User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Brain activation pattern related to gait disturbances in Parkinson's disease

Primary tabs

Crémers, Julien [University of Liège] D'Ostilio, Kevin [University of Liège] Stamatakis, Julien [UCL] Delvaux, Valérie [University Hospital Center of Liège] Garraux, Gaëtan [University Hospital Center of Liège]

Gait disturbances represent a therapeutic challenge in Parkinson's disease (PD). To further investigate their underlying pathophysiological mechanisms, we compared brain activation related to mental imagery of gait between 15 PD patients and 15 age-matched controls using a block-design functional MRI experiment. On average, patients showed altered locomotion relatively to controls, as assessed with a standardized gait test that evaluated the severity of PD-related gait disturbances on a 25-m path. The experiment was conducted in the subjects as they rehearsed themselves walking on the same path with a gait pattern similar as that during locomotor evaluation. Imagined walking times were measured on a trial-by-trial basis as a control of behavioral performance. In both groups, mean imagined walking time was not significantly different from that measured during real gait on the path used for evaluation. The between-group comparison of the mental gait activation pattern with reference to mental imagery of standing showed hypoactivations within parieto-occipital regions, along with the left hippocampus, midline/lateral cerebellum, and presumed pedunculopontine nucleus/mesencephalic locomotor area, in patients. More specifically, the activation level of the right posterior parietal cortex located within the impaired gait-related cognitive network decreased proportionally with the severity of gait disturbances scored on the path used for gait evaluation and mental imagery. These novel findings suggest that the right posterior parietal cortex dysfunction is strongly related to the severity of gait disturbances in PD. This region may represent a target for the development of therapeutic interventions for PD-related gait disturbances. © 2012 Movement Disorder Society.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès interdit
Publication date 2012
Language Anglais
Journal information "Movement Disorders" - Vol. 27, no. 12, p. 1498-1505 (2012)
Peer reviewed yes
Publisher JohnWiley & Sons, Inc.
e-issn 1531-8257
issn 0885-3185
Publication status Publié
Affiliation UCL - SST/ICTM - Institute of Information and Communication Technologies, Electronics and Applied Mathematics
Links
  1. Boonstra Tjitske A, van der Kooij Herman, Munneke Marten, Bloem Bastiaan R, Gait disorders and balance disturbances in Parkinsonʼs disease: clinical update and pathophysiology : , 10.1097/wco.0b013e328305bdaf
  2. Giladi N., Balash Y., The clinical approach to gait disturbances in Parkinson’s disease; maintaining independent mobility, Journal of Neural Transmission. Supplementa ISBN:9783211289273 p.327-332, 10.1007/978-3-211-45295-0_49
  3. Alam M., Schwabe K., Krauss J. K., The pedunculopontine nucleus area: critical evaluation of interspecies differences relevant for its use as a target for deep brain stimulation, 10.1093/brain/awq322
  4. Hanakawa Takashi, Fukuyama Hidenao, Katsumi Yukinori, Honda Manabu, Shibasaki Hiroshi, Enhanced lateral premotor activity during paradoxical gait in Parkinson's disease, 10.1002/1531-8249(199903)45:3<329::aid-ana8>3.0.co;2-s
  5. Hanakawa Takashi, Katsumi Yukinori, Fukuyama Hidenao, Honda Manabu, Hayashi Takuya, Kimura Jun, Shibasaki Hiroshi, Mechanisms underlying gait disturbance in Parkinson's disease, 10.1093/brain/122.7.1271
  6. Snijders Anke H., Leunissen Inge, Bakker Maaike, Overeem Sebastiaan, Helmich Rick C., Bloem Bastiaan R., Toni Ivan, Gait-related cerebral alterations in patients with Parkinson’s disease with freezing of gait, 10.1093/brain/awq324
  7. Shoushtarian Mehrnaz, Murphy Anna, Iansek Robert, Examination of central gait control mechanisms in Parkinson's disease using movement-related potentials, 10.1002/mds.23844
  8. Crémers Julien, Dessoullières Aurélie, Garraux Gaëtan, Hemispheric specialization during mental imagery of brisk walking, 10.1002/hbm.21255
  9. Hughes A J, Daniel S E, Kilford L, Lees A J, Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases., 10.1136/jnnp.55.3.181
  10. Nazem Sarra, Siderowf Andrew D., Duda John E., Ten Have Tom, Colcher Amy, Horn Stacy S., Moberg Paul J., Wilkinson Jayne R., Hurtig Howard I., Stern Matthew B., Weintraub Daniel, Montreal Cognitive Assessment Performance in Patients with Parkinson's Disease with “Normal” Global Cognition According to Mini-Mental State Examination Score : MOCA IN PARKINSON'S DISEASE, 10.1111/j.1532-5415.2008.02096.x
  11. Roberts Ross, Callow Nichola, Hardy Lew, Markland David, Bringer Joy, Movement Imagery Ability: Development and Assessment of a Revised Version of the Vividness of Movement Imagery Questionnaire, 10.1123/jsep.30.2.200
  12. Kegelmeyer D. A, Kloos A. D, Thomas K. M, Kostyk S. K, Reliability and Validity of the Tinetti Mobility Test for Individuals With Parkinson Disease, 10.2522/ptj.20070007
  13. Ashburner John, A fast diffeomorphic image registration algorithm, 10.1016/j.neuroimage.2007.07.007
  14. SMITH S, NICHOLS T, Threshold-free cluster enhancement: Addressing problems of smoothing, threshold dependence and localisation in cluster inference, 10.1016/j.neuroimage.2008.03.061
  15. Jahn Klaus, Deutschländer Angela, Stephan Thomas, Kalla Roger, Wiesmann Martin, Strupp Michael, Brandt Thomas, Imaging human supraspinal locomotor centers in brainstem and cerebellum, 10.1016/j.neuroimage.2007.09.047
  16. Jahn Klaus, Deutschländer Angela, Stephan Thomas, Strupp Michael, Wiesmann Martin, Brandt Thomas, Brain activation patterns during imagined stance and locomotion in functional magnetic resonance imaging, 10.1016/j.neuroimage.2004.05.017
  17. Karachi Carine, Grabli David, Bernard Frédéric A., Tandé Dominique, Wattiez Nicolas, Belaid Hayat, Bardinet Eric, Prigent Annick, Nothacker Hans-Peter, Hunot Stéphane, Hartmann Andreas, Lehéricy Stéphane, Hirsch Etienne C., François Chantal, Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease, 10.1172/jci42642
  18. la Fougère Christian, Zwergal Andreas, Rominger Axel, Förster Stefan, Fesl Gunther, Dieterich Marianne, Brandt Thomas, Strupp Michael, Bartenstein Peter, Jahn Klaus, Real versus imagined locomotion: A [18F]-FDG PET-fMRI comparison, 10.1016/j.neuroimage.2009.12.060
  19. Malouin Francine, Richards Carol L., Jackson Philip L., Dumas Francine, Doyon Julien, Brain activations during motor imagery of locomotor-related tasks: A PET study, 10.1002/hbm.10103
  20. Zwergal Andreas, Linn Jennifer, Xiong Guoming, Brandt Thomas, Strupp Michael, Jahn Klaus, Aging of human supraspinal locomotor and postural control in fMRI, 10.1016/j.neurobiolaging.2010.09.022
  21. Malouin F., Richards C. L., Mental Practice for Relearning Locomotor Skills, 10.2522/ptj.20090029
  22. Jahanshahi Marjan, Jenkins I. Harri, Brown Richard G., Marsden C. David, Passingham Richard E., Brooks David J., Self-initiated versus externally triggered movements : I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson's disease subjects, 10.1093/brain/118.4.913
  23. Jenkins I. Harri, Jahanshahi Marjan, Jueptner Markus, Passingham Richard E., Brooks David J., Self-initiated versus externally triggered movements, 10.1093/brain/123.6.1216
  24. Vacherot François, Attarian Shahram, Vaugoyeau Marianne, Azulay Jean-Philippe, A motor cortex excitability and gait analysis on Parkinsonian patients, 10.1002/mds.23378
  25. Zimmerman Molly E., Lipton Richard B., Pan Jullie W., Hetherington Hoby P., Verghese Joe, MRI- and MRS-derived hippocampal correlates of quantitative locomotor function in older adults, 10.1016/j.brainres.2009.07.043
  26. Ballanger Benedicte, Lozano Andres M., Moro Elena, van Eimeren Thilo, Hamani Clement, Chen Robert, Cilia Roberto, Houle Sylvain, Poon Yu Yan, Lang Anthony E., Strafella Antonio P., Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: A [15O] H2O PET study, 10.1002/hbm.20815
  27. Lewis David A., Melchitzky Darlene S., Sesack Susan R., Whitehead Richard E., Sungyoung Auh, Sampson Allan, Dopamine transporter immunoreactivity in monkey cerebral cortex: Regional, laminar, and ultrastructural localization, 10.1002/cne.1092
  28. Marigold D. S., Drew T., Contribution of cells in the posterior parietal cortex to the planning of visually guided locomotion in the cat: effects of temporary visual interruption, 10.1152/jn.00992.2010
  29. Gwin Joseph T., Gramann Klaus, Makeig Scott, Ferris Daniel P., Electrocortical activity is coupled to gait cycle phase during treadmill walking, 10.1016/j.neuroimage.2010.08.066
  30. Bartels Anna L., de Jong Bauke M., Giladi Nir, Schaafsma Joanna D., Maguire R. Paul, Veenma Lammy, Pruim Jan, Balash Yacov, Youdim Moussa B.H., Leenders Klaus L., Striatal dopa and glucose metabolism in PD patients with freezing of gait, 10.1002/mds.20952
  31. Mattay Venkata S., Tessitore Alessandro, Callicott Joseph H., Bertolino Alessandro, Goldberg Terry E., Chase Thomas N., Hyde Thomas M., Weinberger Daniel R., Dopaminergic modulation of cortical function in patients with Parkinson's disease, 10.1002/ana.10078
  32. Seamans J. K., Durstewitz D., Christie B. R., Stevens C. F., Sejnowski T. J., Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons, 10.1073/pnas.98.1.301
Bibliographic reference Crémers, Julien ; D'Ostilio, Kevin ; Stamatakis, Julien ; Delvaux, Valérie ; Garraux, Gaëtan. Brain activation pattern related to gait disturbances in Parkinson's disease. In: Movement Disorders, Vol. 27, no. 12, p. 1498-1505 (2012)
Permanent URL http://hdl.handle.net/2078.1/161382