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IL-1α induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation.

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Huaux, François Lo Re, Sandra Giordano, Giulia Uwambayinema, Francine Devosse, Raynal Lison, Dominique [UCL]

Macrophages play a central role in immune and tissue responses of granulomatous lung diseases induced by pathogens and foreign bodies. Circulating monocytes are generally viewed as central precursors of these tissue effector macrophages. Here, we provide evidence that granulomas derive from alveolar macrophages serving as a local reservoir for the expansion of activated phagocytic macrophages. By exploring lung granulomatous responses to silica particles in IL-1-deficient mice, we found that the absence of IL-1α, but not IL-1β, was associated with reduced CD11b(high) phagocytic macrophage accumulation and fewer granulomas. This defect was associated with impaired alveolar clearance and resulted in the development of pulmonary alveolar proteinosis (PAP). Reconstitution of IL-1α(-/-) mice with recombinant IL-1α restored lung clearance functions and the pulmonary accumulation of CD11b(high) phagocytic macrophages. Mechanistically, IL-1α induced the proliferation of CD11b(low) alveolar macrophages and differentiated these cells into CD11b(high) macrophages which perform critical phagocytic functions and organize granuloma. We newly discovered here that IL-1α triggers lung responses requiring macrophage proliferation and maturation from tissue-resident macrophages. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2015
Language Anglais
Journal information "Journal of Pathology" - Vol. 235, no.5, p. 698-709 (2015)
Peer reviewed yes
Publisher JohnWiley & Sons Ltd. (Chichester)
issn 0022-3417
e-issn 1096-9896
Publication status Publié
Affiliation UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology
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Bibliographic reference Huaux, François ; Lo Re, Sandra ; Giordano, Giulia ; Uwambayinema, Francine ; Devosse, Raynal ; et. al. IL-1α induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation.. In: Journal of Pathology, Vol. 235, no.5, p. 698-709 (2015)
Permanent URL http://hdl.handle.net/2078.1/157894