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Regulation of calcium channels in smooth muscle: New insights into the role of myosin light chain kinase.

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Martinsen, A Dessy, Chantal [UCL] Morel, N

Smooth muscle myosin light chain kinase (MLCK) plays a crucial role in artery contraction, which regulates blood pressure and blood flow distribution. In addition to this role, MLCK contributes to Ca(2+) flux regulation in vascular smooth muscle (VSM) and in non-muscle cells, where cytoskeleton has been suggested to help Ca(2+) channels trafficking. This conclusion is based on the use of pharmacological inhibitors of MLCK and molecular and cellular techniques developed to down-regulate the enzyme. Dissimilarities have been observed between cells and whole tissues, as well as between large conductance and small resistance arteries. A differential expression in MLCK and ion channels (either voltage-dependent Ca(2+) channels or non-selective cationic channels) could account for these observations, and is in line with the functional properties of the arteries. A potential involvement of MLCK in the pathways modulating Ca(2+) entry in VSM is described in the present review.

Document type Article de périodique (Journal article)
Access type Accès restreint
Publication date 2014
Language Anglais
Journal information "Channels (Austin)" - Vol. 8, no.5, p. 402-413 (2014)
Peer reviewed yes
Publisher Landes Bioscience (Austin)
issn 1933-6950
e-issn 1933-6969
Publication status Publié
Affiliations UCL - SSS/IREC - Institut de recherche expérimentale et clinique
UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique
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Bibliographic reference Martinsen, A ; Dessy, Chantal ; Morel, N. Regulation of calcium channels in smooth muscle: New insights into the role of myosin light chain kinase.. In: Channels (Austin), Vol. 8, no.5, p. 402-413 (2014)
Permanent URL http://hdl.handle.net/2078.1/154140