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Xenotransplanted human prostate carcinoma (DU145) cells develop into carcinomas and cribriform carcinomas: Ultrastructural aspects

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Gilloteaux, Jacques Jamison, James M. Neal, Deborah R. Summers, Jack L. Taper, Henryk [UCL]

Androgen-independent, human prostate carcinoma cells (DU145) develop into solid, carcinomatous xenotransplants on the diaphragm of nu/nu mice. Tumors encompass at least two poorly differentiated cell types: a rapidly dividing, eosinophilic cell comprises the main cell population and a few, but large basophilic cells able to invade the peritoneal stroma, the muscular tissue, lymph vessels. Poor cell contacts, intracytoplasmic lumina, and signet cells are noted. Lysosomal activities are reflected by entoses and programmed cell deaths forming cribriform carcinomas. In large tumors, degraded cells may align with others to facilitate formation of blood supply routes. Malignant cells would spread via ascites and through lymphatics. © 2012 Informa Healthcare USA, Inc.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2012
Language Anglais
Journal information "Ultrastructural Pathology" - Vol. 36, no. 5, p. 294-311 (2012)
Peer reviewed yes
Publisher Informa Healthcare
e-issn 1521-0758
issn 0191-3123
Publication status Publié
Affiliation UCL - SSS/IREC - Institut de recherche expérimentale et clinique
Links
  1. Siegel Rebecca, Naishadham Deepa, Jemal Ahmedin, Cancer statistics, 2012, 10.3322/caac.20138
  2. Jemal Ahmedin, Bray Freddie, Center Melissa M., Ferlay Jacques, Ward Elizabeth, Forman David, Global cancer statistics, 10.3322/caac.20107
  3. Cancer Research UK, Cancer in the United Kingdom (2011)
  4. Miller DC, Cancer Res, 63, 3486 (2003)
  5. Bock Cathryn Hufford, Schwartz Ann G., Ruterbusch Julie J., Levin Albert M., Neslund-Dudas Christine, Land Susan J., Wenzlaff Angela S., Reich David, McKeigue Paul, Chen Wei, Heath Elisabeth I., Powell Isaac J., Kittles Rick A., Rybicki Benjamin A., Results from a prostate cancer admixture mapping study in African-American men, 10.1007/s00439-009-0712-z
  6. Gilloteaux J, Anat Rec (2012)
  7. Mickey DD, Cancer Res, 37, 4049 (1977)
  8. Mickey DD, Prog Clin Biol Res, 37, 67 (1980)
  9. Stone Kenneth R., Mickey Don D., Wunderli Heidi, Mickey George H., Paulson David F., Isolation of a human prostate carcinoma cell line (DU 145), 10.1002/ijc.2910210305
  10. Cohen MB, Cancer Res, 54, 626 (1994)
  11. Dhom G, Pathologie des männlichen Genitale (1991)
  12. Ahn Sung Ku, Kim Kyurae, Choi In Joon, Lee Jin Moo, Adenoid cystic carcinoma of the prostate gland: pathological review with a case report, 10.3349/ymj.1991.32.1.74
  13. Montironi R., Morphological identification of the patterns of prostatic intraepithelial neoplasia and their importance, 10.1136/jcp.53.9.655
  14. Shin Masaru, Takayama Hitoshi, Nonomura Norio, Wakatsuki Akira, Okuyama Akihiko, Aozasa Katsuyuki, Extent and zonal distribution of prostatic intraepithelial neoplasia in patients with prostatic carcinoma in Japan: Analysis of whole-mounted prostatectomy specimens, 10.1002/(sici)1097-0045(20000201)42:2<81::aid-pros1>3.0.co;2-z
  15. Bostwick DG, Rev Urol, 6, 171 (2004)
  16. Epstein Jonathan I., Precursor lesions to prostatic adenocarcinoma, 10.1007/s00428-008-0707-5
  17. Dema A, Rom J Morph Embryol, 51, 413 (2010)
  18. Taper Henryk S., Jamison James M., Gilloteaux Jacques, Gwin Carley A., Gordon Timothy, Summers Jack L., In Vivo Reactivation of DNases in Implanted Human Prostate Tumors After Administration of a Vitamin C/K3 Combination, 10.1177/002215540104900111
  19. Gilloteaux J, Scanning Microsc, 9, 159 (1995)
  20. Aparicio S. R., Marsden P., Application of standard micro-anatomical staining methods to epoxy resin-embedded sections, 10.1136/jcp.22.5.589
  21. Jamison J.M., Gilloteaux J., Venugopal M., Koch J.A., Sowick C., Shah R., Summers J.L., Flow cytometric and ultrastructural aspects of the synergistic antitumor activity of vitamin C-vitamin K3 combinations against human prostatic carcinoma cells, 10.1016/s0040-8166(96)80072-3
  22. VENUGOPAL M, SYNERGISTIC ANTITUMOUR ACTIVITY OF VITAMINS C AND K3AGAINST HUMAN PROSTATE CARCINOMA CELL LINES, 10.1006/cbir.1996.0102
  23. Venugopal Meenakshi, Jamison James M., Gilloteaux Jacques, Koch John A., Summers Marcia, Giammar David, Sowick Colleen, Summers Jack L., Synergistic antitumor activity of vitamins C and K3 on human urologic tumor cell lines, 10.1016/0024-3205(96)00466-3
  24. Jamison JM, Scanning, 21, 107 (1999)
  25. Gilloteaux Jacques, Jamison James M., Neal Deborah R., Cell Death by Autoschizis in TRAMP Prostate Carcinoma Cells as a Result of Treatment by Ascorbate: Menadione Combination, 10.1080/01913120590951239
  26. Jamison JM, Prostate Cancer, 423 (2005)
  27. Doré JF, Anticancer Res, 7, 997 (1987)
  28. Kubota Tetsuro, Metastatic models of human cancer xenografted in the nude mouse: The importance of orthotopic transplantation, 10.1002/jcb.240560103
  29. Turnert Timothy, Chen Philip, Goodly Lyndon J., NWells Alan, EGF receptor signaling enhances in vivo invasiveness of DU-145 human prostate carcinoma cells, 10.1007/bf00123400
  30. Turner T, Clin Cancer Res, 3, 2275 (1997)
  31. Pretlow TG, Cancer Res, 60, 4033 (2000)
  32. Chatterjee Bandana, 10.1023/a:1026057402945
  33. CHATTERJEE SHILLA, PARK EUN SUNG, SOLOFF MELVYN S., Proliferation of DU145 prostate cancer cells is inhibited by suppressing insulin-like growth factor binding protein-2, 10.1111/j.1442-2042.2004.00898.x
  34. Chunthapong Jirapat, Seftor Elisabeth A., Khalkhali-Ellis Zhila, Seftor Richard E.B., Amir Sumaira, Lubaroff David M., Heidger Paul M., Hendrix Mary J.C., Dual roles of E-cadherin in prostate cancer invasion, 10.1002/jcb.20032
  35. Mamoune Asmaa, Kassis Jareer, Kharait Sourabh, Kloeker Susanne, Manos Elisabeth, Jones David A, Wells Alan, DU145 human prostate carcinoma invasiveness is modulated by urokinase receptor (uPAR) downstream of epidermal growth factor receptor (EGFR) signaling, 10.1016/j.yexcr.2004.05.008
  36. Oosterhoff Josien K., Kühne Liesbeth C., Grootegoed J. Anton, Blok Leen J., EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2 : REPS2 Inhibits EGF Signalling, 10.1002/ijc.20612
  37. Mori K., Le Goff B., Charrier C., Battaglia S., Heymann D., Rédini F., DU145 human prostate cancer cells express functional receptor activator of NFκB: New insights in the prostate cancer bone metastasis process, 10.1016/j.bone.2006.11.006
  38. Yu Ching-Han, Kan Shu-Fen, Pu Hsiao-Fung, Jea Chien Eileen, Wang Paulus S., Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and -independent human prostate cancer cells, 10.1111/j.1349-7006.2008.00966.x
  39. Wang Yong, Yue Dan, Li Kai, Liu Yi-Li, Ren Chang-Shan, Wang Ping, The role of TRPC6 in HGF-induced cell proliferation of human prostate cancer DU145 and PC3 cells, 10.1038/aja.2010.85
  40. Lawrence Mitchell G., Margaryan Naira V., Loessner Daniela, Collins Angus, Kerr Kris M., Turner Megan, Seftor Elisabeth A., Stephens Carson R., Lai John, Postovit Lynne-Marie, Clements Judith A., Hendrix Mary J.C., , Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells, 10.1002/pros.21335
  41. Rybak Adrian P., He Lizhi, Kapoor Anil, Cutz Jean-Claude, Tang Damu, Characterization of sphere-propagating cells with stem-like properties from DU145 prostate cancer cells, 10.1016/j.bbamcr.2011.01.018
  42. Shanmugam Muthu K., Rajendran Peramaiyan, Li Feng, Nema Tarang, Vali Shireen, Abbasi Taher, Kapoor Shweta, Sharma Ashish, Kumar Alan Prem, Ho Paul C., Hui Kam M., Sethi Gautam, Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice, 10.1007/s00109-011-0746-2
  43. Willis RA. Pathology of Tumors. Washington, DC: Butterworths; 1960: 148–166.
  44. Drasdo D, Höhme S, Individual-based approaches to birth and death in avascu1ar tumors, 10.1016/s0895-7177(03)00128-6
  45. Kaminski A, Int J Mol Med, 18, 941 (2006)
  46. Visakorpi Tapio, Hyytinen Eija, Koivisto Pasi, Tanner Minna, Keinänen Riitta, Palmberg Christian, Palotie Aarno, Tammela Teuvo, Isola Jorma, Kallioniemi Olli-P., In vivo amplification of the androgen receptor gene and progression of human prostate cancer, 10.1038/ng0495-401
  47. Alimirah Fatouma, Chen Jianming, Basrawala Zane, Xin Hong, Choubey Divaker, DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: Implications for the androgen receptor functions and regulation, 10.1016/j.febslet.2006.03.041
  48. Williams Simon A., Jelinek Christine A., Litvinov Ivan, Cotter Robert J., Isaacs John T., Denmeade Samuel R., Enzymatically active prostate-specific antigen promotes growth of human prostate cancers, 10.1002/pros.21375
  49. Ligęza J, Acta Biochim Pol, 58, 391 (2011)
  50. Higgins L.H., Withers H.G., Garbens A., Love H.D., Magnoni L., Hayward S.W., Moyes C.D., Hypoxia and the metabolic phenotype of prostate cancer cells, 10.1016/j.bbabio.2009.06.003
  51. Dai Yao, Bae Kyungmi, Siemann Dietmar W., Impact of Hypoxia on the Metastatic Potential of Human Prostate Cancer Cells, 10.1016/j.ijrobp.2011.04.027
  52. Guo Z, Oncol Rep, 26, 511 (2011)
  53. Qu-Hong, Nagy J A, Senger D R, Dvorak H F, Dvorak A M, Ultrastructural localization of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to the abluminal plasma membrane and vesiculovacuolar organelles of tumor microvascular endothelium., 10.1177/43.4.7534783
  54. Peng YB, Cancer Sci, 102, 1630 (2011)
  55. Nguyen H.-L., Zucker S., Zarrabi K., Kadam P., Schmidt C., Cao J., Oxidative Stress and Prostate Cancer Progression Are Elicited by Membrane-Type 1 Matrix Metalloproteinase, 10.1158/1541-7786.mcr-11-0033
  56. Ksiazek K, Int J Cancer, 127, 293 (2010)
  57. Navone Nora M., Troncoso Patricia, Pisters Louis L., Goodrow Tamra L., Palmer Judy L., Nichols Warren W., Eschenbach Andrew C. von, Conti Claudio J., p53 Protein Accumulation and Gene Mutation in the Progression of Human Prostate Carcinoma, 10.1093/jnci/85.20.1657
  58. Li J., PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer, 10.1126/science.275.5308.1943
  59. Li Yunru, Su Jie, DingZhang Xiao, Zhang Jianguo, Yoshimoto Maisa, Liu Shuhong, Bijian Krikor, Gupta Ajay, Squire Jeremy A, Alaoui Jamali Moulay A, Bismar Tarek A, PTEN deletion and heme oxygenase-1 overexpression cooperate in prostate cancer progression and are associated with adverse clinical outcome, 10.1002/path.2855
  60. Vo BaoHan T., Khan Shafiq A., Expression of nodal and nodal receptors in prostate stem cells and prostate cancer cells: Autocrine effects on cell proliferation and migration, 10.1002/pros.21326
  61. D'Antonio K. B., Schultz L., Albadine R., Mondul A. M., Platz E. A., Netto G. J., Getzenberg R. H., Decreased Expression of Cyr61 Is Associated with Prostate Cancer Recurrence after Surgical Treatment, 10.1158/1078-0432.ccr-10-1200
  62. Abdulghani Junaid, Gu Lei, Dagvadorj Ayush, Lutz Jacqueline, Leiby Benjamin, Bonuccelli Gloria, Lisanti Michael P., Zellweger Tobias, Alanen Kalle, Mirtti Tuomas, Visakorpi Tapio, Bubendorf Lukas, Nevalainen Marja T., Stat3 Promotes Metastatic Progression of Prostate Cancer, 10.2353/ajpath.2008.071054
  63. Gerstein Amy V., Almeida Teresa Acosta, Zhao Guojing, Chess Eric, Shih Ie-Ming, Buhler Kent, Pienta Kenneth, Rubin Mark A., Vessella Robert, Papadopoulos Nickolas, APC/CTNNB1 (?-catenin) pathway alterations in human prostate cancers, 10.1002/gcc.10037
  64. Park ER, Cell Commun Signal, 7 (2009)
  65. Colella R, Jackson T, Goodwyn E, Matrigel® invasion by the prostate cancer cell lines, PC3 and DU145, and cathepsin L+B activity, 10.1080/10520290400010572
  66. Wu Wei, Walker Ameae M., Human chorionic gonadotropin β (HCGβ) down-regulates E-cadherin and promotes human prostate carcinoma cell migration and invasion, 10.1002/cncr.21549
  67. Ko YH, Ha YR, Kim JW, Kang SG, Jang HA, Kang SH, Park HS, Cheon J, Silencing of the GnRH Type 1 Receptor Blocks the Antiproliferative Effect of the GnRH Agonist, Leuprolide, on the Androgen-Independent Prostate Cancer Cell Line DU145, 10.1177/147323001103900304
  68. Shimoyama Y, Cancer Res, 49, 2128 (1989)
  69. Gilloteaux J, Cytobiologie (previously Eur J Cell Biol), 12, 456 (1976)
  70. Shapiro Lawrence, Fannon Allison M., Kwong Peter D., Thompson Andrew, Lehmann Mogens S., Grübel Gerhard, Legrand Jean-François, Als-Nielsen Jens, Colman David R., Hendrickson Wayne A., Structural basis of cell-cell adhesion by cadherins, 10.1038/374327a0
  71. Rubin Mark A., Mucci Neil R., Figurski Jay, Fecko Alice, Pienta Kenneth J., Day Mark L., E-cadherin expression in prostate cancer: A broad survey using high-density tissue microarray technology, 10.1053/hupa.2001.25902
  72. PAUL R., EWING C.M., JARRARD D.F., ISAACS W.B., The cadherin cell-cell adhesion pathway in prostate cancer progression, 10.1111/j.1464-410x.1997.tb00799.x
  73. De Marzo Angelo M, Knudsen Beatrice, Chan-Tack Kirk, Epstein Jonathan I, E-cadherin expression as a marker of tumor aggressiveness in routinely processed radical prostatectomy specimens, 10.1016/s0090-4295(98)00577-9
  74. Umbas R, Cancer Res, 54, 3929 (1994)
  75. Cheng L, Am J Pathol, 148, 1375 (1996)
  76. Rios-Doria Jonathan, Day Kathleen C., Kuefer Rainer, Rashid Michael G., Chinnaiyan Arul M., Rubin Mark A., Day Mark L., The Role of Calpain in the Proteolytic Cleavage of E-cadherin in Prostate and Mammary Epithelial Cells, 10.1074/jbc.m208772200
  77. Katayama M, Br J Cancer, 69, 580 (1994)
  78. Kuefer R, Clin Cancer Res, 9, 6447 (2003)
  79. Kuefer R, Hofer M D, Zorn C S M, Engel O, Volkmer B G, Juarez-Brito M A, Eggel M, Gschwend J E, Rubin M A, Day M L, Assessment of a fragment of e-cadherin as a serum biomarker with predictive value for prostate cancer, 10.1038/sj.bjc.6602599
  80. Morton RA, Cancer Res, 53, 3585 (1993)
  81. Morita N, Uemura H, Tsumatani K, Cho M, Hirao Y, Okajima E, Konishi N, Hiasa Y, E-cadherin and α-, β- and γ-catenin expression in prostate cancers: correlation with tumour invasion, 10.1038/sj.bjc.6690299
  82. Aaltomaa S, Anticancer Res, 25, 4707 (2005)
  83. Herzig M, Savarese F, Novatchkova M, Semb H, Christofori G, Tumor progression induced by the loss of E-cadherin independent of β-catenin/Tcf-mediated Wnt signaling, 10.1038/sj.onc.1210029
  84. Putzke Aaron P., Ventura Aviva P., Bailey Alexander M., Akture Canan, Opoku-Ansah John, Çeliktaş Müge, Hwang Michael S., Darling Douglas S., Coleman Ilsa M., Nelson Peter S., Nguyen Holly M., Corey Eva, Tewari Muneesh, Morrissey Colm, Vessella Robert L., Knudsen Beatrice S., Metastatic Progression of Prostate Cancer and E-Cadherin, 10.1016/j.ajpath.2011.03.028
  85. Tran Nhan L., Nagle Raymond B., Cress Anne E., Heimark Ronald L., N-Cadherin Expression in Human Prostate Carcinoma Cell Lines, 10.1016/s0002-9440(10)65177-2
  86. Gravdal K., Halvorsen O. J., Haukaas S. A., Akslen L. A., A Switch from E-Cadherin to N-Cadherin Expression Indicates Epithelial to Mesenchymal Transition and Is of Strong and Independent Importance for the Progress of Prostate Cancer, 10.1158/1078-0432.ccr-07-1263
  87. Jennbacken K., Tesan T., Wang W., Gustavsson H., Damber J. E., Welen K., N-cadherin increases after androgen deprivation and is associated with metastasis in prostate cancer, 10.1677/erc-10-0015
  88. Tanaka Hiroshi, Kono Evelyn, Tran Chau P, Miyazaki Hideyo, Yamashiro Joyce, Shimomura Tatsuya, Fazli Ladan, Wada Robert, Huang Jiaoti, Vessella Robert L, An Jaibin, Horvath Steven, Gleave Martin, Rettig Matthew B, Wainberg Zev A, Reiter Robert E, Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance, 10.1038/nm.2236
  89. Kümper Sandra, Ridley Anne J., p120ctn and P-Cadherin but Not E-Cadherin Regulate Cell Motility and Invasion of DU145 Prostate Cancer Cells, 10.1371/journal.pone.0011801
  90. Otto T., Rembrink K., Goepel M., Meyer-Schwickerath M., R�bben H., E-cadherin: a marker for differentiation and invasiveness in prostatic carcinoma, 10.1007/bf00296837
  91. Nalai AK, Exp Cell Res, 317, 2511 (2011)
  92. Huber Margit A, Kraut Norbert, Beug Hartmut, Molecular requirements for epithelial–mesenchymal transition during tumor progression, 10.1016/j.ceb.2005.08.001
  93. Platica M., Ivan E., Holland J. F., Ionescu A., Chen S., Mandeli J., Unger P. D., Platica O., A pituitary gene encodes a protein that produces differentiation of breast and prostate cancer cells, 10.1073/pnas.0307829100
  94. Park ER, Cell Commun Signal, 7 (2009)
  95. Wells C. M., Whale A. D., Parsons M., Masters J. R. W., Jones G. E., PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion, 10.1242/jcs.055707
  96. Nightingale Joanna, Chaudhary Khurram S., Abel Paul D., Stubbs Andrew P., Romanska Hanna M., Mitchell Stephen E., Stamp Gordon W.H., Lalani El-Nasir, Ligand Activation of the Androgen Receptor Downregulates E-Cadherin-Mediated Cell Adhesion and Promotes Apoptosis of Prostatic Cancer Cells, 10.1016/s1476-5586(03)80028-3
  97. Kwok Wai Kei, Ling Ming-Tat, Lee Tak-Wing, Lau Tracy C.M., Zhou Chun, Zhang Xiaomeng, Chua Chee Wai, Chan Kwok W., Chan Franky L., Glackin Carlotta, Wong Yong-Chuan, Wang Xianghong, Up-Regulation of TWIST in Prostate Cancer and Its Implication as a Therapeutic Target, 10.1158/0008-5472.can-04-3785
  98. Kuo Po-Lin, Chen Yen-Hsu, Chen Tun-Chieh, Shen Kun-Hung, Hsu Ya-Ling, CXCL5/ENA78 increased cell migration and epithelial-to-mesenchymal transition of hormone-independent prostate cancer by early growth response-1/snail signaling pathway, 10.1002/jcp.22445
  99. Katayama M, Hirai S, Kamihagi K, Nakagawa K, Yasumoto M, Kato I, Soluble E-cadherin fragments increased in circulation of cancer patients, 10.1038/bjc.1994.106
  100. De Wever Olivier, Derycke Lara, Hendrix An, De Meerleer Gert, Godeau François, Depypere Herman, Bracke Marc, Soluble cadherins as cancer biomarkers, 10.1007/s10585-007-9104-8
  101. Foulds L, Neoplastic Development, 2, 163 (1975)
  102. Coman DR, Cancer Res, 13, 397 (1953)
  103. Wever Olivier, Pauwels Patrick, Craene Bram, Sabbah Michèle, Emami Shahin, Redeuilh Gérard, Gespach Christian, Bracke Marc, Berx Geert, Molecular and pathological signatures of epithelial–mesenchymal transitions at the cancer invasion front, 10.1007/s00418-008-0464-1
  104. Kuroda N, Histol Histopathol, 19, 23 (2004)
  105. Ghadially FN. Ultrastructural Pathology of the Cell and Matrix, vol. 2. Boston: Butterworth-Heinemann; 1997:1072–1083.
  106. Erlandsen RA, Diagnostic Transmission Electron Microscopy of Tumors, 205 (1994)
  107. FERGUSON D.J.P., ANDERSON T.J., WELLS C.A., BATTERSBY S., An ultrastructural study of mucoid carcinoma of the breast: variability of cytoplasmic features, 10.1111/j.1365-2559.1986.tb02566.x
  108. Battifora H, Arch Pathol, 99, 614 (1975)
  109. Tsuchiya S, Acta Pathol Jpn, 31, 45 (1981)
  110. Nesland Jahn, Holm Ruth, Lunde Sigurd, Johannessen Jan Vincents, Diagnostic Problems in Breast Pathology: The Benefit of Ultrastructural and Immunocytochemical Analysis, 10.3109/01913128709048328
  111. Gu CM, Zhonghua Zhong Liu Za Zhi, 12, 264 (1990)
  112. Sobrinho-Simões Manuel, Johannessen Jan Vincents, Gould Victor E., The Diagnostic Significance of Intracytoplasmic Lumina in Metastatic Neoplasms, 10.3109/01913128109081980
  113. QUINCEY C., RAITT N., BELL J., ELLIS I.O., Intracytoplasmic lumina?a useful diagnostic feature of adenocarcinomas, 10.1111/j.1365-2559.1991.tb00898.x
  114. Alroy Joseph, Pauli Bendicht U., Hayden Jamie E., Gould Victor E., Intracytoplasmic lumina in bladder carcinomas, 10.1016/s0046-8177(79)80098-2
  115. Remy L., Marvaldi J., Ripert J. P., Secchi J., Origin of intracellular lumina in HT 29 colonic adenocarcinoma cell line, 10.1007/bf02890123
  116. Boysen Morten, Reith Albrecht, Intracytoplasmic Lumina with and without Cilia in Both Normal and Pathologically Altered Nasal Mucosa, 10.3109/01913128009140554
  117. Ho Khang L., Caccamo Dario V., Garcia Julio H., Intracytoplasmic Lumina in Ependymomas: An Ultrastructural Study, 10.3109/01913129409023206
  118. Remy L., The intracellular lumen: origin, role and implications of a cytoplasmic neostructure, 10.1111/j.1768-322x.1986.tb00446.x
  119. Remy L., Marvaldi J., Rua S., Secchi J., Porte P. Lechene, The role of intracellular lumina in the repolarization process of a colonie adenocarcinoma cell line, 10.1007/bf02890318
  120. HARRIS M., VASUDEV K. S., ANFIELD C., WELLS S., Mucin-producing carcinomas of the breast: ultrastructural observations, 10.1111/j.1365-2559.1978.tb01708.x
  121. Wahnschaffe Ulrich, Emura Makito, Mohr Ulrich, Development of intracytoplasmic lumina in diethylnitrosamine-induced tracheal papillomas of Syrian golden hamster : A light and electron microscopical study, 10.1007/bf02899197
  122. Bosland MC, Cancer Res, 50, 700 (1990)
  123. Dermer GB, Cancer Res, 35, 63 (1975)
  124. Hagiwara Haruo, Ohwada Nobuo, Fujimoto Toyoshi, Intracytoplasmic Lumina in Human Oviduct Epithelium, 10.3109/01913129709021315
  125. Ro Jae Y., El-Naggar Adel, Ayala Alberto G., Mody Dina R., Ordóñez Nelson G., Signet-Ring-Cell Carcinoma of the Prostate : Electron-Microscopic and Immunohistochemical Studies of Eight Cases, 10.1097/00000478-198806000-00005
  126. Kuroda Naoto, Yamasaki Ichiro, Nakayama Hirofumi, Tamura Kenji, Yamamoto Yukio, Miyazaki Eriko, Naruse Keishi, Kiyoku Hiroshi, Hiroi Makoto, Enzan Hideaki, Prostatic signet-ring cell carcinoma: Case report and literature review, 10.1046/j.1440-1827.1999.00876.x
  127. Jiang Z, Zhonghua Bingh Li Xue Za Zhi, 31, 514 (2002)
  128. Leong F.J. W.-M., Leong A.S.-Y., Swift J., Signet-ring Carcinoma of the Prostate, 10.1016/s0344-0338(96)80156-7
  129. Steinbrecher Jerry S., Silverberg Steven G., Signet-ring cell carcinoma of the breast. The mucinous variant of infiltrating lobular carcinoma?, 10.1002/1097-0142(197602)37:2<828::aid-cncr2820370231>3.0.co;2-n
  130. Garfield RE, Lab Invest, 33, 418 (1975)
  131. Brouwer M, Cancer Res, 44, 2947 (1984)
  132. Kerr J F R, Wyllie A H, Currie A R, Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics, 10.1038/bjc.1972.33
  133. Savill J., Recognition and phagocytosis of cells undergoing apoptosis, 10.1093/oxfordjournals.bmb.a011626
  134. Ren Yi, Savill John, Apoptosis: The importance of being eaten, 10.1038/sj.cdd.4400407
  135. Flora Pauline K., Gregory Christopher D., Recognition of apoptotic cells by human macrophages: inhibition by a monocyte/macrophage-specific monoclonal antibody, 10.1002/eji.1830241109
  136. Hart S. P., Haslett C., Dransfield I., Recognition of apoptotic cells by phagocytes, 10.1007/bf01920103
  137. Gregory Christopher D, Pound John D, Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues, 10.1002/path.2792
  138. Overholtzer Michael, Mailleux Arnaud A., Mouneimne Ghassan, Normand Guillaume, Schnitt Stuart J., King Randall W., Cibas Edmund S., Brugge Joan S., A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion, 10.1016/j.cell.2007.10.040
  139. Le Bot N, Nat Cell Biol, 9 (2007)
  140. Mailleux Arnaud A., Overholtzer Michael, Brugge Joan S., L’entose, mort cellulaire par cannibalisme entre cellules tumorales, 10.1051/medsci/2008243246
  141. White Eileen, Entosis: It's a Cell-Eat-Cell World, 10.1016/j.cell.2007.11.015
  142. Qian Youcun, Shi Yufang, Natural killer cells go inside: Entosis versus cannibalism, 10.1038/cr.2009.134
  143. Florey Oliver, Krajcovic Matej, Sun Qiang, Overholtzer Michael, Entosis, 10.1016/j.cub.2009.11.020
  144. Janssen Aniek, Medema René H., Entosis: aneuploidy by invasion, 10.1038/ncb0311-199
  145. Yuan J., Kroemer G., Alternative cell death mechanisms in development and beyond, 10.1101/gad.1984410
  146. Lazarides E., Lindberg U., Actin Is the Naturally Occurring Inhibitor of Deoxyribonuclease I, 10.1073/pnas.71.12.4742
  147. Hitchcock Sarah E., Carlsson Lars, Lindberg Uno, Depolymerization of F-actin by deoxyribonuclease I, 10.1016/0092-8674(76)90203-8
  148. Hitchcock SE, J Biol Chem, 255, 5668 (1980)
  149. KHAITLINA Sofia Y., MORACZEWSKA Joanna, STRZELECKA-GOLASZEWSKA Hanna, The actin/actin interactions involving the N-terminus of the DNase-I-binding loop are crucial for stabilization of the actin filament, 10.1111/j.1432-1033.1993.tb18447.x
  150. Kabsch Wolfgang, Mannherz Hans Georg, Suck Dietrich, Pai Emil F., Holmes Kenneth C., Atomic structure of the actin: DNase I complex , 10.1038/347037a0
  151. Oztug Durer Zeynep A., Diraviyam Karthikeyan, Sept David, Kudryashov Dmitri S., Reisler Emil, F-Actin Structure Destabilization and DNase I Binding Loop Fluctuations, 10.1016/j.jmb.2009.11.001
  152. Taper H S, Evaluation of the validity of the histochemical lead nitrate technique for alkaline and acid deoxyribonuclease., 10.1177/27.11.92502
  153. Taper H S, Reversibility of acid and alkaline deoxyribonuclease deficiency in malignant tumor cells., 10.1177/29.9.7288160
  154. Taper Henryk S., Deckers Christian O., Deckers-Passau Liliane O., Increase in nuclease activity as a possible means for detecting tumor cell sensitivity to anticancer agents, 10.1002/1097-0142(19810201)47:3<523::aid-cncr2820470316>3.0.co;2-r
  155. Taper Henryk S., De Gerlache Jacques, Lans Marc, Roberfroid Marcel, Non-toxic potentiation of cancer chemotherapy by combined C and K3 vitamin pre-treatment, 10.1002/ijc.2910400424
  156. Bussador do Amaral Jônatas, Shiniti Urabayashi Marcel, Maria Machado‑Santelli Gláucia, Cell death and lumen formation in spheroids of MCF-7 cells, 10.1042/cbi20090024
  157. Montironi R., Magi Galluzzi C., Diamanti L., Taborro R., Scarpelli M., Pisani E., Prostatic Intra-epithelial Neoplasia, 10.1016/s0344-0338(11)80363-8
  158. Gilloteaux Jacques, Tomasello Lisa M., Elgison Deborah A., Lipid Deposits and Lipo-mucosomes in Human Cholecystitis and Epithelial Metaplasia in Chronic Cholecystitis, 10.1080/01913120390239962
  159. Qian Bin-Zhi, Li Jiufeng, Zhang Hui, Kitamura Takanori, Zhang Jinghang, Campion Liam R., Kaiser Elizabeth A., Snyder Linda A., Pollard Jeffrey W., CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis, 10.1038/nature10138
  160. Day Eugene D., Vascular Relationships of Tumor and Host*, Progress in Tumor Research ISBN:9783805503884 p.57-97, 10.1159/000385974
  161. Facciabene Andrea, Peng Xiaohui, Hagemann Ian S., Balint Klara, Barchetti Andrea, Wang Li-Ping, Gimotty Phyllis A., Gilks C. Blake, Lal Priti, Zhang Lin, Coukos George, Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells, 10.1038/nature10169
  162. Wernert Nicolas, Kaminski Annette, Haddouti El-Mustapha, Hahne Jens Claus, Tumor-Stroma Interactions of Metastatic Prostate Cancer Cell Lines, Methods in Molecular Biology (2007) ISBN:9781588299444 p.223-237, 10.1007/978-1-59745-304-2_14
  163. Peng Yu-Bing, Zhou Juan, Gao Yan, Li Yu-Hua, Wang Hao, Zhang Ming, Ma Li-Ming, Chen Qi, Da Jun, Wang Zhong, Li Runsheng, Normal prostate-derived stromal cells stimulate prostate cancer development, 10.1111/j.1349-7006.2011.02008.x
  164. Reinhold H.S., Improved microcirculation in irradiated tumours, 10.1016/0014-2964(71)90069-7
  165. Bizik J, Kankuri E, Ristimäki A, Taïeb A, Vapaatalo H, Lubitz W, Vaheri A, Cell–cell contacts trigger programmed necrosis and induce cyclooxygenase-2 expression, 10.1038/sj.cdd.4401317
  166. Carmeliet Peter, Jain Rakesh K., 10.1038/35025220
  167. Gullino PM, J Natl Cancer Inst, 41, 1329 (1978)
  168. Nicosia RF, Cancer Res, 43, 2159 (1983)
Bibliographic reference Gilloteaux, Jacques ; Jamison, James M. ; Neal, Deborah R. ; Summers, Jack L. ; Taper, Henryk. Xenotransplanted human prostate carcinoma (DU145) cells develop into carcinomas and cribriform carcinomas: Ultrastructural aspects. In: Ultrastructural Pathology, Vol. 36, no. 5, p. 294-311 (2012)
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