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PANCA-vasculitis associated with rectal adenocarcinoma

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Hommel, C. Rihova, Z. Mokaddem, F. Libotte, B.

We report the case of a 69-year-old male patient who was admitted for fever, dry cough, recurrent sinusitis with epistaxis, anorexia with weight loss of 20 kg over a 3-month period, myalgia, and mononeuritis multiplex. He was diagnosed with pANCA/anti-MPO associated vasculitis and rectal adenocarcinoma. The tumor was treated by surgical resection. Recurrence of vasculitis occurred during steroid tapering which prompted us to add Mycophenolate mofetyl. A complete remission was achieved. We conclude that in the present case the vasculitis was an independent disease, not a paraneoplastic phenomenon. We discuss the value of different ANCA serologies for diagnostics and follow-up, the epidemiology of vasculitis associated with malignancy, and the concept of vasculitis as a paraneoplastic syndrome.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2014
Language Anglais
Journal information "Acta Clinica Belgica (Multilingual Edition)" - Vol. 69, no. 6, p. 463-466 (2014)
Peer reviewed yes
Publisher Acta Clinica Belgica
issn 0001-5512
Publication status Publié
Links
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Bibliographic reference Hommel, C. ; Rihova, Z. ; Mokaddem, F. ; Libotte, B.. PANCA-vasculitis associated with rectal adenocarcinoma. In: Acta Clinica Belgica (Multilingual Edition), Vol. 69, no. 6, p. 463-466 (2014)
Permanent URL http://hdl.handle.net/2078.1/160410