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Four-year results following treatment of intrabony periodontal defects with an enamel matrix derivative alone or combined with a biphasic calcium phosphate

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Pietruska, Malgorzata Pietruski, Jan Nagy, Katalin Brecx, Michel [UCL] Arweiler, Nicole Birgit Sculean, Anton

The aim of this study was to evaluate the 4-year clinical outcomes following regenerative surgery in intrabony defects with either EMD + BCP or EMD. Twenty-four patients with advanced chronic periodontitis, displaying one-, two-, or three-walled intrabony defect with a probing depth of at least 6 mm, were randomly treated with either EMD + BCP (test) or EMD alone (control). The following clinical parameters were evaluated at baseline, at 1 year and at 4 years after regenerative surgery: plaque index, gingival index, bleeding on probing, probing depth, gingival recession, and clinical attachment level (CAL). The primary outcome variable was CAL. No differences in any of the investigated parameters were observed at baseline between the two groups. The test group demonstrated a mean CAL change from from 10.8 ± 1.6 mm to 7.4 ± 1.6 mm (p < 0.001) and to 7.6 ± 1.7 mm (p < 0.001) at 1 and 4 years, respectively. In the control group, mean CAL changed from 10.4 ± 1.3 at baseline to 6.9 ± 1.0 mm (p < 0.001) at 1 year and 7.2 ± 1.2 mm (p < 0.001) at 4 years. At 4 years, two defects in the test group and three defects in the control group have lost 1 mm of the CAL gained at 1 year. Compared to baseline, at 4 years, a CAL gain of ≥3 mm was measured in 67% of the defects (i.e., in 8 out of 12) in the test group and in 75% of the defects (i.e., in 9 out of 12) in the control group. There were no statistically significant differences in any of the investigated parameters at 1 and at 4 years between the two groups. Within their limits, the present results indicate that: (a) the clinical improvements obtained with both treatments can be maintained over a period of 4 years, and (b) in two- and three-walled intrabony defects, the addition of BCP did not additionally improve the outcomes obtained with EMD alone. In two- and three-walled intrabony defects, the combination of EMD + BCP did not show any advantage over the use of EMD alone.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2012
Language Anglais
Journal information "Clinical Oral Investigations" - Vol. 16, no.4, p. 1191-1197 (2011)
Peer reviewed yes
Publisher Springer ((Germany) Heidelberg)
issn 1432-6981
e-issn 1436-3771
Publication status Publié
Affiliation UCL - (SLuc) Service de parodontologie
MESH Subject Adult ; Female ; Follow-Up Studies ; Gingival Recession ; Granulation Tissue ; Guided Tissue Regeneration, Periodontal ; Humans ; Hydroxyapatites ; Male ; Middle Aged ; Periodontal Attachment Loss ; Alveolar Bone Loss ; Periodontal Index ; Periodontal Pocket ; Prospective Studies ; Root Planing ; Surgical Flaps ; Tooth Cervix ; Treatment Outcome ; Bone Substitutes ; Chelating Agents ; Chronic Periodontitis ; Dental Enamel Proteins ; Dental Plaque Index ; Dental Scaling ; Edetic Acid
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Bibliographic reference Pietruska, Malgorzata ; Pietruski, Jan ; Nagy, Katalin ; Brecx, Michel ; Arweiler, Nicole Birgit ; et. al. Four-year results following treatment of intrabony periodontal defects with an enamel matrix derivative alone or combined with a biphasic calcium phosphate. In: Clinical Oral Investigations, Vol. 16, no.4, p. 1191-1197 (2011)
Permanent URL http://hdl.handle.net/2078.1/158340