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Tryptophan-degrading enzymes in tumoral immune resistance

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van Baren, Nicolas [UCL] Van den Eynde, Benoît [UCL]

Tryptophan is required for T lymphocyte effector functions. Its degradation is one of the mechanisms selected by tumors to resist immune destruction. Two enzymes, tryptophan-2,3-dioxygenase and indoleamine 2,3-dioxygenase 1, control tryptophan degradation through the kynurenine pathway. A third protein, indoleamine 2,3-dioxygenase 2, was identified more recently. All three enzymes were reported to be expressed in tumors, and are candidate targets for pharmacological inhibition aimed at restoring effective anti-tumoral immunity. In this review, we compare these three enzymes in terms of structure, activity, regulation, and expression in healthy and cancerous tissues, in order to appreciate their relevance to tumoral immune resistance.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2015
Language Anglais
Journal information "Frontiers in Immunology" - Vol. 6, no. 34, p. 1-9 (03/02/2015)
Peer reviewed yes
Publisher Frontiers Media
issn 1664-3224
e-issn 1664-3224
Publication status Publié
Affiliation UCL - SSS/DDUV - Institut de Duve
Links
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Permanent URL http://hdl.handle.net/2078.1/157078