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Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota

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Geurts, Lucie [UCL] Everard, Amandine [UCL] Van Hul, Matthias [UCL] Essaghir, Ahmed [UCL] Duparc, Thibaut [UCL] Matamoros, Sébastien [UCL] Plovier, Hubert [UCL] Bergiers, Marie [UCL] Druart, Céline [UCL] Al Houayek, Mireille [UCL] Delzenne, Nathalie M. [UCL] Muccioli, Giulio [UCL] Demoulin, Jean-Baptiste [UCL] Cani, Patrice D. [UCL]

Obesity is a pandemic disease associated with many metabolic alterations and involves several organs and systems. The endocannabinoid system (ECS) appears to be a key regulator of energy homeostasis and metabolism. Here we show that specific deletion of the ECS synthesizing enzyme, NAPE-PLD, in adipocytes induces obesity, glucose intolerance, adipose tissue inflammation and altered lipid metabolism. We report that Napepld-deleted mice present an altered browning programme and are less responsive to cold-induced browning, highlighting the essential role of NAPE-PLD in regulating energy homeostasis and metabolism in the physiological state. Our results indicate that these alterations are mediated by a shift in gut microbiota composition that can partially transfer the phenotype to germ-free mice. Together, our findings uncover a role of adipose tissue NAPE-PLD on whole-body metabolism and provide support for targeting NAPE-PLD-derived bioactive lipids to treat obesity and related metabolic disorders.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2015
Language Anglais
Journal information "Nature Communications" - Vol. 6, p. 6495 [1-15] (2015)
Peer reviewed yes
Publisher Nature Pub. Group ((United Kingdom) London)
e-issn 2041-1723
Publication status Publié
Affiliations UCL - SSS/LDRI - Louvain Drug Research Institute
UCL - SSS/DDUV - Institut de Duve
Links
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Bibliographic reference Geurts, Lucie ; Everard, Amandine ; Van Hul, Matthias ; Essaghir, Ahmed ; Duparc, Thibaut ; et. al. Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota. In: Nature Communications, Vol. 6, p. 6495 [1-15] (2015)
Permanent URL http://hdl.handle.net/2078.1/162016