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Anti-SPAG16 antibodies in primary progressive multiple sclerosis are associated with an elevated progression index.

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de Bock, Laura Fraussen, Judith Villar, Luisa M Álvarez-Cermeño, José Carlos Arlos Van Wijmeersch, Bart Van Pesch, Vincent [UCL] Somers, Veerle

(eng) BACKGROUND AND PURPOSE: Sperm-associated antigen 16 (SPAG16), a sperm protein which is upregulated in reactive astrocytes in multiple sclerosis (MS) lesions, has recently been identified as a novel autoantibody target in MS. The aim of this study was to investigate whether anti-SPAG16 antibody levels differ between MS subtypes (relapsing-remitting, RR; primary or secondary progressive, PP, SP) and whether antibody positivity is associated with clinical characteristics. METHODS: Plasma anti-SPAG16 antibody levels were determined by recombinant protein enzyme-linked immunosorbent assay (ELISA) in 374 MS patients (274 RRMS, 39 SPMS and 61 PPMS) and 106 healthy controls. RESULTS: Significantly elevated anti-SPAG16 antibodies were found in 22% of MS patients with 93% specificity. Anti-SPAG16 seropositivity was associated with an increased Expanded Disability Status Scale (EDSS) in overall MS. A higher proportion of PPMS patients showed anti-SPAG16 antibody reactivity (34%) compared to RRMS (19%) and SPMS (26%), and presented with higher anti-SPAG16 antibody levels. Seropositive PPMS patients had a significantly increased progression index compared to seronegative patients. CONCLUSIONS: Anti-SPAG16 antibodies are associated with an increased EDSS in overall MS, indicating that they are linked to a worse MS disease outcome. Moreover, the presence of anti-SPAG16 antibodies may be a biomarker for a more severe disease in PPMS patients, as indicated by an increased progression index.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2016
Language Anglais
Journal information "European Journal of Neurology" - Vol. 23, no. 4, p. 722-728 (2016)
Peer reviewed yes
Publisher Wiley-Blackwell Publishing Ltd. ((United Kingdom) Oxford)
issn 1351-5101
e-issn 1468-1331
Publication status Publié
Affiliations UCL - (SLuc) Service de neurologie
UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
Keywords Autoantibodies ; Biomarker ; Multiple sclerosis ; SPAG16
Links
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Bibliographic reference de Bock, Laura ; Fraussen, Judith ; Villar, Luisa M ; Álvarez-Cermeño, José Carlos Arlos ; Van Wijmeersch, Bart ; et. al. Anti-SPAG16 antibodies in primary progressive multiple sclerosis are associated with an elevated progression index.. In: European Journal of Neurology, Vol. 23, no. 4, p. 722-728 (2016)
Permanent URL http://hdl.handle.net/2078.1/171994