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A prospective registration study to determine feasibility of hematopoietic SCT in adults with acute leukemia: Planning, expectations and reality

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Labopin, M. Gorin, N.-C. Polge, E. Socié, G. Gurman, G. Poire, Xavier [UCL] Rocha, V.

For adults with acute leukemia, it is important to know whether the therapeutic schemes initially planned were actually implemented. The European Group for Blood and Marrow transplantation Acute Leukemia Working Party prospectively followed 695 consecutive patients who were registered at the time of HLA typing. Of 304 patients with an available matched sibling donor (MSD), SCT was planned in 264, chemotherapy in 33 and autografting in 7. For the rest, an unrelated donor (UD) search was initiated in 198. Among these, 117 were transplanted, 114 received chemotherapy and 77 underwent autografting. Probabilities of receiving a planned treatment were 60 and 65% at 1 and 2 years, respectively. Patients scheduled to receive MSD SCT had an 82% probability, whereas those scheduled to undergo UD SCT had a 57% probability, of receiving their transplant at 1 year. The only factor associated with a lower probability of MSD SCT in first remission was delayed HLA typing (HR=0.82; P=0.03). One year after enrollment, 40% of patients did not follow their initial treatment plan. Because OS was 50% only at 3 years and only 57% of the patients without a MSD underwent SCT, this suggests room for improvement in outcomes for adults with acute leukemia. © 2014 Macmillan Publishers Limited. All rights reserved.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2014
Language Anglais
Journal information "Bone Marrow Transplantation" - Vol. 49, no. 3, p. 376-381 (2014)
Peer reviewed yes
Publisher Nature Publishing Group ((United Kingdom) London)
issn 0268-3369
e-issn 1476-5365
Publication status Publié
Affiliations UCL - SSS/IREC - Institut de recherche expérimentale et clinique
UCL - (SLuc) Service d'hématologie
Links
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Bibliographic reference Labopin, M. ; Gorin, N.-C. ; Polge, E. ; Socié, G. ; Gurman, G. ; et. al. A prospective registration study to determine feasibility of hematopoietic SCT in adults with acute leukemia: Planning, expectations and reality. In: Bone Marrow Transplantation, Vol. 49, no. 3, p. 376-381 (2014)
Permanent URL http://hdl.handle.net/2078.1/164143