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Gut microbiota and GLP-1

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Everard, Amandine [UCL] Cani, Patrice D. [UCL]

A large body of evidence suggests that the regulation of energy balance and glucose homeostasis by fermentable carbohydrates induces specific changes in the gut microbiota. Among the mechanisms, our research group and others have demonstrated that the gut microbiota fermentation (i.e., bacterial digestion of specific compounds) of specific prebiotics or other non-digestible carbohydrates is associated with the secretion of enteroendocrine peptides, such as the glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), produced by L-cells. In this review, we highlight past and recent results describing how dietary manipulation of the gut microbiota, using nutrients or specific microbes, can stimulate GLP-1 secretion in rodents and humans. Furthermore, the purpose of this review is to discuss the putative mechanisms by which specific bacterial metabolites, such as short chain fatty acids, trigger GLP-1 secretion through GPR41/43-dependent mechanisms. Moreover, we conclude by discussing the molecular advance showing that the endocannabinoid system or related bioactive lipids modulated by the gut microbiota may contribute to the regulation of glucose, lipid and energy homeostasis.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès restreint
Publication date 2014
Language Anglais
Journal information "Reviews in Endocrine & Metabolic Disorders" - Vol. 15, no. 3, p. 189-196 (2014)
Peer reviewed yes
Publisher Springer New York LLC ((United States) New York, NY)
issn 1389-9155
e-issn 1573-2606
Publication status Publié
Affiliation UCL - SSS/LDRI - Louvain Drug Research Institute
Links
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Bibliographic reference Everard, Amandine ; Cani, Patrice D.. Gut microbiota and GLP-1. In: Reviews in Endocrine & Metabolic Disorders, Vol. 15, no. 3, p. 189-196 (2014)
Permanent URL http://hdl.handle.net/2078.1/142887