubert Peter, Selkoe Dennis J., Degradation of Amyloid β-Protein by a Metalloprotease Secreted by Microglia and Other Neural and Non-neural Cells, 10.1074/jbc.272.10.6641
  173. Qureshi G. A., Baig S., Bednar I., Södersten P., Forsberg G., Siden A., Increased cerebrospinal fluid concentration of nitrite in Parkinsonʼs disease : , 10.1097/00001756-199508000-00013
  174. Raivich Gennadij, Like cops on the beat: the active role of resting microglia, 10.1016/j.tins.2005.09.001
  175. Ransohoff Richard M., Perry V. Hugh, Microglial Physiology: Unique Stimuli, Specialized Responses, 10.1146/annurev.immunol.021908.132528
  176. Rappold Phillip M., Tieu Kim, Astrocytes and therapeutics for Parkinson’s disease, 10.1016/j.nurt.2010.07.001
  177. Rauert Hilka, Wicovsky Andreas, Müller Nicole, Siegmund Daniela, Spindler Volker, Waschke Jens, Kneitz Christian, Wajant Harald, Membrane Tumor Necrosis Factor (TNF) Induces p100 Processing via TNF Receptor-2 (TNFR2), 10.1074/jbc.m109.037341
  178. Rebeck G.William, Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer's disease, 10.1016/s0304-3940(00)01487-7
  179. Reed-Geaghan E. G., Savage J. C., Hise A. G., Landreth G. E., CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation, 10.1523/jneurosci.3158-09.2009
  180. Rice M.E, Russo-Menna I, Differential compartmentalization of brain ascorbate and glutathione between neurons and glia, 10.1016/s0306-4522(97)00347-3
  181. Rivera-Mancía, Inter., 186, 184 (2010)
  182. Rodríguez J J, Olabarria M, Chvatal A, Verkhratsky A, Astroglia in dementia and Alzheimer's disease, 10.1038/cdd.2008.172
  183. Rogers Jack T., Leiter Lorene M., McPhee Jay, Cahill Catherine M., Zhan Shan-Shan, Potter Huntington, Nilsson Lars N. G., Translation of the Alzheimer Amyloid Precursor Protein mRNA Is Up-regulated by Interleukin-1 through 5′-Untranslated Region Sequences, 10.1074/jbc.274.10.6421
  184. Rogers, Aging, 9, 339 (1988)
  185. Rogers Jack T., Randall Jeffrey D., Cahill Catherine M., Eder Paul S., Huang Xudong, Gunshin Hiromi, Leiter Lorene, McPhee Jay, Sarang Satinder S., Utsuki Tada, Greig Nigel H., Lahiri Debomoy K., Tanzi Rudolph E., Bush Ashley I., Giordano Tony, Gullans Steve R., An Iron-responsive Element Type II in the 5′-Untranslated Region of the Alzheimer's Amyloid Precursor Protein Transcript, 10.1074/jbc.m207435200
  186. Rohn Troy T., Catlin Lindsey W., Immunolocalization of Influenza A Virus and Markers of Inflammation in the Human Parkinson's Disease Brain, 10.1371/journal.pone.0020495
  187. Rus Horea, Cudrici Cornelia, David Stefan, Niculescu Florin, The complement system in central nervous system diseases, 10.1080/08916930600739605
  188. Ryu Jae K., Franciosi Sonia, Sattayaprasert Prasongchai, Kim Seung U., McLarnon James G., Minocycline inhibits neuronal death and glial activation induced by ?-amyloid peptide in rat hippocampus, 10.1002/glia.20051
  189. Salman H., Bergman M., Djaldetti R., Bessler H., Djaldetti M., Decreased phagocytic function in patients with Parkinson's disease, 10.1016/s0753-3322(99)80080-8
  190. Salminen Antero, Ojala Johanna, Kauppinen Anu, Kaarniranta Kai, Suuronen Tiina, Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors, 10.1016/j.pneurobio.2009.01.001
  191. Sapp E., Kegel K. B., Aronin N., Hashikawa T., Uchiyama Y., Tohyama K., Bhide P. G., Vonsattel J. P., Difiglia M., Early and Progressive Accumulation of Reactive Microglia in the Huntington Disease Brain, 10.1093/jnen/60.2.161
  192. Sastre, J. Neurosci., 23, 9796 (2003)
  193. Sastre M., Dewachter I., Rossner S., Bogdanovic N., Rosen E., Borghgraef P., Evert B. O., Dumitrescu-Ozimek L., Thal D. R., Landreth G., Walter J., Klockgether T., van Leuven F., Heneka M. T., Nonsteroidal anti-inflammatory drugs repress  -secretase gene promoter activity by the activation of PPAR , 10.1073/pnas.0503839103
  194. Sastre, Front Aging Neurosci, 2, 20 (2010)
  195. Sastre Magdalena, Klockgether Thomas, Heneka Michael T., Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms, 10.1016/j.ijdevneu.2005.11.014
  196. Sastre Magdalena, Walter Jochen, Gentleman Steve M, Interactions between APP secretases and inflammatory mediators, 10.1186/1742-2094-5-25
  197. Sayre Lawrence M., Zelasko Dawn A., Harris Peggy L. R., Perry George, Salomon Robert G., Smith Mark A., 4-Hydroxynonenal-Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease, 10.1046/j.1471-4159.1997.68052092.x
  198. Scarf Alana M., Ittner Lars M., Kassiou Michael, The Translocator Protein (18 kDa): Central Nervous System Disease and Drug Design, 10.1021/jm8011678
  199. Schapira A. H. V., Cooper J. M., Dexter D., Clark J. B., Jenner P., Marsden C. D., Mitochondrial Complex I Deficiency in Parkinson's Disease, 10.1111/j.1471-4159.1990.tb02325.x
  200. Schilling Gabriele, Coonfield Michael L, Ross Christopher A, Borchelt David R, Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington's disease transgenic mouse model, 10.1016/s0304-3940(01)02326-6
  201. Seabrook Timothy J., Jiang Liying, Maier Marcel, Lemere Cynthia A., Minocycline affects microglia activation, Aβ deposition, and behavior in APP-tg mice, 10.1002/glia.20338
  202. Shaftel S. S., Carlson T. J., Olschowka J. A., Kyrkanides S., Matousek S. B., O'Banion M. K., Chronic Interleukin-1  Expression in Mouse Brain Leads to Leukocyte Infiltration and Neutrophil-Independent Blood Brain Barrier Permeability without Overt Neurodegeneration, 10.1523/jneurosci.1418-07.2007
  203. Shen Yong, Meri Seppo, Yin and Yang: complement activation and regulation in Alzheimer’s disease, 10.1016/j.pneurobio.2003.08.001
  204. Sheng, Aging, 17, 761 (1996)
  205. Sheng J.G., Zhu S.G., Jones R.A., Griffin W.S.T., Mrak R.E., Interleukin-1 Promotes Expression and Phosphorylation of Neurofilament and tau Proteins in Vivo, 10.1006/exnr.2000.7393
  206. Sherwood C. C., Stimpson C. D., Raghanti M. A., Wildman D. E., Uddin M., Grossman L. I., Goodman M., Redmond J. C., Bonar C. J., Erwin J. M., Hof P. R., Evolution of increased glia-neuron ratios in the human frontal cortex, 10.1073/pnas.0605843103
  207. Shi Jian-Quan, Shen Wei, Chen Jun, Wang Bian-Rong, Zhong Ling-Ling, Zhu Yin-Wei, Zhu Hai-Qing, Zhang Qiao-Quan, Zhang Ying-Dong, Xu Jun, Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains, 10.1016/j.brainres.2010.10.053
  208. Sian Jeswinder, Dexter David T., Lees Andrew J., Daniel Susan, Agid Yves, Javoy-Agid France, Jenner Peter, Marsden C. David, Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia, 10.1002/ana.410360305
  209. Silvestri Laura, Camaschella Clara, A potential pathogenetic role of iron in Alzheimer's disease, 10.1111/j.1582-4934.2008.00356.x
  210. Silvestroni Aurelio, Faull Richard L.M., Strand Andrew D., Möller Thomas, Distinct neuroinflammatory profile in post-mortem human Huntingtonʼs disease : , 10.1097/wnr.0b013e32832e34ee
  211. Simmons Danielle A., Casale Malcolm, Alcon Betzi, Pham Nha, Narayan Natasha, Lynch Gary, Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease, 10.1002/glia.20526
  212. Simpson, Aging, 31, 578 (2010)
  213. Singhrao S.K, Neal J.W, Morgan B.P, Gasque P, Increased Complement Biosynthesis By Microglia and Complement Activation on Neurons in Huntington's Disease, 10.1006/exnr.1999.7170
  214. Smith Mark A., Hirai Keisuke, Hsiao Karen, Pappolla Miguel A., Harris Peggy L. R., Siedlak Sandra L., Tabaton Massimo, Perry George, Amyloid-β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress, 10.1046/j.1471-4159.1998.70052212.x
  215. Smith, Amer. J. Pathol, 145, 42 (1994)
  216. Smith, J. Neurosci., 17, 2653 (1997)
  217. Sofroniew Michael V., Molecular dissection of reactive astrogliosis and glial scar formation, 10.1016/j.tins.2009.08.002
  218. Solito, Front. Neuropharmacol., 3, 14 (2012)
  219. Sotrel A., Paskevich P. A., Kiely D. K., Bird E. D., Williams R. S., Myers R. H., Morphometric analysis of the prefrontal cortex in Huntington's disease, 10.1212/wnl.41.7.1117
  220. Stack Edward C., Matson Wayne R., Ferrante Robert J., Evidence of Oxidant Damage in Huntington's Disease: Translational Strategies Using Antioxidants, 10.1196/annals.1427.008
  221. Stack Edward C., Smith Karen M., Ryu Hoon, Cormier Kerry, Chen Minghua, Hagerty Sean W., Del Signore Steven J., Cudkowicz Merit E., Friedlander Robert M., Ferrante Robert J., Combination therapy using minocycline and coenzyme Q10 in R6/2 transgenic Huntington's disease mice, 10.1016/j.bbadis.2005.11.002
  222. Stoy N., Mackay G. M., Forrest C. M., Christofides J., Egerton M., Stone T. W., Darlington L. G., Tryptophan metabolism and oxidative stress in patients with Huntington's disease, 10.1111/j.1471-4159.2005.03070.x
  223. Streit Wolfgang J., Braak Heiko, Xue Qing-Shan, Bechmann Ingo, Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease, 10.1007/s00401-009-0556-6
  224. Streit Wolfgang J., Sammons Nicole W., Kuhns Amanda J., Sparks D. Larry, Dystrophic microglia in the aging human brain, 10.1002/glia.10319
  225. Szydlowska Kinga, Tymianski Michael, Calcium, ischemia and excitotoxicity, 10.1016/j.ceca.2010.01.003
  226. Tai Y. F., Pavese N., Gerhard A., Tabrizi S. J., Barker R. A., Brooks D. J., Piccini P., Microglial activation in presymptomatic Huntington's disease gene carriers, 10.1093/brain/awm044
  227. Tamagno E, Oxidative Stress Increases Expression and Activity of BACE in NT2 Neurons, 10.1006/nbdi.2002.0515
  228. Tamagno, J. Neurochem., 104, 683 (2008)
  229. Tamagno E, Guglielmotto M, Bardini P, Santoro G, Davit A, Di Simone D, Danni O, Tabaton M, Dehydroepiandrosterone reduces expression and activity of BACE in NT2 neurons exposed to oxidative stress, 10.1016/s0969-9961(03)00131-1
  230. Tamagno Elena, Guglielmotto Michela, Monteleone Debora, Tabaton Massimo, Amyloid-β Production: Major Link Between Oxidative Stress and BACE1, 10.1007/s12640-011-9283-6
  231. Tan Jiang-Li, Li Qiao-Xin, Ciccotosto Giuseppe D., Crouch Peter John, Culvenor Janetta Gladys, White Anthony Robert, Evin Genevieve, Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer’s Disease Amyloid Precursor Protein, 10.1371/journal.pone.0061246
  232. Tarkowski Elisabeth, Blennow Kaj, Wallin Anders, Tarkowski Andrzej, 10.1023/a:1020568013953
  233. Taylor Juliet M., Main Bevan S., Crack Peter J., Neuroinflammation and oxidative stress: Co-conspirators in the pathology of Parkinson’s disease, 10.1016/j.neuint.2012.12.016
  234. Terwel D., Steffensen K. R., Verghese P. B., Kummer M. P., Gustafsson J.-A., Holtzman D. M., Heneka M. T., Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-  Expression for Microglial A  Phagocytosis, 10.1523/jneurosci.6546-10.2011
  235. Thal Dietmar Rudolf, Schober Ralf, Birkenmeier Gerd, The subunits of α2-macroglobulin receptor/low density lipoprotein receptor-related protein, native and transformed α2-macroglobulin and interleukin 6 in Alzheimer's disease, 10.1016/s0006-8993(97)01021-4
  236. Thal D. R., Schultz Christian, Dehghani Faramarz, Yamaguchi Haruyasu, Braak Heiko, Braak Eva, Amyloid β-protein (Aβ)-containing astrocytes are located preferentially near N-terminal-truncated Aβ deposits in the human entorhinal cortex, 10.1007/s004010000242
  237. Valencia Antonio, Reeves Patrick B., Sapp Ellen, Li Xueyi, Alexander Jonathan, Kegel Kimberly B., Chase Kathryn, Aronin Neil, DiFiglia Marian, Mutant huntingtin and glycogen synthase kinase 3-β accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease : Lipid Raft Changes in Huntington's Disease, 10.1002/jnr.22184
  238. Valencia A., Sapp E., Kimm J. S., McClory H., Reeves P. B., Alexander J., Ansong K. A., Masso N., Frosch M. P., Kegel K. B., Li X., DiFiglia M., Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease, 10.1093/hmg/dds516
  239. Van Dam Debby, Vloeberghs Ellen, Abramowski Dorothee, Staufenbiel Matthias, De Deyn Peter Paul, APP23 Mice as a Model of Alzheimer's Disease: An Example of a Transgenic Approach to Modeling a CNS Disorder, 10.1017/s1092852900010051
  240. Varvel Nicholas H., Bhaskar Kiran, Kounnas Maria Z., Wagner Steven L., Yang Yan, Lamb Bruce T., Herrup Karl, NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease, 10.1172/jci39716
  241. Verkhratsky Alexei, Olabarria Markel, Noristani Harun N., Yeh Chia-Yu, Rodriguez Jose Julio, Astrocytes in Alzheimer’s disease, 10.1016/j.nurt.2010.05.017
  242. Vitale Giovanni, Salvioli Stefano, Franceschi Claudio, Oxidative stress and the ageing endocrine system, 10.1038/nrendo.2013.29
  243. vom Berg Johannes, Prokop Stefan, Miller Kelly R, Obst Juliane, Kälin Roland E, Lopategui-Cabezas Ileana, Wegner Anja, Mair Florian, Schipke Carola G, Peters Oliver, Winter York, Becher Burkhard, Heppner Frank L, Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline, 10.1038/nm.2965
  244. G. Vonsattel Jean Paul, DiFiglia Marian, Huntington Disease : , 10.1097/00005072-199805000-00001
  245. VONSATTEL JEAN-PAUL, MYERS RICHARD H., STEVENS THOMAS J., FERRANTE ROBERT J., BIRD EDWARD D., RICHARDSON EDWARD P., Neuropathological Classification of Huntingtonʼs Disease : , 10.1097/00005072-198511000-00003
  246. Ward Roberta J., Crichton Robert R., Taylor Deanna L., Corte Laura Della, Srai Surjit K., Dexter David T., Iron and the immune system, 10.1007/s00702-010-0479-3
  247. Watts J. C., Giles K., Grillo S. K., Lemus A., DeArmond S. J., Prusiner S. B., Bioluminescence imaging of A  deposition in bigenic mouse models of Alzheimer's disease, 10.1073/pnas.1019034108
  248. Whitton P S, Inflammation as a causative factor in the aetiology of Parkinson's disease : Inflammation and Parkinson's disease, 10.1038/sj.bjp.0707167
  249. Wild Edward, Magnusson Anna, Lahiri Nayana, Krus Ulrika, Orth Michael, Tabrizi Sarah J, Björkqvist Maria, Abnormal peripheral chemokine profile in Huntington’s disease, 10.1371/currents.rrn1231
  250. Wu, J. Neurosci., 22, 1763 (2002)
  251. Wyss-Coray, Nature Med., 12, 1005 (2006)
  252. Wyss-Coray Tony, Loike John D., Brionne Thomas C., Lu Emily, Anankov Roman, Yan Fengrong, Silverstein Samuel C., Husemann Jens, Adult mouse astrocytes degrade amyloid-β in vitro and in situ, 10.1038/nm838
  253. Yamanaka M., Ishikawa T., Griep A., Axt D., Kummer M. P., Heneka M. T., PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice, 10.1523/jneurosci.1569-12.2012
  254. Yan Shi Du, Yan Shi Fang, Chen Xi, Fu Jin, Chen Ming, Kuppusamy Periannan, Smith Mark A., Perry George, Godman Gabriel C., Nawroth Peter, Zweier Jay L., Stern David, Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide, 10.1038/nm0795-693
  255. Yang, J. Neurosci., 22, 3025 (2002)
  256. Yoshiyama Yasumasa, Higuchi Makoto, Zhang Bin, Huang Shu-Ming, Iwata Nobuhisa, Saido Takaomi C., Maeda Jun, Suhara Tetsuya, Trojanowski John Q., Lee Virginia M.-Y., Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model, 10.1016/j.neuron.2007.01.010
  257. Zecca Luigi, Youdim Moussa B. H., Riederer Peter, Connor James R., Crichton Robert R., Iron, brain ageing and neurodegenerative disorders, 10.1038/nrn1537
  258. Zhang W., Aggregated  -synuclein activates microglia: a process leading to disease progression in Parkinson's disease, 10.1096/fj.04-2751com
  259. Zhu Shan, Stavrovskaya Irina G., Drozda Martin, Kim Betty Y. S., Ona Victor, Li Mingwei, Sarang Satinder, Liu Allen S., Hartley Dean M., Wu Du Chu, Gullans Steven, Ferrante Robert J., Przedborski Serge, Kristal Bruce S., Friedlander Robert M., Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice, 10.1038/417074a
  260. Zuccato C., Valenza M., Cattaneo E., Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease, 10.1152/physrev.00041.2009
Bibliographic reference Sastre, Magdalena ; Katsouri, Loukia ; Birch, Amy M. ; Renziehausen, Alexander ; Dexter, David Trevor ; et. al. Neuroinflammation in Alzheimer's, Parkinson's and Huntington's Diseases. In: Nicola Woodroofe, Sandra Amor, Neuroinflammation and CNS Disorders, Wiley-Blackwell Publishing Ltd.  : (United States) New York, NY 2014, p. 111-150
Permanent URL http://hdl.handle.net/2078.1/173400