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The primary somatosensory cortex and the insula contribute differently to the processing of transient and sustained nociceptive and non-nociceptive somatosensory inputs

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Hu, Li [Key Laboratory of Cognition and Personality and Faculty of Psychology, Southwest University, Chongqing, China] Zhang, Li [Center for Brain and Cognitive Sciences and Department of Psychology, Peking University, Beijing, China] Chen, Rui [Key Laboratory of Cognition and Personality and Faculty of Psychology, Southwest University, Chongqing, China] Yu, Hongbo [Center for Brain and Cognitive Sciences and Department of Psychology, Peking University, Beijing, China] Li, Hong [Research Center for Brain Function and Psychological Science, Shenzhen University, China] Mouraux, André [UCL]

Transient nociceptive stimuli elicit consistent brain responses in the primary and secondary somatosensory cortices (S1, S2), the insula and the anterior and mid-cingulate cortex (ACC/MCC). However, the functional significance of these responses, especially their relationship with sustained pain perception, remains largely unknown. Here, using functional magnetic resonance imaging, we characterize the differential involvement of these brain regions in the processing of sustained nociceptive and non-nociceptive somatosensory input. By comparing the spatial patterns of activity elicited by transient (0.5 ms) and long-lasting (15 and 30 s) stimuli selectively activating nociceptive or non-nociceptive afferents, we found that the contralateral S1 responded more strongly to the onset of non-nociceptive stimulation as compared to the onset of nociceptive stimulation and the sustained phases of nociceptive and non-nociceptive stimulation. Similarly, the anterior insula responded more strongly to the onset of nociceptive stimulation as compared to the onset of non-nociceptive stimulation and the sustained phases of nociceptive and non-nociceptive stimulation. This suggests that S1 is specifically sensitive to changes in incoming non-nociceptive input, whereas the anterior insula is specifically sensitive to changes in incoming nociceptive input. Second, we found that the MCC responded more strongly to the onsets as compared to the sustained phases of both nociceptive and non-nociceptive stimulation, suggesting that it could be involved in the detection of change regardless of sensory modality. Finally, the posterior insula and S2 responded maximally during the sustained phase of non-nociceptive stimulation but not nociceptive stimulation, suggesting that these regions are preferentially involved in processing non-nociceptive somatosensory input.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2015
Language Anglais
Journal information "Human Brain Mapping" - Vol. 36, no.11, p. 4346-4360 (2015)
Peer reviewed yes
Publisher JohnWiley & Sons, Inc. (Hoboken)
issn 1065-9471
e-issn 1097-0193
Publication status Publié
Affiliation UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience
Keywords pain ; sustained brain responses ; functional magnetic resonance imaging (fMRI) ; operculo-insular cortex (OIC) ; anterior and mid-cingulate cortex (ACC and MCC) ; primary somatosensory cortex (S1)
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Bibliographic reference Hu, Li ; Zhang, Li ; Chen, Rui ; Yu, Hongbo ; Li, Hong ; et. al. The primary somatosensory cortex and the insula contribute differently to the processing of transient and sustained nociceptive and non-nociceptive somatosensory inputs. In: Human Brain Mapping, Vol. 36, no.11, p. 4346-4360 (2015)
Permanent URL http://hdl.handle.net/2078.1/172313