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Paraneoplastic antigen Ma2 autoantibodies as specific blood biomarkers for detection of early recurrence of small intestine neuroendocrine tumors.

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Cui, Tao Hurtig, Monica Elgue, Graciela Li, Su-Chen Veronesi, Giulia Essaghir, Ahmed [UCL] Demoulin, Jean-Baptiste [UCL] Giandomenico, Valeria

Small intestine neuroendocrine tumors (SI-NETs) belong to a rare group of cancers. Most patients have developed metastatic disease at the time of diagnosis, for which there is currently no cure. The delay in diagnosis is a major issue in the clinical management of the patients and new markers are urgently needed. We have previously identified paraneoplastic antigen Ma2 (PNMA2) as a novel SI-NET tissue biomarker. Therefore, we evaluated whether Ma2 autoantibodies detection in the blood stream is useful for the clinical diagnosis and recurrence of SI-NETs.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2010
Language Anglais
Journal information "PLoS One" - Vol. 5, no.12, p. e16010 (2010)
Peer reviewed yes
Publisher Public Library of Science
issn 1932-6203
e-issn 1932-6203
Publication status Publié
Affiliations UCL - SSS/DDUV - Institut de Duve
University of Uppsala - Department of Medical Sciences
MESH Subject Adult ; Immunoprecipitation ; Intestinal Neoplasms ; Intestine, Small ; Lung Neoplasms ; Male ; Middle Aged ; Nerve Tissue Proteins ; Neuroendocrine Tumors ; Recurrence ; Sensitivity and Specificity ; Aged ; Small Cell Lung Carcinoma ; Tumor Markers, Biological ; Antigens, Neoplasm ; Autoantibodies ; Chromogranin A ; Disease-Free Survival ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans
Links
  1. Öberg Kjell, Genetics and molecular pathology of neuroendocrine gastrointestinal and pancreatic tumors (gastroenteropancreatic neuroendocrine tumors) : , 10.1097/med.0b013e328320d845
  2. Modlin Irvin M, Oberg Kjell, Chung Daniel C, Jensen Robert T, de Herder Wouter W, Thakker Rajesh V, Caplin Martyn, Delle Fave Gianfranco, Kaltsas Greg A, Krenning Eric P, Moss Steven F, Nilsson Ola, Rindi Guido, Salazar Ramon, Ruszniewski Philippe, Sundin Anders, Gastroenteropancreatic neuroendocrine tumours, 10.1016/s1470-2045(07)70410-2
  3. Klimstra David S., Modlin Irvin R., Adsay N. Volkan, Chetty Runjan, Deshpande Vikram, Gönen Mithat, Jensen Robert T., Kidd Mark, Kulke Matthew H., Lloyd Ricardo V., Moran Cesar, Moss Steven F., Oberg Kjell, OʼToole Dermot, Rindi Guido, Robert Marie E., Suster Saul, Tang Laura H., Tzen Chin-Yuan, Washington Mary Kay, Wiedenmann Betram, Yao James, Pathology Reporting of Neuroendocrine Tumors: Application of the Delphic Consensus Process to the Development of a Minimum Pathology Data Set : , 10.1097/pas.0b013e3181ce1447
  4. KLÖPPEL GÜNTER, PERREN AUREL, HEITZ PHILIPP U., The Gastroenteropancreatic Neuroendocrine Cell System and Its Tumors: The WHO Classification, 10.1196/annals.1294.002
  5. Creutzfeldt Werner, Carcinoid Tumors: Development of Our Knowledge, 10.1007/s002689900020
  6. Modlin Irvin M., Gustafsson Bjorn I., Moss Steven F., Pavel Marianne, Tsolakis Apostolos V., Kidd Mark, Chromogranin A—Biological Function and Clinical Utility in Neuro Endocrine Tumor Disease, 10.1245/s10434-010-1006-3
  7. Moran Cesar A., Suster Saul, Coppola Domenico, Wick Mark R., Neuroendocrine Carcinomas of the Lung: A Critical Analysis, 10.1309/ajcp9h1otmucskqw
  8. K Tsuta (2010)
  9. Yao James C., Hassan Manal, Phan Alexandria, Dagohoy Cecile, Leary Colleen, Mares Jeannette E., Abdalla Eddie K., Fleming Jason B., Vauthey Jean-Nicolas, Rashid Asif, Evans Douglas B., One Hundred Years After “Carcinoid”: Epidemiology of and Prognostic Factors for Neuroendocrine Tumors in 35,825 Cases in the United States, 10.1200/jco.2007.15.4377
  10. Eriksson Barbro, Klöppel Günter, Krenning Eric, Ahlman Hakan, Plöckinger Ursula, Wiedenmann Bertram, Arnold Rudolf, Auernhammer Christoph, Körner Meike, Rindi Guido, Wildi Stefan, Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Tumors – Well-Differentiated Jejunal-Ileal Tumor/Carcinoma, 10.1159/000111034
  11. Modlin Irvin M., Moss Steven F., Chung Daniel C., Jensen Robert T., Snyderwine Elizabeth, Priorities for Improving the Management of Gastroenteropancreatic Neuroendocrine Tumors, 10.1093/jnci/djn275
  12. Welin Staffan, Stridsberg Mats, Cunningham Janet, Granberg Dan, Skogseid Britt, Eriksson Barbro, Janson Eva T., Elevated Plasma Chromogranin A Is the First Indication of Recurrence in Radically Operated Midgut Carcinoid Tumors, 10.1159/000179900
  13. Leja Justyna, Essaghir Ahmed, Essand Magnus, Wester Kenneth, öberg Kjell, Tötterman Thomas H, Lloyd Ricardo, Vasmatzis George, Demoulin Jean-Baptiste, Giandomenico Valeria, Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas, 10.1038/modpathol.2008.174
  14. Schüller Martina, Jenne Dieter, Voltz Raymond, The human PNMA family: Novel neuronal proteins implicated in paraneoplastic neurological disease, 10.1016/j.jneuroim.2005.08.019
  15. Kaltsas G., Androulakis I. I., de Herder W. W., Grossman A. B., Paraneoplastic syndromes secondary to neuroendocrine tumours, 10.1677/erc-10-0024
  16. Gozzard P., Maddison P., Which antibody and which cancer in which paraneoplastic syndromes?, 10.1136/jnnp.2010.224105
  17. Lleo Ana, Invernizzi Pietro, Gao Bin, Podda Mauro, Gershwin M. Eric, Definition of human autoimmunity — autoantibodies versus autoimmune disease, 10.1016/j.autrev.2009.12.002
  18. Tan Kuan Onn, Tan Karen Mei Ling, Chan Shing-Leng, Yee Karen S. Y., Bévort Maja, Ang Khay Chun, Yu Victor C., MAP-1, a Novel Proapoptotic Protein Containing a BH3-like Motif That Associates with Bax through Its Bcl-2 Homology Domains, 10.1074/jbc.m008955200
  19. Behr Rüdiger, Sackett Sara D., Bochkis Irina M., Le Phillip Phuc, Kaestner Klaus H., Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3, 10.1016/j.ydbio.2007.03.525
  20. Voltz Raymond, Gultekin S. Humayun, Rosenfeld Myrna R., Gerstner Elizabeth, Eichen Joseph, Posner Jerome B., Dalmau Josep, A Serologic Marker of Paraneoplastic Limbic and Brain-Stem Encephalitis in Patients with Testicular Cancer, 10.1056/nejm199906103402303
  21. Eichmuller S., Bazhin A., Onconeural Versus Paraneoplastic Antigens?, 10.2174/092986707782023668
  22. Stich Oliver, Jarius Sven, Kleer Barbara, Rasiah Christiane, Voltz Raymond, Rauer Sebastian, Specific antibody index in cerebrospinal fluid from patients with central and peripheral paraneoplastic neurological syndromes, 10.1016/j.jneuroim.2006.11.008
  23. Monstad Sissel Evy, Knudsen Anette, Salvesen Helga B., Aarseth Jan H., Vedeler Christian A., Onconeural antibodies in sera from patients with various types of tumours, 10.1007/s00262-009-0690-y
  24. Hoffmann L A, Jarius S, Pellkofer H L, Schueller M, Krumbholz M, Koenig F, Johannis W, la Fougere C, Newman T, Vincent A, Voltz R, Anti-Ma and anti-Ta associated paraneoplastic neurological syndromes: 22 newly diagnosed patients and review of previous cases, 10.1136/jnnp.2007.118588
  25. Tschernatsch M., Dierkes C., Gerriets T., Hosch J., Stolz E., Kaps M., Krasenbrink I., Claus D., Blaes F., Paraneoplastic neurological syndromes in patients with carcinoid, 10.1111/j.1468-1331.2008.02328.x
  26. Drozdov Ignat, Kidd Mark, Nadler Boaz, Camp Robert L., Mane Shrikant M., Hauso Oyvind, Gustafsson Bjorn I., Modlin Irvin M., Predicting neuroendocrine tumor (carcinoid) neoplasia using gene expression profiling and supervised machine learning, 10.1002/cncr.24180
  27. F Graus, J Clin Oncol, 15, 2866 (1997)
  28. Pujol Jean-Louis, Godard Anne-Laure, Jacot William, Labauge Pierre, Spontaneous Complete Remission of a Non-small Cell Lung Cancer Associated with Anti-Hu Antibody Syndrome, 10.1097/jto.0b013e31802f1c9d
  29. Honnorat J, Cartalat-Carel S, Ricard D, Camdessanche J P., Carpentier A F, Rogemond V, Chapuis F, Aguera M, Decullier E, Duchemin A M, Graus F, Antoine J C, Onco-neural antibodies and tumour type determine survival and neurological symptoms in paraneoplastic neurological syndromes with Hu or CV2/CRMP5 antibodies, 10.1136/jnnp.2007.138016
  30. Syrigos Konstantinos N., Konstantoulakis Manousos M., Fyssas Ioannis, Katsilambros Nikolaos, Golematis Basilios C., Autoantibodies against insulin and β-islet cells in pancreatic adenocarcinoma: A possible explanation for diabetes mellitus, 10.1002/(sici)1097-0215(19960529)66:5<624::aid-ijc7>3.0.co;2-v
  31. Jiang Beihai, Ren Tingting, Dong Bin, Qu Like, Jin Genglin, Li Jianning, Qu Hong, Meng Lin, Liu Caiyun, Wu Jian, Shou Chengchao, Peptide Mimic Isolated by Autoantibody Reveals Human Arrest Defective 1 Overexpression Is Associated with Poor Prognosis for Colon Cancer Patients, 10.2353/ajpath.2010.091178
  32. Dong Jun, Zeng Bo-hang, Xu Li-hua, Wang Jun-ye, Li Man-zhi, Zeng Mu-sheng, Liu Wan-li, Anti-CDC25B autoantibody predicts poor prognosis in patients with advanced esophageal squamous cell carcinoma, 10.1186/1479-5876-8-81
  33. Lenth R. V., Statistical power calculations, 10.2527/jas.2006-449
  34. Rosner B., Grove D., Use of the Mann-WhitneyU-test for clustered data, 10.1002/(sici)1097-0258(19990615)18:11<1387::aid-sim126>3.0.co;2-v
  35. Soreide K., Receiver-operating characteristic curve analysis in diagnostic, prognostic and predictive biomarker research, 10.1136/jcp.2008.061010
  36. Ludbrook John, Royse Alistair G., ANALYSING CLINICAL STUDIES: PRINCIPLES, PRACTICE AND PITFALLS OF KAPLAN–MEIER PLOTS, 10.1111/j.1445-2197.2007.04405.x
  37. van Dijk Paul C., Jager Kitty J., Zwinderman Aeilko H., Zoccali Carmine, Dekker Friedo W., The analysis of survival data in nephrology: basic concepts and methods of Cox regression, 10.1038/ki.2008.294
Bibliographic reference Cui, Tao ; Hurtig, Monica ; Elgue, Graciela ; Li, Su-Chen ; Veronesi, Giulia ; et. al. Paraneoplastic antigen Ma2 autoantibodies as specific blood biomarkers for detection of early recurrence of small intestine neuroendocrine tumors.. In: PLoS One, Vol. 5, no.12, p. e16010 (2010)
Permanent URL http://hdl.handle.net/2078.1/145461