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Male sex is independently associated with faster disability accumulation in relapse-onset MS but not in primary progressive MS

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Ribbons, Karen Ann McElduff, Patrick Boz, Cavit Trojano, Maria Izquierdo, Guillermo Van Pesch, Vincent [UCL] Lechner-Scott, Jeannette

Background: Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females. Methods: Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analysed. Changes in the severity of MS (EDSS) were compared between sexes using a repeated measures analysis in generalised linear mixed models. Kaplan-Meier analysis was used to test for sex difference in the time to reach EDSS milestones 3 and 6 and the secondary progressive MS. Results: In relapse onset MS patients (n = 14,453), males progressed significantly faster in their EDSS than females (0.133 vs 0.112 per year, P<0.001,). Females had a reduced risk of secondary progressive MS (HR (95% CI) = 0.77 (0.67 to 0.90) P = 0.001). In primary progressive MS (n = 1,373), there was a significant increase in EDSS over time in males and females (P<0.001) but there was no significant sex effect on the annualized rate of EDSS change. Conclusion: Among registrants of MSBase, male relapse-onset patients accumulate disability faster than female patients. In contrast, the rate of disability accumulation between male and female patients with primary progressive MS is similar.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2015
Language Anglais
Journal information "PLoS One" - Vol. 10, no. 6, p. e0122686 [1-11] (2015)
Peer reviewed yes
Publisher Public Library of Science ((United States) San Francisco, CA)
issn 1932-6203
e-issn 1932-6203
Publication status Publié
Affiliations UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
UCL - (SLuc) Service de neurologie
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Bibliographic reference Ribbons, Karen Ann ; McElduff, Patrick ; Boz, Cavit ; Trojano, Maria ; Izquierdo, Guillermo ; et. al. Male sex is independently associated with faster disability accumulation in relapse-onset MS but not in primary progressive MS. In: PLoS One, Vol. 10, no. 6, p. e0122686 [1-11] (2015)
Permanent URL http://hdl.handle.net/2078.1/164383