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MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival.

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Steed, Emily Elbediwy, Ahmed Vacca, Barbara Dupasquier, Sébastien Hemkemeyer, Sandra A Pierreux, Christophe [UCL] Matter, Karl

MarvelD3 is a transmembrane component of tight junctions, but there is little evidence for a direct involvement in the junctional permeability barrier. Tight junctions also regulate signaling mechanisms that guide cell proliferation; however, the transmembrane components that link the junction to such signaling pathways are not well understood. In this paper, we show that MarvelD3 is a dynamic junctional regulator of the MEKK1-c-Jun NH2-terminal kinase (JNK) pathway. Loss of MarvelD3 expression in differentiating Caco-2 cells resulted in increased cell migration and proliferation, whereas reexpression in a metastatic tumor cell line inhibited migration, proliferation, and in vivo tumor formation. Expression levels of MarvelD3 inversely correlated with JNK activity, as MarvelD3 recruited MEKK1 to junctions, leading to down-regulation of JNK phosphorylation and inhibition of JNK-regulated transcriptional mechanisms. Interplay between MarvelD3 internalization and JNK activation tuned activation of MEKK1 during osmotic stress, leading to junction dissociation and cell death in MarvelD3-depleted cells. MarvelD3 thus couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2014
Language Anglais
Journal information "The Journal of Cell Biology" - Vol. 204, no. 5, p. 821-38 (2014)
Peer reviewed yes
issn 0021-9525
e-issn 1540-8140
Publication status Publié
Affiliation UCL - SSS/DDUV - Institut de Duve
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Bibliographic reference Steed, Emily ; Elbediwy, Ahmed ; Vacca, Barbara ; Dupasquier, Sébastien ; Hemkemeyer, Sandra A ; et. al. MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival.. In: The Journal of Cell Biology, Vol. 204, no. 5, p. 821-38 (2014)
Permanent URL http://hdl.handle.net/2078.1/140928