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Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages.

Bibliographic reference Paget, Christophe ; Ivanov, Stoyan ; Fontaine, Josette ; Renneson, Joelle ; Blanc, Fany ; et. al. Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages.. In: The Journal of biological chemistry, Vol. 287, no. 12, p. 8816-29 (2012)
Permanent URL http://hdl.handle.net/2078.1/141126
  1. Skold M., Behar S. M., Role of CD1d-Restricted NKT Cells in Microbial Immunity, 10.1128/iai.71.10.5447-5455.2003
  2. Bendelac Albert, Savage Paul B., Teyton Luc, The Biology of NKT Cells, 10.1146/annurev.immunol.25.022106.141711
  3. Tessmer Marlowe S, Fatima Ayesha, Paget Christophe, Trottein Francois, Brossay Laurent, NKT cell immune responses to viral infection, 10.1517/14712590802653601
  4. Ashkar A. A., Rosenthal K. L., Interleukin-15 and Natural Killer and NKT Cells Play a Critical Role in Innate Protection against Genital Herpes Simplex Virus Type 2 Infection, 10.1128/jvi.77.18.10168-10171.2003
  5. Diana Julien, Griseri Thibault, Lagaye Sylvie, Beaudoin Lucie, Autrusseau Elodie, Gautron Anne-Sophie, Tomkiewicz Céline, Herbelin André, Barouki Robert, von Herrath Matthias, Dalod Marc, Lehuen Agnès, NKT Cell-Plasmacytoid Dendritic Cell Cooperation via OX40 Controls Viral Infection in a Tissue-Specific Manner, 10.1016/j.immuni.2008.12.017
  6. Exley Mark A., Bigley Nancy J., Cheng Olivia, Shaulov Angela, Tahir Syed Muhammad Ali, Carter Quincy L., Garcia Jorge, Wang Carren, Patten Kurt, Stills Harold F., Alt Frederick W., Snapper Scott B., Balk Steven P., Innate immune response to encephalomyocarditis virus infection mediated by CD1d, 10.1111/j.1365-2567.2003.01779.x
  7. Grubor-Bauk B., Arthur J. L., Mayrhofer G., Importance of NKT Cells in Resistance to Herpes Simplex Virus, Fate of Virus-Infected Neurons, and Level of Latency in Mice, 10.1128/jvi.00205-08
  8. Grubor-Bauk B., Simmons A., Mayrhofer G., Speck P. G., Impaired Clearance of Herpes Simplex Virus Type 1 From Mice Lacking CD1d or NKT Cells Expressing the Semivariant V 14-J 281 TCR, 10.4049/jimmunol.170.3.1430
  9. Ilyinskii P. O., Wang R., Balk S. P., Exley M. A., CD1d Mediates T-Cell-Dependent Resistance to Secondary Infection with Encephalomyocarditis Virus (EMCV) In Vitro and Immune Response to EMCV Infection In Vivo, 10.1128/jvi.02745-05
  10. Johnson T. R., Hong S., Van Kaer L., Koezuka Y., Graham B. S., NK T Cells Contribute to Expansion of CD8+ T Cells and Amplification of Antiviral Immune Responses to Respiratory Syncytial Virus, 10.1128/jvi.76.9.4294-4303.2002
  11. Kim Edy Y, Battaile John T, Patel Anand C, You Yingjian, Agapov Eugene, Grayson Mitchell H, Benoit Loralyn A, Byers Derek E, Alevy Yael, Tucker Jennifer, Swanson Suzanne, Tidwell Rose, Tyner Jeffrey W, Morton Jeffrey D, Castro Mario, Polineni Deepika, Patterson G Alexander, Schwendener Reto A, Allard John D, Peltz Gary, Holtzman Michael J, Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease, 10.1038/nm1770
  12. Stout-Delgado Heather W., Du Wei, Shirali Anushree C., Booth Carmen J., Goldstein Daniel R., Aging Promotes Neutrophil-Induced Mortality by Augmenting IL-17 Production during Viral Infection, 10.1016/j.chom.2009.09.011
  13. Kronenberg Mitchell, TOWARD AN UNDERSTANDING OF NKT CELL BIOLOGY: Progress and Paradoxes, 10.1146/annurev.immunol.23.021704.115742
  14. Renneson Joelle, Guabiraba Rodrigo, Maillet Isabelle, Marques Rafael E., Ivanov Stoyan, Fontaine Josette, Paget Christophe, Quesniaux Valérie, Faveeuw Christelle, Ryffel Bernhard, Teixeira Mauro M., Trottein François, A Detrimental Role for Invariant Natural Killer T Cells in the Pathogenesis of Experimental Dengue Virus Infection, 10.1016/j.ajpath.2011.06.023
  15. De Santo Carmela, Salio Mariolina, Masri S. Hajar, Lee Laurel Yong-Hwa, Dong Tao, Speak Anneliese O., Porubsky Stefan, Booth Sarah, Veerapen Natacha, Besra Gurdyal S., Gröne Hermann-Josef, Platt Frances M., Zambon Maria, Cerundolo Vincenzo, Invariant NKT cells reduce the immunosuppressive activity of influenza A virus–induced myeloid-derived suppressor cells in mice and humans, 10.1172/jci36264
  16. Kok W. L., Denney L., Benam K., Cole S., Clelland C., McMichael A. J., Ho L.-P., Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection, 10.1189/jlb.0411184
  17. Paget C., Ivanov S., Fontaine J., Blanc F., Pichavant M., Renneson J., Bialecki E., Pothlichet J., Vendeville C., Barba-Speath G., Huerre M.-R., Faveeuw C., Si-Tahar M., Trottein F., Potential Role of Invariant NKT Cells in the Control of Pulmonary Inflammation and CD8+ T Cell Response during Acute Influenza A Virus H3N2 Pneumonia, 10.4049/jimmunol.1002348
  18. Guillot Loïc, Le Goffic Ronan, Bloch Sarah, Escriou Nicolas, Akira Shizuo, Chignard Michel, Si-Tahar Mustapha, Involvement of Toll-like Receptor 3 in the Immune Response of Lung Epithelial Cells to Double-stranded RNA and Influenza A Virus, 10.1074/jbc.m410592200
  19. Mendiratta Sanjeev K, Martin W.David, Hong Seokmann, Boesteanu Alina, Joyce Sebastian, Van Kaer Luc, CD1d1 Mutant Mice Are Deficient in Natural T Cells That PromptlyProduce IL-4, 10.1016/s1074-7613(00)80290-3
  20. Adachi Osamu, Kawai Taro, Takeda Kiyoshi, Matsumoto Makoto, Tsutsui Hiroko, Sakagami Masafumi, Nakanishi Kenji, Akira Shizuo, Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function, 10.1016/s1074-7613(00)80596-8
  21. Hemmi Hiroaki, Kaisho Tsuneyasu, Takeuchi Osamu, Sato Shintaro, Sanjo Hideki, Hoshino Katsuaki, Horiuchi Takao, Tomizawa Hideyuki, Takeda Kiyoshi, Akira Shizuo, Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway, 10.1038/ni758
  22. Kato Hiroki, Takeuchi Osamu, Sato Shintaro, Yoneyama Mitsutoshi, Yamamoto Masahiro, Matsui Kosuke, Uematsu Satoshi, Jung Andreas, Kawai Taro, Ishii Ken J., Yamaguchi Osamu, Otsu Kinya, Tsujimura Tohru, Koh Chang-Sung, Reis e Sousa Caetano, Matsuura Yoshiharu, Fujita Takashi, Akira Shizuo, Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses, 10.1038/nature04734
  23. Kobayashi K. S., Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract, 10.1126/science.1104911
  24. Godfrey Dale I., Kronenberg Mitchell, Going both ways: Immune regulation via CD1d-dependent NKT cells, 10.1172/jci200423594
  25. Kumar Himanshu, Kawai Taro, Kato Hiroki, Sato Shintaro, Takahashi Ken, Coban Cevayir, Yamamoto Masahiro, Uematsu Satoshi, Ishii Ken J., Takeuchi Osamu, Akira Shizuo, Essential role of IPS-1 in innate immune responses against RNA viruses, 10.1084/jem.20060792
  26. Martinon Fabio, Pétrilli Virginie, Mayor Annick, Tardivel Aubry, Tschopp Jürg, Gout-associated uric acid crystals activate the NALP3 inflammasome, 10.1038/nature04516
  27. Kreymborg K., Etzensperger R., Dumoutier L., Haak S., Rebollo A., Buch T., Heppner F. L., Renauld J.-C., Becher B., IL-22 Is Expressed by Th17 Cells in an IL-23-Dependent Fashion, but Not Required for the Development of Autoimmune Encephalomyelitis, 10.4049/jimmunol.179.12.8098
  28. Paget Christophe, Mallevaey Thierry, Speak Anneliese O., Torres David, Fontaine Josette, Sheehan Kathleen C.F., Capron Monique, Ryffel Bernhard, Faveeuw Christelle, Leite de Moraes Maria, Platt Frances, Trottein François, Activation of Invariant NKT Cells by Toll-like Receptor 9-Stimulated Dendritic Cells Requires Type I Interferon and Charged Glycosphingolipids, 10.1016/j.immuni.2007.08.017
  29. Ishikawa Hiroki, Tanaka Kazuo, Kutsukake Etsuko, Fukui Toshie, Sasaki Hiraku, Hata Akihiro, Noda Satoshi, Matsumoto Tetsuya, IFN-γ production downstream of NKT cell activation in mice infected with influenza virus enhances the cytolytic activities of both NK cells and viral antigen-specific CD8+ T cells, 10.1016/j.virol.2010.08.030
  30. Kolls Jay K., Khader Shabaana A., The role of Th17 cytokines in primary mucosal immunity, 10.1016/j.cytogfr.2010.11.002
  31. Ouyang Wenjun, Kolls Jay K., Zheng Yan, The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation, 10.1016/j.immuni.2008.03.004
  32. Eyerich Stefanie, Eyerich Kilian, Cavani Andrea, Schmidt-Weber Carsten, IL-17 and IL-22: siblings, not twins, 10.1016/j.it.2010.06.004
  33. Sonnenberg Gregory F, Fouser Lynette A, Artis David, Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22, 10.1038/ni.2025
  34. Vivier Eric, Spits Hergen, Cupedo Tom, Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?, 10.1038/nri2522
  35. Van Kaer Luc, Joyce Sebastian, Innate Immunity: NKT Cells in the Spotlight, 10.1016/j.cub.2005.05.032
  36. Wolk Kerstin, Kunz Stefanie, Witte Ellen, Friedrich Markus, Asadullah Khusru, Sabat Robert, IL-22 Increases the Innate Immunity of Tissues, 10.1016/j.immuni.2004.07.007
  37. Zenewicz Lauren A., Flavell Richard A., IL-22 and inflammation: Leukin' through a glass onion, 10.1002/eji.200838655
  38. Pickert Geethanjali, Neufert Clemens, Leppkes Moritz, Zheng Yan, Wittkopf Nadine, Warntjen Moritz, Lehr Hans-Anton, Hirth Sebastian, Weigmann Benno, Wirtz Stefan, Ouyang Wenjun, Neurath Markus F., Becker Christoph, STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing, 10.1084/jem.20082683
  39. Zheng Yan, Valdez Patricia A, Danilenko Dimitry M, Hu Yan, Sa Susan M, Gong Qian, Abbas Alexander R, Modrusan Zora, Ghilardi Nico, de Sauvage Frederic J, Ouyang Wenjun, Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens, 10.1038/nm1720
  40. Coquet J. M., Chakravarti S., Kyparissoudis K., McNab F. W., Pitt L. A., McKenzie B. S., Berzins S. P., Smyth M. J., Godfrey D. I., Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population, 10.1073/pnas.0801631105
  41. Doisne J.-M., Becourt C., Amniai L., Duarte N., Le Luduec J.-B., Eberl G., Benlagha K., Skin and Peripheral Lymph Node Invariant NKT Cells Are Mainly Retinoic Acid Receptor-Related Orphan Receptor  t+ and Respond Preferentially under Inflammatory Conditions, 10.4049/jimmunol.0901059
  42. Doisne J.-M., Soulard V., Becourt C., Amniai L., Henrot P., Havenar-Daughton C., Blanchet C., Zitvogel L., Ryffel B., Cavaillon J.-M., Marie J. C., Couillin I., Benlagha K., Cutting Edge: Crucial Role of IL-1 and IL-23 in the Innate IL-17 Response of Peripheral Lymph Node NK1.1- Invariant NKT Cells to Bacteria, 10.4049/jimmunol.1002725
  43. Michel Marie-Laure, Keller Alexandre Castro, Paget Christophe, Fujio Masakazu, Trottein François, Savage Paul B., Wong Chi-Huey, Schneider Elke, Dy Michel, Leite-de-Moraes Maria C., Identification of an IL-17–producing NK1.1negiNKT cell population involved in airway neutrophilia, 10.1084/jem.20061551
  44. Rachitskaya A. V., Hansen A. M., Horai R., Li Z., Villasmil R., Luger D., Nussenblatt R. B., Caspi R. R., Cutting Edge: NKT Cells Constitutively Express IL-23 Receptor and ROR t and Rapidly Produce IL-17 upon Receptor Ligation in an IL-6-Independent Fashion, 10.4049/jimmunol.180.8.5167
  45. Kawano T., CD1d-Restricted and TCR-Mediated Activation of V14 NKT Cells by Glycosylceramides, 10.1126/science.278.5343.1626
  46. Brigl Manfred, Bry Lynn, Kent Sally C, Gumperz Jenny E, Brenner Michael B, Mechanism of CD1d-restricted natural killer T cell activation during microbial infection, 10.1038/ni1002
  47. Mattner Jochen, DeBord Kristin L., Ismail Nahed, Goff Randal D., Cantu Carlos, Zhou Dapeng, Saint-Mezard Pierre, Wang Vivien, Gao Ying, Yin Ning, Hoebe Kasper, Schneewind Olaf, Walker David, Beutler Bruce, Teyton Luc, Savage Paul B., Bendelac Albert, Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections, 10.1038/nature03408
  48. Nagarajan N. A., Kronenberg M., Invariant NKT Cells Amplify the Innate Immune Response to Lipopolysaccharide, 10.4049/jimmunol.178.5.2706
  49. Salio M., Speak A. O., Shepherd D., Polzella P., Illarionov P. A., Veerapen N., Besra G. S., Platt F. M., Cerundolo V., Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation, 10.1073/pnas.0710145104
  50. Tyznik A. J., Tupin E., Nagarajan N. A., Her M. J., Benedict C. A., Kronenberg M., Cutting Edge: The Mechanism of Invariant NKT Cell Responses to Viral Danger Signals, 10.4049/jimmunol.181.7.4452
  51. Allen Irving C., Scull Margaret A., Moore Chris B., Holl Eda K., McElvania-TeKippe Erin, Taxman Debra J., Guthrie Elizabeth H., Pickles Raymond J., Ting Jenny P.-Y., The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA, 10.1016/j.immuni.2009.02.005
  52. Diebold S. S., Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA, 10.1126/science.1093616
  53. Hornung V., Ellegast J., Kim S., Brzozka K., Jung A., Kato H., Poeck H., Akira S., Conzelmann K.-K., Schlee M., Endres S., Hartmann G., 5'-Triphosphate RNA Is the Ligand for RIG-I, 10.1126/science.1132505
  54. Ichinohe Takeshi, Pang Iris K, Iwasaki Akiko, Influenza virus activates inflammasomes via its intracellular M2 ion channel, 10.1038/ni.1861
  55. Koyama S., Ishii K. J., Kumar H., Tanimoto T., Coban C., Uematsu S., Kawai T., Akira S., Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination, 10.4049/jimmunol.179.7.4711
  56. Lund J. M., Alexopoulou L., Sato A., Karow M., Adams N. C., Gale N. W., Iwasaki A., Flavell R. A., Recognition of single-stranded RNA viruses by Toll-like receptor 7, 10.1073/pnas.0400937101
  57. Venkataswamy Manjunatha M., Porcelli Steven A., Lipid and glycolipid antigens of CD1d-restricted natural killer T cells, 10.1016/j.smim.2009.10.003
  58. Pichlmair A., Schulz O., Tan C. P., Naslund T. I., Liljestrom P., Weber F., Reis e Sousa C., RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates, 10.1126/science.1132998
  59. Sabbah Ahmed, Chang Te Hung, Harnack Rosalinda, Frohlich Victoria, Tominaga Kaoru, Dube Peter H, Xiang Yan, Bose Santanu, Activation of innate immune antiviral responses by Nod2, 10.1038/ni.1782
  60. Thomas Paul G., Dash Pradyot, Aldridge Jerry R., Ellebedy Ali H., Reynolds Cory, Funk Amy J., Martin William J., Lamkanfi Mohamed, Webby Richard J., Boyd Kelli L., Doherty Peter C., Kanneganti Thirumala-Devi, The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1, 10.1016/j.immuni.2009.02.006
  61. Yoneyama Mitsutoshi, Kikuchi Mika, Natsukawa Takashi, Shinobu Noriaki, Imaizumi Tadaatsu, Miyagishi Makoto, Taira Kazunari, Akira Shizuo, Fujita Takashi, The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses, 10.1038/ni1087
  62. Wolk Kerstin, Witte Ellen, Witte Katrin, Warszawska Katarzyna, Sabat Robert, Biology of interleukin-22, 10.1007/s00281-009-0188-x
  63. Sonnenberg Gregory F., Nair Meera G., Kirn Thomas J., Zaph Colby, Fouser Lynette A., Artis David, Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A, 10.1084/jem.20092054
  64. Graf Rolf, Schiesser Marc, Reding Theresia, Appenzeller Philippe, Sun Li-Kang, Fortunato Franco, Perren Aurel, Bimmler Daniel, Exocrine Meets Endocrine: Pancreatic Stone Protein and Regenerating Protein—Two Sides of the Same Coin, 10.1016/j.jss.2005.09.030
  65. Gad Hans Henrik, Dellgren Christoffer, Hamming Ole J., Vends Susanne, Paludan Søren R., Hartmann Rune, Interferon-λ Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family, 10.1074/jbc.m109.002923
  66. Diana Julien, Lehuen Agnès, NKT cells: Friend or foe during viral infections? : Highlights, 10.1002/eji.200939800
  67. Kulkarni R. R., Haeryfar S. M., Sharif S., The invariant NKT cell subset in anti-viral defenses: a dark horse in anti-influenza immunity?, 10.1189/jlb.0410191
  68. Wilson Michael T., Singh Avneesh K., Van Kaer Luc, Immunotherapy with ligands of natural killer T cells, 10.1016/s1471-4914(02)02325-0
  69. Hobbs J. A., Cho S., Roberts T. J., Sriram V., Zhang J., Xu M., Brutkiewicz R. R., Selective Loss of Natural Killer T Cells by Apoptosis following Infection with Lymphocytic Choriomeningitis Virus, 10.1128/jvi.75.22.10746-10754.2001
  70. Motsinger Alison, Haas David W., Stanic Aleksandar K., Van Kaer Luc, Joyce Sebastian, Unutmaz Derya, CD1d-restricted Human Natural Killer T Cells Are Highly Susceptible to Human Immunodeficiency Virus 1 Infection, 10.1084/jem.20011712
  71. Bender Armin, Albert Matthew, Reddy Anita, Feldman Mary, Sauter Birthe, Kaplan Gilla, Hellman Wilhelmine, Bhardwaj Nina, The Distinctive Features of Influenza Virus Infection of Dendritic Cells, 10.1016/s0171-2985(98)80078-8
  72. Hao X., Kim T. S., Braciale T. J., Differential Response of Respiratory Dendritic Cell Subsets to Influenza Virus Infection, 10.1128/jvi.02367-07
  73. Manicassamy B., Manicassamy S., Belicha-Villanueva A., Pisanelli G., Pulendran B., Garcia-Sastre A., Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus, 10.1073/pnas.0914994107
  74. Goffic Ronan Le, Balloy Viviane, Lagranderie Micheline, Alexopoulou Lena, Escriou Nicolas, Flavell Richard, Chignard Michel, Si-Tahar Mustapha, Detrimental Contribution of the Toll-Like Receptor (TLR)3 to Influenza A Virus–Induced Acute Pneumonia, 10.1371/journal.ppat.0020053
  75. Poeck Hendrik, Bscheider Michael, Gross Olaf, Finger Katrin, Roth Susanne, Rebsamen Manuele, Hannesschläger Nicole, Schlee Martin, Rothenfusser Simon, Barchet Winfried, Kato Hiroki, Akira Shizuo, Inoue Satoshi, Endres Stefan, Peschel Christian, Hartmann Gunther, Hornung Veit, Ruland Jürgen, Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production, 10.1038/ni.1824
  76. Leite-De-Moraes, J. Immunol., 163, 5871 (1999)
  77. Wesley Johnna D., Tessmer Marlowe S., Chaukos Deanna, Brossay Laurent, NK Cell–Like Behavior of Vα14i NK T Cells during MCMV Infection, 10.1371/journal.ppat.1000106
  78. Colonna Marco, Interleukin-22-Producing Natural Killer Cells and Lymphoid Tissue Inducer-like Cells in Mucosal Immunity, 10.1016/j.immuni.2009.06.008
  79. Brigl Manfred, Brenner Michael B., How invariant natural killer T cells respond to infection by recognizing microbial or endogenous lipid antigens, 10.1016/j.smim.2009.10.006
  80. Spits Hergen, Di Santo James P, The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling, 10.1038/ni.1962
  81. Martin Bruno, Hirota Keiji, Cua Daniel J., Stockinger Brigitta, Veldhoen Marc, Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals, 10.1016/j.immuni.2009.06.020
  82. Simonian Philip L., Wehrmann Fabian, Roark Christina L., Born Willi K., O'Brien Rebecca L., Fontenot Andrew P., γδ T cells protect against lung fibrosis via IL-22, 10.1084/jem.20100061
  83. Sutton Caroline E., Lalor Stephen J., Sweeney Cheryl M., Brereton Corinna F., Lavelle Ed C., Mills Kingston H.G., Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity, 10.1016/j.immuni.2009.08.001
  84. Wahl C., Wegenka U. M., Leithauser F., Schirmbeck R., Reimann J., IL-22-Dependent Attenuation of T Cell-Dependent (ConA) Hepatitis in Herpes Virus Entry Mediator Deficiency, 10.4049/jimmunol.0802810
  85. Aujla Shean J, Chan Yvonne R, Zheng Mingquan, Fei Mingjian, Askew David J, Pociask Derek A, Reinhart Todd A, McAllister Florencia, Edeal Jennifer, Gaus Kristi, Husain Shahid, Kreindler James L, Dubin Patricia J, Pilewski Joseph M, Myerburg Mike M, Mason Carol A, Iwakura Yoichiro, Kolls Jay K, IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia, 10.1038/nm1710
  86. Hoegl Sandra, Bachmann Malte, Scheiermann Patrick, Goren Itamar, Hofstetter Christian, Pfeilschifter Josef, Zwissler Bernhard, Muhl Heiko, Protective Properties of Inhaled IL-22 in a Model of Ventilator-Induced Lung Injury, 10.1165/rcmb.2009-0440oc
  87. Guo H., Topham D. J., Interleukin-22 (IL-22) Production by Pulmonary Natural Killer Cells and the Potential Role of IL-22 during Primary Influenza Virus Infection, 10.1128/jvi.00187-10
  88. Nieuwenhuis Edward E.S., Matsumoto Tetsuya, Lindenbergh Dicky, Willemsen Rob, Kaser Arthur, Simons-Oosterhuis Ytje, Brugman Sylvia, Yamaguchi Keizo, Ishikawa Hiroki, Aiba Yuji, Koga Yasuhiro, Samsom Janneke N., Oshima Kenshiro, Kikuchi Mami, Escher Johanna C., Hattori Masahira, Onderdonk Andrew B., Blumberg Richard S., Cd1d-dependent regulation of bacterial colonization in the intestine of mice, 10.1172/jci36509
  89. Wingender G., Kronenberg M., Role of NKT cells in the digestive system. IV. The role of canonical natural killer T cells in mucosal immunity and inflammation, 10.1152/ajpgi.00437.2007
  90. Tupin Emmanuel, Kinjo Yuki, Kronenberg Mitchell, The unique role of natural killer T cells in the response to microorganisms, 10.1038/nrmicro1657
  91. Dambacher Julia, Beigel Florian, Zitzmann Kathrin, Heeg Malte H.J., Göke Burkhard, Diepolder Helmut M., Auernhammer Christoph J., Brand Stephan, The role of interleukin-22 in hepatitis C virus infection, 10.1016/j.cyto.2007.11.016
  92. Pagliaccetti Nicole E., Chu Esther N., Bolen Christopher R., Kleinstein Steven H., Robek Michael D., Lambda and alpha interferons inhibit hepatitis B virus replication through a common molecular mechanism but with different in vivo activities, 10.1016/j.virol.2010.02.022
  93. Doss M., White M. R., Tecle T., Gantz D., Crouch E. C., Jung G., Ruchala P., Waring A. J., Lehrer R. I., Hartshorn K. L., Interactions of  -,  -, and  -Defensins with Influenza A Virus and Surfactant Protein D, 10.4049/jimmunol.0804049
  94. Klotman Mary E., Chang Theresa L., Defensins in innate antiviral immunity, 10.1038/nri1860
  95. Leikina Eugenia, Delanoe-Ayari Helene, Melikov Kamran, Cho Myoung-Soon, Chen Andrew, Waring Alan J, Wang Wei, Xie Yongming, Loo Joseph A, Lehrer Robert I, Chernomordik Leonid V, Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins, 10.1038/ni1248
  96. Brigl Manfred, Tatituri Raju V.V., Watts Gerald F.M., Bhowruth Veemal, Leadbetter Elizabeth A., Barton Nathaniel, Cohen Nadia R., Hsu Fong-Fu, Besra Gurdyal S., Brenner Michael B., Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection, 10.1084/jem.20102555