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Serum club cell protein 16 is associated with asymptomatic airway responsiveness in adults: Findings from the French epidemiological study on the genetics and environment of asthma

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Rava, Marta Le Moual, Nicole Dumont, Xavier [UCL] Guerra, Stefano Siroux, Valerie Bernard, Alfred [UCL] Nadif, Rachel

Background and objective: Club cell secretory protein (CC-16) is a sensitive biomarker of airways epithelium integrity. It has gained interest as a biological marker in chronic lung diseases because of its presumed relationship to inflammation. Little is known about the association between CC-16 serum level and asthma, lung function and airway responsiveness (AR). Methods: SerumCC-16 level was determined by latex immunoassay in 1298 participants from the French Epidemiological case-control and family-based study on Genetics and Environment of Asthma (EGEA) (mean age 43 years; 49% men, 38% with asthma). Prebronchodilator lung function (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC) and degree of AR, expressed as a function of the dose–response slope to methacholine test were measured. Standardized residuals CC-16 z-scores were obtained by regressing CC-16 level on the glomerular filtration rate. CC-16 z-scores were correlated with asthma, lung function and AR in participants with and without asthma. Results: CC-16 geometric mean level was 12.4 g/L (range: 2.2–70.6 g/L). In participants without asthma, lower CC-16 z-scores was associated with impaired FEV1/FVC% (β = 0.50 (95% CI: 0.06, 0.95) and with higher degree of AR (β = 0.24 (95% CI: 0.09, 0.39)). CC-16 was not associated with impaired lung function or AR in participants with asthma.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès interdit
Publication date 2015
Language Anglais
Journal information "Respirology" - Vol. 20, no.8, p. 1198-1205 (2015)
Peer reviewed yes
Publisher Wiley-Blackwell Publishing Asia (Richmond)
issn 1323-7799
e-issn 1440-1843
Publication status Publié
Affiliation UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology
Links
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Bibliographic reference Rava, Marta ; Le Moual, Nicole ; Dumont, Xavier ; Guerra, Stefano ; Siroux, Valerie ; et. al. Serum club cell protein 16 is associated with asymptomatic airway responsiveness in adults: Findings from the French epidemiological study on the genetics and environment of asthma. In: Respirology, Vol. 20, no.8, p. 1198-1205 (2015)
Permanent URL http://hdl.handle.net/2078.1/168563