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Concise review : Pancreas regeneration: recent advances and perspectives

Bibliographic reference Lysy, Philippe ; Weir, Gordon C ; Bonner-Weir, Susan. Concise review : Pancreas regeneration: recent advances and perspectives. In: Stem Cells Translational Medicine, Vol. 1, no. 2, p. 150-159 (2012)
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  1. Atkinson M. A., Bluestone J. A., Eisenbarth G. S., Hebrok M., Herold K. C., Accili D., Pietropaolo M., Arvan P. R., Von Herrath M., Markel D. S., Rhodes C. J., How Does Type 1 Diabetes Develop?: The Notion of Homicide or  -Cell Suicide Revisited, 10.2337/db10-1797
  2. Halban Philippe A., German Michael S., Kahn Steven E., Weir Gordon C., Current Status of Islet Cell Replacement and Regeneration Therapy, 10.1210/jc.2009-1819
  3. Desgraz Renaud, Bonal Claire, Herrera Pedro L., β-Cell regeneration: the pancreatic intrinsic faculty, 10.1016/j.tem.2010.09.004
  4. Dor Yuval, Brown Juliana, Martinez Olga I., Melton Douglas A., Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation, 10.1038/nature02520
  5. Meier J. J., Butler A. E., Saisho Y., Monchamp T., Galasso R., Bhushan A., Rizza R. A., Butler P. C.,  -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans, 10.2337/db07-1369
  6. Willcox A., Richardson S. J., Bone A. J., Foulis A. K., Morgan N. G., Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes, 10.1007/s00125-010-1817-6
  7. Meier J. J., Bhushan A., Butler A. E., Rizza R. A., Butler P. C., Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?, 10.1007/s00125-005-1949-2
  8. Pipeleers Daniël, Ling Zhidong, Pancreatic beta cells in insulin-dependent diabetes, 10.1002/dmr.5610080303
  9. Keenan H. A., Sun J. K., Levine J., Doria A., Aiello L. P., Eisenbarth G., Bonner-Weir S., King G. L., Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study, 10.2337/db10-0676
  10. Butler A. E., Janson J., Bonner-Weir S., Ritzel R., Rizza R. A., Butler P. C.,  -Cell Deficit and Increased  -Cell Apoptosis in Humans With Type 2 Diabetes, 10.2337/diabetes.52.1.102
  11. Rahier, Diabetes Obes Metab 2008;10 Suppl, 4, 32
  12. Perl S., Kushner J. A., Buchholz B. A., Meeker A. K., Stein G. M., Hsieh M., Kirby M., Pechhold S., Liu E. H., Harlan D. M., Tisdale J. F., Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined byin VivoThymidine Analog Incorporation and Radiocarbon Dating, 10.1210/jc.2010-0932
  13. Veld P. I., De Munck N., Van Belle K., Buelens N., Ling Z., Weets I., Haentjens P., Pipeleers-Marichal M., Gorus F., Pipeleers D.,  -Cell Replication Is Increased in Donor Organs From Young Patients After Prolonged Life Support, 10.2337/db09-1698
  14. Jovanovic L., Knopp R. H., Brown Z., Conley M. R., Park E., Mills J. L., Metzger B. E., Aarons J. H., Holmes L. B., Simpson J. L., Declining Insulin Requirement in the Late First Trimester of Diabetic Pregnancy, 10.2337/diacare.24.7.1130
  15. Assche F. A., Aerts L., Prins F. De, A MORPHOLOGICAL STUDY OF THE ENDOCRINE PANCREAS IN HUMAN PREGNANCY, 10.1111/j.1471-0528.1978.tb15835.x
  16. Butler A. E., Cao-Minh L., Galasso R., Rizza R. A., Corradin A., Cobelli C., Butler P. C., Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy, 10.1007/s00125-010-1809-6
  17. Bonner-Weir S., Li W.-C., Ouziel-Yahalom L., Guo L., Weir G. C., Sharma A.,  -Cell Growth and Regeneration: Replication Is Only Part of the Story, 10.2337/db10-0084
  18. Kopp J. L., Dubois C. L., Schaffer A. E., Hao E., Shih H. P., Seymour P. A., Ma J., Sander M., Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas, 10.1242/dev.056499
  19. Furuyama Kenichiro, Kawaguchi Yoshiya, Akiyama Haruhiko, Horiguchi Masashi, Kodama Sota, Kuhara Takeshi, Hosokawa Shinichi, Elbahrawy Ashraf, Soeda Tsunemitsu, Koizumi Masayuki, Masui Toshihiko, Kawaguchi Michiya, Takaori Kyoichi, Doi Ryuichiro, Nishi Eiichiro, Kakinoki Ryosuke, Deng Jian Min, Behringer Richard R, Nakamura Takashi, Uemoto Shinji, Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine, 10.1038/ng.722
  20. Criscimanna Angela, Speicher Julie A., Houshmand Golbahar, Shiota Chiyo, Prasadan Krishna, Ji Baoan, Logsdon Craig D., Gittes George K., Esni Farzad, Duct Cells Contribute to Regeneration of Endocrine and Acinar Cells Following Pancreatic Damage in Adult Mice, 10.1053/j.gastro.2011.07.003
  21. Xu Xiaobo, D'Hoker Joke, Stangé Geert, Bonné Stefan, De Leu Nico, Xiao Xiangwei, Van De Casteele Mark, Mellitzer Georg, Ling Zhidong, Pipeleers Danny, Bouwens Luc, Scharfmann Raphael, Gradwohl Gerard, Heimberg Harry, β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas, 10.1016/j.cell.2007.12.015
  22. Bonner-Weir S., Baxter L. A., Schuppin G. T., Smith F. E., A Second Pathway for Regeneration of Adult Exocrine and Endocrine Pancreas: A Possible Recapitulation of Embryonic Development, 10.2337/diab.42.12.1715
  23. Li W.-C., Rukstalis J. M., Nishimura W., Tchipashvili V., Habener J. F., Sharma A., Bonner-Weir S., Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats, 10.1242/jcs.065268
  24. Martin-Pagola A., Sisino G., Allende G., Dominguez-Bendala J., Gianani R., Reijonen H., Nepom G. T., Ricordi C., Ruiz P., Sageshima J., Ciancio G., Burke G. W., Pugliese A., Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity, 10.1007/s00125-008-1105-x
  25. Reers C., Erbel S., Esposito I., Schmied B., Buchler M. W, Nawroth P. P, Ritzel R. A, Impaired islet turnover in human donor pancreata with aging, 10.1530/eje-08-0596
  26. Yamamoto K., Miyagawa J., Waguri M., Sasada R., Igarashi K., Li M., Nammo T., Moriwaki M., Imagawa A., Yamagata K., Nakajima H., Namba M., Tochino Y., Hanafusa T., Matsuzawa Y., Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion, 10.2337/diabetes.49.12.2021
  27. Suarez-Pinzon W. L., Power R. F., Yan Y., Wasserfall C., Atkinson M., Rabinovitch A., Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice, 10.2337/db08-0688
  28. Brand Stephen J., Tagerud Sven, Lambert Philip, Magil Sheila G., Tatarkiewicz Krystyna, Doiron Kathryn, Yan Yanhua, Pharmacological Treatment of Chronic Diabetes by Stimulating Pancreatic beta-Cell Regeneration with Systemic Co-administration of EGF and Gastrin, 10.1034/j.1600-0773.2002.910621.x
  29. Suarez-Pinzon W. L., Yan Y., Power R., Brand S. J., Rabinovitch A., Combination Therapy With Epidermal Growth Factor and Gastrin Increases  -Cell Mass and Reverses Hyperglycemia in Diabetic NOD Mice, 10.2337/diabetes.54.9.2596
  30. Rosenberg Lawrence, Lipsett Mark, Yoon Ji-Won, Prentki Marc, Wang Rennian, Jun Hee-Sook, Pittenger Gary L., Taylor-Fishwick David, Vinik Aaron I., A Pentadecapeptide Fragment of Islet Neogenesis-Associated Protein Increases Beta-Cell Mass and Reverses Diabetes in C57BL/6J Mice : , 10.1097/01.sla.0000143270.99191.10
  31. Fleming Alexander, Rosenberg Lawrence, Prospects and Challenges for Islet Regeneration as a Treatment for Diabetes: A Review of Islet Neogenesis Associated Protein, 10.1177/193229680700100214
  32. Dungan Kathleen M., Buse John B., Ratner Robert E., Effects of therapy in type 1 and type 2 diabetes mellitus with a peptide derived from islet neogenesis associated protein (INGAP), 10.1002/dmrr.999
  33. Nauck M. A., Kleine N., �rskov C., Holst J. J., Willms B., Creutzfeldt W., Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients, 10.1007/bf00401145
  34. Rachman J., Barrow B. A., Levy J. C., Turner R. C., Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM, 10.1007/s001250050664
  35. Garber A. J., Long-Acting Glucagon-Like Peptide 1 Receptor Agonists: A review of their efficacy and tolerability, 10.2337/dc11-s231
  36. Xu G., Stoffers D. A., Habener J. F., Bonner-Weir S., Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats, 10.2337/diabetes.48.12.2270
  37. Sturis Jeppe, Gotfredsen Carsten F, Rømer John, Rolin Bidda, Ribel Ulla, Brand Christian L, Wilken Michael, Wassermann Karsten, Deacon Carolyn F, Carr Richard D, Knudsen Lotte Bjerre, GLP-1 derivative liraglutide in rats withβ-cell deficiencies: influence of metabolic state onβ-cell mass dynamics, 10.1038/sj.bjp.0705397
  38. Garber A. J., Incretin Effects on  -Cell Function, Replication, and Mass: The human perspective, 10.2337/dc11-s230
  39. Mfopou J. K., Chen B., Sui L., Sermon K., Bouwens L., Recent Advances and Prospects in the Differentiation of Pancreatic Cells From Human Embryonic Stem Cells, 10.2337/db10-0439
  40. Soria B., Roche E., Berna G., Leon-Quinto T., Reig J. A., Martin F., Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice, 10.2337/diabetes.49.2.157
  41. Mao Gen-hong, Chen Gui-an, Bai Hai-yan, Song Tian-ran, Wang Yan-xia, The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells, 10.1016/j.biomaterials.2008.12.030
  42. Zhang Donghui, Jiang Wei, Liu Meng, Sui Xin, Yin Xiaolei, Chen Song, Shi Yan, Deng Hongkui, Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells, 10.1038/cr.2009.28
  43. D'Amour Kevin A, Bang Anne G, Eliazer Susan, Kelly Olivia G, Agulnick Alan D, Smart Nora G, Moorman Mark A, Kroon Evert, Carpenter Melissa K, Baetge Emmanuel E, Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells, 10.1038/nbt1259
  44. Kroon Evert, Martinson Laura A, Kadoya Kuniko, Bang Anne G, Kelly Olivia G, Eliazer Susan, Young Holly, Richardson Mike, Smart Nora G, Cunningham Justine, Agulnick Alan D, D'Amour Kevin A, Carpenter Melissa K, Baetge Emmanuel E, Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo, 10.1038/nbt1393
  45. Borowiak Malgorzata, Maehr René, Chen Shuibing, Chen Alice E., Tang Weiping, Fox Julia L., Schreiber Stuart L., Melton Douglas A., Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells, 10.1016/j.stem.2009.01.014
  46. Chen Shuibing, Borowiak Malgorzata, Fox Julia L, Maehr René, Osafune Kenji, Davidow Lance, Lam Kelvin, Peng Lee F, Schreiber Stuart L, Rubin Lee L, Melton Douglas, A small molecule that directs differentiation of human ESCs into the pancreatic lineage, 10.1038/nchembio.154
  47. Chung Won-Suk, Stainier Didier Y.R., Intra-Endodermal Interactions Are Required for Pancreatic β Cell Induction, 10.1016/j.devcel.2008.02.012
  48. Van Hoof Dennis, Mendelsohn Adam D., Seerke Rina, Desai Tejal A., German Michael S., Differentiation of human embryonic stem cells into pancreatic endoderm in patterned size-controlled clusters, 10.1016/j.scr.2011.02.004
  49. Higuchi Y., Shiraki N., Yamane K., Qin Z., Mochitate K., Araki K., Senokuchi T., Yamagata K., Hara M., Kume K., Kume S., Synthesized basement membranes direct the differentiation of mouse embryonic stem cells into pancreatic lineages, 10.1242/jcs.066886
  50. Fujikawa Takahisa, Oh Seh-Hoon, Pi Liya, Hatch Heather M., Shupe Tom, Petersen Bryon E., Teratoma Formation Leads to Failure of Treatment for Type I Diabetes Using Embryonic Stem Cell-Derived Insulin-Producing Cells, 10.1016/s0002-9440(10)62488-1
  51. Wang Pei, Rodriguez Ryan T., Wang Jing, Ghodasara Amar, Kim Seung K., Targeting SOX17 in Human Embryonic Stem Cells Creates Unique Strategies for Isolating and Analyzing Developing Endoderm, 10.1016/j.stem.2011.01.017
  52. Kahan Brenda, Magliocca Joseph, Merriam Fabiola, Treff Nathan, Budde Melisa, Nelson Jeffrey, Browning Victoria, Ziehr Benjamin, Odorico Jon, Elimination of tumorigenic stem cells from differentiated progeny and selection of definitive endoderm reveals a Pdx1+ foregut endoderm stem cell lineage, 10.1016/j.scr.2010.10.003
  53. Jiang Wei, Sui Xin, Zhang Donghui, Liu Meng, Ding Mingxiao, Shi Yan, Deng Hongkui, CD24: A Novel Surface Marker for PDX1-Positive Pancreatic Progenitors Derived from Human Embryonic Stem Cells, 10.1002/stem.608
  54. Polo Jose M, Liu Susanna, Figueroa Maria Eugenia, Kulalert Warakorn, Eminli Sarah, Tan Kah Yong, Apostolou Effie, Stadtfeld Matthias, Li Yushan, Shioda Toshi, Natesan Sridaran, Wagers Amy J, Melnick Ari, Evans Todd, Hochedlinger Konrad, Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells, 10.1038/nbt.1667
  55. Bar-Nur Ori, Russ Holger A., Efrat Shimon, Benvenisty Nissim, Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells, 10.1016/j.stem.2011.06.007
  56. Mutskov Vesco, Raaka Bruce M., Felsenfeld Gary, Gershengorn Marvin C., The Human Insulin Gene Displays Transcriptionally Active Epigenetic Marks in Islet-Derived Mesenchymal Precursor Cells in the Absence of Insulin Expression, 10.1634/stemcells.2007-0325
  57. Marro Samuele, Pang Zhiping P., Yang Nan, Tsai Miao-Chih, Qu Kun, Chang Howard Y., Südhof Thomas C., Wernig Marius, Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons, 10.1016/j.stem.2011.09.002
  58. Takahashi Kazutoshi, Tanabe Koji, Ohnuki Mari, Narita Megumi, Ichisaka Tomoko, Tomoda Kiichiro, Yamanaka Shinya, Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors, 10.1016/j.cell.2007.11.019
  59. Tateishi Keisuke, He Jin, Taranova Olena, Liang Gaoyang, D'Alessio Ana C., Zhang Yi, Generation of Insulin-secreting Islet-like Clusters from Human Skin Fibroblasts, 10.1074/jbc.m806597200
  60. Maehr R., Chen S., Snitow M., Ludwig T., Yagasaki L., Goland R., Leibel R. L., Melton D. A., Generation of pluripotent stem cells from patients with type 1 diabetes, 10.1073/pnas.0906894106
  61. Alipio Z., Liao W., Roemer E. J., Waner M., Fink L. M., Ward D. C., Ma Y., Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic  -like cells, 10.1073/pnas.1007884107
  62. Zhu F. F., Zhang P. B., Zhang D. H., Sui X., Yin M., Xiang T. T., Shi Y., Ding M. X., Deng H., Generation of pancreatic insulin-producing cells from rhesus monkey induced pluripotent stem cells, 10.1007/s00125-011-2246-x
  63. Liu Shih-Ping, Fu Ru-Huei, Huang Yu-Chuen, Chen Shih-Yin, Chien Ying-Jiun, Hsu Chien Yu, Tsai Chang-Hai, Shyu Woei-Cherng, Lin Shinn-Zong, Induced Pluripotent Stem (iPS) Cell Research Overview, 10.3727/096368910x532828
  64. Gore Athurva, Li Zhe, Fung Ho-Lim, Young Jessica E., Agarwal Suneet, Antosiewicz-Bourget Jessica, Canto Isabel, Giorgetti Alessandra, Israel Mason A., Kiskinis Evangelos, Lee Je-Hyuk, Loh Yuin-Han, Manos Philip D., Montserrat Nuria, Panopoulos Athanasia D., Ruiz Sergio, Wilbert Melissa L., Yu Junying, Kirkness Ewen F., Belmonte Juan Carlos Izpisua, Rossi Derrick J., Thomson James A., Eggan Kevin, Daley George Q., Goldstein Lawrence S. B., Zhang Kun, Somatic coding mutations in human induced pluripotent stem cells, 10.1038/nature09805
  65. Laurent Louise C., Ulitsky Igor, Slavin Ileana, Tran Ha, Schork Andrew, Morey Robert, Lynch Candace, Harness Julie V., Lee Sunray, Barrero Maria J., Ku Sherman, Martynova Marina, Semechkin Ruslan, Galat Vasiliy, Gottesfeld Joel, Belmonte Juan Carlos Izpisua, Murry Chuck, Keirstead Hans S., Park Hyun-Sook, Schmidt Uli, Laslett Andrew L., Muller Franz-Josef, Nievergelt Caroline M., Shamir Ron, Loring Jeanne F., Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture, 10.1016/j.stem.2010.12.003
  66. Warren Luigi, Manos Philip D., Ahfeldt Tim, Loh Yuin-Han, Li Hu, Lau Frank, Ebina Wataru, Mandal Pankaj K., Smith Zachary D., Meissner Alexander, Daley George Q., Brack Andrew S., Collins James J., Cowan Chad, Schlaeger Thorsten M., Rossi Derrick J., Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA, 10.1016/j.stem.2010.08.012
  67. Anokye-Danso Frederick, Trivedi Chinmay M., Juhr Denise, Gupta Mudit, Cui Zheng, Tian Ying, Zhang Yuzhen, Yang Wenli, Gruber Peter J., Epstein Jonathan A., Morrisey Edward E., Highly Efficient miRNA-Mediated Reprogramming of Mouse and Human Somatic Cells to Pluripotency, 10.1016/j.stem.2011.03.001
  68. Hu K., Yu J., Suknuntha K., Tian S., Montgomery K., Choi K.-D., Stewart R., Thomson J. A., Slukvin I. I., Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells, 10.1182/blood-2010-07-298331
  69. Maekawa Momoko, Yamaguchi Kei, Nakamura Tomonori, Shibukawa Ran, Kodanaka Ikumi, Ichisaka Tomoko, Kawamura Yoshifumi, Mochizuki Hiromi, Goshima Naoki, Yamanaka Shinya, Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1, 10.1038/nature10106
  70. Feng Bo, Ng Jia-Hui, Heng Jian-Chien Dominic, Ng Huck-Hui, Molecules that Promote or Enhance Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells, 10.1016/j.stem.2009.03.005
  71. Zhu Saiyong, Li Wenlin, Zhou Hongyan, Wei Wanguo, Ambasudhan Rajesh, Lin Tongxiang, Kim Janghwan, Zhang Kang, Ding Sheng, Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds, 10.1016/j.stem.2010.11.015
  72. Gershengorn M. C., Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor Cells, 10.1126/science.1101968
  73. Russ Holger A., Ravassard Philippe, Kerr-Conte Julie, Pattou Francois, Efrat Shimon, Epithelial-Mesenchymal Transition in Cells Expanded In Vitro from Lineage-Traced Adult Human Pancreatic Beta Cells, 10.1371/journal.pone.0006417
  74. Russ H. A., Bar Y., Ravassard P., Efrat S., In Vitro Proliferation of Cells Derived From Adult Human  -Cells Revealed By Cell-Lineage Tracing, 10.2337/db07-1283
  75. Chase L. G., Ulloa-Montoya F., Kidder B. L., Verfaillie C. M., Islet-Derived Fibroblast-Like Cells Are Not Derived via Epithelial-Mesenchymal Transition From Pdx-1 or Insulin-Positive Cells, 10.2337/db06-1165
  76. Atouf F., Park C. H., Pechhold K., Ta M., Choi Y., Lumelsky N. L., No Evidence for Mouse Pancreatic  -Cell Epithelial-Mesenchymal Transition In Vitro, 10.2337/db06-1446
  77. Weinberg N., Ouziel-Yahalom L., Knoller S., Efrat S., Dor Y., Lineage Tracing Evidence for In Vitro Dedifferentiation but Rare Proliferation of Mouse Pancreatic  -Cells, 10.2337/db06-1654
  78. Seaberg Raewyn M, Smukler Simon R, Kieffer Timothy J, Enikolopov Grigori, Asghar Zeenat, Wheeler Michael B, Korbutt Gregory, van der Kooy Derek, Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages, 10.1038/nbt1004
  79. Smukler Simon R., Arntfield Margot E., Razavi Rozita, Bikopoulos George, Karpowicz Phillip, Seaberg Raewyn, Dai Feihan, Lee Simon, Ahrens Rosemary, Fraser Paul E., Wheeler Michael B., van der Kooy Derek, The Adult Mouse and Human Pancreas Contain Rare Multipotent Stem Cells that Express Insulin, 10.1016/j.stem.2011.01.015
  80. Bonner-Weir S., Taneja M., Weir G. C., Tatarkiewicz K., Song K.-H., Sharma A., O'Neil J. J., In vitro cultivation of human islets from expanded ductal tissue, 10.1073/pnas.97.14.7999
  81. Gao R., Ustinov J., Pulkkinen M.-A., Lundin K., Korsgren O., Otonkoski T., Characterization of Endocrine Progenitor Cells and Critical Factors for Their Differentiation in Human Adult Pancreatic Cell Culture, 10.2337/diabetes.52.8.2007
  82. Hao Ergeng, Tyrberg Björn, Itkin-Ansari Pamela, Lakey Jonathan R T, Geron Ifat, Monosov Edward Z, Barcova Maria, Mercola Mark, Levine Fred, Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas, 10.1038/nm1367
  83. Yatoh S., Dodge R., Akashi T., Omer A., Sharma A., Weir G. C., Bonner-Weir S., Differentiation of Affinity-Purified Human Pancreatic Duct Cells to  -Cells, 10.2337/db06-1670
  84. Baertschiger Reto M., Bosco Domenico, Morel Philippe, Serre-Beinier Veronique, Berney Thierry, Buhler Leo H., Gonelle-Gispert Carmen, Mesenchymal Stem Cells Derived From Human Exocrine Pancreas Express Transcription Factors Implicated in Beta-Cell Development : , 10.1097/mpa.0b013e31815fcb1e
  85. Seeberger Karen L, Dufour Jannette M, Shapiro Andrew M James, Lakey Jonathan R T, Rajotte Ray V, Korbutt Gregory S, Expansion of mesenchymal stem cells from human pancreatic ductal epithelium, 10.1038/labinvest.3700377
  86. Bertelli, Am J Physiol, 273, C1641 (1997)
  87. Hesselson Daniel, Anderson Ryan M., Stainier Didier Y.R., Suppression of Ptf1a Activity Induces Acinar-to-Endocrine Conversion, 10.1016/j.cub.2011.03.041
  88. Desai Biva M., Oliver-Krasinski Jennifer, De Leon Diva D., Farzad Cyrus, Hong Nankang, Leach Steven D., Stoffers Doris A., Preexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regeneration, 10.1172/jci29988
  89. Zhou Qiao, Brown Juliana, Kanarek Andrew, Rajagopal Jayaraj, Melton Douglas A., In vivo reprogramming of adult pancreatic exocrine cells to β-cells, 10.1038/nature07314
  90. Collombat Patrick, Xu Xiaobo, Ravassard Philippe, Sosa-Pineda Beatriz, Dussaud Sébastien, Billestrup Nils, Madsen Ole D., Serup Palle, Heimberg Harry, Mansouri Ahmed, The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells, 10.1016/j.cell.2009.05.035
  91. Thorel Fabrizio, Népote Virginie, Avril Isabelle, Kohno Kenji, Desgraz Renaud, Chera Simona, Herrera Pedro L., Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss, 10.1038/nature08894
  92. Gianani Roberto, Beta cell regeneration in human pancreas, 10.1007/s00281-010-0235-7
  93. Fomina-Yadlin D., Kubicek S., Walpita D., Dancik V., Hecksher-Sorensen J., Bittker J. A., Sharifnia T., Shamji A., Clemons P. A., Wagner B. K., Schreiber S. L., Small-molecule inducers of insulin expression in pancreatic  -cells, 10.1073/pnas.1010018107
  94. Rezania A., Riedel M. J., Wideman R. D., Karanu F., Ao Z., Warnock G. L., Kieffer T. J., Production of Functional Glucagon-Secreting  -Cells From Human Embryonic Stem Cells, 10.2337/db10-0573
  95. Saisho Yoshifumi, Manesso Erica, Butler Alexandra E., Galasso Ryan, Kavanagh Kylie, Flynn Mickey, Zhang Li, Clark Paige, Gurlo Tatyana, Toffolo Gianna M., Cobelli Claudio, Wagner Janice D., Butler Peter C., Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes, 10.2337/db09-1368
  96. Ferber Sarah, Halkin Amir, Cohen Hofit, Ber Idit, Einav Yulia, Goldberg Iris, Barshack Iris, Seijffers Rhona, Kopolovic Juri, Kaiser Nurit, Karasik Avraham, 10.1038/75050
  97. Sapir T., Shternhall K., Meivar-Levy I., Blumenfeld T., Cohen H., Skutelsky E., Eventov-Friedman S., Barshack I., Goldberg I., Pri-Chen S., Ben-Dor L., Polak-Charcon S., Karasik A., Shimon I., Mor E., Ferber S., Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells, 10.1073/pnas.0405277102
  98. Kaneto H., Nakatani Y., Miyatsuka T., Matsuoka T.-a., Matsuhisa M., Hori M., Yamasaki Y., PDX-1/VP16 Fusion Protein, Together With NeuroD or Ngn3, Markedly Induces Insulin Gene Transcription and Ameliorates Glucose Tolerance, 10.2337/diabetes.54.4.1009
  99. Rowe Cliff, Goldring Christopher E. P., Kitteringham Neil R., Jenkins Rosalind E., Lane Brian S., Sanderson Christopher, Elliott Victoria, Platt Vivien, Metcalfe Peter, Park B. Kevin, Network Analysis of Primary Hepatocyte Dedifferentiation Using a Shotgun Proteomics Approach, 10.1021/pr1001687
  100. Marigliano Marco, Bertera Suzanne, Grupillo Maria, Trucco Massimo, Bottino Rita, Pig-to-Nonhuman Primates Pancreatic Islet Xenotransplantation: An Overview, 10.1007/s11892-011-0213-z
  101. Hering Bernhard J, Wijkstrom Martin, Graham Melanie L, Hårdstedt Maria, Aasheim Tor C, Jie Tun, Ansite Jeffrey D, Nakano Masahiko, Cheng Jane, Li Wei, Moran Kathleen, Christians Uwe, Finnegan Colleen, Mills Charles D, Sutherland David E, Bansal-Pakala Pratima, Murtaugh Michael P, Kirchhof Nicole, Schuurman Henk-Jan, Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates, 10.1038/nm1369
  102. Cardona K., Milas Z., Strobert E., Cano J., Jiang W., Safley S. A., Gangappa S., Hering B. J., Weber C. J., Pearson T. C., Larsen C. P., Engraftment of Adult Porcine Islet Xenografts in Diabetic Nonhuman Primates Through Targeting of Costimulation Pathways, 10.1111/j.1600-6143.2007.01933.x
  103. Sun Y, Ma X, Zhou D, Vacek I, Sun A M, Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression., 10.1172/jci118929
  104. Dufrane Denis, Goebbels Rose-Marie, Gianello Pierre, Alginate Macroencapsulation of Pig Islets Allows Correction of Streptozotocin-Induced Diabetes in Primates up to 6 Months Without Immunosuppression : , 10.1097/tp.0b013e3181f6e267
  105. Elliott R.B., Escobar L., Tan P.L.J., Garkavenko O., Calafiore R., Basta P., Vasconcellos A.V., Emerich D.F., Thanos C., Bambra C., Intraperitoneal Alginate-Encapsulated Neonatal Porcine Islets in a Placebo-Controlled Study With 16 Diabetic Cynomolgus Primates, 10.1016/j.transproceed.2005.09.038
  106. Elliott Robert B., Escobar Livia, Tan Paul L. J., Muzina Maria, Zwain Sahar, Buchanan Christina, Live encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation : Porcine islets 9.5 yr after implant, 10.1111/j.1399-3089.2007.00384.x
  107. Klymiuk, Mol Reprod Dev, 77, 209 (2010)
  108. Salem, Stem Cells, 28, 585 (2010)
  109. Chao Kuo Ching, Chao Kuo Fang, Fu Yu Show, Liu Shing Hwa, Islet-Like Clusters Derived from Mesenchymal Stem Cells in Wharton's Jelly of the Human Umbilical Cord for Transplantation to Control Type 1 Diabetes, 10.1371/journal.pone.0001451
  110. Hocking Anne M., Gibran Nicole S., Mesenchymal stem cells: Paracrine signaling and differentiation during cutaneous wound repair, 10.1016/j.yexcr.2010.05.009
  111. Lee Jae W., Fang Xiaohui, Krasnodembskaya Anna, Howard James P., Matthay Michael A., Concise Review: Mesenchymal Stem Cells for Acute Lung Injury: Role of Paracrine Soluble Factors, 10.1002/stem.643
  112. Bell, Stem Cells Dev (2011)
  113. Ezquer Fernando, Ezquer Marcelo, Simon Valeska, Conget Paulette, The Antidiabetic Effect of MSCs Is Not Impaired by Insulin Prophylaxis and Is Not Improved by a Second Dose of Cells, 10.1371/journal.pone.0016566
  114. Lee R. H., Seo M. J., Reger R. L., Spees J. L., Pulin A. A., Olson S. D., Prockop D. J., Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice, 10.1073/pnas.0608249103
  115. Ratajczak Mariusz Z., Liu Rui, Ratajczak Janina, Kucia Magda, Shin Dong-Myung, The role of pluripotent embryonic-like stem cells residing in adult tissues in regeneration and longevity, 10.1016/j.diff.2011.01.006
  116. Basta Giuseppe, Calafiore Riccardo, Immunoisolation of Pancreatic Islet Grafts with No Recipient’s Immunosuppression: Actual and Future Perspectives, 10.1007/s11892-011-0219-6
  117. Hernández Rosa Ma, Orive Gorka, Murua Ainhoa, Pedraz José Luis, Microcapsules and microcarriers for in situ cell delivery☆, 10.1016/j.addr.2010.02.004
  118. Calafiore R., Basta G., Luca G., Lemmi A., Montanucci M. P., Calabrese G., Racanicchi L., Mancuso F., Brunetti P., Microencapsulated Pancreatic Islet Allografts Into Nonimmunosuppressed Patients With Type 1 Diabetes: First two cases, 10.2337/diacare.29.01.06.dc05-1270
  119. Tuch B. E., Keogh G. W., Williams L. J., Wu W., Foster J. L., Vaithilingam V., Philips R., Safety and Viability of Microencapsulated Human Islets Transplanted Into Diabetic Humans, 10.2337/dc09-0744
  120. O'Sullivan Esther S., Vegas Arturo, Anderson Daniel G., Weir Gordon C., Islets Transplanted in Immunoisolation Devices: A Review of the Progress and the Challenges that Remain, 10.1210/er.2010-0026
  121. Fort Alexander, Fort Nicholas, Ricordi Camillo, Stabler Cherie L., Biohybrid Devices and Encapsulation Technologies for Engineering a Bioartificial Pancreas, 10.3727/096368908786991498
  122. Toso Christian, Mathe Zolta., Morel Philipp., Oberholzer José, Bosco Domenico, Sainz-Vidal Dianelys, Hunkeler David, Buhler Le. H., Wandrey Christine, Berney Thierry, Effect of Microcapsule Composition and Short-Term Immunosuppression on Intraportal Biocompatibility, 10.3727/000000005783983223
  123. Lee Dong Yun, Park Sang Jin, Nam Jong Hee, Byun Youngro, A combination therapy of PEGylation and immunosuppressive agent for successful islet transplantation, 10.1016/j.jconrel.2005.10.023
  124. Lee Dong Yun, Park Sang Jin, Lee Seulki, Nam Jong Hee, Byun Youngro, Highly Poly(Ethylene) Glycolylated Islets Improve Long-Term Islet Allograft Survival without Immunosuppressive Medication, 10.1089/ten.2006.0009
  125. Moya Monica L., Garfinkel Marc R., Liu Xiang, Lucas Stephanie, Opara Emmanuel C., Greisler Howard P., Brey Eric M., Fibroblast Growth Factor-1 (FGF-1) Loaded Microbeads Enhance Local Capillary Neovascularization, 10.1016/j.jss.2009.06.003
  126. Tibell, Cell Transplant, 10, 591 (2001)
  127. Rafael E., Wu G. S., Hultenby K., Tibell A., Wernerson A., Improved Survival of Macroencapsulated Islets of Langerhans by Preimplantation of the Immunoisolating Device: A Morphometric Study, 10.3727/000000003108746957
  128. Lee Seung-Hee, Hao Ergeng, Savinov Alexei Y., Geron Ifat, Strongin Alex Y., Itkin-Ansari Pamela, Human β-cell Precursors Mature Into Functional Insulin-producing Cells in an Immunoisolation Device: Implications for Diabetes Cell Therapies : , 10.1097/tp.0b013e31819c86ea
  129. Waldron-Lynch Frank, Herold Kevan C., Immunomodulatory therapy to preserve pancreatic β-cell function in type 1 diabetes, 10.1038/nrd3402
  130. Sherry Nicole, Hagopian William, Ludvigsson Johnny, Jain Sunil M, Wahlen Jack, Ferry Robert J, Bode Bruce, Aronoff Stephen, Holland Christopher, Carlin David, King Karen L, Wilder Ronald L, Pillemer Stanley, Bonvini Ezio, Johnson Syd, Stein Kathryn E, Koenig Scott, Herold Kevan C, Daifotis Anastasia G, Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial, 10.1016/s0140-6736(11)60931-8
  132. Shapiro A. M. James, State of the Art of Clinical Islet Transplantation and Novel Protocols of Immunosuppression, 10.1007/s11892-011-0217-8
  133. Posselt Andrew M., Szot Gregory L., Frassetto Lynda A., Masharani Umesh, Tavakol Mehdi, Amin Raj, McElroy Joan, Ramos Marissa D., Kerlan Robert K., Fong Lawrence, Vincenti Flavio, Bluestone Jeffrey A., Stock Peter G., Islet Transplantation in Type 1 Diabetic Patients Using Calcineurin Inhibitor-Free Immunosuppressive Protocols Based on T-Cell Adhesion or Costimulation Blockade : , 10.1097/tp.0b013e3181fe1377
  134. Abdi R., Fiorina P., Adra C. N., Atkinson M., Sayegh M. H., Immunomodulation by Mesenchymal Stem Cells: A Potential Therapeutic Strategy for Type 1 Diabetes, 10.2337/db08-0180
  135. Jurewicz M., Yang S., Augello A., Godwin J. G., Moore R. F., Azzi J., Fiorina P., Atkinson M., Sayegh M. H., Abdi R., Congenic Mesenchymal Stem Cell Therapy Reverses Hyperglycemia in Experimental Type 1 Diabetes, 10.2337/db10-0542
  136. Madec A. M., Mallone R., Afonso G., Abou Mrad E., Mesnier A., Eljaafari A., Thivolet C., Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells, 10.1007/s00125-009-1374-z
  137. Couri Carlos E. B., C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus, 10.1001/jama.2009.470
  138. Ballinger, Surgery, 72, 175 (1972)
  139. Duvivier-Kali V. F., Omer A., Parent R. J., O'Neil J. J., Weir G. C., Complete Protection of Islets Against Allorejection and Autoimmunity by a Simple Barium-Alginate Membrane, 10.2337/diabetes.50.8.1698
  140. Bennet W., Sundberg B., Groth C. G., Brendel M. D., Brandhorst D., Brandhorst H., Bretzel R. G., Elgue G., Larsson R., Nilsson B., Korsgren O., Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation?, 10.2337/diabetes.48.10.1907
  141. Dufrane Denis, Goebbels Rose-Marie, Saliez Alain, Guiot Yves, Gianello Pierre, Six-Month Survival of Microencapsulated Pig Islets and Alginate Biocompatibility in Primates: Proof of Concept : , 10.1097/
  142. Kobayashi Tsunehiro, Aomatsu Yukio, Iwata Hiroo, Kin Tatsuya, Kanehiro Hiromichi, Hisanga Michiyoshi, Ko Saiho, Nagao Mitsuo, Harb George, Nakajima Yoshiyuki, Survival of Microencapsulated Islets at 400 Days Posttransplantation in the Omental Pouch of NOD Mice, 10.3727/000000006783981954
  143. Guan J., Behme M. T., Zucker P., Atkison P., Hramiak I., Zhong R., Dupre J., Glucose turnover and insulin sensitivity in rats with pancreatic islet transplants, 10.2337/diabetes.47.7.1020
  144. Echeverri G. J., McGrath K., Bottino R., Hara H., Dons E. M., van der Windt D. J., Ekser B., Casu A., Houser S., Ezzelarab M., Wagner R., Trucco M., Lakkis F. G., Cooper D. K. C., Endoscopic Gastric Submucosal Transplantation of Islets (ENDO-STI): Technique and Initial Results in Diabetic Pigs, 10.1111/j.1600-6143.2009.02815.x
  145. Wang Wenjing, Gu Yuanjun, Tabata Yasuhiko, Miyamoto Masaaki, Hori Hiroshi, Nagata Natsuki, Touma Maki, Balamurugan A. N., Kawakami Yoshiyuki, Nozawa Masumi, Inoue Kazutomo, REVERSAL OF DIABETES IN MICE BY XENOTRANSPLANTATION OF A BIOARTIFICIAL PANCREAS IN A PREVASCULARIZED SUBCUTANEOUS SITE1 : , 10.1097/00007890-200201150-00023
  146. Lau J., Mattsson G., Carlsson C., Nyqvist D., Kohler M., Berggren P.-O., Jansson L., Carlsson P.-O., Implantation Site-Dependent Dysfunction of Transplanted Pancreatic Islets, 10.2337/db06-1258
  147. Prockop D. J., Olson S. D., Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions, 10.1182/blood-2006-03-013433
  148. Gholamrezanezhad Ali, Mirpour Sahar, Bagheri Mohammad, Mohamadnejad Mehdi, Alimoghaddam Kamran, Abdolahzadeh Leila, Saghari Mohsen, Malekzadeh Reza, In vivo tracking of 111In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis, 10.1016/j.nucmedbio.2011.03.008
  149. Cai, Am J Nucl Med Mol Imaging, 1, 18 (2011)
  150. Naujok Ortwin, Burns Chris, Jones Peter M, Lenzen Sigurd, Insulin-producing Surrogate β-cells From Embryonic Stem Cells: Are We There Yet?, 10.1038/mt.2011.165