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Are hospitalized or ambulatory patients with heart failure treated in accordance with European Society of Cardiology guidelines? Evidence from 12,440 patients of the ESC Heart Failure Long-Term Registry.

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Maggioni, Aldo P Anker, Stefan D Dahlström, Ulf Filippatos, Gerasimos Ponikowski, Piotr Kaminski, Ludovic [UCL]

AimsTo evaluate how recommendations of European guidelines regarding pharmacological and non-pharmacological treatments for heart failure (HF) are adopted in clinical practice.Methods and resultsThe ESC-HF Long-Term Registry is a prospective, observational study conducted in 211 Cardiology Centres of 21 European and Mediterranean countries, members of the European Society of Cardiology (ESC). From May 2011 to April 2013, a total of 12 440 patients were enrolled, 40.5% with acute HF and 59.5% with chronic HF. Intravenous treatments for acute HF were heterogeneously administered, irrespective of guideline recommendations. In chronic HF, with reduced EF, renin-angiotensin system (RAS) blockers, beta-blockers, and mineralocorticoid antagonists (MRAs) were used in 92.2, 92.7, and 67.0% of patients, respectively. When reasons for non-adherence were considered, the real rate of undertreatment accounted for 3.2, 2.3, and 5.4% of the cases, respectively. About 30% of patients received the target dosage of these drugs, but a documented reason for not achieving the target dosage was reported in almost two-thirds of them. The more relevant reasons for non-implantation of a device, when clinically indicated, were related to doctor uncertainties on the indication, patient refusal, or logistical/cost issues.ConclusionThis pan-European registry shows that, while in patients with acute HF, a large heterogeneity of treatments exists, drug treatment of chronic HF can be considered largely adherent to recommendations of current guidelines, when the reasons for non-adherence are taken into account. Observations regarding the real possibility to adhere fully to current guidelines in daily clinical practice should be seriously considered when clinical practice guidelines have to be written. © 2013 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2013. For permissions please email: journals.permissions@oup.com

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2013
Language Anglais
Journal information "European Journal of Heart Failure" - Vol. 15, no.10, p. 1173-1184 (2013)
Peer reviewed yes
Publisher Oxford University Press ((United Kingdom) Oxford)
issn 1388-9842
e-issn 1879-0844
Publication status Publié
Affiliation UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur
MESH Subject Adrenergic beta-Antagonists ; Europe ; Female ; Guideline Adherence ; Heart Failure ; Hospitalization ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Male ; Middle Aged ; Mineralocorticoid Receptor Antagonists ; Aged ; Nitrates ; Platelet Aggregation Inhibitors ; Practice Guidelines as Topic ; Registries ; Ambulatory Care ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Cardiology ; Cardiotonic Agents ; Defibrillators, Implantable ; Diuretics
Links
  1. Tavazzi L., Senni M., Metra M., Gorini M., Cacciatore G., Chinaglia A., Di Lenarda A., Mortara A., Oliva F., Maggioni A. P., , Multicenter Prospective Observational Study on Acute and Chronic Heart Failure: One-Year Follow-up Results of IN-HF (Italian Network on Heart Failure) Outcome Registry, 10.1161/circheartfailure.112.000161
  2. Maggioni Aldo P., Dahlström Ulf, Filippatos Gerasimos, Chioncel Ovidiu, Leiro Marisa Crespo, Drozdz Jaroslaw, Fruhwald Friedrich, Gullestad Lars, Logeart Damien, Fabbri Gianna, Urso Renato, Metra Marco, Parissis John, Persson Hans, Ponikowski Piotr, Rauchhaus Mathias, Voors Adriaan A., Nielsen Olav Wendelboe, Zannad Faiez, Tavazzi Luigi, , EURObservationalResearch Programme: regional differences and 1-year follow-up results of the Heart Failure Pilot Survey (ESC-HF Pilot), 10.1093/eurjhf/hft050
  3. Jhund P. S., MacIntyre K., Simpson C. R., Lewsey J. D., Stewart S., Redpath A., Chalmers J. W.T., Capewell S., McMurray J. J.V., Long-Term Trends in First Hospitalization for Heart Failure and Subsequent Survival Between 1986 and 2003: A Population Study of 5.1 Million People, 10.1161/circulationaha.108.812172
  4. Schaufelberger M, Decreasing one-year mortality and hospitalization rates for heart failure in Sweden Data from the Swedish Hospital Discharge Registry 1988 to 2000, 10.1016/j.ehj.2003.12.012
  5. Dickstein Kenneth, Cohen-Solal Alain, Filippatos Gerasimos, McMurray John J.V., Ponikowski Piotr, Poole-Wilson Philip Alexander, Strömberg Anna, van Veldhuisen Dirk J., Atar Dan, Hoes Arno W., Keren Andre, Mebazaa Alexandre, Nieminen Markku, Priori Silvia Giuliana, Swedberg Karl, Vahanian Alec, Camm John, De Caterina Raffaele, Dean Veronica, Dickstein Kenneth, Filippatos Gerasimos, Funck-Brentano Christian, Hellemans Irene, Kristensen Steen Dalby, McGregor Keith, Sechtem Udo, Silber Sigmund, Tendera Michal, Widimsky Petr, Zamorano Jose Luis, Tendera Michal, Auricchio Angelo, Bax Jeroen, Böhm Michael, Corrà Ugo, della Bella Paolo, Elliott Perry M., Follath Ferenc, Gheorghiade Mihai, Hasin Yonathan, Hernborg Anders, Jaarsma Tiny, Komajda Michel, Kornowski Ran, Piepoli Massimo, Prendergast Bernard, Tavazzi Luigi, Vachiery Jean-Luc, Verheugt Freek W. A., Zamorano Jose Luis, Zannad Faiez, , , , ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008‡ : The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaborati, 10.1016/j.ejheart.2008.08.005
  6. McMurray, Eur J Heart Fail, 14, 803 (2012)
  7. , Jessup M., Abraham W. T., Casey D. E., Feldman A. M., Francis G. S., Ganiats T. G., Konstam M. A., Mancini D. M., Rahko P. S., Silver M. A., Stevenson L. W., Yancy C. W., 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in Collaboration With the International Society for Heart and Lung Transplantation, 10.1161/circulationaha.109.192064
  8. , Dickstein Kenneth, Vardas Panos E., Auricchio Angelo, Daubert Jean-Claude, Linde Cecilia, McMurray John, Ponikowski Piotr, Priori Silvia Giuliana, Sutton Richard, van Veldhuisen Dirk J., Vahanian Alec, Auricchio Angelo, Bax Jeroen, Ceconi Claudio, Dean Veronica, Filippatos Gerasimos, Funck-Brentano Christian, Hobbs Richard, Kearney Peter, McDonagh Theresa, Popescu Bogdan A., Reiner Zeljko, Sechtem Udo, Sirnes Per Anton, Tendera Michal, Vardas Panos, Widimsky Petr, Tendera Michal, Anker Stefan D., Blanc Jean-Jacques, Gasparini Maurizio, Hoes Arno W., Israel Carsten W., Kalarus Zbigniew, Merkely Bela, Swedberg Karl, Camm A. John, , , , 2010 Focused Update of ESC Guidelines on device therapy in heart failure : An update of the 2008 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure and the 2007 ESC Guidelines for cardiac and re, 10.1093/eurjhf/hfq192
  9. Williams Scott C., Schmaltz Stephen P., Morton David J., Koss Richard G., Loeb Jerod M., Quality of Care in U.S. Hospitals as Reflected by Standardized Measures, 2002–2004, 10.1056/nejmsa043778
  10. Fonarow Gregg C., Adherence to Heart Failure Quality-of-Care Indicators in US Hospitals : Analysis of the ADHERE Registry, 10.1001/archinte.165.13.1469
  11. Shah Bimal, Hernandez Adrian F., Liang Li, Al-Khatib Sana M., Yancy Clyde W., Fonarow Gregg C., Peterson Eric D., Hospital Variation and Characteristics of Implantable Cardioverter-Defibrillator Use in Patients With Heart Failure, 10.1016/j.jacc.2008.09.045
  12. Stafford Randall S, Radley David C, The underutilization of cardiacmedications of proven benefit, 1990 to 2002, 10.1016/s0735-1097(02)02670-0
  13. Fonarow G. C., Yancy C. W., Albert N. M., Curtis A. B., Stough W. G., Gheorghiade M., Heywood J. T., McBride M. L., Mehra M. R., O'Connor C. M., Reynolds D., Walsh M. N., Heart Failure Care in the Outpatient Cardiology Practice Setting: Findings From IMPROVE HF, 10.1161/circheartfailure.108.772228
  14. Maggioni Aldo P., Dahlström Ulf, Filippatos Gerasimos, Chioncel Ovidiu, Leiro Marisa Crespo, Drozdz Jaroslaw, Fruhwald Friedrich, Gullestad Lars, Logeart Damien, Metra Marco, Parissis John, Persson Hans, Ponikowski Piotr, Rauchhaus Mathias, Voors Adriaan, Nielsen Olav Wendelboe, Zannad Faiez, Tavazzi Luigi, , EURObservationalResearch Programme: The Heart Failure Pilot Survey (ESC-HF Pilot), 10.1093/eurjhf/hfq154
  15. Dickstein K., Bogale N., Priori S., Auricchio A., Cleland J. G., Gitt A., Limbourg T., Linde C., van Veldhuisen D. J., Brugada J., , The European cardiac resynchronization therapy survey, 10.1093/eurheartj/ehp359
  16. van Veldhuisen Dirk J., Maass Alexander H., Priori Silvia G., Stolt Pelle, van Gelder Isabelle C., Dickstein Kenneth, Swedberg Karl, Implementation of device therapy (cardiac resynchronization therapy and implantable cardioverter defibrillator) for patients with heart failure in Europe: changes from 2004 to 2008, 10.1093/eurjhf/hfp149
  17. O'Connor Christopher M., Stough Wendy Gattis, Gallup Dianne S., Hasselblad Vic, Gheorghiade Mihai, Demographics, Clinical Characteristics, and Outcomes of Patients Hospitalized for Decompensated Heart Failure: Observations From the IMPACT-HF Registry, 10.1016/j.cardfail.2004.08.160
  18. Mosterd A., Hoes A. W, Clinical epidemiology of heart failure, 10.1136/hrt.2003.025270
  19. Adams Kirkwood F., Fonarow Gregg C., Emerman Charles L., LeJemtel Thierry H., Costanzo Maria Rosa, Abraham William T., Berkowitz Robert L., Galvao Marie, Horton Darlene P., Characteristics and outcomes of patients hospitalized for heart failure in the United States: Rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE), 10.1016/j.ahj.2004.08.005
  20. Gheorghiade Mihai, Abraham William T., Albert Nancy M., Greenberg Barry H., O’Connor Christopher M., She Lilin, Stough Wendy Gattis, Yancy Clyde W., Young James B., Fonarow Gregg C., OPTIMIZE-HF Investigators and Coordinators for the, Systolic Blood Pressure at Admission, Clinical Characteristics, and Outcomes in Patients Hospitalized With Acute Heart Failure, 10.1001/jama.296.18.2217
  21. Tavazzi L., Nationwide survey on acute heart failure in cardiology ward services in Italy, 10.1093/eurheartj/ehi845
  22. Abraham William T., Fonarow Gregg C., Albert Nancy M., Stough Wendy Gattis, Gheorghiade Mihai, Greenberg Barry H., O'Connor Christopher M., Sun Jie Lena, Yancy Clyde W., Young James B., Predictors of In-Hospital Mortality in Patients Hospitalized for Heart Failure, 10.1016/j.jacc.2008.04.028
  23. Nieminen M. S., Brutsaert D., Dickstein K., Drexler H., Follath F., Harjola V.-P., Hochadel M., Komajda M., Lassus J., Lopez-Sendon J. L., Ponikowski P., Tavazzi L., , EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population, 10.1093/eurheartj/ehl193
  24. Partovian Chohreh, Gleim Scott R., Mody Purav S., Li Shu-Xia, Wang Haiyan, Strait Kelly M., Allen Larry A., Lagu Tara, Normand Sharon-Lise T., Krumholz Harlan M., Hospital Patterns of Use of Positive Inotropic Agents in Patients With Heart Failure, 10.1016/j.jacc.2012.07.011
  25. McMurray John, Cohen-Solal Alain, Dietz Rainer, Eichhorn Eric, Erhardt Leif, Hobbs F.D. Richard, Krum Henry, Maggioni Aldo, McKelvie Robert S., Piña Ileana L., Soler-Soler Jordi, Swedberg Karl, Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: Putting guidelines into practice, 10.1016/j.ejheart.2005.07.002
  26. Düngen Hans-Dirk, Apostolović Svetlana, Inkrot Simone, Tahirović Elvis, Töpper Agnieszka, Mehrhof Felix, Prettin Christiane, Putniković Biljana, Nešković Aleksandar N., Krotin Mirjana, Sakač Dejan, Lainščak Mitja, Edelmann Frank, Wachter Rolf, Rau Thomas, Eschenhagen Thomas, Doehner Wolfram, Anker Stefan D., Waagstein Finn, Herrmann-Lingen Christoph, Gelbrich Goetz, Dietz Rainer, , Titration to target dose of bisoprolol vs. carvedilol in elderly patients with heart failure: the CIBIS-ELD trial, 10.1093/eurjhf/hfr020
  27. Cullington Damien, Goode Kevin M., Clark Andrew L., Cleland John G.F., Heart rate achieved or beta-blocker dose in patients with chronic heart failure: which is the better target?, 10.1093/eurjhf/hfs060
  28. Heart Failure Society of America, HFSA 2010 Comprehensive Heart Failure Practice Guideline, 10.1016/j.cardfail.2010.04.004
Bibliographic reference Maggioni, Aldo P ; Anker, Stefan D ; Dahlström, Ulf ; Filippatos, Gerasimos ; Ponikowski, Piotr ; et. al. Are hospitalized or ambulatory patients with heart failure treated in accordance with European Society of Cardiology guidelines? Evidence from 12,440 patients of the ESC Heart Failure Long-Term Registry.. In: European Journal of Heart Failure, Vol. 15, no.10, p. 1173-1184 (2013)
Permanent URL http://hdl.handle.net/2078.1/156916